AutismKB 2.0

Annotation Detail for ADM


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Basic Information Top
Gene Symbol:ADM ( AM )
Gene Full Name: adrenomedullin
Band: 11p15.4
Quick LinksEntrez ID:133; OMIM: 103275; Uniprot ID:ADML_HUMAN; ENSEMBL ID: ENSG00000148926; HGNC ID: 259
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1724Vascular disease
1782Henoch-Schoenlein purpura
1781Rheumatoid arthritis
1795Amnionitis
1804Chronic obstructive airway disease
1825Oligospermia
1831Prostate cancer
1843Metastasis to lymph nodes
1856Obesity
1859Ovarian cancer
1878Ischemia
1889Hyperinsulinism
1896Adrenoleukodystrophy
1904Diabetes mellitus
1944Breast cancer
1976Squamous cell cancer
2091Hypertension
2069Schizophrenia
2075Heart failure
2083IGA glomerulonephritis
2105Primary hyperparathyroidism
2106Pancreas cancer
2107Proteinuria
2111Systemic infection
2154Adenoma
2205Uveitis
2241Infertility
Desease Name
CARDIOVASCULAR
nephropathy in other diseases
hypertension
METABOLIC
blood pressure, arterial urinary sodium
diabetes, type 2
Desease Name
Schizophrenia, bipolar disorder and depression (combined)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ADM mRNAincreases expression 17547211
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of ADM mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of ADM mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of ADM mRNAincreases expression 11264010
18544908
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADM proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of ADM mRNAincreases expression 17113911
D013196 Dihydrotestosterone VEGFA protein affects the reaction [Dihydrotestosterone results in increased expression of ADM mRNA]affects reaction|increases expression 17113911
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADM mRNAaffects expression 16483693
D000965 Antimony Antimony results in increased expression of ADM mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of ADM mRNAincreases expression 17547211
C006632 arsenic trioxide arsenic trioxide results in increased expression of ADM mRNAincreases expression 19128835
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ADM mRNAincreases expression 18687144
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of ADM mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADM mRNAincreases expression 20106945
20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADM mRNAincreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADM mRNAincreases expression 15003993
14729362
D002104 Cadmium Cadmium results in increased expression of ADM mRNAincreases expression 21172416
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADM mRNAincreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADM mRNAincreases expression 16713642
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADM proteinincreases expression 16713642
16610064
D002857 Chromium Chromium results in increased expression of ADM mRNAincreases expression 17547211
D003345 Corticosterone Corticosterone results in increased expression of ADM mRNAincreases expression 15755911
D003520 Cyclophosphamide ADM protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D016572 Cyclosporine Cyclosporine results in increased expression of ADM mRNAincreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNAaffects cotreatment|decreases expression 16054899
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of ADM mRNAdecreases expression 15885261
D004178 Diquat Diquat results in increased expression of ADM mRNAincreases expression 21172416
D004958 Estradiol Estradiol affects the expression of ADM mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADM mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADM mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADM mRNAincreases expression 12655037
15834898
D005419 Flavonoids Flavonoids results in increased expression of ADM mRNAincreases expression 18035473
D005472 Fluorouracil ADM protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005485 Flutamide Flutamide results in decreased expression of ADM mRNAdecreases expression 15885261
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of ADMincreases expression 18687144
D015759 Ionomycin Ionomycin results in decreased expression of ADM mRNAdecreases expression 11470465
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNAaffects cotreatment|decreases expression 16054899
D007545 Isoproterenol Isoproterenol results in increased expression of ADM mRNAincreases expression 17250927
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNAaffects cotreatment|increases expression 17250927
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM proteinaffects cotreatment|increases expression 17250927
C119620 kenpaullone kenpaullone results in decreased expression of ADM mRNAdecreases expression 17993264
D008345 Manganese Manganese results in increased expression of ADM mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ADM mRNAincreases expression 17175027
D008628 Mercury Mercury results in increased expression of ADM mRNAincreases expression 17547211
D009151 Mustard Gas Mustard Gas results in increased expression of ADM mRNAincreases expression 15674844
D009151 Mustard Gas Mustard Gas results in increased expression of ADM mRNAincreases expression 18988085
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of ADM mRNAincreases expression 16052530
C022838 nickel chloride nickel chloride results in increased expression of ADM mRNAincreases expression 17547211
D009566 Nitrates ADM protein affects the abundance of Nitratesaffects abundance 15370692
C007350 nitrofen nitrofen results in increased expression of ADM mRNAincreases expression 16226985
C007350 nitrofen nitrofen results in increased expression of ADM proteinincreases expression 16226985
