AutismKB 2.0

Annotation Detail for NHEDC2


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Basic Information Top
Gene Symbol:NHEDC2 ( FLJ23984,NHA2,NHE10 )
Gene Full Name: Na+/H+ exchanger domain containing 2
Band: 4q24
Quick LinksEntrez ID:133308; OMIM: 611789; Uniprot ID:NHDC2_HUMAN; ENSEMBL ID: ENSG00000164038; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NHEDC2 mRNAaffects expression 17555576
D008094 Lithium NHEDC2 protein affects the transport of [Sodium co-treated with Lithium]affects cotreatment|affects transport 18000046
D010693 Phloretin Phloretin results in decreased activity of NHEDC2 proteindecreases activity 18000046
D012964 Sodium NHEDC2 protein affects the transport of [Sodium co-treated with Lithium]affects cotreatment|affects transport 18000046
D012965 Sodium Chloride NHEDC2 protein affects the abundance of Sodium Chlorideaffects abundance 18000046
D013629 Tamoxifen Tamoxifen affects the expression of NHEDC2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000544 Alzheimer Disease Lithium 3.5219621015
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001714 Bipolar Disorder Lithium 4.4620338123 17594078 19153942 20046352
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819410462 19487384 20859285 19011961 19244106 15668708 11161223 20544844 20390343 18855134 18425577 17893378 21152245 18815881 19103187 19115204 16818667 18351453 17242785 17049068 21138602 18629630 16273361 19142967 18821012 17440819 19066611 19189210 18997820 19189212 20005174 16202921 16873071 15565566 19288272 19084267 18984771 19221464 20135344 19200415 20065188 19155303 17261762 19059307 19289846
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1016105132 17333356 17681005 17110522 16919318 15861022 11677210
MESH:D007644 Darier Disease Lithium 6.3720338123
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 6.1619244398
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2420544844 19155303 16202921 17893378
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D006330 Heart Defects, Congenital Lithium 4.3619638421
MESH:D006973 Hypertension Sodium Chloride 4.1411507004
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 5.199499605
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3116684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8114580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D009203 Myocardial Infarction Lithium 4.0316288908
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19189210 19196722
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D012640 Seizures Lithium 4.1819660546
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013226 Status Epilepticus Lithium 6.3119951488 19430551 19570321
MESH:D013274 Stomach Neoplasms Sodium Chloride 3.3816646055
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.458653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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