AutismKB 2.0

Annotation Detail for ADORA2A


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Basic Information Top
Gene Symbol:ADORA2A ( ADORA2,RDC8,hA2aR )
Gene Full Name: adenosine A2a receptor
Band: 22q11.23
Quick LinksEntrez ID:135; OMIM: 102776; Uniprot ID:AA2AR_HUMAN; ENSEMBL ID: ENSG00000100014,ENSG00000128271; HGNC ID: 263
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500624NGF-independant TRKA activation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1745Huntington disease
1804Chronic obstructive airway disease
1826Cystic fibrosis
1836Panic disorder
1902Kidney failure
1907Depression
2037Phobic anxiety disorder
2091Hypertension
2069Schizophrenia
2074Asthma
2075Heart failure
2226Thrombocytosis
Desease Name
caffeine consumption
CHEMDEPENDENCY
PSYCH
migraine migraine with aura
anxiety disorder
NEUROLOGICAL
caffeine-induced anxiety.
panic disorder
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A proteinaffects binding|increases activity 16793905
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine ADORA2A protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineincreases response to substance 11172060
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A proteinaffects binding|increases activity 19966059
19749167
15452191
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]decreases reaction|increases expression 19966059
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]decreases reaction|increases expression 19966059
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]decreases reaction|increases expression 19966059
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADORA2A mRNAaffects expression 21346803
C057837 3,7-dimethyl-1-propargylxanthine 3,7-dimethyl-1-propargylxanthine binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 11023991
C098657 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 16793905
C098657 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 19749167
C081320 8-(3-chlorostyryl)caffeine ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeineincreases response to substance 11172060
C081320 8-(3-chlorostyryl)caffeine 8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 19966059
C081320 8-(3-chlorostyryl)caffeine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]decreases reaction|increases expression 19966059
C081320 8-(3-chlorostyryl)caffeine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]decreases reaction|increases expression 19966059
D000082 Acetaminophen Acetaminophen affects the expression of ADORA2A mRNAaffects expression 17562736
D000109 Acetylcholine ADORA2A protein results in increased susceptibility to Acetylcholineincreases response to substance 16616212
D000109 Acetylcholine ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]decreases reaction|increases response to substance 16616212
D000241 Adenosine Adenosine results in increased activity of ADORA2A proteinincreases activity 16793905
C008436 adenosine 5'-methylenediphosphate adenosine 5'-methylenediphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]decreases reaction|increases expression 19966059
C008436 adenosine 5'-methylenediphosphate adenosine 5'-methylenediphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
C523965 alpha,beta-methyleneadenosine 5'-diphosphate alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADORA2A mRNAaffects expression 16483693
D000661 Amphetamine ADORA2A gene polymorphism results in increased susceptibility to Amphetamineincreases response to substance 16118787
D000661 Amphetamine ADORA2A protein affects the susceptibility to Amphetamineaffects response to substance 16118787
D000661 Amphetamine ADORA2A protein affects the reaction [Amphetamine results in increased expression of PDYN mRNA]affects reaction|increases expression 12700712
D000661 Amphetamine ADORA2A protein results in increased susceptibility to Amphetamineincreases response to substance 12700712
D002110 Caffeine ADORA2A protein results in increased susceptibility to Caffeineincreases response to substance 11172060
D002110 Caffeine Caffeine analog binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 15452191
D002110 Caffeine Caffeine results in decreased expression of ADORA2A mRNAdecreases expression 16771831
D002251 Carbon Tetrachloride ADORA2A gene mutant form results in decreased susceptibility to Carbon Tetrachloridedecreases response to substance 16783407
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADORA2A mRNAincreases expression 18263696
D003024 Clozapine Clozapine results in decreased expression of ADORA2A mRNAdecreases expression 17266109
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of ADORA2A mRNAdecreases expression 15620428
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of ADORA2A mRNAdecreases expression 15620428
D004958 Estradiol Estradiol results in increased expression of ADORA2A mRNAincreases expression 20068009
D005419 Flavonoids Flavonoids results in increased expression of ADORA2A mRNAincreases expression 18035473
D006220 Haloperidol ADORA2A protein affects the susceptibility to Haloperidolaffects response to substance 11172060
C111599 istradefylline istradefylline binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 19467297
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ADORA2A mRNAincreases expression 16387843
