AutismKB 2.0

Annotation Detail for COPA


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Basic Information Top
Gene Symbol:COPA ( FLJ26320,HEP-COP )
Gene Full Name: coatomer protein complex, subunit alpha
Band: 1q23.2
Quick LinksEntrez ID:1314; OMIM: 601924; Uniprot ID:COPA_HUMAN; ENSEMBL ID: ENSG00000122218; HGNC ID: 2230
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Membrane Trafficking
Pathway IDPathway Name
200130C-MYB transcription factor network
200167Arf1 pathway
No data
Pathway IDPathway Name
500011COPI Mediated Transport
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of COPA mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of COPA mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of COPA mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of COPA mRNAincreases expression 20106945
C051890 irinotecan irinotecan analog results in increased expression of COPA mRNAincreases expression 18927307
C494474 perchlorate perchlorate results in increased expression of COPA mRNAincreases expression 18801409
C009277 sodium arsenate sodium arsenate results in increased expression of COPA mRNAincreases expression 16882884
D014415 Tunicamycin Tunicamycin results in increased expression of COPA mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin results in increased methylation of COPA promoterincreases methylation 16973722
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.897296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.389022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.3819486331
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 17159606 18259882 16391804 18509181 17454858 16303861
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.7310525206
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0612868966 8156756 14531868 18759878 11906362 2524372 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.6218692083 6679447 18289764 7440962 18648102 1440618 6482804 9328219 11289319 9022650 9653073 16192314 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6216081117 12540782 19085960 12705907 10774834 11421492 15968718 11529661 16109766 14725611 12392966 11834606 15619225 19739265 12594235 16177239 19370779 11287661 19164858 12153990 18713872 17522070 16485898 19416960 11739529 17906064 11743745 11461765 2444490 10915739 19420014 12958197 19923254 14986274 10663392 14550746 16393943 16781746 17562736 18071297 16227642
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 6.6218186108
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Cyclosporine 3.0619224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D018149 Glucose Intolerance sodium arsenate 5.3019446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 12.227505956
MESH:D006042 Goiter perchlorate 12.2218801409
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 16610002 19460945 16611625 12969438 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.656587162 3712494 598648 1399818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.0618186108
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.163581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.1618259882
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.986679447
MESH:D009436 Neural Tube Defects sodium arsenate 7.9819446573 18186108 11749123 10525206
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1819015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.046582329 6587162 3712494 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26746
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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