AutismKB 2.0

Annotation Detail for COMP


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Basic Information Top
Gene Symbol:COMP ( EDM1,EPD1,MED,MGC131819,MGC149768,PSACH,THBS5 )
Gene Full Name: cartilage oligomeric matrix protein
Band: 19p13.11
Quick LinksEntrez ID:1311; OMIM: 600310; Uniprot ID:COMP_HUMAN; ENSEMBL ID: ENSG00000105664; HGNC ID: 2227
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05144Malaria
hsa04350TGF-beta signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
osteoarthritis
No data
Desease Name
Pseudoachondroplasia
Epiphyseal dysplasia, multiple 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of COMP mRNAincreases expression 18648102
D000537 Aluminum Oxide Aluminum Oxide results in increased expression of COMP mRNAincreases expression 19464052
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of COMP mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of COMP mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of COMP mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COMP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMP mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in increased expression of COMP mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COMP mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COMP mRNAincreases expression 20067830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMP mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.3111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.023712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.026695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9520435547
MESH:D001943 Breast Neoplasms Estradiol 1.9519861407 17018787 16675129 18497071 17261762 17289903 14630087 12948864
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.053581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4519486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4517110522 17681005 17333356 15861022 16919318 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 16354765 15340226 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108156756 14531868 11906362 11298694 12868966 18759878 2524372 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.896679447 9022650 18289764 7440962 18692083 9328219 6482804 8291058 11289319 9653073 1440618 18648102 16192314
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.1311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:C535501 Epiphyseal dysplasia, multiple, 1 marker/mechanism 7670472 9887340
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.533581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 8.5417967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2012621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 16354765 8697196 18606429 15340226
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.8718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.8716393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007593 Joint Instability marker/mechanism 9887340
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.20598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2417053015 18816296 6695378 18569708 20135361 20464547 20064080 20869020 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 10.4216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity Dietary Fats 2.3317217161 11836018 20518802 16723640 18674790 18457598 21332399 19632207 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010003 Osteoarthritis marker/mechanism 7670472
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:C535819 Pseudoachondroplasia marker/mechanism 7670471 7670472 9887340
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 3712494 1399818 7505956 6587162
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05144 Malaria
KEGG:04145 Phagosome
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26744
    • No data
    Releated disease ID Related disease Name
    PA445180Osteogenesis Imperfecta
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01373 - Calcium
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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