AutismKB 2.0

Annotation Detail for COMT


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Basic Information Top
Gene Symbol:COMT ( - )
Gene Full Name: catechol-O-methyltransferase
Band: 22q11.21
Quick LinksEntrez ID:1312; OMIM: 116790; Uniprot ID:COMT_HUMAN; ENSEMBL ID: ENSG00000093010; HGNC ID: 2228
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6342noradrenaline and adrenaline degradation
PWY-6334L-dopa degradation
PWY6666-2dopamine degradation
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Synaptic Transmission
Biological oxidations
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
Pathway IDPathway Name
500215Methylation
500157Enzymatic degradation of Dopamine by monoamine oxidase
500156Enzymatic degradation of dopamine by COMT
500155Dopamine clearance from the synaptic cleft
Related Diseases/Disorders Top
No data
No data
Desease Name
obsessive compulsive disorder
ovarian cancer
bipolar disorder
neuroticism
cognitive function
Parkinson's disease
AGING
menarche
CARDIOVASCULAR
Osteoarthritis, Hip
CHEMDEPENDENCY
performance on the Wisconsin Card Sorting Test
menopause
hormone disturbance
skeletal muscle properties
schizotypal traits
aggressive personality traits
Arthralgia
CANCER
PSYCH
Weight Gain
Depression, Postpartum
PHARMACOGENOMIC
alcoholism
breast cancer
hypertension
bipolar affective disorder.
suicide
anorexia nervosa
adenomyosis endometriosis
personality disorders
NEUROLOGICAL
eating disorders
smoking cessation
psychiatric manifestations of velo-cardio-facial syndrome
schizophrenia
prostate carcinoma
METABOLIC
obesity
information processing
REPRODUCTION
psychoses
major depressive disorder
panic disorder
obsessive compusive diorder
sex hormone binding globulin
estradiol
oxidative stress
heroin abuse
No data
Desease Name
Schizophrenia, susceptibility to
Panic disorder, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C433466 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone results in decreased activity of COMT proteindecreases activity 20334432
C433466 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone binds to COMT proteinaffects binding 12584150
C433466 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone results in decreased activity of COMT proteindecreases activity 12584150
C433466 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone COMT protein results in increased methylation of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanoneincreases methylation 12584150
C048152 1-carboxysalsolinol COMT protein results in increased methylation of 1-carboxysalsolinolincreases methylation 11160877
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of COMT mRNAincreases expression 19933214
C053499 2,3-dihydroxynaphthalene COMT protein results in increased methylation of 2,3-dihydroxynaphthaleneincreases methylation 11160877
C053499 2,3-dihydroxynaphthalene COMT protein results in increased methylation of 2,3-dihydroxynaphthaleneincreases methylation 11160877
C475868 2-hydroxy-3-methoxyestradiol COMT protein affects the chemical synthesis of 2-hydroxy-3-methoxyestradiolaffects chemical synthesis 15377160
C001390 2-hydroxyestradiol COMT protein affects the metabolism of 2-hydroxyestradiolaffects metabolic processing 15377160
C001390 2-hydroxyestradiol COMT protein results in increased methylation of 2-hydroxyestradiolincreases methylation 11160877
C001390 2-hydroxyestradiol COMT protein results in increased methylation of 2-hydroxyestradiolincreases methylation 11160877
C001390 2-hydroxyestradiol COMT protein results in increased metabolism of and results in decreased activity of 2-hydroxyestradioldecreases activity|increases metabolic processing 18497090
C022830 2-methoxyestradiol COMT protein affects the chemical synthesis of 2-methoxyestradiolaffects chemical synthesis 15377160
C022830 2-methoxyestradiol COMT protein results in increased chemical synthesis of 2-methoxyestradiolincreases chemical synthesis 15292328
C423629 3,4,5,6-tetrachlorocatechol COMT protein results in increased methylation of 3,4,5,6-tetrachlorocatecholincreases methylation 11160877
C032940 3,4-dihydroxyacetophenone COMT protein results in increased methylation of 3,4-dihydroxyacetophenoneincreases methylation 11160877
C000989 3,4-dihydroxymandelic acid COMT protein results in increased methylation of 3,4-dihydroxymandelic acidincreases methylation 11160877
C066344 3-methoxycatechol COMT protein results in increased methylation of 3-methoxycatecholincreases methylation 11160877
C420684 3-O-methyl-DOPA [entacapone results in decreased activity of COMT protein] which results in decreased abundance of 3-O-methyl-DOPAdecreases abundance|decreases activity 12898346
C420684 3-O-methyl-DOPA [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of 3-O-methyl-DOPAdecreases abundance|decreases activity 10047930
7566641
11248589
12898346
C420684 3-O-methyl-DOPA [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3-O-methyl-DOPAdecreases activity|increases abundance 11432539
C025525 3-O-methylgallic acid COMT protein results in increased methylation of 3-O-methylgallic acidincreases methylation 11160877
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of COMT mRNAaffects expression 21346803
C038861 4-chlorocatechol COMT protein results in increased methylation of 4-chlorocatecholincreases methylation 11160877
C038861 4-chlorocatechol COMT protein results in increased methylation of 4-chlorocatecholincreases methylation 11160877
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of COMT mRNAdecreases expression 12419474
C014036 4-hydroxyestradiol-17 beta COMT protein affects the metabolism of 4-hydroxyestradiol-17 betaaffects metabolic processing 15377160
C014036 4-hydroxyestradiol-17 beta COMT protein results in increased methylation of 4-hydroxyestradiol-17 betaincreases methylation 18192686
C014036 4-hydroxyestradiol-17 beta daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
C014036 4-hydroxyestradiol-17 beta Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
C014036 4-hydroxyestradiol-17 beta Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
C014036 4-hydroxyestradiol-17 beta COMT protein results in increased metabolism of and results in decreased activity of 4-hydroxyestradiol-17 betadecreases activity|increases metabolic processing 18497090
C013074 4-isopropylcatechol COMT protein results in increased methylation of 4-isopropylcatecholincreases methylation 11160877
C013074 4-isopropylcatechol COMT protein results in increased methylation of 4-isopropylcatecholincreases methylation 11160877
C018599 4-methylcatechol COMT protein results in increased methylation of 4-methylcatecholincreases methylation 11160877
C018599 4-methylcatechol COMT protein results in increased methylation of 4-methylcatecholincreases methylation 11160877
C001833 4-nitrocatechol COMT protein results in increased methylation of 4-nitrocatecholincreases methylation 11160877
C001833 4-nitrocatechol COMT protein results in increased methylation of 4-nitrocatecholincreases methylation 11160877
C027802 5-hydroxydopamine COMT protein results in increased methylation of 5-hydroxydopamineincreases methylation 11160877
D000082 Acetaminophen Acetaminophen affects the expression of COMT mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of COMT mRNAdecreases expression 17202762
18246545
D000255 Adenosine Triphosphate [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphatedecreases abundance|decreases activity 14975680
D000255 Adenosine Triphosphate [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphatedecreases abundance|decreases activity 14975680
D012435 S-Adenosylhomocysteine S-Adenosylhomocysteine results in decreased activity of COMT proteindecreases activity 10064789
D012436 S-Adenosylmethionine [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]decreases activity|decreases reaction|increases abundance 16758261
D006710 Homocysteine [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]decreases activity|decreases reaction|increases abundance 16758261
D000643 Ammonium Chloride Ammonium Chloride affects the expression of COMT mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of COMT mRNAincreases expression 12420312
D003913 Dextroamphetamine COMT gene SNP affects the susceptibility to Dextroamphetamineaffects response to substance 12716966
D000661 Amphetamine Amphetamine results in increased expression of COMT mRNAincreases expression 16916582
D000661 Amphetamine COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine]affects reaction|increases abundance 14574438
D001545 Benserazide COMT protein results in increased methylation of Benserazideincreases methylation 11160877
D001545 Benserazide COMT protein results in increased methylation of Benserazideincreases methylation 11160877
