AutismKB 2.0

Annotation Detail for CPA1


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Basic Information Top
Gene Symbol:CPA1 ( CPA )
Gene Full Name: carboxypeptidase A1 (pancreatic)
Band: 7q32.2
Quick LinksEntrez ID:1357; OMIM: 114850; Uniprot ID:CBPA1_HUMAN; ENSEMBL ID: ENSG00000091704; HGNC ID: 2296
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CPA1 mRNAaffects cotreatment|decreases expression 16984957
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CPA1 mRNAaffects cotreatment|decreases expression 16984957
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPA1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in decreased expression of CPA1 mRNAdecreases expression 15901920
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CPA1 mRNAincreases expression 19638242
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of CPA1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CPA1 mRNAdecreases expression 15901920
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of CPA1 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in decreased expression of CPA1 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in decreased expression of CPA1 mRNAdecreases expression 15901920
C042763 olive oil olive oil analog affects the expression of CPA1 mRNAaffects expression 17349074
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CPA1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CPA1 mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CPA1 mRNAincreases expression 20055451
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.8617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.8718287403
MESH:D000138 Acidosis Ethanol 10.8711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000230 Adenocarcinoma Genistein 4.4211473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 25.9716628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 25.9719052882 18056438 19061943 16434500 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 25.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 25.9716835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D050197 Atherosclerosis olive oil 4.3816216721
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D001943 Breast Neoplasms Genistein 1.9716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7816807293 17428255 17173139 17162532 17138121 19822196 17978847 16540662 19519916 20935162 16288022 16830150 18506893 19107877 11831363 16698587 19701751 20007298 20084675 19383236 19171122 20101231 19539802 19335982 18785209 3581430 19394651 21159647 20524982 18978308 17761372 16779866 20432363 20512989 18494052 18056438 19418558 16569478 20214788 17055752 10737359 18971187 16681979 3084413 16502159 19208518 10672840 19919837 16878318 16935385 16328049 18210153 18393292 19052882 18665156 18788625 18691550 20727157 20514400
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.7815763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7816924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D006332 Cardiomegaly Ethanol 6.9919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 8.0916332659
MESH:D002318 Cardiovascular Diseases olive oil 8.0916216721
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.912727394 21159647 7505956 17174075
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 16.6516628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 16.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 16.6516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417333356 16105132 11677210 16919318 17110522 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0612621046 8697196 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 4.0417686920
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0410194807 11873399 19302082 15513904 15451039 11198716 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0420055451 15322242 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.2216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2217107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3919107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.3911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 12.8717686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.7716704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 25.6020387270 21071580
MESH:D005234 Fatty Liver Ethanol 25.6016409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.6015345470
MESH:D005234 Fatty Liver Fish Oils 25.6018620774
MESH:D005234 Fatty Liver pirinixic acid 25.6019236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Ethanol 4.8315046732
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 7.1417686920 20471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Ethanol 3.7818783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Fish Oils 4.8415752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.6411484837
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5418785209
MESH:D007249 Inflammation Flavonoids 8.5417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5412878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.4916393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007569 Jaw Abnormalities Ethanol 10.3915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3916580747
MESH:D007859 Learning Disorders Ethanol 4.3115451040
MESH:D007938 Leukemia Genistein 3.0617468513 18980019
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9618522880 18665156 20032147 18407596 19638242
MESH:D008103 Liver Cirrhosis Ethanol 6.9615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0418166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617347304 17207112
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 10.9816835634 18644402
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.989163691 19690152 20501860 21278145 16942905 20492335 19256749 12112319 19255062 19638242 19996281 19426721 20583210 19499222 18978307 20405173 20118626 10737359 21047994 15885732 2862719 20452335 19427195 19812893 19073162 20137499 21167192 18754104 19833225 19254457 21071580 19090486 19642983 20434301 19850985 2422723 19294768 12771043 20101389 15175105 18644402 18648771 19551842 18977376
MESH:D008113 Liver Neoplasms pirinixic acid 10.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.9321159647 19004024 19519916 18775883 19126423 18079962 17174075 19009564 18282651 18544905 18093689 2563599 3124819 19539802 9362446 16267830 16842330 17854601 18308698 18253720 18164116 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9312151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2820512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9914578162 12929590
MESH:D008569 Memory Disorders Ethanol 4.2815451040 18411066
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction Genistein 5.7817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6016411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.498820588
MESH:D009369 Neoplasms pirinixic acid 5.4917405874
MESH:D009421 Nervous System Malformations bisphenol A 16.9816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 16.9816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9814600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6219005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5312384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.9010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9011896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3916740699
MESH:D011471 Prostatic Neoplasms Genistein 3.3916925846 15256057 15378649
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures Ethanol 3.229754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6218456281
MESH:D013274 Stomach Neoplasms Ethanol 2.6218456281
MESH:D013276 Stomach Ulcer Ethanol 8.2017918041 9562338 11906479 17189318 16755016 9211565
MESH:D013276 Stomach Ulcer olive oil 8.2012498302 16252198
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02494 - Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB02652 - L-[(N-Hydroxyamino)Carbonyl]Phenylalanine
DB03012 - Phenylalanine-N-Sulfonamide
DB03201 - D-Cysteine
DB03441 - 2-Benzyl-3-Iodopropanoic Acid
DB04058 - D-[(Amino)Carbonyl]Phenylalanine
DB04316 - D-[(N-Hydroxyamino)Carbonyl]Phenylalanine
DB06924 - (2R)-2-benzyl-3-nitropropanoic acid
DB07351 - O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE
DB07484 - (2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid
DB07506 - L-BENZYLSUCCINIC ACID
DB08368 - OCTANE-1,3,5,7-TETRACARBOXYLIC ACID
DB08762 - O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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