AutismKB 2.0

Annotation Detail for COX5B


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Basic Information Top
Gene Symbol:COX5B ( COXVB )
Gene Full Name: cytochrome c oxidase subunit Vb
Band: 2q11.2
Quick LinksEntrez ID:1329; OMIM: 123866; Uniprot ID:COX5B_HUMAN; ENSEMBL ID: ENSG00000135940; HGNC ID: 2269
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
Pathway IDPathway Name
500282Respiratory electron transport
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of COX5B mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of COX5B mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of COX5B mRNAaffects expression 16483693
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]decreases reaction|increases expression 16964424
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of COX5B mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of COX5B mRNAincreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of COX5B mRNAincreases expression 17805973
D003300 Copper Copper affects the expression of COX5B proteinaffects expression 17182794
C014347 decitabine decitabine results in increased expression of COX5B proteinincreases expression 19294695
D002945 Cisplatin Cisplatin results in increased expression of COX5B mRNAincreases expression 15471895
15464296
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNAaffects cotreatment|increases expression 18313992
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of COX5B mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COX5B mRNAaffects cotreatment|increases expression 17942748
D010269 Paraquat Paraquat results in decreased expression of COX5B mRNAdecreases expression 17077588
D012402 Rotenone Rotenone results in increased expression of COX5B mRNAincreases expression 18191903
D012402 Rotenone Rotenone results in increased expression of COX5B mRNAincreases expression 19013527
D013629 Tamoxifen Tamoxifen affects the expression of COX5B mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COX5B mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COX5B mRNAincreases expression 20399798
17942748
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of COX5B mRNAdecreases expression 18087596
C012589 trichostatin A trichostatin A results in increased expression of COX5B proteinincreases expression 19294695
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.799612607
MESH:D058186 Acute Kidney Injury Cisplatin 3.9217670903 15814532 12690470
MESH:D000230 Adenocarcinoma Cisplatin 4.4217638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.5015814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.733712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7311874814
MESH:D000544 Alzheimer Disease Copper 3.2216962711 17119284 16325427 16886094 16410023 16866297
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.2710694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.8416614410
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1719898480
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D001932 Brain Neoplasms Copper 4.5117079463
MESH:D001943 Breast Neoplasms Cisplatin 2.3519526202 18382427
MESH:D001943 Breast Neoplasms Copper 2.3515986119 17079463
MESH:D001943 Breast Neoplasms decitabine 2.3519208741 18320071
MESH:D001943 Breast Neoplasms Tamoxifen 2.3519410462 19011961 21138602 11161223 19103187 19084267 16818667 20135344 16273361 15668708 19244106 19115204 19289846 19155303 18425577 18629630 17242785 15565566 18997820 17893378 17049068 20544844 18351453 19288272 19059307 20390343 17440819 19221464 19066611 19189212 20065188 18815881 19142967 19189210 16202921 20859285 18821012 19200415 20005174 19487384 16873071 18855134 21152245 18984771 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7416192424 10355542 16124888 3786805 16011737 16227642 16050911 15721981 18705752 15700767 16097048 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5518788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.5517982673
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.9016685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.9011212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.706189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.7019215824
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 7.7011212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Copper 6.9817327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.547505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5420889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.759022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7517333356 17681005 17110522 16105132 15861022 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7515273666
MESH:D015179 Colorectal Neoplasms decitabine 2.7518981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7718759878 11906362 8156756 8970840 12868966 11298694 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 4.8416964424
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.8417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.106482804 1440618 11289319 9328219 18692083 6679447 18289764 9653073 18648102 7440962 9022650 16192314 8291058
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.1019336974 21278145 10092053 4309450 6884620 17522070 2869522 15968718 15027814 19085960 7179309 9327722 11566570 16177239 15998439 10915739 6623471 7440962 3786805 7120509 16227642 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1020420201
MESH:D004362 Drug Toxicity Cisplatin 19.4112649298 12231392 19839026 15033597
MESH:D004362 Drug Toxicity Lamivudine 19.4115040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 19.4111462148
MESH:D004362 Drug Toxicity Zidovudine 19.4115040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.9319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.9319294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0216202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.223581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2220426865
MESH:D004938 Esophageal Neoplasms Cisplatin 7.2215173087 16481741 16785472 17638652 15464296
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.4815959796 16239168 12795759 19224547 17595544 61145 12631006 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4815345470
MESH:D005234 Fatty Liver Tamoxifen 18.4819224547 14986274
MESH:D005234 Fatty Liver Zidovudine 18.4818299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4720067830
MESH:D005909 Glioblastoma trichostatin A 3.8018801729
MESH:D005911 Gliosis Paraquat 5.1411124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.9215464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 7.9219215824
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 4.6712579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.096705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0919900420 19110552
MESH:D006509 Hepatitis B Lamivudine 5.0617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0616476009 15631357 12044531 15274664 15309715
MESH:D006521 Hepatitis, Chronic Copper 5.2517338147
MESH:D006527 Hepatolenticular Degeneration Copper 5.1317276780 17182432 17109627 19888908 16607473
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8512621046 15340226 16120746
MESH:D015658 HIV Infections Lamivudine 6.9820032539 11141242 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 6.9811141242 11698656 20032539 11363243 17358032
MESH:D006689 Hodgkin Disease Cisplatin 3.5616200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 16354765 18606429 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male decitabine 11.0917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.0917937319