C095105 bexarotene bexarotene results in decreased expression of COMT mRNAdecreases expression 16648578
C095105 bexarotene bexarotene results in increased expression of COMT mRNAincreases expression 16648578
C466310 BIA 3-335 BIA 3-335 results in decreased activity of COMT proteindecreases activity 15566291
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of COMT mRNAincreases expression 15912405
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of COMT mRNAdecreases expression 12419474
C040048 caffeic acid COMT protein results in increased methylation of caffeic acidincreases methylation 11160877
D002230 Carbidopa COMT protein results in increased methylation of Carbidopaincreases methylation 11160877
D002230 Carbidopa COMT protein results in increased methylation of Carbidopaincreases methylation 11160877
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of COMT mRNAdecreases expression 16239168
D002259 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT proteindecreases activity 14975680
D002259 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphatedecreases abundance|decreases activity 14975680
C034221 catechol COMT protein results in increased methylation of catecholincreases methylation 11160877
C034221 catechol COMT protein results in increased methylation of catecholincreases methylation 11160877
D002395 Catecholamines Catecholamines inhibits the reaction [COMT protein results in increased methylation of Estradiol]decreases reaction|increases methylation 15292328
D002395 Catecholamines COMT protein affects the metabolism of Catecholaminesaffects metabolic processing 15292328
C023386 chlorinated dibenzofurans [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 15858227
C023386 chlorinated dibenzofurans [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in increased expression of COMT mRNAaffects cotreatment|increases expression 15858227
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of COMT mRNAincreases expression 18812211
D003000 Clonidine Clonidine results in increased expression of COMT mRNAincreases expression 12423672
D003024 Clozapine COMT gene polymorphism results in increased susceptibility to Clozapineincreases response to substance 17123785
D003024 Clozapine COMT protein affects the susceptibility to Clozapineaffects response to substance 17123785
D003024 Clozapine [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]decreases activity|increases abundance|increases reaction 15190105
C004742 daidzein daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
C004742 daidzein daidzein results in decreased activity of COMT proteindecreases activity 18497090
18192686
C004742 daidzein daidzein results in decreased expression of COMT mRNAdecreases expression 18497090
18192686
C004742 daidzein fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18497090
18192686
D003907 Dexamethasone Dexamethasone results in increased expression of COMT mRNAincreases expression 16962226
D003976 Diazinon Diazinon results in decreased expression of COMT mRNAdecreases expression 18812211
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNAaffects cotreatment|increases expression 15784690
D004026 Dieldrin Dieldrin results in increased expression of COMT mRNAincreases expression 18812211
D004041 Dietary Fats Dietary Fats results in decreased expression of COMT mRNAdecreases expression 18042831
D004041 Dietary Fats [Tetrachlorodibenzodioxin co-treated with Dietary Fats] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 20435547
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 18544905
C061532 dihydrexidine COMT protein results in increased methylation of dihydrexidineincreases methylation 11160877
C061532 dihydrexidine COMT protein results in increased methylation of dihydrexidineincreases methylation 11160877
D015102 3,4-Dihydroxyphenylacetic Acid COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acidincreases methylation 11160877
D015102 3,4-Dihydroxyphenylacetic Acid [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 11793163
D015102 3,4-Dihydroxyphenylacetic Acid COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acidincreases methylation 11160877
D015102 3,4-Dihydroxyphenylacetic Acid [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 15190105
16012872
D015102 3,4-Dihydroxyphenylacetic Acid [tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]decreases abundance|decreases activity|increases reaction 12957500
D015102 3,4-Dihydroxyphenylacetic Acid [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 12957500
C010117 dihydroxyphenylethylene glycol COMT protein results in increased methylation of dihydroxyphenylethylene glycolincreases methylation 11160877
D004280 Dobutamine COMT protein results in increased methylation of Dobutamineincreases methylation 11160877
D004280 Dobutamine Dobutamine results in increased expression of COMT mRNAincreases expression 12423672
D007980 Levodopa COMT protein results in increased methylation of Levodopaincreases methylation 11160877
D007980 Levodopa [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]decreases activity|decreases reaction|increases abundance 16758261
D007980 Levodopa [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]decreases activity|decreases reaction|increases abundance 16758261
D007980 Levodopa [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopadecreases activity|increases abundance 11432539
9333106
10047930
10872643
10809409
12898346
D007980 Levodopa COMT protein results in increased methylation of Levodopaincreases methylation 11160877
D007980 Levodopa Levodopa binds to COMT proteinaffects binding 12584150
D004298 Dopamine COMT protein results in increased methylation of Dopamineincreases methylation 11160877
D004298 Dopamine [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 12898346
D004298 Dopamine [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 7566641
12898346
11248589
D004298 Dopamine COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine]affects reaction|increases abundance 14574438
D004298 Dopamine COMT protein results in increased methylation of Dopamineincreases methylation 11160877
D004298 Dopamine [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]decreases activity|increases abundance|increases reaction 15190105
D004391 Dust Dust results in decreased expression of COMT mRNAdecreases expression 17805423
C071192 entacapone [entacapone results in decreased activity of COMT protein] which results in decreased abundance of 3-O-methyl-DOPAdecreases abundance|decreases activity 12898346
C071192 entacapone [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 12898346
C071192 entacapone entacapone results in decreased activity of COMT proteindecreases activity 15566291
20334432
C071192 entacapone entacapone binds to COMT proteinaffects binding 19783845
C071192 entacapone entacapone results in decreased activity of COMT proteindecreases activity 20334432
19783845
C071192 entacapone entacapone results in decreased activity of COMT proteindecreases activity 19198095
D004837 Epinephrine COMT protein results in increased methylation of Epinephrineincreases methylation 11160877
D004837 Epinephrine [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrinedecreases activity|increases abundance 11248589
D004837 Epinephrine COMT protein results in increased methylation of Epinephrineincreases methylation 10064789
D004837 Epinephrine [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrineincreases abundance|increases methylation 8821542
10064789
D004837 Epinephrine tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]decreases reaction|increases abundance|increases methylation 8821542
C007628 esculetin COMT protein results in increased methylation of esculetinincreases methylation 11160877
D004958 Estradiol COMT protein polymorphism results in decreased abundance of Estradiol analogdecreases abundance 15288375
D004958 Estradiol Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
D004958 Estradiol Estradiol results in decreased activity of COMT proteindecreases activity 18192686
18497090
D004958 Estradiol Estradiol results in decreased expression of COMT mRNAdecreases expression 18497090
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18497090
18192686
D004958 Estradiol Catecholamines inhibits the reaction [COMT protein results in increased methylation of Estradiol]decreases reaction|increases methylation 15292328
D004958 Estradiol COMT protein results in increased metabolism of and results in decreased activity of Estradioldecreases activity|increases metabolic processing 18566989
D004958 Estradiol COMT protein results in increased methylation of Estradiolincreases methylation 15292328
