AutismKB 2.0

Annotation Detail for CD109


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Basic Information Top
Gene Symbol:CD109 ( CPAMD7,DKFZp762L1111,FLJ38569,FLJ41966,RP11-525G3.1 )
Gene Full Name: CD109 molecule
Band: 6q13
Quick LinksEntrez ID:135228; OMIM: 608859; Uniprot ID:CD109_HUMAN; ENSEMBL ID: ENSG00000156535; HGNC ID: 21685
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CD109 mRNAincreases expression 16788091
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CD109 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CD109 mRNAincreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CD109 mRNAincreases expression 17484886
D004958 Estradiol Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD109 mRNA]increases expression|increases reaction 16977382
D007501 Iron Iron deficiency results in increased expression of CD109 mRNAincreases expression 20368581
D008070 Lipopolysaccharides Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD109 mRNA]increases expression|increases reaction 16977382
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CD109 mRNAincreases expression 16977382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CD109 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2911850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.4511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.9916640825
MESH:D000544 Alzheimer Disease Iron 3.0416640825 16563566
MESH:D000740 Anemia Iron 9.6916566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.6911748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.8717162259 17163184 16569441 17375513 17147795
MESH:D000756 Anemia, Sideroblastic Iron 5.0516910769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001145 Arrhythmias, Cardiac Iron 4.6016604332
MESH:D001260 Ataxia Telangiectasia Iron 5.7915336622
MESH:D050197 Atherosclerosis Iron 3.8416640825 16632123
MESH:D001321 Autistic Disorder Iron 2.7717352947
MESH:D001424 Bacterial Infections Iron 5.5316640825
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms marker/mechanism 18507500
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.7917289903 17018787 12948864 18497071 16675129 19861407 14630087 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815673190 15700767 16227642 15721981 16050911 16097048 16192424 16011737 16124888 10355542 18705752 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D009202 Cardiomyopathies Iron 4.1916640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5316604332
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Iron 2.9216640825
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247 18507500
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003920 Diabetes Mellitus Iron 4.6716604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.7216506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9215027814 19085960 10092053 2869522 7120509 7440962 21278145 16177239 7179309 16227642 3732212 10915739 3786805 11566570 15998439 9327722 6884620 15968718 6623471 4309450 19336974 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7315821434 17637181 15328337
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9816239168 61145 17595544 16045604 15959796 19224547 12795759 12631006
MESH:D005234 Fatty Liver Iron 8.9816640825
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever Lipopolysaccharides 4.249205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005621 Friedreich Ataxia Iron 5.7316604332 16640825
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006432 Hemochromatosis Iron 4.6616640825 17053826 16574947 17255318 16604332 17236123
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006486 Hemosiderosis Iron 5.5916604332
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006525 Hepatitis, Viral, Human Iron 5.8516640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.2417182432
MESH:D006529 Hepatomegaly Iron 9.7916890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.7912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D015658 HIV Infections Iron 3.7816597321
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 18606429 8697196 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007006 Hypogonadism Iron 4.5616640825
MESH:D007037 Hypothyroidism Iron 5.3916640825
MESH:D007249 Inflammation Lipopolysaccharides 5.4517255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1116393666 16627594
MESH:D019189 Iron Metabolism Disorders Iron 12.4817163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 12.4817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1815610895
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D020961 Lewy Body Disease Iron 5.7316563566
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.3411408273 17157831 17174718 16221502 17334410 16239168 21278145 16943688 11903743
MESH:D008103 Liver Cirrhosis Iron 7.3416640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1615370692 15362042 17761835 18187930 17708605 18339082 18472094 15123356 12389079 18481824 14512876 18166357 16011737 18205269 12649538 16027843 16136751 17766677 18006644 17565644 17869086 17944888 14716496 18317297 15052691 18705752 17823541 15057751 18376398 16116963 16638106 18279442 18263696 15996030 14748882 18395095 17714472 10355542 17922224 17631135 14716833 12632512 17976157 16192424 16015684 14724832 17481882 17721639 12445418 12741479 15818738 15650968 18054572 12586293 18251166 15893842 16097048 18429990 17900296 11481614 18277467 12609069 15925388 20821823 14620537 18420326 18472332 18210741 16033810 18395914 15931870 17525996 12666154 12898905 17698563 15876570 15959796 12546737 18156304 16248980 15730626 13678700 12445421 17640975 12958196 15338365 18412020 17557913 18418968 12632514 12667390 17805973 15673190
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1612878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1317285989 16246199 15720792 15830285 16964402
MESH:D008108 Liver Diseases, Alcoholic Iron 5.3116737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 15.1115890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.1120195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.1119294768
MESH:D008113 Liver Neoplasms Iron 15.1120302851 16640825
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.1116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.648603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6412151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.066695378 18520028 20135361 20064080 18816296 17053015 20464547 20869020 18569708
MESH:D008175 Lung Neoplasms Iron 5.0616640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0611884234 19555203
MESH:D008268 Macular Degeneration Iron 4.1016640825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.0517086897
MESH:D009181 Mycoses Iron 5.8516640825
MESH:D017202 Myocardial Ischemia Iron 9.8216604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.8212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.3516810080
MESH:D015428 Myocardial Reperfusion Injury Iron 9.3516604332
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009404 Nephrotic Syndrome Iron 4.7317178036
MESH:D009421 Nervous System Malformations Estradiol 10.4211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D019636 Neurodegenerative Diseases Iron 4.4417296847 16604332
MESH:D010003 Osteoarthritis Iron 4.1016640825
MESH:D010024 Osteoporosis Iron 3.9916640825 16648989
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010212 Papilloma Iron 4.7912065085
MESH:D020447 Parasomnias Iron 6.3917352947
MESH:D010300 Parkinson Disease Iron 3.3916640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010900 Pituitary Diseases Iron 6.0516604332
MESH:D011014 Pneumonia Lipopolysaccharides 4.8911605937 12224865
MESH:D011041 Poisoning Iron 4.5516604332
MESH:D017119 Porphyria Cutanea Tarda Iron 11.9816640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.9818163543
MESH:D011225 Pre-Eclampsia Iron 4.6116640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011528 Protozoan Infections Iron 6.3916640825
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012148 Restless Legs Syndrome Iron 4.7216930377
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.0919755658 10029692
MESH:D012878 Skin Neoplasms Iron 10.0912065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.0916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013398 Sudden Infant Death Iron 5.7916640825
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014376 Tuberculosis Iron 4.2216597321
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134949237
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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