D009599 Nitroprusside Nitroprusside results in decreased expression of ADM mRNAdecreases expression 12899678
D010100 Oxygen Oxygen deficiency results in increased expression of ADM mRNAincreases expression 17968679
17175027
D010126 Ozone Ozone results in increased expression of ADM mRNAincreases expression 16716893
D010656 Phenylephrine ADM protein results in decreased susceptibility to Phenylephrinedecreases response to substance 15370692
D010656 Phenylephrine ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]decreases reaction|increases expression 11470465
D010656 Phenylephrine ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 11470465
D010656 Phenylephrine ADM protein results in decreased susceptibility to Phenylephrinedecreases response to substance 15370692
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNAaffects cotreatment|increases expression 17250927
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM proteinaffects cotreatment|increases expression 17250927
D010656 Phenylephrine Phenylephrine results in decreased expression of ADM mRNAdecreases expression 11470465
D010656 Phenylephrine Phenylephrine results in decreased secretion of ADM proteindecreases secretion 11470465
D010656 Phenylephrine Phenylephrine results in increased expression of ADM mRNAincreases expression 17250927
D010656 Phenylephrine Phenylephrine results in increased expression of ADM proteinincreases expression 17250927
C121565 pifithrin pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]decreases reaction|increases expression 20064835
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of ADM mRNAincreases expression 17547211
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ADM mRNAaffects cotreatment|decreases expression 16054899
C025462 sulindac sulfide sulindac sulfide results in increased expression of ADM mRNAincreases expression 16184548
D013629 Tamoxifen Tamoxifen affects the expression of ADM mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]decreases reaction|increases expression 20064835
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADM mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of ADM proteinincreases expression|increases secretion 16343043
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of ADM mRNAdecreases expression 11470465
D014212 Tretinoin Tretinoin results in increased expression of ADM mRNAincreases expression 16054129
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of ADM mRNAincreases expression 19465080
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of ADM mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.7518287403
MESH:D000138 Acidosis Zinc Sulfate 8.757265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3717505938
MESH:D058186 Acute Kidney Injury pifithrin 4.3817670903
MESH:D055371 Acute Lung Injury Oxygen 4.0216759491
MESH:D000230 Adenocarcinoma arsenic trioxide 11.5919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.5920464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 11.5911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.5914692618
MESH:D000230 Adenocarcinoma Fluorouracil 11.5917638652
MESH:D000236 Adenoma Benzo(a)pyrene 5.646695378
MESH:D000236 Adenoma beta-Naphthoflavone 5.6419389873
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8216835633
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.2516487989
MESH:D000505 Alopecia Tretinoin 3.1615955085
MESH:D000544 Alzheimer Disease Ozone 5.8615513908
MESH:D000544 Alzheimer Disease rosiglitazone 5.8619621015
MESH:D000544 Alzheimer Disease sulindac sulfide 5.8618759972
MESH:D000740 Anemia Fluorouracil 7.0515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.0511748828
MESH:D000756 Anemia, Sideroblastic Manganese 9.3416910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 9.3416910769
MESH:D000799 Angioedema Acetaminophen 3.2710982225
MESH:D000860 Anoxia Oxygen 9.6420872349
MESH:D000860 Anoxia Zinc Sulfate 9.647265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5219183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6217460149
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.3415014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.3411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.1317659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.1315885639
MESH:D001169 Arthritis, Experimental Tretinoin 10.1316412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1016292516
MESH:D001249 Asthma Mustard Gas 6.7210378619
MESH:D001249 Asthma Ozone 6.7217854713 16373670
MESH:D001249 Asthma Tretinoin 6.7216456186
MESH:D050197 Atherosclerosis Cadmium 6.0415687053
MESH:D050197 Atherosclerosis Oxygen 6.0416391483
MESH:D001321 Autistic Disorder marker/mechanism 12579522
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Mercury 2.1517497416
MESH:D001327 Autoimmune Diseases Mercury 4.3216634805
MESH:D001471 Barrett Esophagus Tretinoin 3.8616935849
MESH:D001768 Blister Mustard Gas 4.5919167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.4116206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3815746008
MESH:D001919 Bradycardia Isoproterenol 9.086740701
MESH:D001919 Bradycardia Phenylephrine 9.0815306635
MESH:D001930 Brain Injuries Nitroprusside 5.1414637104
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.1517474063 20146248
MESH:D001943 Breast Neoplasms Chromium 6.1515986119
MESH:D001943 Breast Neoplasms Cyclophosphamide 6.1511325840 15136595 12006526 16978400 18323546 17020986 15093573 18234424 17388661
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 6.1515061365
MESH:D001943 Breast Neoplasms Estradiol 6.1517018787 14630087 16675129 17261762 18497071 17289903 19861407 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 6.1518357371 19217205 18608205 15136595 16110121 16595493 16557594