D004967 Estrogens COMT gene polymorphism affects the metabolism of Estrogensaffects metabolic processing 15777990
D004967 Estrogens COMT protein affects the metabolism of Estrogensaffects metabolic processing 15987428
D004967 Estrogens Estrogens results in decreased expression of COMT proteindecreases expression 17138778
D002393 Estrogens, Catechol COMT protein polymorphism results in decreased metabolism of Estrogens, Catecholdecreases metabolic processing 15288375
D002393 Estrogens, Catechol COMT protein results in increased methylation of and results in decreased activity of Estrogens, Catecholdecreases activity|increases methylation 15455371
D002393 Estrogens, Catechol COMT protein results in increased metabolism of and results in decreased activity of Estrogens, Catecholdecreases activity|increases metabolic processing 18566989
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNAaffects cotreatment|increases expression 17942748
C017875 fisetin [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 proteinaffects cotreatment|decreases activity 16037419
C070081 fulvestrant fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18497090
18192686
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18192686
18497090
C070081 fulvestrant fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18192686
18497090
D019833 Genistein fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA]decreases expression|decreases reaction 18192686
18497090
D019833 Genistein Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol-17 beta]decreases reaction|increases methylation 18192686
D019833 Genistein Genistein results in decreased activity of COMT proteindecreases activity 18192686
18497090
D019833 Genistein Genistein results in decreased expression of COMT mRNAdecreases expression 18497090
18192686
D006719 Homovanillic Acid [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 11793163
D006719 Homovanillic Acid [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 16012872
15190105
C029424 hydrazine hydrazine results in decreased expression of COMT proteindecreases expression 15370871
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of COMT mRNAdecreases expression 12419474
D016627 Oxidopamine COMT protein results in increased methylation of Oxidopamineincreases methylation 11160877
D007545 Isoproterenol COMT protein results in increased methylation of Isoproterenolincreases methylation 11160877
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 18544905
C067713 lactacystin lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]decreases reaction|increases expression 17138778
C035420 levodopa methyl ester COMT protein results in increased methylation of levodopa methyl esterincreases methylation 11160877
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 results in increased activity of COMT proteinincreases activity 17573159
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of COMT proteinincreases expression 17573159
D019290 Megestrol Acetate Megestrol Acetate results in increased expression of COMT proteinincreases expression 16939895
D008676 Metanephrine [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrineincreases abundance|increases methylation 8821542
10064789
D008676 Metanephrine tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]decreases reaction|increases abundance|increases methylation 8821542
D008694 Methamphetamine COMT gene polymorphism affects the susceptibility to Methamphetamineaffects response to substance 19462300
D008727 Methotrexate Methotrexate results in increased expression of COMT mRNAincreases expression 15120968
D008750 Methyldopa COMT protein results in increased methylation of Methyldopaincreases methylation 11160877
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]decreases abundance|decreases activity|increases reaction 12957500
C040015 myricetin [myricetin co-treated with COMT protein] results in decreased activity of DNMT1 proteinaffects cotreatment|decreases activity 16037419
D009532 Nickel Nickel results in decreased expression of COMT mRNAdecreases expression 18812211
C506350 nitrocatechol COMT protein results in increased methylation of nitrocatechol analogincreases methylation 11160877
D009638 Norepinephrine COMT protein results in increased methylation of Norepinephrineincreases methylation 11160877
D009638 Norepinephrine [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrinedecreases activity|increases abundance 11248589
C076029 olanzapine olanzapine results in increased expression of COMT mRNAincreases expression 15964593
C057726 OR486 OR486 binds to COMT proteinaffects binding 12584150
C057726 OR486 OR486 results in decreased activity of COMT proteindecreases activity 12584150
10064789
C057726 OR486 OR486 results in decreased activity of COMT proteindecreases activity 15507517
15292328
C041786 palm oil palm oil results in decreased expression of COMT mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of COMT mRNAincreases expression 17935786
D010634 Phenobarbital Phenobarbital results in decreased expression of COMT mRNAdecreases expression 16510358
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of COMT mRNAaffects expression 17651324
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COMT mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of COMT mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in decreased expression of COMT mRNAdecreases expression 16940010
D028321 Plant Preparations COMT gene polymorphism affects the susceptibility to Plant Preparationsaffects response to substance 17602170
D011078 Polychlorinated Biphenyls [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 15858227
D011078 Polychlorinated Biphenyls [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in increased expression of COMT mRNAaffects cotreatment|increases expression 15858227
C008954 polychlorodibenzo-4-dioxin [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 15858227
C008954 polychlorodibenzo-4-dioxin [Polychlorinated Biphenyls co-treated with polychlorodibenzo-4-dioxin co-treated with chlorinated dibenzofurans] results in increased expression of COMT mRNAaffects cotreatment|increases expression 15858227
D011374 Progesterone Progesterone results in decreased expression of COMT proteindecreases expression 17138778
C009091 protocatechuic acid COMT protein results in increased methylation of protocatechuic acidincreases methylation 11160877
C009091 protocatechuic acid COMT protein results in increased methylation of protocatechuic acidincreases methylation 11160877
D011748 Pyrogallol COMT protein results in increased methylation of Pyrogallolincreases methylation 11160877
D011794 Quercetin [Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 proteinaffects cotreatment|decreases activity 16037419
D011794 Quercetin Quercetin results in decreased activity of COMT proteindecreases activity 15507517
D018967 Risperidone Risperidone results in increased expression of COMT mRNAincreases expression 15964593
D013629 Tamoxifen COMT protein affects the metabolism of Tamoxifenaffects metabolic processing 15288375
C038096 tert-butylcatechol COMT protein results in increased methylation of tert-butylcatecholincreases methylation 11160877
C038096 tert-butylcatechol COMT protein results in increased methylation of tert-butylcatecholincreases methylation 11160877
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of COMT mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Dietary Fats] results in decreased expression of COMT mRNAaffects cotreatment|decreases expression 20435547
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COMT mRNAincreases expression 19933214
18796159
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine COMT protein results in increased methylation of 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineincreases methylation 11160877
C066340 tolcapone tolcapone results in decreased activity of COMT proteindecreases activity 11793426
16758261
7768073
11248589
11432539
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]decreases activity|decreases reaction|increases abundance 16758261
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]decreases activity|decreases reaction|increases abundance 16758261
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of 3-O-methyl-DOPAdecreases abundance|decreases activity 10047930
11248589
7566641
12898346
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphatedecreases abundance|decreases activity 14975680
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 11793163
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 11793163
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3-O-methyl-DOPAdecreases activity|increases abundance 11432539
