AutismKB 2.0

Annotation Detail for LIN54


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Basic Information Top
Gene Symbol:LIN54 ( CXCDC1,DKFZp686L1814,JC8.6,MGC129905,MIP120 )
Gene Full Name: lin-54 homolog (C. elegans)
Band: 4q21.22
Quick LinksEntrez ID:132660; OMIM: 613367; Uniprot ID:LIN54_HUMAN; ENSEMBL ID: ENSG00000189308; HGNC ID: 25397
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LIN54 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LIN54 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LIN54 mRNAdecreases expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of LIN54 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of LIN54 mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIN54 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8020435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016192424 15673190 16124888 15721981 18705752 15700767 10355542 16227642 16050911 3786805 16097048 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5814986274 10774834 14725611 19370779 19739265 12392966 16781746 16081117 19085960 15619225 12958197 2444490 10915739 19923254 17906064 17562736 11461765 11743745 12705907 11739529 16227642 19420014 11287661 12540782 19416960 16393943 16177239 14550746 16109766 16485898 11421492 11529661 18071297 12594235 15968718 19164858 11834606 10663392 17522070 18713872 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5811566570 21278145 3786805 4309450 3732212 15998439 6884620 15968718 10092053 2869522 7179309 19085960 15027814 17522070 7120509 6623471 19336974 16177239 10915739 16227642 9327722 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9515959796 19224547 12631006 61145 12795759 16045604 17595544 16239168
MESH:D005234 Fatty Liver Dietary Fats 8.9519551842 17967931 18296743 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 17.3418705752
MESH:D005355 Fibrosis Dietary Fats 17.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.3420067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Dietary Fats 5.4020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1511408273 17174718 16943688 17157831 16239168 16221502 21278145 17334410 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.1518296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3617823541 12632514 17805973 15673190 14748882 17761835 15057751 15338365 16116963 15730626 12389079 17708605 12666154 18205269 15818738 15123356 15925388 16011737 18006644 18279442 14620537 18339082 17714472 14724832 16248980 14716833 12445418 12445421 16638106 17565644 15370692 11481614 17922224 12667390 14512876 16033810 18210741 17766677 12546737 12958196 15931870 10355542 17944888 18418968 18395914 18429990 16015684 17976157 18472094 15959796 14716496 18166357 18705752 18187930 18054572 15362042 18277467 15893842 17557913 20821823 17698563 12632512 12898905 15876570 18376398 17721639 12649538 12586293 17481882 18420326 18251166 16027843 18412020 12609069 18317297 17900296 18472332 15052691 17869086 18395095 16136751 17631135 12741479 15650968 15996030 18263696 13678700 16097048 16192424 18481824 18156304 17525996 17640975
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Acetaminophen 4.1219460945 16611625 19784758 12587719 19014921 11587558 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1215720792 16246199 16964402 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.4416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.4416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3712151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2518520028 18816296 17053015 20064080 6695378 18569708 20135361 20869020 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2519555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 2.3411836018 21332399 20132043 17217161 20518802 18674790 19632207 18457598 16723640
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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