AutismKB 2.0

Annotation Detail for ADORA2B


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Basic Information Top
Gene Symbol:ADORA2B ( ADORA2 )
Gene Full Name: adenosine A2b receptor
Band: 17p12
Quick LinksEntrez ID:136; OMIM: 600446; Uniprot ID:AA2BR_HUMAN; ENSEMBL ID: ENSG00000170425; HGNC ID: 264
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200130C-MYB transcription factor network
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1943Adenocarcinoma
1944Breast cancer
2091Hypertension
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000241 Adenosine ADORA2B protein affects the susceptibility to Adenosineaffects response to substance 16920807
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ADORA2B proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADORA2B mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of ADORA2B mRNAdecreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of ADORA2B mRNA]decreases expression|decreases reaction 12205029
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of ADORA2B mRNAaffects expression 17331233
C518875 BAY 60-6583 BAY 60-6583 binds to and results in increased activity of ADORA2B proteinaffects binding|increases activity 19749167
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADORA2B mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADORA2B mRNAdecreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADORA2B mRNAincreases expression 15336504
C006862 butylphen butylphen results in increased expression of ADORA2B mRNAincreases expression 10571726
D002104 Cadmium Cadmium results in increased expression of ADORA2B mRNAincreases expression 21172416
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADORA2B mRNAincreases expression 17484886
18263696
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ADORA2B mRNAaffects cotreatment|increases expression 19684285
D016572 Cyclosporine Cyclosporine results in increased expression of ADORA2B mRNAincreases expression 20106945
D002945 Cisplatin ADORA2B protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of ADORA2B mRNAincreases expression 16314067
D004178 Diquat Diquat results in increased expression of ADORA2B mRNAincreases expression 21172416
D019830 Adenosine-5'-(N-ethylcarboxamide) ADORA2B protein affects the susceptibility to Adenosine-5'-(N-ethylcarboxamide)affects response to substance 16920807
C029938 nickel sulfate nickel sulfate results in increased expression of ADORA2B mRNAincreases expression 16314067
C006253 pirinixic acid pirinixic acid results in decreased expression of ADORA2B mRNAdecreases expression 17426115
C045950 propiconazole propiconazole results in decreased expression of ADORA2B mRNAdecreases expression 19423681
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of ADORA2B mRNAaffects cotreatment|increases expression 19059307
C446685 systhane systhane results in decreased expression of ADORA2B mRNAdecreases expression 19423681
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of ADORA2B mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ADORA2B mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADORA2B mRNAincreases expression 19684285
C032910 triadimefon triadimefon results in decreased expression of ADORA2B mRNAdecreases expression 19423681
C025643 vinclozolin vinclozolin results in increased expression of ADORA2B mRNAincreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6211752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.7515814532 17670903 12690470
MESH:D055371 Acute Lung Injury nickel sulfate 8.4412718980 16100012 11954676 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 8.4418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3320464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 4.3317638652 11798837
MESH:D000236 Adenoma Benzo(a)pyrene 2.526695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000419 Albuminuria Raloxifene 4.3817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.4915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D050197 Atherosclerosis Cadmium 3.5115687053
MESH:D001321 Autistic Disorder Adenosine 3.8920468076
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6514601052
MESH:D001930 Brain Injuries Raloxifene 4.2516580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2620146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 2.2619526202 18382427
MESH:D001943 Breast Neoplasms Raloxifene 2.2616912660 15572757 17595753 15775269 16837676 17049068 17242785 15758505 17440819 17952589 17261762 17893378
MESH:D001943 Breast Neoplasms Tamoxifen 2.2618855134 19084267 16273361 19288272 16202921 20544844 18351453 18629630 11161223 20390343 19059307 21152245 19103187 19200415 20135344 19011961 19142967 19189210 21138602 17893378 19289846 15565566 20065188 17261762 18984771 18815881 17049068 19155303 20005174 15668708 19487384 20859285 19066611 19189212 17440819 19115204 17242785 19221464 19244106 16818667 16873071 18425577 19410462 18821012 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5616124888 15700767 16011737 3786805 16050911 10355542 16192424 15721981 16097048 15673190 18705752 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.2921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2918788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.2917982673
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.2916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9616685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5420419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.546189445 17066447 18337622