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 7566641
11248589
12898346
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrinedecreases activity|increases abundance 11248589
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopadecreases activity|increases abundance 11432539
9333106
10809409
12898346
10047930
10872643
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrinedecreases activity|increases abundance 11248589
C066340 tolcapone tolcapone results in decreased activity of COMT proteindecreases activity 15566291
20334432
C066340 tolcapone COMT protein results in increased methylation of tolcaponeincreases methylation 12584150
C066340 tolcapone tolcapone binds to COMT proteinaffects binding 19783845
C066340 tolcapone tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]decreases reaction|increases abundance|increases methylation 8821542
C066340 tolcapone tolcapone results in decreased activity of COMT proteindecreases activity 20334432
19783845
15190105
16012872
10064789
2089102
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]decreases activity|increases abundance|increases reaction 15190105
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 15190105
16012872
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 15190105
16012872
C066340 tolcapone tolcapone results in decreased activity of COMT proteindecreases activity 12957500
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]decreases abundance|decreases activity|increases reaction 12957500
C066340 tolcapone [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases activity|increases abundance 12957500
C066340 tolcapone tolcapone results in decreased activity of COMT proteindecreases activity 10651109
1977408
D014334 Tropolone Tropolone results in decreased activity of COMT proteindecreases activity 10064789
C025643 vinclozolin vinclozolin affects the expression of COMT mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 13.027525203
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 13.0212039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.026195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.0215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.6518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 3.939612607
MESH:D055371 Acute Lung Injury Nickel 6.4316166738
MESH:D055371 Acute Lung Injury pirinixic acid 6.4318653653
MESH:D000230 Adenocarcinoma daidzein 7.2811473722
MESH:D000230 Adenocarcinoma Estradiol 7.2811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2814692618
MESH:D000230 Adenocarcinoma Genistein 7.2811473722
MESH:D000236 Adenoma Diethylnitrosamine 2.266695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.4519061943 19052882 16434500 18056438 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.4517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4516835633
MESH:D000303 Adrenal Cortex Diseases Catecholamines 6.396895166
MESH:D000380 Agranulocytosis Clozapine 4.1614617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.3611874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.3616487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 9.3611874814
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.3611080934
MESH:D000544 Alzheimer Disease entacapone 4.1720150427
MESH:D000544 Alzheimer Disease tolcapone 4.1720150427
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.1416459022 16916582 18475255 15010207
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.4610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1411748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.4117084956
MESH:D000799 Angioedema Acetaminophen 2.9110982225
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 8.1712183048
MESH:D000855 Anorexia Amphetamine 8.1716101753 16084549 12183048 12005258
MESH:D001008 Anxiety Disorders vinclozolin 2.8819015723
MESH:D001161 Arteriosclerosis Dietary Fats 6.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 6.9511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 5.2317659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.2315885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 2.8117286800
MESH:D020817 Asperger Syndrome Risperidone 4.6916401163
MESH:D001260 Ataxia Telangiectasia Quercetin 4.0615336622
MESH:D001284 Atrophy fulvestrant 3.9711514358
MESH:D001289 Attention Deficit Disorder with Hyperactivity marker/mechanism 10490706
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 6.8014699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 6.8018349709
MESH:D001321 Autistic Disorder marker/mechanism 16917939
MESH:D001321 Autistic Disorder Acetaminophen 4.4118445737
MESH:D001321 Autistic Disorder Homocysteine 4.4116297937 20468076
MESH:D001321 Autistic Disorder Norepinephrine 4.418570775
MESH:D001321 Autistic Disorder olanzapine 4.4117069543 18685284
MESH:D001321 Autistic Disorder Risperidone 4.4118026891 15492353 15994720 19368416 16239862 16379507 19013209 19232924 16948927 17929164 19154706 17069546 16730335 15930063 16601648 17019624 18349709 18775368 15543515 18278980 18080171
MESH:D001321 Autistic Disorder S-Adenosylhomocysteine 4.4116917939 20468076
MESH:D001321 Autistic Disorder S-Adenosylmethionine 4.4116917939 19056591
MESH:D001327 Autoimmune Diseases Quercetin 3.5219761891
MESH:D001714 Bipolar Disorder Risperidone 3.9618278980 19154706
MESH:D001778 Blood Coagulation Disorders pirinixic acid 6.0119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.0112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1015746008
MESH:D001919 Bradycardia Isoproterenol 4.286740701
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.4017868700
MESH:D001930 Brain Injuries Progesterone 3.3715845082 15380490 15665606
MESH:D001943 Breast Neoplasms marker/mechanism 9407957 15455371 16077979
MESH:D001943 Breast Neoplasms 2-hydroxyestradiol 15.3816675129
MESH:D001943 Breast Neoplasms 2-methoxyestradiol 15.3815219808 18223236
MESH:D001943 Breast Neoplasms 4-hydroxyestradiol-17 beta 15.3816675129
MESH:D001943 Breast Neoplasms bexarotene 15.3816818667 16344269
MESH:D001943 Breast Neoplasms Dieldrin 15.3815770527 11859874
MESH:D001943 Breast Neoplasms Dietary Fats 15.3820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 15.3817474063
MESH:D001943 Breast Neoplasms Estradiol 15.3814630087 12948864 19861407 16675129 18497071 17018787 17261762 17289903
MESH:D001943 Breast Neoplasms Estrogens, Catechol 15.3817261777
MESH:D001943 Breast Neoplasms fulvestrant 15.3818984771
MESH:D001943 Breast Neoplasms Genistein 15.3816541309 16873071 17200150
MESH:D001943 Breast Neoplasms Methotrexate 15.3816978400
MESH:D001943 Breast Neoplasms Nickel 15.3815986119
MESH:D001943 Breast Neoplasms Plant Preparations 15.3817398067
MESH:D001943 Breast Neoplasms Progesterone 15.3817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Quercetin 15.3818628248
MESH:D001943 Breast Neoplasms Tamoxifen 15.3819142967 15668708 19103187 19288272 18351453 17261762 18855134 19115204 16202921 11161223 19244106 15565566 18984771 19189210 17049068 19221464 17242785 19200415 18425577 18815881 16873071 20544844 19289846 20135344 19059307 19011961 21138602 19155303 19410462 19189212 20859285 17893378 20065188 19084267 16273361 18629630 18997820 21152245 18821012 20390343 16818667 19066611 17440819 20005174 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 15.3820435547
MESH:D002105 Cadmium Poisoning Quercetin 4.6116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.893786805 16097048 10355542 16124888 15721981 16011737 15700767 16050911 15673190 16192424 16227642 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6119066611
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 15341023
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.753084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.7518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 14.7518494052 19701751 16779866 16878318 19822196 18788625 16569478 19919837 18665156 18506893 20512989 16935385 19107877 17978847 20727157 19171122 16328049 17138121 10737359 17055752 18056438 20214788 20101231 17173139 16681979 16288022 16502159 20514400 20524982 10672840 19418558 17761372 19383236 18210153 20432363 18393292 21159647 19335982 16830150 19519916 11831363 19539802 16540662 17428255 18971187 3581430 17162532 3084413 20007298 16807293 19208518 20935162 18978308 19052882 18691550 18785209 16698587 20084675 19394651
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.7516924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 14.7515341023
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.7516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.7520935162 20007298 6705139 1701930 17173139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 14.7512508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.7516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 2.8216247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.0617234771
