AutismKB 2.0

Annotation Detail for MAP3K8


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Basic Information Top
Gene Symbol:MAP3K8 ( COT,EST,ESTF,FLJ10486,MEKK8,TPL2,Tpl-2,c-COT )
Gene Full Name: mitogen-activated protein kinase kinase kinase 8
Band: 10p11.23
Quick LinksEntrez ID:1326; OMIM: 191195; Uniprot ID:M3K8_HUMAN; ENSEMBL ID: ENSG00000107968; HGNC ID: 6860
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200129JNK signaling in the CD4+ TCR pathway
200088Ras signaling in the CD4+ TCR pathway
200062TCR signaling in naive CD8+ T cells
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00054Toll receptor signaling pathway
Pathway IDPathway Name
500485CD28 dependent PI3K/Akt signaling
500490Interleukin-1 signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of MAP3K8 mRNAincreases expression 20359517
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K8 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MAP3K8 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP3K8 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased phosphorylation of and results in increased activity of MAP3K8 proteinincreases activity|increases phosphorylation 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased expression of PTGS2 mRNA]affects reaction|increases expression 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased expression of PTGS2 protein]affects reaction|increases expression 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK8 protein]affects reaction|increases phosphorylation 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK9 protein]affects reaction|increases phosphorylation 19808956
C015001 arsenite MAP3K8 protein affects the reaction [arsenite results in increased secretion of Dinoprostone]affects reaction|increases secretion 19808956
D001554 Benzene Benzene results in increased expression of MAP3K8 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAP3K8 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of MAP3K8 proteindecreases expression 17621267
D002117 Calcitriol Calcitriol results in increased expression of MAP3K8 mRNAincreases expression 16002434
D004317 Doxorubicin MAP3K8 mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP3K8 mRNAaffects cotreatment|increases expression 17942748
C004912 ethylbenzene ethylbenzene results in increased expression of MAP3K8 mRNAincreases expression 20359517
D008070 Lipopolysaccharides Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 proteinincreases activity|increases phosphorylation 19159680
D008070 Lipopolysaccharides Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 protein]increases activity|increases phosphorylation|increases reaction 19159680
D008070 Lipopolysaccharides MAP3K8 protein affects the reaction [Lipopolysaccharides affects the transport of and affects the localization of TNF mRNA]affects localization|affects reaction|affects transport 11163183
D008070 Lipopolysaccharides MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11163183
D008070 Lipopolysaccharides MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11163183
D008070 Lipopolysaccharides MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]affects reaction|increases secretion 11163183
D008070 Lipopolysaccharides MAP3K8 protein affects the susceptibility to Lipopolysaccharidesaffects response to substance 11163183
D008094 Lithium Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 protein]increases activity|increases phosphorylation|increases reaction 19159680
D008094 Lithium Lithium results in increased degradation of MAP3K8 protein alternative formincreases degradation 19159680
D008094 Lithium [Lithium results in increased degradation of NFKB1 protein] inhibits the reaction [NFKB1 protein binds to MAP3K8 protein]affects binding|decreases reaction|increases degradation 19159680
D008094 Lithium Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 proteinincreases activity|increases phosphorylation 19159680
D008094 Lithium [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 proteinincreases activity|increases phosphorylation 19159680
D008752 Methylene Chloride Methylene Chloride results in increased expression of MAP3K8 mRNAincreases expression 20359517
D009151 Mustard Gas Mustard Gas results in increased expression of MAP3K8 mRNAincreases expression 15674843
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP3K8 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP3K8 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in increased expression of MAP3K8 mRNAincreases expression 18070364
D015232 Dinoprostone MAP3K8 protein affects the reaction [arsenite results in increased secretion of Dinoprostone]affects reaction|increases secretion 19808956
C037219 quinoline quinoline analog results in decreased activity of MAP3K8 proteindecreases activity 16973359
C037219 quinoline quinoline analog results in decreased activity of MAP3K8 proteindecreases activity 16973359
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNAaffects cotreatment|decreases expression 19059307
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of MAP3K8 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of MAP3K8 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of MAP3K8 mRNAincreases expression 12016162
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAP3K8 mRNAincreases expression 20106945
11489354
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP3K8 mRNAaffects cotreatment|increases expression 17942748
D014050 Toluene Toluene results in increased expression of MAP3K8 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of MAP3K8 mRNAincreases expression 20359517
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of MAP3K8 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of MAP3K8 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.2818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.6817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.516695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.8117942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D000419 Albuminuria Doxorubicin 10.6821441931
MESH:D000419 Albuminuria Raloxifene 10.6817308373 17451421
MESH:D000544 Alzheimer Disease Lithium 4.5519621015
MESH:D000544 Alzheimer Disease Raloxifene 4.5515800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000741 Anemia, Aplastic Benzene 4.1814761424 17661222 11369114
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001014 Aortic Aneurysm Dinoprostone 5.3710231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.1819183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 11.1810388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001249 Asthma Mustard Gas 2.6410378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001477 Bartter Syndrome Dinoprostone 5.5015976003