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2915775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3620889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.3617332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 7.2019486331
MESH:D002779 Cholestasis pirinixic acid 7.2019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8415340226 8697196 15668235 12621046 16354765
MESH:D002972 Cleft Palate triadimefon 5.8416781842
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7819159591 17373747
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 2.7715834900 16875885
MESH:D003456 Cryptorchidism vinclozolin 4.1214966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 6.9215491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.9216780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.4017308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4019279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.9811566570 9327722 19336974 15998439 7179309 4309450 15027814 16177239 10092053 3732212 2869522 17522070 6884620 6623471 15968718 3786805 16227642 7440962 7120509 10915739 19085960 21278145
MESH:D056486 Drug-Induced Liver Injury Diquat 5.9818164269 18445702
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9820420201
MESH:D004362 Drug Toxicity Cisplatin 7.6212649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6211462148
MESH:D004487 Edema pirinixic acid 10.2512083418
MESH:D004487 Edema Raloxifene 10.2515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.5215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.5219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9019155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004827 Epilepsy Adenosine 4.6811404469
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.9216481741 15464296 17638652 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.4616045604 61145 12631006 19224547 15959796 16239168 17595544 12795759
MESH:D005234 Fatty Liver Cyclosporine 22.4619224547
MESH:D005234 Fatty Liver pirinixic acid 22.4620131406 19236843
MESH:D005234 Fatty Liver Raloxifene 22.4617473493
MESH:D005234 Fatty Liver Tamoxifen 22.4614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.4118705752
MESH:D005355 Fibrosis Cyclosporine 13.4112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4120067830
MESH:D005756 Gastritis Diquat 5.3515046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5615102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.1019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0511294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3811110106
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 24.7819176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly propiconazole 24.7817178688 17178689
MESH:D006529 Hepatomegaly systhane 24.7817178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 24.7812621046 16120746 15340226
MESH:D006529 Hepatomegaly triadimefon 24.7817178689 17178688
MESH:D006689 Hodgkin Disease Cisplatin 3.4116200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 16354765 15340226 8697196 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006973 Hypertension Cyclosporine 8.0710903974
MESH:D006973 Hypertension Raloxifene 8.0715787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D007248 Infertility, Male Diquat 6.834850670
MESH:D007248 Infertility, Male vinclozolin 6.8316467254
MESH:D007249 Inflammation Tamoxifen 4.5019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5012878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.4916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6416580747
MESH:D007569 Jaw Abnormalities triadimefon 9.6415992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9115464296
MESH:D007674 Kidney Diseases Cadmium 9.4816962696 16322080 16226777
MESH:D007674 Kidney Diseases Cisplatin 9.4812649298 19839026 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Cyclosporine 9.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6912371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6918625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5611231351
MESH:D007889 Leiomyoma Raloxifene 4.2816973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5016417039
MESH:D008064 Lipidoses Tamoxifen 2.9915342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6811903743 16943688 21278145 16221502 17174718 16239168 17334410 11408273 17157831
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 6.4418263696
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4417869086 17640975 18472332 16011737 16136751 15818738 17557913 18263696 12898905 18420326 12632514 18418968 18006644 12632512 14748882 18429990 12546737 17976157 14512876 15876570 18054572 12958196 15370692 12609069 18472094 10355542 15730626 12667390 17698563 17766677 14620537 13678700 18277467 17761835 15673190 15362042 15931870 17708605 12445418 16192424 12649538 17714472 18210741 12741479 16248980 17721639 18395914 18376398 16638106 16027843 15338365 18395095 15925388 12445421 18412020 17631135 17922224 15996030 12389079 18279442 17481882 18187930 17805973 15123356 17900296 14716833 15959796 18205269 11481614 12586293 16097048 18156304 17823541 18339082 18317297 18251166 15052691 17525996 17944888 15650968 16015684 18481824 15893842 16116963 20821823 17565644 18705752 14724832 16033810 18166357 14716496 12666154 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4815720792 17285989 15830285 16964402 16246199
MESH:D008107 Liver Diseases propiconazole 6.4819363144
MESH:D008107 Liver Diseases triadimefon 6.4819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4916899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.4418177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.4421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.4419294768