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 3.3117418620
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.8017572228
MESH:D006332 Cardiomegaly Isoproterenol 11.4811179087 7544033
MESH:D006332 Cardiomegaly Norepinephrine 11.4811179087
MESH:D006332 Cardiomegaly Quercetin 11.4819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.4816120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases daidzein 11.7616332659
MESH:D002318 Cardiovascular Diseases Genistein 11.7616332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.7616936243
MESH:D002318 Cardiovascular Diseases Plant Preparations 11.7616862667
MESH:D016893 Carotid Stenosis Plant Preparations 5.2215158307
MESH:D002375 Catalepsy Norepinephrine 4.638216760
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 8.9514694615
MESH:D002386 Cataract Acetaminophen 8.9510977129
MESH:D002386 Cataract Adenosine Triphosphate 8.9515003327
MESH:D002389 Catatonia olanzapine 5.3216772815 18071103
MESH:D002471 Cell Transformation, Neoplastic 4-hydroxyestradiol-17 beta 7.4918226522 18566989
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.492727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.364080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.6719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.6716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 5.3317110522 17333356 15861022 16919318 11677210 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 5.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.6316354765 8697196 12621046 15340226 15668235
MESH:D003072 Cognition Disorders marker/mechanism 17123785
MESH:D003072 Cognition Disorders Clozapine 4.0717123785
MESH:D003110 Colonic Neoplasms Dexamethasone 4.2915824018
MESH:D003110 Colonic Neoplasms Genistein 4.2917182828
MESH:D003110 Colonic Neoplasms Quercetin 4.2915741050 17191121 19440933 16640504 11134977 19056647 17148506
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.6115531428
MESH:D015179 Colorectal Neoplasms Quercetin 2.6118095365 18852136
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 6.5415095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 6.5417141729 14669216
MESH:D003324 Coronary Artery Disease Homocysteine 5.3116379339
MESH:D003324 Coronary Artery Disease Plant Preparations 5.3115158307
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.9917728286
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.999562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9920055451 10048152 15322242
MESH:D016638 Critical Illness Estrogens 5.0316670151
MESH:D003456 Cryptorchidism vinclozolin 3.4614966744
MESH:D003550 Cystic Fibrosis Methotrexate 3.4419747007
MESH:D016757 Death, Sudden, Cardiac Risperidone 4.6920210726
MESH:D003704 Dementia Polychlorinated Biphenyls 7.8216140633
MESH:D003704 Dementia Risperidone 7.8211575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.4619031437
MESH:D003866 Depressive Disorder entacapone 6.417768276
MESH:D003866 Depressive Disorder tolcapone 6.417768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.1010440460
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 4.6412438553
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.6417100760 17244072 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9118249437
MESH:D003877 Dermatitis, Contact Nickel 3.792952479
MESH:D003882 Dermatomyositis Methotrexate 4.2520191521
MESH:D002658 Developmental Disabilities olanzapine 4.0117069543
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 2.9719496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 9.9016402076
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 9.9016647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.9020387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.9016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.9017107852
MESH:D003928 Diabetic Nephropathies Estradiol 6.2019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 6.2019279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.6017187935
MESH:D003967 Diarrhea Dexamethasone 2.867237001
MESH:D004062 DiGeorge Syndrome marker/mechanism
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.3615331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.3616379507
MESH:D053207 Diurnal Enuresis Risperidone 5.7417822346
MESH:D004314 Down Syndrome Risperidone 4.3518349709
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.5721346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5712594235 14550746 16109766 14986274 19164858 10915739 16081117 19739265 15968718 19416960 16485898 11461765 16177239 18071297 17562736 10663392 19085960 17906064 16393943 17522070 19370779 11529661 18713872 11834606 10774834 12705907 19923254 16227642 2444490 14725611 12540782 11287661 15619225 16781746 12153990 11421492 19420014 12958197 11739529 11743745 12392966
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.5715968718 6884620 19085960 15998439 21278145 3786805 9327722 19336974 16227642 11566570 4309450 15027814 10915739 10092053 7120509 7179309 16177239 2869522 3732212 7440962 6623471 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5719107877
MESH:D056486 Drug-Induced Liver Injury entacapone 12.5719783845
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5720420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 12.5719783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.1719426721
MESH:D004362 Drug Toxicity Lamivudine 13.7615040536
MESH:D004362 Drug Toxicity Plant Preparations 13.7611033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.7611462148
MESH:D004362 Drug Toxicity Zidovudine 13.7615040536
MESH:D004409 Dyskinesia, Drug-Induced Levodopa 9.5115893579 3690436
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 9.5111455177
MESH:D050171 Dyslipidemias Clozapine 6.4816402076
MESH:D050171 Dyslipidemias Dietary Fats 6.4818367378
MESH:D004417 Dyspnea Diazinon 3.8816487989
MESH:D004421 Dystonia Phenobarbital 3.151851702
MESH:D004485 Eczema Dexamethasone 3.5912438553
MESH:D004487 Edema Dexamethasone 6.7519703484
MESH:D004487 Edema pirinixic acid 6.7512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 2.9718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.3112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.3117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3119031437
MESH:D004714 Endometrial Hyperplasia Genistein 3.6816402032
MESH:D016889 Endometrial Neoplasms daidzein 16.3311473722
MESH:D016889 Endometrial Neoplasms Estradiol 16.3319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Estrogens, Catechol 16.3318566989
MESH:D016889 Endometrial Neoplasms Genistein 16.3311473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.3319155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 6.2316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.239294722 10568697
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 4.6812954792
MESH:D004751 Enteritis Clonidine 5.208982514
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.223659116
MESH:D004828 Epilepsies, Partial Phenobarbital 2.953922381 11558140
MESH:D004827 Epilepsy Epinephrine 8.10821787
MESH:D004827 Epilepsy Norepinephrine 8.10821787
MESH:D004827 Epilepsy Phenobarbital 8.1020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 2.756401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.113659116
MESH:D007172 Erectile Dysfunction daidzein 4.1514972507
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.1816302075
MESH:D004938 Esophageal Neoplasms Plant Preparations 3.3016510608
MESH:D017889 Exfoliation Syndrome Homocysteine 4.7916504073
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 11.6219578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 11.6219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.2811564622
MESH:D005221 Fatigue Amphetamine 4.6919890266
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.4316239168 17595544 61145 15959796 19224547 12795759 12631006 16045604
MESH:D005234 Fatty Liver Dietary Fats 24.4319551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 24.4321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.4315345470
MESH:D005234 Fatty Liver pirinixic acid 24.4320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 24.4319224547 14986274
MESH:D005234 Fatty Liver Zidovudine 24.4318299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.5611858732
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 4.4016997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.2719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.9318705752
MESH:D005355 Fibrosis Dietary Fats 13.9318296743