MESH:D007248 Infertility, Male Paraquat 11.094850670
MESH:D007249 Inflammation Tamoxifen 8.2719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2712878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 8.2718590791
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Cisplatin 3.2212231392 12649298 18289764 15190930 19839026
MESH:D007676 Kidney Failure, Chronic Copper 4.8616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.306582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.3018625569
MESH:D007680 Kidney Neoplasms Zidovudine 12.3012579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007859 Learning Disorders Copper 4.7517134702
MESH:D007938 Leukemia decitabine 3.0518980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3720370541
MESH:D007951 Leukemia, Myeloid decitabine 3.9618454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.2518460780 18704418 19010910 18206229 17679729 19387464
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.2518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D008064 Lipidoses Tamoxifen 3.1215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7811408273 17174718 16221502 11903743 16239168 17334410 16943688 17157831 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4110355542 16136751 15052691 17805973 12632512 15931870 16192424 18317297 17631135 15925388 16033810 14620537 15893842 17565644 16097048 18210741 15876570 15057751 17640975 15370692 12445421 12632514 17900296 16116963 12667390 15338365 17525996 12666154 18205269 12546737 13678700 18277467 18187930 15673190 18420326 12445418 18418968 14748882 12609069 18705752 18395095 12649538 18156304 12898905 17976157 16015684 15650968 17922224 16011737 16248980 17766677 12389079 18263696 17823541 14716833 17698563 15959796 14512876 14724832 15730626 18279442 18006644 17721639 17869086 12958196 14716496 12586293 18166357 15996030 18481824 17761835 11481614 15123356 18054572 15362042 20821823 18339082 17557913 15818738 17944888 17708605 17481882 17714472 18472094 18251166 18472332 18376398 16638106 16027843 18395914 12741479 18412020 18429990
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0716246199 15720792 15830285 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.6119294768
MESH:D008113 Liver Neoplasms Copper 10.6120302851
MESH:D008113 Liver Neoplasms Tamoxifen 10.6116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.62598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.6215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6212151625
MESH:D008175 Lung Neoplasms Cisplatin 6.5617225452 6189445 11798837
MESH:D008175 Lung Neoplasms Tamoxifen 6.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5619555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.5611091918 12111688 16288123 3440675
MESH:D008175 Lung Neoplasms Zidovudine 6.5618800350
MESH:D008223 Lymphoma decitabine 3.3919470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5914580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008545 Melanoma Cisplatin 7.3112393984 17023156 11135225 16248763 12374674 16432458 12883367 18505091 17761969 15577323 18332650 16809738 18176117
MESH:D008545 Melanoma decitabine 7.3116505122 17785578
MESH:D008545 Melanoma Tamoxifen 7.3112393984 19393235
MESH:D008545 Melanoma trichostatin A 7.3116505122
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.3915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.3915990972
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.8517268249 17109627
MESH:D008654 Mesothelioma Cisplatin 3.2317638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8117358032
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3115006635
MESH:D009101 Multiple Myeloma decitabine 7.5518172295
MESH:D009101 Multiple Myeloma trichostatin A 7.5518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3619157545 18608210 16882708 19010910
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Cisplatin 5.3116773208
MESH:D009369 Neoplasms decitabine 5.3119116145 17925555 19470736
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Copper 4.9117308104
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4615464296
MESH:D009410 Nerve Degeneration Paraquat 8.5216893418
MESH:D009410 Nerve Degeneration Rotenone 8.5215790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.886679447
MESH:D009447 Neuroblastoma Cisplatin 3.438761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.668761367
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010051 Ovarian Neoplasms Cisplatin 8.0317225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms decitabine 8.0319259094 19331143
MESH:D010051 Ovarian Neoplasms trichostatin A 8.0319331143
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.7519003803
MESH:D010190 Pancreatic Neoplasms decitabine 8.7519294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.7519294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010300 Parkinson Disease Paraquat 5.5311124998 12911755 16510128 11445065 11181820 15451049 16140633 15824117
MESH:D010300 Parkinson Disease Rotenone 5.5315451049 18191903 11445065 16140633 11535288 16412576 19232380 18619942 19114014
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3916190885
MESH:D020734 Parkinsonian Disorders Rotenone 4.0415574749 18197244 15927086 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D011014 Pneumonia Paraquat 4.4212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 12.3017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.3017616702
MESH:D011471 Prostatic Neoplasms Copper 2.8317308104 17079463
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8315067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.8319789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9017997886 16324872
MESH:D051437 Renal Insufficiency Cisplatin 4.3715464296
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8611700416
MESH:D012135 Respiratory Sounds Paraquat 9.8111874814
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 9.8118410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.803692021
MESH:D012162 Retinal Degeneration Paraquat 8.8016458197
MESH:D012206 Rhabdomyolysis Lamivudine 5.509296927
MESH:D012208 Rhabdomyosarcoma decitabine 4.3619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3914601052
MESH:D012559 Schizophrenia Copper 3.0816842975
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8316192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 5.8318590791
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Cisplatin 3.5517522103 18396642 15958060
MESH:D013274 Stomach Neoplasms decitabine 3.5519037991
MESH:D013274 Stomach Neoplasms Zidovudine 3.5517696246
MESH:D013736 Testicular Neoplasms Cisplatin 4.5915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.137505956 6582329 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms decitabine 7.1317967635
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.668074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.6612973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.6617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.668653321 16712894 17572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 15.6612846360
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms decitabine 4.8817785578
MESH:D014625 Vaginal Neoplasms Cisplatin 11.0715577323
MESH:D014625 Vaginal Neoplasms Zidovudine 11.0712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04260 Cardiac muscle contraction
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02659 - Cholic Acid
DB04464 - N-Formylmethionine
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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