MESH:D001943 Breast Neoplasms Oxygen 6.1517263869
MESH:D001943 Breast Neoplasms Tamoxifen 6.1517242785 20544844 18425577 19155303 19289846 18629630 18821012 15565566 19066611 19084267 19059307 15668708 18855134 20135344 19103187 19011961 19244106 11161223 16818667 20859285 19142967 20390343 18997820 21152245 16273361 19189212 17049068 19221464 20005174 17893378 18984771 19189210 17440819 21138602 18351453 18815881 19487384 17261762 20065188 19410462 16202921 19288272 19115204 19200415 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.1520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.1516443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2319059883 18417511 14754758 17626835 15516495 18315731 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.5915286001
MESH:D001991 Bronchitis Antimony 5.568768112
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4017687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8111589617
MESH:D002100 Cachexia Ozone 4.1716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2316050911 16124888 3786805 18705752 16192424 16097048 10355542 16011737 15721981 16227642 15700767 15673190
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0916051944
MESH:D002277 Carcinoma Fluorouracil 6.6817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.6816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.433084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 17.4312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 17.4316217749 15553829 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 17.4318788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 17.4319701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.4316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 17.4317971768 16332177 17088986 17045692 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 17.4316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 17.431917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3216152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.2312391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3019014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 5.8316201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.8318695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.1420419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.1418986760 16280240 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.1418922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.1416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1217572228
MESH:D006332 Cardiomegaly Isoproterenol 9.6211179087 7544033
MESH:D006332 Cardiomegaly Phenylephrine 9.6216170337 11754973 17287366 15728586 17124262 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.6218850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 5.7810334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.7810334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.1116936243
MESH:D002386 Cataract Acetaminophen 6.0410977129
MESH:D002386 Cataract Tretinoin 6.0417460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 8.9317332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.9312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.9318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0216129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D002779 Cholestasis Cyclosporine 6.3519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.3517110522 16919318 17333356 11677210 15861022 17681005 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.5816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.878697196 16354765 15340226 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 4.879407595
MESH:D003092 Colitis Tretinoin 3.1617035595
MESH:D003110 Colonic Neoplasms Dexamethasone 3.4815824018
MESH:D003110 Colonic Neoplasms Fluorouracil 3.4815001691 17287894 16510598 17169374 18772588 17172411 17725105 17016597 16340194 17018589
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.3820501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.3816282729 17401013 18448328 16331619 16524972 18383874 20501625 17016601 18802399 17594712 17695437 15289873 14970324 18509181 16391804 17454858 17255274 16303861 17094418 15148649 18949393 18288408
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.4310525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.4317728286
MESH:D019465 Craniofacial Abnormalities nitrofen 6.4311405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.4310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.4316925845 17551590 9211117 10589399 9224671 9664655 9142499 14991402 9125849 8800419
MESH:D003556 Cystitis Cyclophosphamide 4.4118483878 15643279 12913760 15276878 18433785 18372110 12161096 12388444 17979934 16413132 17010015 10498854 16989017 16614059 18295254 18093676 10700343 11948286 18710439 16651033
MESH:D007644 Darier Disease Fluorouracil 4.2316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8119031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 8.7712438553
MESH:D017449 Dermatitis, Allergic Contact Mercury 8.7716823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 8.7716823706
MESH:D003920 Diabetes Mellitus rosiglitazone 3.8217446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.6111751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0218772604
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 3.9212642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9217107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.2519279558
MESH:D003967 Diarrhea Dexamethasone 3.187237001
MESH:D004283 Dog Diseases Antimony 5.0912019027