MESH:D005355 Fibrosis Quercetin 13.9319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9320067830
MESH:D005756 Gastritis Acetaminophen 2.7516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.3716417039
MESH:D005901 Glaucoma Homocysteine 4.4316504073
MESH:D005909 Glioblastoma Genistein 8.2916598420
MESH:D005909 Glioblastoma myricetin 8.2919804834
MESH:D005909 Glioblastoma Quercetin 8.2919804834
MESH:D005910 Glioma Quercetin 2.6017643826
MESH:D005911 Gliosis Paraquat 4.2311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.6610696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.2516518429
MESH:D034381 Hearing Loss marker/mechanism 19898482
MESH:D006330 Heart Defects, Congenital Homocysteine 8.1719638421
MESH:D006330 Heart Defects, Congenital polychlorodibenzo-4-dioxin 8.1711294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.1710048152 11294989
MESH:D006333 Heart Failure Dobutamine 8.3717440445
MESH:D006333 Heart Failure Isoproterenol 8.3718097624
MESH:D006333 Heart Failure pirinixic acid 8.3720558911
MESH:D006402 Hematologic Diseases Zidovudine 3.8612579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 6.7319110552 19900420
MESH:D006505 Hepatitis Diazinon 6.7316487989
MESH:D006509 Hepatitis B Lamivudine 4.2617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.2616476009 12044531 15631357 15309715 15274664
MESH:D006521 Hepatitis, Chronic Methyldopa 5.7414986274
MESH:D006529 Hepatomegaly Phenobarbital 9.2816109766
MESH:D006529 Hepatomegaly pirinixic acid 9.2818467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.2812621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.657520565
MESH:D006558 Herpes Genitalis Estradiol 4.1015709030
MESH:D015658 HIV Infections Lamivudine 7.7011141242 20032539 9296927 17530837
MESH:D015658 HIV Infections Nickel 7.7017263646
MESH:D015658 HIV Infections Zidovudine 7.7011363243 11698656 17358032 20032539 11141242
MESH:D019584 Hot Flashes Estradiol 2.8317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1116959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 1.9616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.6216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 2.7721332399
MESH:D006943 Hyperglycemia pirinixic acid 11.1220558911
MESH:D006943 Hyperglycemia Quercetin 11.1211834736 18262572
MESH:D006943 Hyperglycemia Risperidone 11.1218278980
MESH:D020138 Hyperhomocysteinemia Homocysteine 7.6317369066 18234410 17292331
MESH:D020138 Hyperhomocysteinemia Levodopa 7.6316787708 16275827
MESH:D006948 Hyperkinesis Amphetamine 19.9714960337 1977408
MESH:D006948 Hyperkinesis Clozapine 19.9716046005
MESH:D006948 Hyperkinesis dihydrexidine 19.9714960337
MESH:D006948 Hyperkinesis Methamphetamine 19.9717658665
MESH:D006949 Hyperlipidemias Dietary Fats 2.7721332399
MESH:D006963 Hyperphagia olanzapine 5.3117933447
MESH:D006973 Hypertension daidzein 8.6017169123
MESH:D006973 Hypertension Dexamethasone 8.6017042910
MESH:D006973 Hypertension Quercetin 8.6018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.1915338365
MESH:D046110 Hypertension, Pregnancy-Induced Clonidine 5.2716612254
MESH:D006984 Hypertrophy Isoproterenol 4.3612791704
MESH:D007021 Hypospadias Ethinyl Estradiol 2.9116569931 16945680
MESH:D007022 Hypotension Dopamine 14.896740701
MESH:D007022 Hypotension Epinephrine 14.896740701
MESH:D007022 Hypotension Isoproterenol 14.896740701
MESH:D007022 Hypotension Norepinephrine 14.896740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.5115869954
MESH:D007247 Infertility, Female Dieldrin 7.4610630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 7.4612013081
MESH:D007248 Infertility, Male Diazinon 13.9912948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.9917937319
MESH:D007248 Infertility, Male fulvestrant 13.9911514358
MESH:D007248 Infertility, Male Paraquat 13.994850670
MESH:D007248 Infertility, Male vinclozolin 13.9916467254
MESH:D007249 Inflammation Dexamethasone 15.478960868 11099482
MESH:D007249 Inflammation Dietary Fats 15.4720412841
MESH:D007249 Inflammation Diethylnitrosamine 15.4718785209
MESH:D007249 Inflammation Nickel 15.4716166738
MESH:D007249 Inflammation Progesterone 15.4715869954
MESH:D007249 Inflammation Tamoxifen 15.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.4712878042 12200463
MESH:D007251 Influenza, Human Quercetin 3.5816624496
MESH:D007333 Insulin Resistance Dietary Fats 8.4118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 8.4116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 8.4116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.5016580747
MESH:D007627 Keloid Quercetin 4.0617086741
MESH:D007674 Kidney Diseases Acetaminophen 6.5315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.5315618244
MESH:D007674 Kidney Diseases Quercetin 6.5316962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.4416518626
MESH:D007680 Kidney Neoplasms Estradiol 8.0815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0818625569
MESH:D007680 Kidney Neoplasms Zidovudine 8.0812579204
MESH:D007805 Language Development Disorders Methotrexate 4.249562676
MESH:D007938 Leukemia Genistein 4.7018980019 17468513
MESH:D007938 Leukemia Quercetin 4.7017468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 3.5820370541
MESH:D007984 Leydig Cell Tumor vinclozolin 3.8216417039
MESH:D008064 Lipidoses Clozapine 5.7217567588
MESH:D008064 Lipidoses Tamoxifen 5.7217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.4011408273 11903743 16239168 17334410 16943688 17174718 17157831 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 14.4018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.4018665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Methotrexate 14.4014986274
MESH:D008103 Liver Cirrhosis Phenobarbital 14.4021047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.5718166357 16097048 14724832 13678700 17823541 16011737 14748882 17640975 16116963 16027843 15057751 14716833 18472332 18429990 14716496 12741479 15650968 12667390 11481614 12632512 15893842 17761835 18481824 15123356 18317297 15876570 17944888 18205269 18705752 12609069 20821823 10355542 16015684 17525996 12666154 12958196 17565644 18418968 18277467 17766677 15931870 15362042 12445418 17631135 12546737 17721639 18395914 15818738 16248980 18279442 18210741 18395095 17922224 18156304 17805973 16192424 14620537 17708605 15338365 15996030 18412020 12445421 16638106 17900296 16136751 15959796 17869086 18187930 18054572 17976157 18006644 15052691 17481882 16033810 18251166 12586293 15925388 18339082 12649538 18420326 12632514 18263696 12898905 17698563 17557913 18472094 15673190 17714472 18376398 12389079 15370692 14512876 15730626
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 13.5716718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.5714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 13.5717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 13.5717724770
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 13.5712741479
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 13.5715983038
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.5718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.5712878042
MESH:D008107 Liver Diseases Acetaminophen 8.6612969438 16610002 19014921 12587719 19460945 11587558 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6616246199 16964402 15720792 15830285 17285989
MESH:D008107 Liver Diseases Chlorpyrifos 8.6615991261
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6617034775
MESH:D008107 Liver Diseases Phenobarbital 8.6619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 6.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 6.7016899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.6919294768
MESH:D008113 Liver Neoplasms Dieldrin 17.699539021 8742319
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.699163691 19255062 18754104 2862719 21047994 21071580 18644402 16942905 19833225 2422723 19256749 19642983 19690152 20501860 20405173 15885732 20492335 18978307 10737359 21167192 19812893 19850985 19638242 18977376 19294768 19073162 19499222 20583210 21278145 19427195 12112319 19551842 19426721 20118626 20452335 20101389 12771043 15175105 20137499 20434301 19996281 19254457 19090486 18648771
MESH:D008113 Liver Neoplasms Phenobarbital 17.6919812893 19482888 15975961 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 17.6920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 17.6918980244
