AutismKB 2.0

Annotation Detail for CPE


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Basic Information Top
Gene Symbol:CPE ( - )
Gene Full Name: carboxypeptidase E
Band: 4q32.3
Quick LinksEntrez ID:1363; OMIM: 114855; Uniprot ID:CBPE_HUMAN; ENSEMBL ID: ENSG00000109472; HGNC ID: 2303
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200046Arf6 trafficking events
Pathway IDPathway Name
P04395Vasopressin synthesis
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcohol dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CPE mRNAdecreases expression 12419474
D000111 Acetylcysteine Acetylcysteine results in decreased expression of CPE mRNAdecreases expression 16084531
D019386 Alendronate Alendronate affects the expression of CPE mRNAaffects expression 16079270
D001104 Arbutin Arbutin results in increased expression of CPE mRNAincreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CPE mRNAdecreases expression 19128835
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPE mRNAaffects cotreatment|increases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CPE mRNAincreases expression 20382639
C006780 bisphenol A bisphenol A results in decreased expression of CPE mRNAdecreases expression 12075121
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CPE mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CPE mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CPE mRNAincreases expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPE mRNAaffects cotreatment|increases expression 18164116
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of CPE mRNAdecreases expression 16084531
D004958 Estradiol Estradiol affects the expression of CPE mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPE mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of CPE mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CPE mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CPE mRNAdecreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CPE mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CPE mRNAaffects expression 16079270
17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CPE mRNAdecreases expression 12075121
17557909
16174780
D005419 Flavonoids Flavonoids results in increased expression of CPE mRNAincreases expression 18035473
D005472 Fluorouracil CPE protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil Fluorouracil results in increased expression of CPE proteinincreases expression 15352031
D019833 Genistein Genistein results in decreased expression of CPE mRNAdecreases expression 12075121
C051890 irinotecan irinotecan analog results in increased expression of CPE mRNAincreases expression 18927307
C011890 kojic acid kojic acid results in increased expression of CPE mRNAincreases expression 16595896
D016210 Methacholine Chloride CPE gene mutant form results in increased susceptibility to Methacholine Chlorideincreases response to substance 16002559
D009020 Morphine Morphine results in increased expression of CPE mRNAincreases expression 20144693
D010126 Ozone CPE gene mutant form promotes the reaction [Ozone results in increased expression of CCL2 protein]increases expression|increases reaction 16002559
D010126 Ozone CPE gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]increases expression|increases reaction 16002559
D010126 Ozone CPE gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein]increases expression|increases reaction 16002559
D010126 Ozone CPE gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]increases expression|increases reaction 16002559
D010126 Ozone CPE gene mutant form results in increased susceptibility to Ozoneincreases response to substance 16002559
D010126 Ozone Ozone results in decreased expression of CPE mRNAdecreases expression 12763052
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CPE mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CPE mRNAincreases expression 19482888
D010795 Phthalic Acids Phthalic Acids results in increased expression of CPE mRNAincreases expression 15728792
D020849 Raloxifene Raloxifene affects the expression of CPE mRNAaffects expression 16079270
D013629 Tamoxifen Tamoxifen affects the expression of CPE mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of CPE mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPE mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CPE mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CPE mRNAaffects cotreatment|decreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of CPE mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000230 Adenocarcinoma arsenic trioxide 12.8519825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 12.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8514692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.8517638652
MESH:D000230 Adenocarcinoma Genistein 12.8511473722
MESH:D000236 Adenoma beta-Naphthoflavone 6.4119389873
MESH:D000236 Adenoma Diethylnitrosamine 6.416695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.9116434500 19052882 19061943 17162532 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.9117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9116835633
MESH:D000419 Albuminuria Raloxifene 4.3617451421 17308373
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Ozone 4.1815513908
MESH:D000544 Alzheimer Disease Raloxifene 4.1815800139
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9510965797
MESH:D000740 Anemia Fluorouracil 7.9717963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4616292516
MESH:D001249 Asthma epigallocatechin gallate 7.5916516891
MESH:D001249 Asthma Ozone 7.5916373670 17854713
MESH:D001249 Asthma Tretinoin 7.5916456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2020106747
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.8219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.0616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001930 Brain Injuries Raloxifene 4.2316580743