MESH:D001714 Bipolar Disorder Lithium 4.2020338123 19153942 20046352 17594078
MESH:D001768 Blister Mustard Gas 4.9119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes 2-xylene 11.277457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.2715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9816183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4514601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0917868700
MESH:D001930 Brain Injuries Progesterone 10.1615380490 15665606 15845082
MESH:D001930 Brain Injuries Raloxifene 10.1616580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.6017150277
MESH:D001943 Breast Neoplasms Benzene 8.0217162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.0220146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 8.0211237771
MESH:D001943 Breast Neoplasms decitabine 8.0219208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 8.0216096432 16115903 15994142 17369602 15939500 17983394 16264153 16595493 18695136 16935488 15692762 15634643 18628466 15567936 16826403 18234424 15136595 15668708 19526202 17426702 15993339 11325840 16322301 18382427
MESH:D001943 Breast Neoplasms Methylene Chloride 8.0215986119
MESH:D001943 Breast Neoplasms Progesterone 8.0217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 8.0217952589 17242785 17595753 16912660 17261762 17893378 16837676 15758505 17049068 15572757 15775269 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 8.0220065188 21138602 20005174 11161223 19200415 19084267 19059307 16202921 17242785 19189210 21152245 19115204 18984771 15565566 19288272 19410462 18629630 18351453 20859285 19142967 19487384 20135344 19066611 19221464 19289846 19189212 18821012 18815881 17261762 17893378 18425577 19011961 17440819 19155303 20390343 15668708 19103187 20544844 18997820 18855134 16818667 16273361 19244106 17049068 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0220435547
MESH:D001943 Breast Neoplasms Trichloroethylene 8.0215986119
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7317687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.853084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.8521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.8516234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular quinoline 10.85598648
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.8517306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.8516924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.051485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.5520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.5511237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.5519215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.556189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.5518572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3715792986 18627295 16612575 17974986 17928571 17308081 16278810 16269455 16455267 17131338 16242529 15505089 15811867 16651473 17382496 16731534 16952015 16109756 17007740 16364871 17329180 17351982 17924179 17519947 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8617334414 16243910
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2815775269
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 6.7216192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7219524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.609294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1515861022 17681005 17333356 16919318 17110522 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 7.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0015340226 12621046 8697196 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.3815800139
MESH:D003092 Colitis Selenium 3.5417936198
MESH:D003110 Colonic Neoplasms arsenite 3.8415037631
MESH:D003110 Colonic Neoplasms decitabine 3.8417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.6318981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6318802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 5.2415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 5.249294310
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.2419769572
MESH:D007644 Darier Disease Lithium 5.6620338123
MESH:D003643 Death Toluene 5.426431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9617474826
MESH:D003872 Dermatitis Benzene 4.5215902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.5019244398
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.3517308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2517187935
MESH:D003967 Diarrhea Dinoprostone 4.3211488427 7237001 10446763
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2212705907 12594235 11834606 11529661 16227642 2444490 19739265 19420014 11287661 19164858 10915739 17522070 12958197 12540782 16781746 11743745 14986274 12392966 16109766 16485898 19416960 19370779 16177239 12153990 18071297 10774834 19085960 11421492 14725611 19923254 17906064 15619225 11461765 17562736 16081117 10663392 15968718 11739529 16393943 14550746 18713872
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.2217416283
MESH:D056486 Drug-Induced Liver Injury Selenium 11.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2220420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 11.227120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.5118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5111462148
MESH:C538011 Eales disease Vitamin E 4.459068938
MESH:D004487 Edema Mustard Gas 14.649260866 11428631 11402378 11428647
MESH:D004487 Edema pirinixic acid 14.6412083418
MESH:D004487 Edema Raloxifene 14.6415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 26.2215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 26.2212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 26.2217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 26.2215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 26.2219031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8719294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0417359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0417893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Progesterone 8.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9118037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1515328337 15821434 17637181
MESH:D004890 Erythema Mustard Gas 4.919357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver arsenite 22.3118296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.3115345470
