AutismKB 2.0

Annotation Detail for ACOT12


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Basic Information Top
Gene Symbol:ACOT12 ( CACH-1,Cach,MGC105114,STARD15,THEAL )
Gene Full Name: acyl-CoA thioesterase 12
Band: 5q14.1
Quick LinksEntrez ID:134526; OMIM: NA; Uniprot ID:ACO12_HUMAN; ENSEMBL ID: ENSG00000172497; HGNC ID: 24436
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACOT12 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACOT12 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ACOT12 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of ACOT12 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACOT12 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of ACOT12 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACOT12 mRNAdecreases expression 20106945
D002994 Clofibrate Clofibrate affects the expression of ACOT12 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ACOT12 mRNAdecreases expression 20106945
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased activity of ACOT12 proteinincreases activity 16476568
D005001 Ethionine Ethionine affects the expression of ACOT12 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of ACOT12 mRNAaffects expression 19483382
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACOT12 mRNAincreases expression 16221955
C006253 pirinixic acid pirinixic acid results in increased expression of ACOT12 mRNAincreases expression 17426115
18301758
C006253 pirinixic acid pirinixic acid affects the expression of ACOT12 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ACOT12 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACOT12 mRNAdecreases expression 18796159
D013853 Thioacetamide Thioacetamide affects the expression of ACOT12 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.686734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7820041841 18218290 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 3.8918651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.3319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.3319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.3319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.3319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.3319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.3312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.3319483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9020146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.863084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 8.861701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.8617997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0818974383
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.166135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.161399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1612371664
MESH:D002637 Chest Pain Omeprazole 5.1115447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.4918291259
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.8518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.8518551238
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.9416882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.9418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2012958197 11529661 10915739 16781746 11287661 10663392 14986274 19739265 11834606 12540782 16227642 12153990 16081117 14550746 19416960 14725611 11461765 15968718 18071297 12594235 12705907 16109766 17522070 17562736 11421492 10774834 17906064 15619225 11739529 11743745 16393943 16177239 19923254 2444490 18713872 19370779 19164858 12392966 16485898 19420014 19085960
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.2018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.2012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3121218061 16613094 15991576 17151854
MESH:D050171 Dyslipidemias Clofibrate 4.0516707586
MESH:D004487 Edema perfluorooctanoic acid 11.3617259670 12083418
MESH:D004487 Edema pirinixic acid 11.3612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.7216456712
MESH:D005234 Fatty Liver Amiodarone 18.6614986274
MESH:D005234 Fatty Liver Clofibrate 18.6619224547
MESH:D005234 Fatty Liver Cyclosporine 18.6619224547
MESH:D005234 Fatty Liver pirinixic acid 18.6620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5517276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 4.2016456712
MESH:D006529 Hepatomegaly Amiodarone 20.6215265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 20.623609246
MESH:D006529 Hepatomegaly pirinixic acid 20.6216221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.6215340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.8016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.8012083418
MESH:D006937 Hypercholesterolemia Amiodarone 3.859751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 11.5717991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.578137927 18031379
MESH:D007249 Inflammation perfluorooctanoic acid 5.1112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.7518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2612371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0819248655
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.228812269
MESH:D008064 Lipidoses Amiodarone 3.4917567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4612175628 18295389 12557150 11172339 18263696 15075984 16511523 16098781 18606216 18032466 17127702 16126171 18395095 15095483 16489207 15716488 15465738 11682029 12891558 15158331 15362042 15316131 17050028 18031379 12085344 18416461 18615449 15078482 17355460 12679928 16248980 11481614 16343077 15288473 15288472 15334695 16097051 15474484 17292413 12531686 18458672 14739098 10677585 17629604 18380797
MESH:D008107 Liver Diseases Acetaminophen 4.1116611625 11587558 16610002 12587719 12969438 19460945 19014921 19784758
MESH:D008107 Liver Diseases Thioacetamide 4.1115158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.5817276928 15313186 15633222 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.907678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.9021137059 20195826
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 17.9011940454
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.9014757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 17.9020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.9016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.692876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4818516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1820869020 18520028 20135361 20464547 20064080 17053015 18569708 6695378 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1819555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009181 Mycoses Amiodarone 4.9017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.327678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7911141357
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 12.019802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 12.019802331
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.8212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.6417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9817292933
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8411597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8218551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0818724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4419755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4416192470
MESH:D013272 Stomach Diseases Omeprazole 4.6018545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 7.5118087811
MESH:D013276 Stomach Ulcer Omeprazole 7.5111906479 10750652 15991576 18237397 17977527 16755016
MESH:D013610 Tachycardia Amiodarone 4.2711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1719225199
MESH:D013959 Thyroid Diseases Amiodarone 12.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.0512697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.6615710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8519584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.1817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.9610091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:00620 Pyruvate metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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