MESH:D008113 Liver Neoplasms Tamoxifen 17.6916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.6916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.4212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.4217942915 18544905 3124819 19539802 18093689 16267830 19004024 19009564 18164116 18775883 17854601 18079962 19519916 19126423 18282651 9362446 21159647 18308698 16842330 17174075 2563599 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 18.4218544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.421399818 18308698 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 18.421423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.4219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.4212151625
MESH:D008133 Long QT Syndrome Dobutamine 6.6719353679
MESH:D008133 Long QT Syndrome olanzapine 6.6720210726
MESH:D008171 Lung Diseases Dobutamine 3.8716638327
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.0918516814
MESH:D008175 Lung Neoplasms bexarotene 7.6217849452
MESH:D008175 Lung Neoplasms Dexamethasone 7.6215824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.6220512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Quercetin 7.6216280456
MESH:D008175 Lung Neoplasms Tamoxifen 7.6218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.6211884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 7.6218800350
MESH:D008223 Lymphoma Methotrexate 3.2617352296
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.2511161223
MESH:D015674 Mammary Neoplasms, Animal marker/mechanism 18424824
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.8619428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 11.8919196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.8917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 11.8914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.8917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.8919196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Estradiol 9.5619453300
MESH:D020149 Manganese Poisoning Tamoxifen 9.5619453300
MESH:D008545 Melanoma Tamoxifen 1.7419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.2715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.6719513568
MESH:D008591 Meningomyelocele Homocysteine 4.6416602021
MESH:D001523 Mental Disorders Clozapine 8.3816856516
MESH:D001523 Mental Disorders olanzapine 8.3816856516
MESH:D001523 Mental Disorders Risperidone 8.3816856516 16596465
MESH:D008607 Mental Retardation Risperidone 3.7018349709
MESH:D008659 Metabolic Diseases olanzapine 4.5519142110
MESH:D024821 Metabolic Syndrome X Clozapine 7.5919142101
MESH:D024821 Metabolic Syndrome X Risperidone 7.5919142101
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 4.9017358032
MESH:D019964 Mood Disorders Risperidone 4.9317019624
MESH:D009041 Motion Sickness Dextroamphetamine 4.591613127
MESH:D009062 Mouth Neoplasms Plant Preparations 4.0317418620
MESH:D052016 Mucositis Methotrexate 4.3717488658
MESH:D009101 Multiple Myeloma Dexamethasone 2.8215867202 15744524 16118317
MESH:D009135 Muscular Diseases pirinixic acid 2.6216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 2.949809623
MESH:D009203 Myocardial Infarction Genistein 12.6317141266
MESH:D009203 Myocardial Infarction Homocysteine 12.6317412321
MESH:D009203 Myocardial Infarction Isoproterenol 12.6315740881 19595682 19172585 16584858 16697266 16538859 17052832
MESH:D009203 Myocardial Infarction pirinixic acid 12.6319151258
MESH:D009203 Myocardial Infarction Quercetin 12.6319595682
MESH:D017202 Myocardial Ischemia Dobutamine 6.8512447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 18.8016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 18.8017141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 18.8015642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 18.8016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 18.8019207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.5617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.139029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.1319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1219410462
MESH:D009369 Neoplasms Dieldrin 5.268820588
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Quercetin 5.2615185748
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 7.8619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 7.8619189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 2.8317289903
MESH:D009410 Nerve Degeneration Paraquat 2.9816893418
MESH:D009421 Nervous System Malformations Estradiol 11.3416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 11.3416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.3414600291
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 18.2412349958
MESH:D019636 Neurodegenerative Diseases Acetaminophen 18.2418514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 18.2415183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 18.2420387270
MESH:D019636 Neurodegenerative Diseases Oxidopamine 18.2418514411
MESH:D020078 Neurogenic Inflammation Quercetin 3.5117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.1820387270
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.6916725203
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 6.6915081274
MESH:D053206 Nocturnal Enuresis Risperidone 5.4017822346
MESH:D009765 Obesity Clozapine 7.8119142110 18515891
MESH:D009765 Obesity Dietary Fats 7.8119632207 16723640 18674790 20132043 21332399 18457598 17217161 11836018 20518802
MESH:D009765 Obesity olanzapine 7.8118515891
MESH:D009765 Obesity pirinixic acid 7.8120558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.2914694615
MESH:D010018 Osteomalacia Phenobarbital 3.4517016548
MESH:D010024 Osteoporosis Genistein 2.6319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 7.3116169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 7.3119495926
MESH:D010051 Ovarian Neoplasms Estradiol 7.9119401270
MESH:D010051 Ovarian Neoplasms Genistein 7.9119005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.9116525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 7.9119005980
MESH:D010146 Pain Acetaminophen 1.6816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 6.0416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 6.0416965848
MESH:D010190 Pancreatic Neoplasms Quercetin 6.0416965848
MESH:D010195 Pancreatitis Methyldopa 5.0110484002
MESH:D016584 Panic Disorder marker/mechanism
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8311578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.2112065085
MESH:D010300 Parkinson Disease 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone 32.2820334432 12584150
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 32.2815451049 16140633 11181820
MESH:D010300 Parkinson Disease BIA 3-335 32.2815566291
MESH:D010300 Parkinson Disease Carbidopa 32.287566641
MESH:D010300 Parkinson Disease Dieldrin 32.2817291500 16809432 11181820 16112328 11445065
MESH:D010300 Parkinson Disease entacapone 32.2811586115 17089403 20334432 19578428 19783845
MESH:D010300 Parkinson Disease Homocysteine 32.2816275827
MESH:D010300 Parkinson Disease Levodopa 32.2819594199 11432539 18328768 20334432 7566641
MESH:D010300 Parkinson Disease Paraquat 32.2812911755 11181820 11445065 15824117 16140633 16510128 15451049 11124998
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 32.2816702228
MESH:D010300 Parkinson Disease tolcapone 32.289754991 8635184 8739811 1977408 19783845 9591521 11586115 9305320 11746615 16758261 7566641 18328768 19578428 11793426 20334432 17089403 10651109 20216409 9333106 9708959 11432539
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 8.4315893579 11771942
MESH:D010302 Parkinson Disease, Secondary Paraquat 8.4316190885
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 15.3712349958
MESH:D020734 Parkinsonian Disorders entacapone 15.3718722529
MESH:D020734 Parkinsonian Disorders Homovanillic Acid 15.378817341
MESH:D020734 Parkinsonian Disorders Levodopa 15.3711246459 18722529 8817341
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3212520081
MESH:D010523 Peripheral Nervous System Diseases 4-methylcatechol 5.3918219259
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 4.5711550810
MESH:D011014 Pneumonia Paraquat 3.5412504350
MESH:D011041 Poisoning Diazinon 3.5217603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.6818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.782563599
MESH:D011230 Precancerous Conditions Phenobarbital 10.782563599
MESH:D011230 Precancerous Conditions Quercetin 10.7819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 2.9521297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 6.4811399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 6.4818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.0218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.0520887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms 2-methoxyestradiol 2.0816356831
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Estrogens, Catechol 2.0817261777
MESH:D011471 Prostatic Neoplasms fisetin 2.0818922931