MESH:D002545 Brain Ischemia Morphine 4.9019211983
MESH:D001943 Breast Neoplasms bisphenol A 5.5817123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5817474063
MESH:D001943 Breast Neoplasms Estradiol 5.5812948864 16675129 17289903 19861407 18497071 17261762 17018787 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 5.5815136595 16110121 19217205 18608205 16595493 16557594 18357371
MESH:D001943 Breast Neoplasms Genistein 5.5817200150 16541309 16873071
MESH:D001943 Breast Neoplasms Raloxifene 5.5815775269 16912660 15758505 17595753 17242785 16837676 17049068 15572757 17261762 17952589 17893378 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 5.5819142967 15668708 19103187 19155303 18351453 15565566 16202921 19084267 19059307 19189210 16273361 20859285 18855134 11161223 16873071 18815881 20005174 19200415 19487384 20135344 17049068 18629630 18425577 19011961 16818667 21152245 17440819 19221464 19244106 19288272 20390343 17893378 18997820 19189212 18821012 20544844 19289846 19115204 20065188 17261762 19410462 17242785 21138602 18984771 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.5816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4918417511 15516495 17626835 18315731 14754758 19059883 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002100 Cachexia Ozone 4.4916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5415700767 16097048 15721981 18705752 15673190 16124888 16227642 16192424 3786805 16011737 10355542 16050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.0816217749 14691202 15553829 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.0818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.0816807293 16878318 19052882 17173139 18393292 16288022 20935162 10672840 3084413 20514400 18210153 17055752 19394651 17138121 19701751 19171122 20084675 18506893 18785209 17978847 19335982 19539802 3581430 19208518 19519916 17761372 17428255 18788625 16935385 19919837 16502159 18978308 18494052 20524982 19418558 16830150 20214788 20101231 21159647 16569478 19383236 19107877 20432363 17162532 16328049 16779866 20727157 20512989 18971187 16698587 18056438 11831363 19822196 18665156 20007298 10737359 18691550 16681979 16540662
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.0816799960 17045692 17088986 18930000 17971768 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.0820935162 20007298 17173139 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.081917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.2517015178
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2518986760 16280240 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 6.9416332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9415775269
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.7020889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 14.7018226522
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.7021159647 2727394 7505956 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7015861022 17333356 17110522 16105132 16919318 17681005 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4212621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003072 Cognition Disorders Raloxifene 4.3815800139
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6316340194 17725105 17018589 16510598 18772588 15001691 17287894 17016597 17172411 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.6317182828
MESH:D003110 Colonic Neoplasms irinotecan 5.6317287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3820501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.3817594712 18288408 17695437 18949393 16524972 17016601 17255274 15289873 18802399 17401013 18448328 17454858 16391804 15148649 14970324 16331619 17094418 18383874 16303861 18509181 16282729 20501625
MESH:D015179 Colorectal Neoplasms irinotecan 3.3816303861 16391804 17454858 18259882 18509181 17159606 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6016925845 8800419 9224671 9125849 10589399 9211117 14991402 9142499 17551590 9664655
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.1619747007
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9617474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.7620387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 9.7616988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.7616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.7617107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.8319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.8317308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.8319279558
MESH:D003967 Diarrhea Morphine 4.292540324
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 8.3911287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.3911566570 6884620 19336974 2869522 10092053 6623471 7179309 15968718 15027814 15998439 16177239 7440962 9327722 17522070 4309450 3786805 16227642 21278145 7120509 10915739 3732212 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004487 Edema Raloxifene 6.1315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.9915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9919031437
MESH:D004700 Endocrine System Diseases marker/mechanism 15358678
MESH:D004714 Endometrial Hyperplasia Genistein 4.3416402032
MESH:D016889 Endometrial Neoplasms Estradiol 16.4719148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.4711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.4719155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 16.4716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.8812903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.8815173087 16337965 16785472 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 27.8515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.8515959796 19224547 17595544 61145 12795759 16239168 12631006 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8515345470
