AutismKB 2.0

Annotation Detail for CPEB2


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Basic Information Top
Gene Symbol:CPEB2 ( CPE-BP2,CPEB-2,MGC119575,MGC119576,MGC119577,hCPEB-2 )
Gene Full Name: cytoplasmic polyadenylation element binding protein 2
Band: 4p15.32
Quick LinksEntrez ID:132864; OMIM: 610605; Uniprot ID:CPEB2_HUMAN; ENSEMBL ID: ENSG00000137449; HGNC ID: 21745
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CPEB2 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CPEB2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CPEB2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CPEB2 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of CPEB2 mRNAincreases expression 18687144
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPEB2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of CPEB2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CPEB2 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CPEB2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPEB2 mRNAaffects cotreatment|affects expression 17602206
D002117 Calcitriol Calcitriol results in increased expression of CPEB2 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of CPEB2 mRNAincreases expression 17555868
C006253 pirinixic acid pirinixic acid results in increased expression of CPEB2 mRNAincreases expression 18445702
18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CPEB2 mRNAincreases expression 17555868
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CPEB2 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D000236 Adenoma Diethylnitrosamine 2.9110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.2216434500 17620307 17162532 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.2216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.2216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Calcitriol 1.9611237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Estradiol 1.9616675129 17018787 12948864 14630087 17289903 18497071 19861407 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.033084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0320432363 19208518 21159647 18665156 16698587 18210153 16681979 16878318 16779866 19052882 18691550 19107877 16540662 17055752 17428255 17761372 16830150 18393292 20935162 16502159 19822196 20514400 18494052 17162532 20007298 19418558 3581430 20214788 19335982 16328049 18056438 18971187 18978308 19383236 11831363 20512989 17138121 10737359 19701751 18788625 17173139 20727157 20084675 16935385 20524982 16569478 19539802 20101231 19519916 3084413 19394651 10672840 18785209 19919837 19171122 17978847 16288022 16807293 18506893
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.0316924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6511237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.646135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.6417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 15668235 12621046 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3310663392 10915739 19416960 16781746 12540782 15968718 16485898 19085960 17562736 14986274 12392966 12958197 11461765 17906064 11739529 16109766 18713872 12705907 16393943 16081117 14550746 16227642 19370779 11834606 10774834 16177239 18071297 19739265 11743745 11287661 12153990 19164858 14725611 12594235 11529661 11421492 17522070 15619225 19923254 19420014 2444490
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0615138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.0519148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.7019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7319176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7312621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.0718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.338314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.3315618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5312371664
MESH:D007680 Kidney Neoplasms Estradiol 18.5315610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818407596 19638242 18665156 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9912969438 16611625 19460945 19014921 19784758 16610002 12587719 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.657678174
MESH:D008113 Liver Neoplasms Clofibric Acid 14.6517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.6519426721 15885732 20137499 20583210 20405173 19427195 10737359 19073162 19499222 19833225 20492335 9163691 12771043 19255062 19690152 19996281 21278145 21047994 12112319 19256749 19638242 21167192 19294768 21071580 2422723 19642983 18644402 16942905 20452335 2862719 20118626 15175105 19551842 18648771 18978307 19090486 19850985 19812893 20501860 20434301 18754104 19254457 20101389 18977376
MESH:D008113 Liver Neoplasms pirinixic acid 14.6515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.172876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1718775883 18253720 17854601 17942915 2563599 18164116 16267830 9362446 17174075 16842330 18079962 18282651 19539802 18093689 19009564 19126423 18544905 19004024 21159647 19519916 3124819 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1712151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1617365036
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2820970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2216966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.603581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11896295 11222880 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2916289102 15754350 18247401 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0615814490 17365031 17322281 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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