AutismKB 2.0

Annotation Detail for CPA2


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Basic Information Top
Gene Symbol:CPA2 ( - )
Gene Full Name: carboxypeptidase A2 (pancreatic)
Band: 7q32.2
Quick LinksEntrez ID:1358; OMIM: 600688; Uniprot ID:CBPA2_HUMAN; ENSEMBL ID: ENSG00000158516; HGNC ID: 2297
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CPA2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CPA2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPA2 mRNAaffects expression 16483693
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of CPA2 mRNAdecreases expression 18178546
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of CPA2 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of CPA2 mRNAaffects cotreatment|increases expression 17347304
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of CPA2 promoteraffects acetylation|affects methylation 18448484
C006253 pirinixic acid pirinixic acid results in increased expression of CPA2 mRNAincreases expression 17426115
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of CPA2 promoteraffects acetylation|affects methylation 18448484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.2018926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 11.4418287403
MESH:D000138 Acidosis Ethanol 11.4411192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2216712894 17306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451039 15451040
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 4.1711141031
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.8418788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8417306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D006332 Cardiomegaly Ethanol 3.5419332462
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.176135515
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 12.1719716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.1720056578 19524636
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 3.2515513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3319302082 11873399 11198716 15451040 15451039 15513904 10194807
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.5117851650
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.5111566570
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms Ethanol 2.7916704527
MESH:D005234 Fatty Liver Ethanol 14.5616409862 19236843 18620774
MESH:D005234 Fatty Liver Fish Oils 14.5618620774
MESH:D005234 Fatty Liver pirinixic acid 14.5620131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15513904 10194807 15451040
MESH:D005756 Gastritis Ethanol 5.0115046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 19772884 18467677
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006930 Hyperalgesia Ethanol 3.8818783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Fish Oils 4.9715752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.8211484837
MESH:D007248 Infertility, Male sodium arsenite 3.1212646999 15346721
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Ethanol 4.6115513904
MESH:D007674 Kidney Diseases sodium arsenite 2.9120008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.817678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.8116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.662876786 2876784 6135515
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 17077188 16712894 19931552 15276417
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008569 Memory Disorders Ethanol 4.4218411066 15451040
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009369 Neoplasms sodium arsenite 5.2511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4915276417 17306315
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0312384795
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.6818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.6818551238
MESH:D012640 Seizures Ethanol 10.689754883
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4217431481
MESH:D012878 Skin Neoplasms sodium arsenite 2.7819524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 3.7316755016 11906479 9562338 17918041 17189318 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.5716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.5716049721
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 12.5720375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.5717306315 11723127 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
Pathway ID Pathway Name
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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