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ADORA2A proteinincreases expression 16387843
C029938 nickel sulfate nickel sulfate results in increased expression of ADORA2A mRNAincreases expression 16780908
D010269 Paraquat Paraquat affects the expression of ADORA2A mRNAaffects expression 16854511
D010269 Paraquat Paraquat results in increased expression of ADORA2A mRNAincreases expression 17077588
D010622 Phencyclidine Phencyclidine results in decreased expression of ADORA2A mRNAdecreases expression 17266109
D010656 Phenylephrine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]decreases reaction|increases expression 19966059
D010656 Phenylephrine 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D010656 Phenylephrine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]decreases reaction|increases expression 19966059
D010656 Phenylephrine 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]decreases reaction|increases expression 19966059
D010656 Phenylephrine adenosine 5'-methylenediphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]decreases reaction|increases expression 19966059
D010656 Phenylephrine adenosine 5'-methylenediphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D010656 Phenylephrine ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]affects reaction|increases expression 19966059
D010656 Phenylephrine alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D010656 Phenylephrine Phenylephrine results in increased expression of ADORA2A mRNAincreases expression 19966059
D010656 Phenylephrine Phenylephrine results in increased expression of ADORA2A proteinincreases expression 19966059
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]decreases reaction|increases expression 19966059
D020849 Raloxifene Raloxifene results in increased expression of ADORA2A mRNAincreases expression 15849065
D013654 Taurine Taurine results in decreased expression of ADORA2A mRNAdecreases expression 16579726
D013853 Thioacetamide ADORA2A gene mutant form results in decreased susceptibility to Thioacetamidedecreases response to substance 16783407
D013853 Thioacetamide Thioacetamide results in increased expression of ADORA2A mRNAincreases expression 16783407
C097270 ZM 241385 ZM 241385 binds to and results in decreased activity of ADORA2A proteinaffects binding|decreases activity 16616212
C097270 ZM 241385 ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]decreases reaction|increases response to substance 16616212
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 4.286734493
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.5818653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 8.5811954676 12718980 16100012 19131640
MESH:D000230 Adenocarcinoma Estradiol 2.0311473722
MESH:D000380 Agranulocytosis Clozapine 4.7716160616 14617031 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4711874814
MESH:D000419 Albuminuria Raloxifene 4.3117308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7618475255 16916582 16459022 15010207
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D000855 Anorexia Amphetamine 4.7612183048 16101753 16084549 12005258
MESH:D001008 Anxiety Disorders marker/mechanism 16118787
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8617460149
MESH:D001321 Autistic Disorder Acetaminophen 2.4018445737
MESH:D001321 Autistic Disorder Adenosine 2.4020468076
MESH:D001321 Autistic Disorder Haloperidol 2.4019368416 18080171
MESH:D001778 Blood Coagulation Disorders Thioacetamide 3.9119483382
MESH:D001919 Bradycardia Phenylephrine 4.2515306635
MESH:D001930 Brain Injuries Raloxifene 4.1916580743
MESH:D001943 Breast Neoplasms Estradiol 2.3417261762 18497071 19861407 17018787 16675129 14630087 17289903 12948864
MESH:D001943 Breast Neoplasms Raloxifene 2.3417440819 16912660 17261762 15572757 15758505 17893378 17049068 16837676 17952589 17595753 15775269 17242785
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4915700767 16124888 15673190 16097048 3786805 16011737 16227642 18705752 15721981 16192424 10355542 16050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.3116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.313084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.3118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3116924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.3117997003
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8217572228
MESH:D006332 Cardiomegaly Phenylephrine 3.3711754973 16170337 17124262 17287366 15728586 11179087
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2415775269
MESH:D002375 Catalepsy Haloperidol 4.611977408 15215559
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5718566989
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.0418291259
MESH:D003072 Cognition Disorders Clozapine 10.7217123785
MESH:D003072 Cognition Disorders Raloxifene 10.7215800139
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.1716037377
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7318551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5720210726
MESH:D003704 Dementia Haloperidol 4.3211575062
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4016780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.9116882537
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9016402076
MESH:D058065 Diabetic Cardiomyopathies Taurine 5.7616025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.1919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.1917308373 17451421 15920148