MESH:D005234 Fatty Liver Raloxifene 27.8517473493
MESH:D005234 Fatty Liver Tamoxifen 27.8514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.3618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.3620067830
MESH:D005355 Fibrosis Tretinoin 13.3617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005909 Glioblastoma Genistein 6.6816598420
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2518337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1114991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.3711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 7.6416109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6415340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Alendronate 7.7316769263
MESH:D006930 Hyperalgesia Tretinoin 7.7316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006973 Hypertension Raloxifene 4.9115787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Diethylnitrosamine 14.5418785209
MESH:D007249 Inflammation Flavonoids 14.5417296493
MESH:D007249 Inflammation Methacholine Chloride 14.5418249437
MESH:D007249 Inflammation Tamoxifen 14.5419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.5412200463 12878042
MESH:D007333 Insulin Resistance marker/mechanism 15358678
MESH:D007333 Insulin Resistance bisphenol A 6.9116393666
MESH:D007333 Insulin Resistance Estradiol 6.9116393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.4515618244
MESH:D007680 Kidney Neoplasms Estradiol 11.3115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.3116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3118625569
MESH:D007889 Leiomyoma Raloxifene 4.2716973256
MESH:D007938 Leukemia arsenic trioxide 9.7915070760
MESH:D007938 Leukemia Genistein 9.7917468513 18980019
MESH:D007938 Leukemia Tretinoin 9.7917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7219850784 16968895 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1117869043 17107899 15622746 16966277 16330433 19642359 12679006 15213294 17217047 16823087 12712474 11468182 12018890 16112521 17712046 19035177 9834237 11161223 16331271 19075265 15336539 19225113 15748426 16891316 17649720
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1119035177 17294898 17217047 9834237 17107899 16788101 19642359 17649720 17368321 17361223 17339181 16823087 16331271 16891316 16935935 19075265 16766008 17506722 17301526 17712046 19029980 12679006 16140955 19225113 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Tamoxifen 2.9815342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2416239168 16943688 21278145 16221502 11903743 11408273 17157831 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2418665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.4315057751 12741479 17565644 17766677 16015684 15996030 20821823 15362042 14716496 17525996 15893842 17721639 15650968 18279442 18705752 18156304 12666154 15123356 17944888 14716833 18481824 17976157 18166357 12667390 18317297 15052691 11481614 18376398 14724832 15876570 17823541 18418968 16116963 18187930 18395914 17640975 18472094 16011737 18006644 17714472 15370692 12445421 14512876 16192424 15730626 15818738 14620537 18263696 12546737 10355542 12649538 15959796 15673190 16027843 15925388 17631135 17557913 18205269 17869086 18395095 18472332 12632512 17481882 18429990 12898905 12958196 12632514 12609069 14748882 18339082 17698563 16097048 17922224 13678700 16136751 17900296 17761835 18420326 16638106 12586293 17805973 16033810 15338365 18251166 18412020 17708605 18054572 15931870 12389079 16248980 18210741 12445418 18277467
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 10.4317481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.4314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.4317823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.4316248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1516246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1517034775
MESH:D008107 Liver Diseases Phenobarbital 6.1519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4816899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 24.3114682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.3121295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.3119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.3118648771 15175105 19833225 19812893 2862719 19690152 20434301 12112319 19642983 20452335 19427195 19254457 20101389 21278145 21167192 19499222 19090486 19638242 20501860 12771043 19996281 20137499 19551842 21047994 15885732 10737359 19073162 19426721 2422723 20405173 20583210 18644402 21071580 19256749 18978307 20492335 19850985 9163691 20118626 18754104 19294768 19255062 18977376 16942905
MESH:D008113 Liver Neoplasms Fluorouracil 24.3115113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 24.3119073162 19482888 15975961 8742319 19812893 21047994
MESH:D008113 Liver Neoplasms Tamoxifen 24.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.3116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.9420377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.9418164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.9419539802 3124819 18775883 17942915 18544905 18093689 18079962 18253720 19009564 17174075 16267830 18164116 17854601 19519916 16842330 21159647 9362446 2563599 18282651 19004024 18308698 19126423
MESH:D008114 Liver Neoplasms, Experimental kojic acid 25.9418544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.941399818 17172636 6150874 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.9412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008171 Lung Diseases Acetylcysteine 7.3012815614
MESH:D008171 Lung Diseases Ozone 7.308266340 19066396
MESH:D055370 Lung Injury Ozone 3.6120417186
