AutismKB 2.0

Annotation Detail for CPA3


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Basic Information Top
Gene Symbol:CPA3 ( MC-CPA )
Gene Full Name: carboxypeptidase A3 (mast cell)
Band: 3q24
Quick LinksEntrez ID:1359; OMIM: 114851; Uniprot ID:CBPA3_HUMAN; ENSEMBL ID: ENSG00000163751; HGNC ID: 2298
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa04614Renin-angiotensin system
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C020888 1,2-dielaidoylphosphatidylethanolamine 1,2-dielaidoylphosphatidylethanolamine results in decreased expression of CPA3 mRNAdecreases expression 14668052
D000082 Acetaminophen Acetaminophen affects the expression of CPA3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPA3 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in decreased expression of CPA3 mRNAdecreases expression 20739668
C014347 decitabine decitabine results in increased expression of CPA3 mRNAincreases expression 19194470
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPA3 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of CPA3 mRNAincreases expression 18035473
D019833 Genistein Genistein results in decreased expression of CPA3 mRNAdecreases expression 12075121
C010176 halofuginone halofuginone results in increased expression of CPA3 mRNAincreases expression 17180598
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of CPA3 mRNAincreases expression 15159207
D012643 Selenium Selenium results in decreased expression of CPA3 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of CPA3 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPA3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CPA3 mRNAdecreases expression 20159946
16120747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000230 Adenocarcinoma Genistein 4.4211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3817123778
MESH:D001943 Breast Neoplasms decitabine 2.3818320071 19208741
MESH:D001943 Breast Neoplasms Genistein 2.3816541309 16873071 17200150
MESH:D001943 Breast Neoplasms Hexachlorobenzene 2.3812709520 15061365
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6616507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3616332659
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9317110522 17681005 11677210 16105132 17333356 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 15668235 8697196 12621046 16354765
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms decitabine 3.9317616700
MESH:D003110 Colonic Neoplasms Genistein 3.9317182828
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2717906064 12540782 11461765 19923254 18071297 12153990 16081117 10774834 12705907 16485898 11743745 14550746 16177239 17562736 10915739 12594235 11287661 19370779 19739265 2444490 14725611 16393943 16781746 10663392 16109766 19164858 19085960 11529661 18713872 11834606 11739529 17522070 15968718 15619225 19416960 19420014 16227642 12958197 14986274 11421492 12392966
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006965 Hyperplasia halofuginone 5.3511874485
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male decitabine 11.5417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.5417937319
MESH:D007248 Infertility, Male sodium arsenite 11.5415346721 12646999
MESH:D007249 Inflammation Flavonoids 5.1317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312878042 12200463
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007333 Insulin Resistance bisphenol A 3.3416393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.1120008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007938 Leukemia decitabine 6.6519235587 18980019
MESH:D007938 Leukemia Genistein 6.6518980019 17468513
MESH:D007951 Leukemia, Myeloid decitabine 4.0819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918704418 19010910 19387464 18206229 17679729 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D008103 Liver Cirrhosis halofuginone 4.0717180598
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.7017823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 3.7014739098 11172339 12175628 18458672 16489207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 12969438 16610002 12587719 19784758 16611625 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms sodium arsenite 4.5416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 6.341423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3217077188 15276417 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3211884234 19555203
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3315318939
MESH:D008545 Melanoma decitabine 3.4917785578 16505122
MESH:D008545 Melanoma sodium arsenite 3.4919082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009101 Multiple Myeloma decitabine 3.4018172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4319157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009369 Neoplasms decitabine 5.3519116145 19470736 17925555
MESH:D009369 Neoplasms sodium arsenite 5.3511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009421 Nervous System Malformations bisphenol A 16.9811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 16.9816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9814600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms decitabine 8.1119331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 8.1119005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1117306315 15276417
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 11.429918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.4218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.9010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9011118676 11896295 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6216039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012871 Skin Diseases halofuginone 3.5311874485
MESH:D012878 Skin Neoplasms sodium arsenite 5.7119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3917967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.3516712894 16452187 17306315 11723127
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
KEGG:04614 Renin-angiotensin system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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