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.3210663392 12594235 12153990 19164858 14550746 16485898 12705907 15968718 12540782 11739529 11287661 15619225 10915739 19370779 11529661 19085960 17906064 19923254 12958197 16081117 14986274 10774834 16781746 16109766 16227642 16393943 11834606 19420014 14725611 12392966 19739265 16177239 19416960 18713872 11461765 17562736 18071297 11743745 11421492 2444490 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.3211566570 21278145 6884620 17522070 7179309 9327722 15027814 10915739 2869522 7440962 10092053 15968718 19085960 4309450 15998439 16227642 7120509 6623471 3732212 16177239 19336974 3786805
MESH:D056486 Drug-Induced Liver Injury Diquat 7.3218445702 18164269
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.3220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3311462148
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 9.0116487989
MESH:D004417 Dyspnea Oxygen 9.0120016425
MESH:D004485 Eczema Dexamethasone 3.9212438553
MESH:D004487 Edema Dexamethasone 16.3719703484
MESH:D004487 Edema Mustard Gas 16.379260866 11428631 11428647 11402378
MESH:D004487 Edema rosiglitazone 16.3712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.3711000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 16.377812673 9599246 8113982 11698051 16716910 15177302 8273558
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.0318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.1719031437
MESH:D016889 Endometrial Neoplasms Estradiol 10.1818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.1816202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 10.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.539294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 3.6711006010
MESH:D004890 Erythema Mustard Gas 4.599357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.1912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.1916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.1915173087 17638652 16337965 16785472 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4016938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 24.1815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.1812795759 16239168 15959796 17595544 16045604 19224547 12631006 61145
MESH:D005234 Fatty Liver Cyclosporine 24.1819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.1815345470
MESH:D005234 Fatty Liver rosiglitazone 24.1819196556
MESH:D005234 Fatty Liver Tamoxifen 24.1819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 16.6218705752
MESH:D005355 Fibrosis Cyclosporine 16.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.6220067830
MESH:D005355 Fibrosis Tretinoin 16.6217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7216904648
MESH:D005739 Gas Poisoning Oxygen 4.6420016425
MESH:D005756 Gastritis Acetaminophen 9.5416983495
MESH:D005756 Gastritis Diquat 9.5415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.658708960
MESH:D005909 Glioblastoma Manganese 6.1717043766
MESH:D005909 Glioblastoma Tretinoin 6.1717312396
MESH:D005910 Glioma Fluorouracil 2.6216145905
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9511389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0210696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.4816376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.4715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.3420471113
MESH:D006330 Heart Defects, Congenital nitrofen 13.3416080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.349664655 14991402
MESH:D006331 Heart Diseases pifithrin 4.1914766674
MESH:D006333 Heart Failure Isoproterenol 3.8818097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8515720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.7411918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8311000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.9614986274
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0119110552 19900420
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 8.0116487989
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.4517063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.3516120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.657520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 5.6518280292 16292651 11076806 16863852 15136996 15764645 7760232 7576705 12194112 10359170 15088113 17270546 18280291 11685700 16490937 10370017 9476886 15707848 15793718 10898222 12746050 9575882 15756563 9473106 8863223 15185205 12547725 11051153 12505043 12021965 17245593 9698600 16473863 10646786 11588001 9859898 16080930 10370016 17618886 7520565 10693666 11057544 18958481 15578192 10541330 11409163 11584395 12904592 11329586 12759764 10898224 12407540 16720372
MESH:D006558 Herpes Genitalis Estradiol 4.4515709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.3217606976 16135485
MESH:D019584 Hot Flashes Estradiol 3.1817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4716354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia marker/mechanism 17043245
MESH:D006930 Hyperalgesia Acetaminophen 10.4816870215
MESH:D006930 Hyperalgesia rosiglitazone 10.4812083418
MESH:D006930 Hyperalgesia Tretinoin 10.4816870215
MESH:D017588 Hyperandrogenism Flutamide 4.8815356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0116778211
MESH:D006973 Hypertension Cyclosporine 10.3210903974
MESH:D006973 Hypertension Dexamethasone 10.3217042910
MESH:D006973 Hypertension Phenylephrine 10.3212717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.3218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5415338365
MESH:D006984 Hypertrophy Isoproterenol 9.3112791704
MESH:D006984 Hypertrophy Phenylephrine 9.3118502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2616569931 16945680
MESH:D007022 Hypotension Isoproterenol 8.036740701
MESH:D007022 Hypotension Zinc Sulfate 8.037265320