MESH:D008113 Liver Neoplasms pirinixic acid 24.4420007298 15890375 16377806
MESH:D008113 Liver Neoplasms propiconazole 24.4419028983
MESH:D008113 Liver Neoplasms Tamoxifen 24.4416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.4416984957
MESH:D008113 Liver Neoplasms triadimefon 24.4419028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.568603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.5615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental propiconazole 21.5617178689
MESH:D008114 Liver Neoplasms, Experimental systhane 21.5617178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.5612151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 21.5617178689
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8017365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.2714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.2718569708 18520028 18816296 20464547 20869020 17053015 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms Cisplatin 6.276189445 11798837 17225452
MESH:D008175 Lung Neoplasms Tamoxifen 6.2718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2719555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.4811731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:D008545 Melanoma Cisplatin 5.0812374674 17023156 11135225 16248763 12883367 17761969 18332650 16432458 12393984 16809738 15577323 18505091 18176117
MESH:D008545 Melanoma Dinitrochlorobenzene 5.0817334785 12202904
MESH:D008545 Melanoma Tamoxifen 5.0812393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.7415990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.7415990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.2018303189 16966607 16166281
MESH:D008654 Mesothelioma Cisplatin 6.2017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.291613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009101 Multiple Myeloma Raloxifene 3.2816497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6111141357
MESH:D009369 Neoplasms Cisplatin 7.6116773208
MESH:D009369 Neoplasms pirinixic acid 7.6117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719200415 19189210 19196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0014600291
MESH:D009447 Neuroblastoma Cisplatin 3.338761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.478761367
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D010024 Osteoporosis Raloxifene 3.2619059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0215758505 17893378 17823083 15579764
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8119769630 15464296 6897625 17225452
MESH:D010190 Pancreatic Neoplasms Cisplatin 2.9119003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0915464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1515687053
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6710923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.1117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7311118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.7318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7018220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1517292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.1517075824
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1516220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1515067354
MESH:D011472 Prostatitis vinclozolin 4.7018629315
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9415814490 17975199 17322281 17365031
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D051437 Renal Insufficiency Cisplatin 4.1815464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2114601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7710029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.778532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7716192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1115464296
MESH:D013088 Spermatocele Tamoxifen 4.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.4818396642 15958060 17522103
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.4215464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms triadimefon 3.9217178689
MESH:D013978 Tibial Fractures Raloxifene 4.9819048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.2217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.2217225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.2217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2217572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.0116803524
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3915577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D014839 Vomiting Cisplatin 4.4911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24585
    • No data
    Releated disease ID Related disease Name
    PA445208Pain
    PA443434Arthritis, Rheumatoid
    PA443431Arthritis, Experimental
    PA443829Cystic Fibrosis
    Releated drug ID Related drug Name
    PA448015acetaminophen
    PA448385amitriptyline
    PA164712462Antiinflammatory agents, non-steroids
    PA450550morphine
    PA450732oxcarbazepine
    PA448710caffeine
    PA450428methotrexate
    PA451647theophylline
    PA10004adalimumab
    PA452639infliximab
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00277 antagonist Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00640 agonist Adenosine Analgesics;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents;Cardiac drugs
    DB00824 antagonist Enprofylline Anti-Asthmatic Agents;Antiarrhythmic Agents;Bronchodilator Agents
    DB04932 - Defibrotide Antithrombotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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