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.0815721890
MESH:D011471 Prostatic Neoplasms Quercetin 2.0814715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011472 Prostatitis vinclozolin 4.0218629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.4116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 3.5712752131
MESH:D011565 Psoriasis Methotrexate 3.0217410198
MESH:D011595 Psychomotor Agitation olanzapine 4.6918685284
MESH:D011618 Psychotic Disorders Clozapine 3.4715331141
MESH:D011654 Pulmonary Edema Isoproterenol 4.3310903255
MESH:D011658 Pulmonary Fibrosis Paraquat 2.4817997886 16324872
MESH:D051437 Renal Insufficiency Methotrexate 3.8217352296
MESH:D015427 Reperfusion Injury pirinixic acid 1.8519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 6.4518379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 6.4511700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 6.9916611668 17119214 11874814
MESH:D012135 Respiratory Sounds Paraquat 6.9911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.9618990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 3.9716611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 3.1416458197
MESH:D012206 Rhabdomyolysis Lamivudine 4.629296927
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4318045962
MESH:D012554 Schistosomiasis japonica Quercetin 4.6116862918
MESH:D012559 Schizophrenia marker/mechanism 16234811 17123785 18583979
MESH:D012559 Schizophrenia Clozapine 6.0717726453 17667964 20107430 20168265 20521326 18806925 16141801 19369910 11763009 11151749 18855531 17123785 20580759 20521320 20452607
MESH:D012559 Schizophrenia Homocysteine 6.0716641680
MESH:D012559 Schizophrenia olanzapine 6.0717726453 20107430 20521326
MESH:D012559 Schizophrenia Risperidone 6.0718278980 20107430 19154706
MESH:C537537 Segawa syndrome, autosomal recessive Homovanillic Acid 11.338817341
MESH:C537537 Segawa syndrome, autosomal recessive Levodopa 11.338817341
MESH:D012640 Seizures Clonidine 4.4910087439
MESH:D012640 Seizures Phenobarbital 4.493137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 3.906407741
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.166418539
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.3712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.378532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3716192470
MESH:D012893 Sleep Disorders Risperidone 4.6018278980
MESH:D007319 Sleep Initiation and Maintenance Disorders Clonidine 4.8018280681
MESH:D013088 Spermatocele Ethinyl Estradiol 8.4816709447
MESH:D013088 Spermatocele Tamoxifen 8.4816709447
MESH:D013119 Spinal Cord Injuries Progesterone 7.8516503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 7.8519457130
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.491977408
MESH:D013272 Stomach Diseases Dexamethasone 3.4215472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
MESH:D013274 Stomach Neoplasms Zidovudine 2.3417696246
MESH:D013276 Stomach Ulcer Dexamethasone 2.7115138204
MESH:D013576 Syndactyly Methotrexate 4.169562676
MESH:D013610 Tachycardia Norepinephrine 4.563261545
MESH:D017180 Tachycardia, Ventricular olanzapine 8.3220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 8.3220210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.7611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.3615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 2.9712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 4.767505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 4.761399818
MESH:D013978 Tibial Fractures Estradiol 3.7519048282
MESH:D016171 Torsades de Pointes Dobutamine 4.4419353679
MESH:D005879 Tourette Syndrome Risperidone 5.0419154706
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 11.6219578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 11.6219578428
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 5.8011251952
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.8016720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.8017572228 16712894 8653321
MESH:D014570 Urologic Diseases Diazinon 4.3516487989
MESH:D014581 Urticaria Acetaminophen 2.1410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.4314692618
MESH:D014605 Uveitis Dexamethasone 3.891336536
MESH:D014625 Vaginal Neoplasms Zidovudine 3.8712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.2318097624
MESH:D020257 Ventricular Remodeling Isoproterenol 4.7718097624
MESH:D014820 Vitiligo tolcapone 4.3210573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3215886252
MESH:D015430 Weight Gain Clozapine 16.7320521320 20107430 17502770 16141801 16402076 20564506
MESH:D015430 Weight Gain Dietary Fats 16.7316723640
MESH:D015430 Weight Gain olanzapine 16.7320107430 19434072 17933447
MESH:D015430 Weight Gain Risperidone 16.7316379507 20564506
MESH:D015431 Weight Loss Clozapine 4.1617933447
MESH:D014947 Wounds and Injuries Estrogens 3.9711172683
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
KEGG:00140 Steroid hormone biosynthesis
REACT:13685 Synaptic Transmission
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA117
    • Releated gene ID Related gene Name
    PA117COMT
    Releated disease ID Related disease Name
    PA446411Endometrial Neoplasms
    PA447215Psychotic Disorders
    PA446878Cocaine-Related Disorders
    PA447197Attention Deficit Disorder with Hyperactivity
    PA447321Depressive Disorder, Major
    PA445398Pre-Eclampsia
    PA447216Schizophrenia
    PA447211Obsessive-Compulsive Disorder
    PA447212Panic Disorder
    PA447199Bipolar Disorder
    PA447196Anxiety Disorders
    PA445208Pain
    PA445093Nervous System Diseases
    PA447207Depressive Disorder
    PA443560Breast Neoplasms
    PA445042Narcolepsy
    PA446892Hyperhomocysteinemia
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445876Tobacco Use Disorder
    PA443355Anemia, Sickle Cell
    PA447209Mood Disorders
    PA445819Temporomandibular Joint Disorders
    PA443450Asthma
    PA445062Neoplasms
    PA445254Parkinson Disease
    PA446876Substance-Related Disorders
    PA443937Drug Toxicity
    PA162263534Ototoxicity
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA445917Tremor
    Releated drug ID Related drug Name
    PA164754789conjugated estrogens
    PA449509estrogens
    PA164712445Antihypertensives
    PA451145propranolol
    PA452229antidepressants
    PA449015citalopram
    PA449673fluoxetine
    PA449396dopamine
    PA449088codeine
    PA449072cocaine
    PA451720tolcapone
    PA10066duloxetine
    PA448049adenosine
    PA450423l-methionine
    PA448687bupropion
    PA452233antipsychotics
    PA450688olanzapine
    PA452619heroin
    PA451257risperidone
    PA450550morphine
    PA452610sparteine
    PA450530modafinil
    PA451892cyanocobalamin
    PA449692folic acid
    PA1318870083,4-methylenedioxymethamphetamine
    PA450213levodopa
    PA449470epinephrine
    PA450379mercaptopurine
    PA448497aspirin
    PA450453l-methyldopa
    PA452604xenobiotics
    PA450626nicotine
    PA449396dopamine
    PA449014cisplatin
    PA450464methylphenidate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00323 inhibitor Tolcapone Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Enzyme Inhibitors
    DB00494 inhibitor Entacapone Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Enzyme Inhibitors
    DB02105 - 3,5-Dinitrocatechol
    DB03336 - BIA
    DB03907 - N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide
    DB07462 - (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
    DB08049 - 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
    Drugbank ID Action Drug Name Description
    DB00118 - S-Adenosylmethionine Dietary supplement;Micronutrient
    DB00158 - Folic Acid Dietary supplement;Micronutrient;Vitamin B Complex;Hematinics
    DB00161 - L-Valine Dietary supplements;Essential Amino Acids;Micronutrients
    DB00255 - Diethylstilbestrol Antineoplastic Agents, Hormonal;Carcinogens;Estrogens, Non-Steroidal
    DB00286 substrate Prempro Estrogens
    DB00295 - Paregorique Narcotics;Analgesics;Opiate Agonists;Analgesics, Opioid
    DB00494 inhibitor Entacapone Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Enzyme Inhibitors
    DB00745 - Modafinil Central Nervous System Stimulants;Central Nervous System Agents;Anorexigenic Agents;Stimulants;Neuroprotective Agents
    DB00841 - Dobutamine Sympathomimetics;Adrenergic beta-Agonists;Cardiotonic Agents;Sympathomimetic
    DB00968 - Supres 250 Tab Antihypertensive Agents;Sympatholytics;Adrenergic alpha-Agonists
    DB00988 - Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01141 substrate Micafungin Antifungals;Antifungal Agents
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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