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.8718306037
MESH:D007154 Immune System Diseases Cyclophosphamide 4.7516076520
MESH:D020244 Infarction, Middle Cerebral Artery pifithrin 5.1219475672
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9412013081
MESH:D007248 Infertility, Male Cyclophosphamide 12.967193160 16517039
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 12.9612948891 17192596
MESH:D007248 Infertility, Male Diquat 12.964850670
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.9617937319
MESH:D007249 Inflammation Dexamethasone 19.2911099482 8960868
MESH:D007249 Inflammation Flavonoids 19.2917296493
MESH:D007249 Inflammation Mustard Gas 19.2916001271 17524151 11428647 8975870 11402378 11428620 9357497 9260866 11428631
MESH:D007249 Inflammation rosiglitazone 19.2912083418
MESH:D007249 Inflammation Tamoxifen 19.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.2912200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 19.297562506 7812673 11698051 8273558 15177302
MESH:D007333 Insulin Resistance Estradiol 6.3416393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 6.3416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2417551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.8718306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8615604871
MESH:D007674 Kidney Diseases Acetaminophen 23.5012587719 15629191
MESH:D007674 Kidney Diseases Cadmium 23.5016226777 16322080 16962696
MESH:D007674 Kidney Diseases Chromium 23.5017934191
MESH:D007674 Kidney Diseases Cyclosporine 23.5010903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 23.5015618244
MESH:D007674 Kidney Diseases Mercury 23.5017934191
MESH:D007674 Kidney Diseases Potassium Dichromate 23.5019665454
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9612371664
MESH:D007680 Kidney Neoplasms Estradiol 13.9615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.9616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.9618625569
MESH:D007896 Leishmaniasis Antimony 4.3321182181 21063981 12019027 10953559 15220340
MESH:D016773 Leishmaniasis, Cutaneous Antimony 7.5419141829 8889330 11475954
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 7.5415237267
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 4.9211370249 7854095 9643325 10881086 10651420
MESH:D007898 Leishmaniasis, Visceral Antimony 7.287554475 11105143 1899875 7854095 7875148 8142506 20495762
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.2812707265
MESH:D007938 Leukemia arsenic trioxide 8.7515070760
MESH:D007938 Leukemia Cyclophosphamide 8.7510602166
MESH:D007938 Leukemia Tretinoin 8.7517143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2317008537 18172266 17802794 18587576 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.1914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.1910373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.7919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.7916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.4420471514 17050201 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.4419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 10.669834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.6616966277 15748426 11161223 12712474 12679006 16331271 17869043 9834237 16823087 16330433 15622746 17712046 19225113 17217047 17649720 15336539 19035177 12018890 19642359 19075265 16112521 11468182 15213294 17107899 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.6619225113 19075265 16935935 16823087 17217047 17294898 17339181 16891316 17301526 17361223 16331271 9834237 16766008 17712046 17368321 16788101 19035177 17649720 19029980 17506722 15748426 12679006 16140955 19642359 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8116882451
MESH:D007970 Leukopenia Cyclophosphamide 4.4010052129 11830472
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 7.2512745335
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.259224671
MESH:D008064 Lipidoses Tamoxifen 2.7415342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.4817334410 11903743 16239168 17157831 21278145 16943688 16221502 17174718 11408273
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 16610064 15370692
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.4318395914 18187930 18339082 16192424 15362042 12958196 10355542 18156304 18205269 18429990 15996030 15959796 12632514 18263696 15338365 14716833 17708605 16011737 18412020 17976157 15123356 18418968 16248980 18395095 12741479 12667390 17761835 12609069 15818738 13678700 12898905 18420326 18376398 17525996 17721639 12445421 12586293 17640975 17805973 15876570 18251166 17766677 18279442 17900296 18210741 16097048 17714472 16033810 17557913 17631135 15931870 15052691 15673190 16027843 18006644 12632512 18481824 14724832 14716496 15370692 15925388 12649538 12389079 16015684 16136751 12445418 18277467 12666154 18317297 16116963 17823541 11481614 18472094 15057751 20821823 18054572 17869086 14748882 14512876 16638106 18166357 15650968 14620537 17698563 18472332 17565644 15730626 17944888 17922224 15893842 17481882 18705752 12546737
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 9.4316718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 9.4317347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.4318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.3119014921 16611625 12969438 16610002 19460945 19784758 12587719 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.3116964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.7717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.7716899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.529163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 21.5214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.5221137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.5221295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.5219294768