MESH:D008175 Lung Neoplasms arsenic trioxide 8.1419825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.146695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 8.1415246190
MESH:D008175 Lung Neoplasms Ozone 8.148597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 8.1418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0716891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.0714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.0719196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.8119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8119453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma epigallocatechin gallate 4.9611746506 17992120
MESH:D008545 Melanoma Tamoxifen 4.9612393984 19393235
MESH:D008545 Melanoma Tretinoin 4.9616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008679 Metaplasia Ozone 4.8610496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3015863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4518986760 16757204
MESH:D052016 Mucositis irinotecan 4.7617159606
MESH:D009101 Multiple Myeloma arsenic trioxide 6.8415949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Raloxifene 6.8416497877
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.2417962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9317596541
MESH:D009203 Myocardial Infarction Genistein 2.7617141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.8917141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009232 Myxoma Raloxifene 5.3016343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 12.8314720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.839029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 12.8318259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Fluorouracil 4.7516928823 18600527 18239605
MESH:D009369 Neoplasms Tretinoin 4.7516594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009421 Nervous System Malformations bisphenol A 28.2311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 28.2311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 28.2316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2314600291
MESH:D009421 Nervous System Malformations Tretinoin 28.239125849
MESH:D009436 Neural Tube Defects Acetylcysteine 11.3519446573
MESH:D009436 Neural Tube Defects arsenic trioxide 11.3510525206
MESH:D009436 Neural Tube Defects Tretinoin 11.359142499
MESH:D009447 Neuroblastoma irinotecan 3.358761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1420387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.488761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009765 Obesity marker/mechanism 15358678
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010024 Osteoporosis Alendronate 11.2317882678
MESH:D010024 Osteoporosis Genistein 11.2319401787
MESH:D010024 Osteoporosis Raloxifene 11.2317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.3816169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.3815579764 17823083 17893378 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.6416624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.6419401270
MESH:D010051 Ovarian Neoplasms Genistein 10.6419005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.6416936753
MESH:D010146 Pain Morphine 6.6018699797 16273134 15215642 20225289 6776300 15275824
MESH:D010146 Pain Tretinoin 6.6016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.3615580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.3616540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3616500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.3616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010538 Peritonitis Ozone 3.8916369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2511550810
MESH:D011014 Pneumonia Ozone 4.1518929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.412563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.6910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6911896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0616740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0616925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0616536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011693 Purpura Raloxifene 5.3015770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8018722050 18286688 15538739 16160472
MESH:D015427 Reperfusion Injury Morphine 4.0119211983
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.3012210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7316646077
MESH:D012640 Seizures Phenobarbital 2.534039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1217007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1216424979 15786421 17522103 17172411 18396642 19084572 18567086 16951190 17498489 19015929
MESH:D013274 Stomach Neoplasms irinotecan 6.1215723263
MESH:D013274 Stomach Neoplasms Tretinoin 6.1217261132
MESH:D013276 Stomach Ulcer Acetylcysteine 3.7817918041
MESH:D020521 Stroke Raloxifene 3.6316837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.5819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.587505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.581399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.5817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 12.8819048282
MESH:D013978 Tibial Fractures Raloxifene 12.8819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.8220435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.8217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8217572228 8653321 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7416129372
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04940 Type I diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26824
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00030 - Insulin recombinant Hypoglycemic Agents
    DB00071 - Insulin, porcine Hypoglycemic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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