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2515331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.0710774834 19416960 16177239 11461765 16393943 11287661 16781746 10663392 17522070 18713872 14725611 17906064 19370779 19739265 16081117 12153990 12392966 10915739 12958197 18071297 12705907 19420014 16109766 12540782 11421492 19923254 16227642 2444490 14986274 15619225 19085960 11739529 15968718 19164858 16485898 11743745 17562736 12594235 11834606 14550746 11529661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.0716177239 7179309 15968718 10092053 2869522 6884620 19085960 19336974 21278145 3786805 10915739 3732212 15998439 7120509 4309450 15027814 16227642 7440962 6623471 9327722 17522070 11566570
MESH:D056486 Drug-Induced Liver Injury Prazosin 14.0718071297
MESH:D056486 Drug-Induced Liver Injury Taurine 14.079328219
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 14.0712963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D050171 Dyslipidemias Clozapine 3.9716402076
MESH:D004487 Edema Raloxifene 3.0915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.7215845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.7911473722 19148513 18566989
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1017637181 15328337 15821434
MESH:D004827 Epilepsy Adenosine 4.6511404469
MESH:D005221 Fatigue Amphetamine 5.3019890266
MESH:D005218 Fat Necrosis Thioacetamide 5.4216456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.1216045604 15959796 12795759 17595544 12631006 16239168 61145 19224547
MESH:D005234 Fatty Liver Raloxifene 7.1217473493
MESH:D005334 Fever Lipopolysaccharides 3.7611852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 3.1718705752
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005910 Glioma alpha,beta-methyleneadenosine 5'-diphosphate 5.1917643826
MESH:D005911 Gliosis Paraquat 4.8611124998
MESH:D006331 Heart Diseases Raloxifene 3.3311110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3118665440 17276928 15929193
MESH:D006505 Hepatitis Caffeine 14.2911394713
MESH:D006505 Hepatitis Carbon Tetrachloride 14.2919110552 19900420
MESH:D006505 Hepatitis Thioacetamide 14.2916456712
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006930 Hyperalgesia Acetaminophen 7.4716870215
MESH:D006930 Hyperalgesia Prazosin 7.4712727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006948 Hyperkinesis Amphetamine 10.8114960337 1977408
MESH:D006948 Hyperkinesis Clozapine 10.8116046005
MESH:D006973 Hypertension Phenylephrine 5.2712717712 8949925
MESH:D006973 Hypertension Raloxifene 5.2717577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D006984 Hypertrophy Phenylephrine 4.2918502941 12791704
MESH:D007248 Infertility, Male Paraquat 3.064850670
MESH:D007249 Inflammation Flavonoids 4.8617296493
MESH:D007249 Inflammation Lipopolysaccharides 4.869205823 17963957 17237260 17255318 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7816393666 16627594
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D007674 Kidney Diseases Acetaminophen 5.3212587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.3215618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.5816705839
MESH:D007680 Kidney Neoplasms Estradiol 6.5815610895
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D008064 Lipidoses Clozapine 3.7517567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6516221502 17157831 17334410 16943688 17174718 21278145 11903743 16239168 11408273
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 16783407
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 8.2418263696
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2418418968 18472094 18187930 18395914 15876570 16248980 17525996 15931870 12741479 18210741 17640975 17922224 15362042 16638106 17708605 17714472 18156304 12898905 15730626 17805973 17761835 17557913 12958196 15338365 15673190 18412020 16192424 14748882 12632514 16136751 12667390 15818738 15123356 17869086 15996030 18472332 18339082 17481882 18429990 18251166 16027843 12546737 12632512 12649538 12445421 18376398 17766677 18277467 12586293 16116963 17631135 17565644 15052691 14724832 12445418 14716833 17944888 14620537 18205269 16011737 15959796 13678700 17900296 12666154 12609069 15057751 14716496 15370692 15925388 16015684 11481614 15650968 17698563 14512876 10355542 17823541 18317297 18395095 16033810 18006644 18705752 20821823 15893842 18263696 17721639 18166357 18054572 18279442 12389079 18481824 17976157 16097048 18420326
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.2412878042
MESH:D008106 Liver Cirrhosis, Experimental Taurine 8.2415893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.2417629604 16126171 18458672 12531686 18295389 17127702 11682029 15078482 15288472 15288473 15474484 18032466 16343077 15316131 15158331 10677585 15095483 16489207 17355460 18263696 18031379 15334695 16248980 15075984 17292413 16098781 15716488 18416461 16511523 16097051 18380797 12679928 12557150 11481614 15362042 17050028 12175628 14739098 18606216 11172339 18615449 18395095 15465738 12891558 12085344
MESH:D008107 Liver Diseases Acetaminophen 6.0712969438 16610002 19460945 19784758 16611625 19014921 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0715720792 16964402 15830285 17285989 16246199