MESH:D008113 Liver Neoplasms Fluorouracil 21.5218383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 21.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.5216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.708603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.7020377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.7018164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9115213294
MESH:D008171 Lung Diseases Mustard Gas 10.2718702808 18161513
MESH:D008171 Lung Diseases nitrofen 10.279614859 16863852 9859898 17245593
MESH:D008171 Lung Diseases Ozone 10.278266340 19066396
MESH:D055370 Lung Injury Asbestos, Crocidolite 12.1417365036
MESH:D055370 Lung Injury Oxygen 12.1418339021
MESH:D055370 Lung Injury Ozone 12.1420417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 18.2014755239
MESH:D008175 Lung Neoplasms arsenic trioxide 18.2019825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.2020064080 18816296 20135361 18569708 20869020 6695378 18520028 17053015 20464547
MESH:D008175 Lung Neoplasms Dexamethasone 18.2011195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 18.2015246190
MESH:D008175 Lung Neoplasms Mustard Gas 18.203148597 8781369
MESH:D008175 Lung Neoplasms Ozone 18.208597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 18.2018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.2011884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 18.2011807781
MESH:D008175 Lung Neoplasms Vehicle Emissions 18.209255578
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2315086387
MESH:D008223 Lymphoma Cyclophosphamide 3.4312854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.0716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7011911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2019428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 14.8112807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.8111408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 14.8116827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.8114580682 19196723 11731420 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.818985016
MESH:D020149 Manganese Poisoning Estradiol 19.0619453300
MESH:D020149 Manganese Poisoning Manganese 19.0616568477 19453300 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 19.0619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5317453147
MESH:D008545 Melanoma Tamoxifen 2.8912393984 19393235
MESH:D008545 Melanoma Tretinoin 2.8916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.0019513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.0016388313
MESH:D008591 Meningomyelocele Tretinoin 3.8716940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 2.9316166281 18303189 16966607
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.9117261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2116801185
MESH:D008679 Metaplasia Ozone 4.5310496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.0616757204 18986760
MESH:D009069 Movement Disorders Manganese 4.4916551646
MESH:D009101 Multiple Myeloma arsenic trioxide 6.0619549372 19417148 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma Dexamethasone 6.0615744524 16118317 15867202
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.3416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 10.349809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.3417596541
MESH:D009203 Myocardial Infarction Isoproterenol 3.5916584858 17052832 19595682 16697266 19172585 15740881 16538859
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8416810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4216624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 9.3511141357
MESH:D009369 Neoplasms Cyclophosphamide 9.3518854779
MESH:D009369 Neoplasms Fluorouracil 9.3518239605 18600527 16928823
MESH:D009369 Neoplasms Tretinoin 9.3516594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8118481113 19348381
MESH:D009410 Nerve Degeneration Manganese 3.8416551646
MESH:D009421 Nervous System Malformations Estradiol 13.2316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.2314600291
MESH:D009421 Nervous System Malformations Tretinoin 13.239125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.0110525206
MESH:D009436 Neural Tube Defects Tretinoin 6.019142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.3216115947 15176712 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4118514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.3212837982 8761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0416436463
MESH:D009503 Neutropenia Cyclophosphamide 7.808291058
MESH:D009503 Neutropenia Mustard Gas 7.807688884 16761898
MESH:D009845 Oligospermia Cyclophosphamide 4.1516517039
MESH:D010051 Ovarian Neoplasms arsenic trioxide 6.6219769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 6.6219401270
MESH:D010051 Ovarian Neoplasms Tretinoin 6.6216936753
MESH:D010146 Pain marker/mechanism 17043245
MESH:D010146 Pain Acetaminophen 8.6416870215
MESH:D010146 Pain Cyclophosphamide 8.6412161096 18093676
MESH:D010146 Pain Tretinoin 8.6416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 13.7815580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 13.7811332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 13.7816929163 16500647 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 13.7815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.7815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1611578682
MESH:D010212 Papilloma Hydrogen Peroxide 7.7912065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.7912065085 18922899 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.6419927285
MESH:D010300 Parkinson Disease Manganese 3.1411181820
