AutismKB 2.0

Annotation Detail for WDR36


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Basic Information Top
Gene Symbol:WDR36 ( DKFZp686I1650,GLC1G,TA-WDRP,TAWDRP,UTP21 )
Gene Full Name: WD repeat domain 36
Band: 5q22.1
Quick LinksEntrez ID:134430; OMIM: 609669; Uniprot ID:WDR36_HUMAN; ENSEMBL ID: ENSG00000134987; HGNC ID: 30696
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
plasma eosinophil count
eosinophilic esophagitis (pediatric)
Desease Name
Eosinophilic esophagitis (pediatric)
Plasma eosinophil count
Desease Name
Glaucoma 1, open angle, G
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WDR36 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of WDR36 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of WDR36 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of WDR36 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WDR36 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WDR36 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of WDR36 mRNAaffects expression 17484886
D002117 Calcitriol Calcitriol results in increased expression of WDR36 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of WDR36 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR36 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR36 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of WDR36 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.287525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma marker/mechanism 19198610
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0911237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 16192424 16011737 16050911 3786805 16097048 16227642 18705752 15673190 15721981 15700767 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.123581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.123084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.1218788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6611237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.7414694615
MESH:D002386 Cataract Acetaminophen 7.7410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.856135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.857505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8520889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.289022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817110522 17333356 16919318 15861022 17681005 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 12621046 15668235 8697196 15340226
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.7015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111298694 11906362 8970840 12868966 18759878 8156756 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.431440618 8291058 11289319 18648102 16192314 6482804 9328219 9022650 6679447 18692083 18289764 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.4321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.4318713872 14725611 14550746 10663392 12540782 19420014 17906064 16109766 12153990 11461765 11743745 14986274 11529661 17522070 12705907 11834606 18071297 17562736 11739529 19370779 16227642 10915739 16177239 12392966 10774834 19164858 19739265 15968718 19085960 15619225 12594235 16485898 11421492 16393943 16081117 16781746 19923254 19416960 2444490 12958197 11287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.4316177239 6884620 19085960 10092053 7440962 7179309 3786805 2869522 11566570 15968718 19336974 9327722 6623471 10915739 15998439 16227642 7120509 17522070 21278145 4309450 3732212 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.7615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7612538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2716239168 12631006 17595544 12795759 15959796 16045604 19224547 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
OMIM:609887 GLAUCOMA 1, OPEN ANGLE, G marker/mechanism
OMIM:137760 GLAUCOMA, PRIMARY OPEN ANGLE marker/mechanism
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.256582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917334410 11903743 21278145 17157831 16221502 11408273 16239168 16943688 17174718
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3315673190 17900296 17714472 13678700 15338365 11481614 18279442 15123356 18210741 14716496 18429990 18472094 12898905 17944888 12741479 18156304 12586293 12667390 18412020 18054572 12632514 14748882 16027843 15931870 18251166 18420326 18395914 18187930 17805973 18339082 16248980 18006644 15730626 18166357 17708605 18263696 15996030 17698563 12546737 18277467 17557913 18481824 18205269 17976157 10355542 15362042 18376398 14716833 17721639 17761835 16033810 17823541 16097048 17565644 17631135 18705752 15057751 12632512 16116963 16192424 17869086 17922224 14620537 12609069 15876570 16011737 12958196 16638106 17525996 18395095 15893842 15650968 12445421 14512876 15052691 15925388 18317297 15370692 17481882 17640975 18418968 16136751 12666154 14724832 12389079 15818738 17766677 12649538 12445418 16015684 15959796 20821823 18472332
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0316610002 19014921 19784758 16611625 12587719 12969438 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0315830285 16964402 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.727678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.962876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.961399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.9612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.9612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.157678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 22.9812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 22.9816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 22.984026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 22.9814694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5116289102 15754350 12479363 16644109 18247401
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016587162 1399818 7505956 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134933637
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA444282Glaucoma, Open-Angle
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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