AutismKB 2.0

Annotation Detail for DCBLD2


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Basic Information Top
Gene Symbol:DCBLD2 ( CLCP1,ESDN )
Gene Full Name: discoidin, CUB and LCCL domain containing 2
Band: 3q12.1
Quick LinksEntrez ID:131566; OMIM: 608698; Uniprot ID:DCBD2_HUMAN; ENSEMBL ID: ENSG00000057019; HGNC ID: 24627
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DCBLD2 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DCBLD2 mRNAincreases expression 17484886
C014347 decitabine [decitabine affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 mRNAaffects expression|affects methylation 18314483
C014347 decitabine [decitabine affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 proteinaffects expression|affects methylation 18314483
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 mRNAaffects cotreatment|affects expression|affects methylation 18314483
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 proteinaffects cotreatment|affects expression|affects methylation 18314483
D002117 Calcitriol Calcitriol results in increased expression of DCBLD2 mRNAincreases expression 16002434
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DCBLD2 geneincreases mutagenesis 16495775
C006253 pirinixic acid pirinixic acid results in increased expression of DCBLD2 mRNAincreases expression 18301758
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNAaffects cotreatment|increases expression 19059307
C025462 sulindac sulfide sulindac sulfide results in increased expression of DCBLD2 mRNAincreases expression 12734198
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNAaffects cotreatment|increases expression 19059307
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 mRNAaffects cotreatment|affects expression|affects methylation 18314483
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 proteinaffects cotreatment|affects expression|affects methylation 18314483
C012589 trichostatin A [trichostatin A affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 mRNAaffects expression|affects methylation 18314483
C012589 trichostatin A [trichostatin A affects the methylation of DCBLD2 promoter] which affects the expression of DCBLD2 proteinaffects expression|affects methylation 18314483
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Ethylnitrosourea 3.816695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.7315800139
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7318759972
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4516436596 15144691 16357521 18412241 16651633
MESH:D001943 Breast Neoplasms Calcitriol 2.0311237771
MESH:D001943 Breast Neoplasms decitabine 2.0319208741 18320071
MESH:D001943 Breast Neoplasms Raloxifene 2.0317893378 17242785 16912660 17261762 16837676 15572757 15775269 17952589 17440819 15758505 17049068 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.0320065188 19084267 16202921 19221464 18821012 20544844 18351453 17893378 18997820 15565566 20005174 18815881 18425577 20390343 18855134 19155303 19289846 15668708 16818667 19142967 19066611 19189210 18984771 19011961 19487384 11161223 16873071 19115204 19059307 19288272 17242785 19200415 20859285 18629630 21138602 20135344 19410462 17261762 16273361 21152245 19244106 19189212 19103187 17440819 17049068
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915721981 16097048 10355542 16050911 15700767 16192424 15673190 18705752 3786805 16011737 16227642 16124888
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0818788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5012391285
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0311237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0319215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.0417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.0417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8416003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.5519279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.083786805 19085960 6884620 16227642 7120509 15968718 19336974 21278145 11566570 6623471 7179309 9327722 15998439 10915739 10092053 17522070 15027814 7440962 16177239 3732212 4309450 2869522
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004487 Edema pirinixic acid 7.4612083418
MESH:D004487 Edema Raloxifene 7.4615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 16.6515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.6515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.6519031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.9319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.9319294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1519155303 17893378 16202921 20544844
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2812631006 61145 15959796 16239168 12795759 16045604 17595544 19224547
MESH:D005234 Fatty Liver pirinixic acid 20.2820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 20.2817473493
MESH:D005234 Fatty Liver Tamoxifen 20.2819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D005909 Glioblastoma Ethylnitrosourea 8.0816436596
MESH:D005909 Glioblastoma trichostatin A 8.0818801729
MESH:D005910 Glioma Ethylnitrosourea 3.5518412241 16357521 16651633
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19176532 19772884
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Raloxifene 2.9215787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007248 Infertility, Male decitabine 3.3117581917
MESH:D007249 Inflammation Tamoxifen 2.4319457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.2217379185
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2218625569
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1717236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3617679729 18704418 18460780 19387464 19010910 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917157831 17334410 11408273 17174718 16943688 16221502 16239168 11903743 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5517900296 12546737 18420326 15730626 15123356 12666154 12445421 17823541 17631135 18395914 16097048 14716496 15818738 17714472 16192424 18210741 17525996 16248980 17721639 18376398 12741479 16638106 12632512 17922224 18279442 18412020 15996030 15338365 18205269 17805973 12586293 14748882 18429990 18472332 17640975 12632514 18156304 12898905 17766677 16015684 18395095 18277467 16011737 17557913 18263696 15673190 14716833 15931870 17976157 18251166 17761835 20821823 18187930 14620537 15052691 17944888 18166357 12445418 12667390 15650968 16027843 17698563 16033810 15057751 18418968 18472094 15959796 18705752 15876570 18054572 18481824 15925388 13678700 17869086 17708605 12389079 15362042 14512876 12958196 16136751 10355542 15370692 18339082 11481614 12609069 15893842 17481882 12649538 16116963 14724832 18006644 17565644 18317297
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16246199 17285989 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7419294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.7416684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7112014681 15583823
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.806695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Tamoxifen 2.8018625569
MESH:D008223 Lymphoma decitabine 8.3119470736
MESH:D008223 Lymphoma Ethylnitrosourea 8.3115790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.6718041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6714580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma decitabine 5.3916505122 17785578
MESH:D008545 Melanoma Tamoxifen 5.3919393235 12393984
MESH:D008545 Melanoma trichostatin A 5.3916505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma decitabine 12.9918172295
MESH:D009101 Multiple Myeloma Raloxifene 12.9916497877
MESH:D009101 Multiple Myeloma trichostatin A 12.9918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4719010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms decitabine 5.2817925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516003739 17160924 16651423
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010024 Osteoporosis Raloxifene 3.4919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms decitabine 5.4219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.4219331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.8619294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.8619294695
MESH:D055728 Primary Myelofibrosis decitabine 13.1617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.1617616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1212479363 15754350 18247401 16289102 16644109
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1216220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1219789329 18798265
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D013088 Spermatocele Tamoxifen 4.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms marker/mechanism 18314483
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7717616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.7717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7717572228 8653321 16712894
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.8518645019
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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