MESH:D020734 Parkinsonian Disorders Manganese 3.9816140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6712520081
MESH:D010409 Penile Diseases Antimony 5.189643325
MESH:D010493 Pericarditis Antimony 5.5520465667
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8215687053
MESH:D010538 Peritonitis Ozone 3.5816369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3410923243
MESH:D011014 Pneumonia Ozone 3.8318007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.2815727166
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.5015356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0218163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.7412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.6721297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.6721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.6311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2717292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.2717075824
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2717136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.2716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2718626508 19082440
MESH:D011471 Prostatic Neoplasms Flutamide 2.273169114
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2715067354
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 7.6515861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.6518058305
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011625 Pterygium Tretinoin 4.2316723453
MESH:D011654 Pulmonary Edema Isoproterenol 4.6810903255
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 7.9417975199 15814490 17365031 17322281
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 7.9416636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 7.9410334151 17620002 17266442 17720292 17894541
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5315538739 18286688 16160472 18722050
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.7611700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 7.7617627322 18339021
MESH:D012135 Respiratory Sounds Vehicle Emissions 4.6718950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5816116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4216646077
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3016636934
MESH:D012852 Sinusitis Phenylephrine 4.147327846
MESH:D012871 Skin Diseases Mustard Gas 2.5516961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.6119755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 18.6112065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 18.618532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.6116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 18.6118404319 11807781 8330346 12065085 8985016
MESH:D012878 Skin Neoplasms Tretinoin 18.6116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.6416709447
MESH:D013088 Spermatocele Tamoxifen 9.6416709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9516517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4719457130
MESH:D013272 Stomach Diseases Dexamethasone 3.7615472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.1017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.1020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.1018567086 17172411 17498489 17522103 19015929 16424979 18396642 19084572 16951190 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.1017261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.0015138204
MESH:D013345 Subarachnoid Hemorrhage pifithrin 5.4818364113
MESH:D013398 Sudden Infant Death Oxygen 4.9812563064
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.4912837982
MESH:D013610 Tachycardia Nitroprusside 5.0815306635
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.7019014326
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 9.7016940797
MESH:D013964 Thyroid Neoplasms Tretinoin 9.7016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.1119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.1916280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.1916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4015213294
MESH:D014352 Trypanosomiasis Antimony 5.3515220340
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.1011780464 12973940 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.1017053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.1014692829
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.108653321 16712894 17572228
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 13.1011144890
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.1616487989
MESH:D014581 Urticaria Acetaminophen 2.4610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.8116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.8116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.9114692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 7.9118645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.0316752155
MESH:D014605 Uveitis Cyclosporine 9.851336536
MESH:D014605 Uveitis Dexamethasone 9.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0212125929
MESH:D020301 Vasospasm, Intracranial pifithrin 5.0518364113
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0315869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.5718097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.1218097624
MESH:D014820 Vitiligo Tretinoin 3.5216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6715886252
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8617120751
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24580
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA450801paroxetine
    PA449015citalopram
    PA449673fluoxetine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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