MESH:D008107 Liver Diseases Thioacetamide 6.0715158337 16337175 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.7817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.7816899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 14.7815313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 4.6511940454
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.4412014681 15583823
MESH:D055370 Lung Injury Lipopolysaccharides 3.7221114838
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3811807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D001523 Mental Disorders Clozapine 7.3916856516
MESH:D001523 Mental Disorders Haloperidol 7.3916856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1719142101
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2316497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0616810080
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5618551238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009410 Nerve Degeneration Paraquat 3.4916893418
MESH:D009421 Nervous System Malformations Estradiol 3.3716427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8718514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 7.8715183010
MESH:D009765 Obesity Clozapine 2.9418515891 19142110
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1712819281 16049721
MESH:D010024 Osteoporosis Raloxifene 3.2119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9617823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.1319401270
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010300 Parkinson Disease Paraquat 2.7111181820 15451049 16510128 16140633 11124998 15824117 11445065 12911755
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1416190885
MESH:D011014 Pneumonia Lipopolysaccharides 10.1411605937 12224865
MESH:D011014 Pneumonia Paraquat 10.1412504350
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.4516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.4516536755 16220300 15731164
MESH:D011595 Psychomotor Agitation Haloperidol 4.6711575062
MESH:D011618 Psychotic Disorders Clozapine 8.4615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.4611575062
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8017997886 16324872
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6411700416
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 7.919413022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 7.9110835634
MESH:D012135 Respiratory Sounds Paraquat 3.7711874814
MESH:D012162 Retinal Degeneration Paraquat 3.6516458197
MESH:D012559 Schizophrenia Clozapine 3.9420107430 17667964 18855531 16141801 17726453 20452607 20168265 19369910 20580759 18806925 20521320 11763009 17123785 20521326 11151749
MESH:D012559 Schizophrenia Haloperidol 3.941830565 18513383 19369910 20107430
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3418551238
MESH:D012852 Sinusitis Phenylephrine 4.417327846
MESH:D012893 Sleep Disorders Caffeine 5.0219395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.8017225163
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.121977408
MESH:D020521 Stroke Raloxifene 3.5916837676
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.4320210726
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D013978 Tibial Fractures Estradiol 12.7119048282
MESH:D013978 Tibial Fractures Raloxifene 12.7119048282
MESH:D014202 Tremor istradefylline 6.6119467297
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.8116049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.8117572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0210091137
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D015430 Weight Gain Clozapine 4.2220564506 17502770 16141801 20107430 16402076 20521320
MESH:D015431 Weight Loss Clozapine 4.7817933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24584
    • Releated gene ID Related gene Name
    PA24584ADORA2A
    Releated disease ID Related disease Name
    PA445254Parkinson Disease
    PA444354Headache
    PA446876Substance-Related Disorders
    PA445208Pain
    PA443434Arthritis, Rheumatoid
    PA443431Arthritis, Experimental
    PA443937Drug Toxicity
    Releated drug ID Related drug Name
    PA448049adenosine
    PA448015acetaminophen
    PA448385amitriptyline
    PA164712462Antiinflammatory agents, non-steroids
    PA450550morphine
    PA450732oxcarbazepine
    PA450428methotrexate
    PA448710caffeine
    PA451647theophylline
    PA10004adalimumab
    PA452639infliximab
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00201 multitarget Wigraine Tab Central Nervous System Stimulants;Anorexigenic Agents;Phosphodiesterase Inhibitors
    DB00277 antagonist Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00358 antagonist Mefloquine Antimalarials
    DB00640 agonist Adenosine Analgesics;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents;Cardiac drugs
    DB00651 antagonist Dyphylline Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00806 antagonist Pentoxifylline Free Radical Scavengers;Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors;Radiation-Protective Agents;Hematologic Agents;Hemorrheologic Agents
    DB01303 antagonist Oxtriphylline Bronchodilator Agents
    DB01412 antagonist Theobromine Vasodilator Agents;Bronchodilator Agents
    DB04932 - Defibrotide Antithrombotic Agents
    DB08770 - 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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