AutismKB 2.0

Annotation Detail for COX7A1


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Basic Information Top
Gene Symbol:COX7A1 ( COX7A,COX7AH,COX7AM )
Gene Full Name: cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
Band: 19q13.12
Quick LinksEntrez ID:1346; OMIM: 123995; Uniprot ID:CX7A1_HUMAN; ENSEMBL ID: ENSG00000161281; HGNC ID: 2287
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa04260Cardiac muscle contraction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of COX7A1 mRNAdecreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of COX7A1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of COX7A1 mRNAincreases expression 15003993
D002945 Cisplatin Cisplatin results in increased expression of COX7A1 mRNAincreases expression 15464296
D010126 Ozone Ozone results in decreased expression of COX7A1 mRNAdecreases expression 12763052
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of COX7A1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of COX7A1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of COX7A1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of COX7A1 mRNAdecreases expression 18070364
D012643 Selenium Selenium results in decreased expression of COX7A1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D058186 Acute Kidney Injury Cisplatin 4.1612690470 15814532 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Cisplatin 2.7917638652 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.6917854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.2014601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Cisplatin 2.4319526202 18382427
MESH:D001943 Breast Neoplasms Progesterone 2.4317614352 15562024 16175315
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8416777450 18417511 15516495 18315731 17626835 14754758 19059883
MESH:D002100 Cachexia Ozone 5.0316183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.823581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8217982673
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8217173139 20007298 1701930 6705139 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0912023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8717066447 6189445 18337622
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1020889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3519486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 2524372 8970840 11906362 18759878 12868966 14531868 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.107440962 18692083 1440618 18289764 16192314 9328219 6482804 9653073 9022650 11289319 18648102 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:D004362 Drug Toxicity Cisplatin 4.0012649298 15033597 19839026 12231392
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.563581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5620426865
MESH:D004938 Esophageal Neoplasms Cisplatin 7.5616785472 16481741 15464296 15173087 17638652
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8515464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5915464296
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619772884 16221962 19176532 18467677
MESH:D006689 Hodgkin Disease Cisplatin 3.7716170182 16200630
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007249 Inflammation Progesterone 2.6915869954
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4615464296
MESH:D007674 Kidney Diseases Cisplatin 3.3512649298 15190930 12231392 18289764 19839026
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.1111231351
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0021047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.698742319 21047994 19482888 15975961 19073162 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 4.6920007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.356587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.352563599 1399818 6150874 17172636 18308698
MESH:D008171 Lung Diseases Ozone 3.5119066396 8266340
MESH:D055370 Lung Injury Ozone 4.1120417186
MESH:D008175 Lung Neoplasms Cisplatin 2.8317225452 11798837 6189445
MESH:D008175 Lung Neoplasms Ozone 2.837614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5515318939
MESH:D008545 Melanoma Cisplatin 2.4917023156 15577323 16248763 12393984 16432458 11135225 18505091 12374674 17761969 18176117 16809738 12883367 18332650
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0615990972
MESH:D008654 Mesothelioma Cisplatin 6.5917638057
MESH:D008654 Mesothelioma Selenium 6.5915107826
MESH:D008679 Metaplasia Ozone 5.4210496685
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Cisplatin 5.4116773208
MESH:D009369 Neoplasms pirinixic acid 5.4117405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.8115464296
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009447 Neuroblastoma Cisplatin 3.548761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.988761367
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Cisplatin 5.3015464296 17225452 19769630 6897625
MESH:D010051 Ovarian Neoplasms Progesterone 5.3017393432 16525653
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.6819003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6816965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5515464296
MESH:D010538 Peritonitis Ozone 4.3916369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.6617638057
MESH:D011014 Pneumonia Ozone 4.6818007984 18929643 18381685
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D051437 Renal Insufficiency Cisplatin 4.6715464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6714601052
MESH:D012640 Seizures Phenobarbital 2.823137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6615464296
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 18396642 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.8515464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.671399818 7505956 3712494 6582329 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.671399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.488074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.4817225452 12973940 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4016803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8715577323
MESH:D014839 Vomiting Cisplatin 5.0311897121
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04260 Cardiac muscle contraction
KEGG:05016 Huntington's disease
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02659 - Cholic Acid
DB04464 - N-Formylmethionine
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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