MESH:D005234 Fatty Liver pirinixic acid 22.3120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 22.3117473493
MESH:D005234 Fatty Liver Tamoxifen 22.3119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Dinoprostone 8.9216997862 11852909
MESH:D005334 Fever Lipopolysaccharides 8.929205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.6219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6219069698
MESH:D005355 Fibrosis arsenite 8.0218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.0220067830
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005909 Glioblastoma Doxorubicin 3.1917150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.4119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.4115692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.9720471113
MESH:D006330 Heart Defects, Congenital Lithium 14.9719638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.9711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 14.9716080930
MESH:D006331 Heart Diseases Doxorubicin 7.2816495754 17888722 18006777 16707910 17875725 16330681 14766674 16879835 16244372 18674790 16144979 12587719 16244371
MESH:D006331 Heart Diseases Raloxifene 7.2811110106
MESH:D006333 Heart Failure Doxorubicin 10.9417481944
MESH:D006333 Heart Failure pirinixic acid 10.9420558911
MESH:D006333 Heart Failure Selenium 10.9417162251
MESH:D006390 Hemangioendothelioma quinoline 5.65598648
MESH:D006394 Hemangiosarcoma Doxorubicin 8.8915692506
MESH:D006394 Hemangiosarcoma quinoline 8.89598648
MESH:D006402 Hematologic Diseases Benzene 4.4316183116
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly 2-xylene 13.197457028 7457013
MESH:D006529 Hepatomegaly pirinixic acid 13.1916221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.1915340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 6.8018501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.8012676792
MESH:D019584 Hot Flashes Vitamin E 3.7214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.4716870215
MESH:D006930 Hyperalgesia Dinoprostone 7.4716793879
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006973 Hypertension Benzene 8.1617940673
MESH:D006973 Hypertension Raloxifene 8.1617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male decitabine 10.2917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2917937319
MESH:D007248 Infertility, Male sodium arsenite 10.2912646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 14.5112878042 9205823 17237260 17963957 17255318
MESH:D007249 Inflammation Mustard Gas 14.5111428647 9357497 9260866 11428631 11402378 8975870 16001271 17524151 11428620
MESH:D007249 Inflammation Progesterone 14.5115869954
MESH:D007249 Inflammation Tamoxifen 14.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.5112878042 12200463
MESH:D007251 Influenza, Human Selenium 10.1316624496
MESH:D007251 Influenza, Human Vitamin E 10.1316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4716306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007674 Kidney Diseases Acetaminophen 13.3015629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 13.3015369732 15699352 16775033
MESH:D007674 Kidney Diseases sodium arsenite 13.3020008137
MESH:D007674 Kidney Diseases Vitamin E 13.3012488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2516707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.2516518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.8518625569
MESH:D007889 Leiomyoma Raloxifene 4.2716973256
MESH:D007938 Leukemia Benzene 6.2515935818 14694614 17119257 18335105
MESH:D007938 Leukemia decitabine 6.2519235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9116085563
MESH:D007951 Leukemia, Myeloid Benzene 9.0617506065
MESH:D007951 Leukemia, Myeloid decitabine 9.0618454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.0419478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0417679729 18460780 18206229 19387464 19010910 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2118055864
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.2918296743
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 10.4315816358
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.4316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.4312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.4316169303
MESH:D008107 Liver Diseases Acetaminophen 4.1912969438 16611625 11587558 16610002 19460945 12587719 19014921 19784758
MESH:D008107 Liver Diseases Dinoprostone 4.1915816358
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0216871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.7415890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.7421137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 16.7420007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 16.7416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 16.7416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.7416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.078603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.0712562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.0716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.0712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 17.077955063
MESH:D008171 Lung Diseases Mustard Gas 11.4318702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 11.4319095001
MESH:D008171 Lung Diseases Vitamin E 11.4316863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5614698565
MESH:D055370 Lung Injury Lipopolysaccharides 3.7721114838
MESH:D008175 Lung Neoplasms marker/mechanism
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.8514755239
MESH:D008175 Lung Neoplasms arsenite 19.8516809336
MESH:D008175 Lung Neoplasms Benzene 19.8512562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.8518816296 18520028 18569708 17053015 20464547 20869020 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 19.8517418594 6189445
MESH:D008175 Lung Neoplasms Methylene Chloride 19.8515172992
MESH:D008175 Lung Neoplasms Mustard Gas 19.853148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 19.8517306315 19931552 16712894 17077188 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 19.8518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.8511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 19.8511062179
MESH:D008223 Lymphoma Benzene 11.6717584886 17119257
MESH:D008223 Lymphoma decitabine 11.6719470736
MESH:D008223 Lymphoma Doxorubicin 11.6716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3215621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.2512562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.2519428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 17.1711921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.1715458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.1717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 17.1715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.1714580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3019453300
MESH:D008545 Melanoma decitabine 6.9316505122 17785578
MESH:D008545 Melanoma Doxorubicin 6.9316827129
MESH:D008545 Melanoma sodium arsenite 6.9319082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.9312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008607 Mental Retardation Toluene 3.579294310
MESH:D008654 Mesothelioma Doxorubicin 5.9617638057
MESH:D008654 Mesothelioma Selenium 5.9615107826
MESH:D020326 Migraine without Aura Dinoprostone 5.0311304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3015863610
MESH:D019957 Motor Skills Disorders Toluene 5.019294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D052016 Mucositis Doxorubicin 4.5417415656
MESH:D009101 Multiple Myeloma Benzene 11.2517119195
MESH:D009101 Multiple Myeloma decitabine 11.2518172295
MESH:D009101 Multiple Myeloma Raloxifene 11.2516497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2419010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction Doxorubicin 9.0319429709 15857846
MESH:D009203 Myocardial Infarction Lithium 9.0316288908
MESH:D009203 Myocardial Infarction pirinixic acid 9.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7616411023
MESH:D009232 Myxoma Raloxifene 5.3016343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.1518259882
MESH:D009362 Neoplasm Metastasis quinoline 9.15598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.1519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.4511141357
MESH:D009369 Neoplasms decitabine 14.4519116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 14.4517405874
MESH:D009369 Neoplasms sodium arsenite 14.4511559025
MESH:D009369 Neoplasms Trichloroethylene 14.4511911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 4.1715738583
MESH:D009401 Nephrosis Doxorubicin 4.5316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7915640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9814600291
MESH:D009436 Neural Tube Defects Benzene 7.0115643154
MESH:D009436 Neural Tube Defects sodium arsenite 7.0112854658
MESH:D009447 Neuroblastoma Doxorubicin 3.1415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D009503 Neutropenia Mustard Gas 3.7416761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases Benzene 3.9715913788 17479406 16737584 17178637 15727169 15576619 15935809 17119257 15612468
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.2318500342
MESH:D010024 Osteoporosis Raloxifene 3.2515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0017823083 15579764 17893378 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.9215930896
MESH:D010051 Ovarian Neoplasms Benzene 10.6912562636
MESH:D010051 Ovarian Neoplasms decitabine 10.6919259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 10.6916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.6915276417 17306315
MESH:D010146 Pain Acetaminophen 2.2016870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.6819294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9117983394
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9117638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.3112224865 11605937
MESH:D011041 Poisoning Mustard Gas 3.5715727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.4917616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5315572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0618247401 16644109 16289102 12479363 15754350
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0618437689 15749863 15897917 16868541 16729912 16888761
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0615731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011537 Pruritus Ethinyl Estradiol 8.7016919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.7018058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317720292 17266442 17620002 17894541 10334151
MESH:D011693 Purpura Raloxifene 5.3015770314
MESH:D051437 Renal Insufficiency Doxorubicin 3.9817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7718045962
MESH:D012509 Sarcoma Doxorubicin 3.7815625365 18313854 16767912 17710206 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5417846226
MESH:D012640 Seizures Lithium 6.2919660546
MESH:D012640 Seizures Toluene 6.299294310 6431079
MESH:D012871 Skin Diseases Mustard Gas 4.8112880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 4.8118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.6119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 12.6115692506
MESH:D012878 Skin Neoplasms sodium arsenite 12.6118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3216767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.0516503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.0519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013226 Status Epilepticus Lithium 5.5419570321 19430551 19951488
MESH:D013274 Stomach Neoplasms Benzene 3.3212562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.322093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.3219037991
MESH:D020521 Stroke Raloxifene 8.0716837676
MESH:D020521 Stroke Vitamin E 8.0716517955
MESH:D013733 Testicular Diseases Toluene 4.7110048760 10514026
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013953 Thymus Neoplasms Benzene 4.7110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms decitabine 6.8117967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.8117909728 16010429
MESH:D013978 Tibial Fractures Raloxifene 4.9619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.6217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.6219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.6217653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.6217572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.6217306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.6216712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5511813266
MESH:D014594 Uterine Neoplasms Benzene 8.7912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7914692618
MESH:D014604 Uveal Neoplasms decitabine 4.6617785578
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9817638931 17334414 16364871 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30606
    • No data
    No data
    Releated drug ID Related drug Name
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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