AutismKB 2.0

Annotation Detail for CLDN3


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Basic Information Top
Gene Symbol:CLDN3 ( C7orf1,CPE-R2,CPETR2,HRVP1,RVP1 )
Gene Full Name: claudin 3
Band: 7q11.23
Quick LinksEntrez ID:1365; OMIM: 602910; Uniprot ID:CLD3_HUMAN; ENSEMBL ID: ENSG00000165215; HGNC ID: 2045
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol CLDN3 protein results in increased susceptibility to 1-UFT protocolincreases response to substance 16734730
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLDN3 mRNAaffects expression 21346803
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of CLDN3 mRNAdecreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CLDN3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CLDN3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of CLDN3 mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLDN3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CLDN3 mRNAdecreases expression 20106945
C095105 bexarotene bexarotene results in increased expression of CLDN3 mRNAincreases expression 16648578
C110904 capecitabine CLDN3 protein results in increased susceptibility to capecitabineincreases response to substance 16734730
D016572 Cyclosporine Cyclosporine results in decreased expression of CLDN3 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]affects binding|affects cotreatment|decreases reaction 17986852
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C014347 decitabine decitabine inhibits the reaction [MBD2 protein binds to CLDN3 promoter]affects binding|decreases reaction 17986852
C014347 decitabine decitabine promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|increases reaction 17986852
C014347 decitabine decitabine promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|increases reaction 17986852
C014347 decitabine decitabine results in increased expression of CLDN3 mRNAincreases expression 16367923
17986852
C014347 decitabine decitabine results in increased expression of CLDN3 proteinincreases expression 17986852
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 mRNA]increases expression|increases reaction 17986852
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 protein]increases expression|increases reaction 17986852
C121718 dicyclanil dicyclanil results in increased expression of CLDN3 mRNAincreases expression 15664270
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of CLDN3 mRNAdecreases expression 15149470
C025034 doxifluridine CLDN3 protein results in increased susceptibility to doxifluridineincreases response to substance 16734730
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CLDN3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CLDN3 mRNAaffects cotreatment|decreases expression 17942748
D017313 Fenretinide Fenretinide results in increased expression of CLDN3 mRNAincreases expression 16671099
D007529 Isoflavones Isoflavones results in decreased expression of CLDN3 mRNAdecreases expression 17374662
C011890 kojic acid kojic acid results in decreased expression of CLDN3 mRNAdecreases expression 16595896
D015741 Metribolone Metribolone results in increased expression of CLDN3 mRNAincreases expression 17010196
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN3 protein]decreases expression|decreases reaction 17478549
D017239 Paclitaxel CLDN3 protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CLDN3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CLDN3 mRNAdecreases expression 18445702
D011374 Progesterone Progesterone affects the expression of CLDN3 mRNAaffects expression 17251523
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in decreased expression of CLDN3 protein]decreases expression|decreases reaction 17478549
D011374 Progesterone Progesterone results in decreased expression of CLDN3 proteindecreases expression 17478549
C079198 S 1 (combination) CLDN3 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CLDN3 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CLDN3 mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CLDN3 mRNAdecreases expression 16054898
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CLDN3 mRNAincreases expression 16960034
C012589 trichostatin A [decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]affects binding|affects cotreatment|decreases reaction 17986852
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]affects binding|affects cotreatment|increases reaction 17986852
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 mRNA]increases expression|increases reaction 17986852
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 protein]increases expression|increases reaction 17986852
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8214692618
MESH:D000230 Adenocarcinoma Fenretinide 6.8210697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.193712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.196695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 16.2117162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.2116835633
MESH:D000505 Alopecia Isoflavones 4.5517569567
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8111289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.3715867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515845082 15380490 15665606
MESH:D001932 Brain Neoplasms Fenretinide 4.1716187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6220146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 5.6216818667 16344269
MESH:D001943 Breast Neoplasms capecitabine 5.6212972520 18473752
MESH:D001943 Breast Neoplasms decitabine 5.6219208741 18320071
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.6215324884 17129689
MESH:D001943 Breast Neoplasms Fenretinide 5.6216601279
MESH:D001943 Breast Neoplasms Paclitaxel 5.6218223236 11325840 18234424 16115903 16244791 15136595 16273361 18323546
MESH:D001943 Breast Neoplasms Progesterone 5.6216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 13.5517162532
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.5516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.5516270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.5516313753
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 6.0116247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 6.0118212800 18347146
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.4019215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.4016274795
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 10.4015984520
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Isoflavones 4.0117689850
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1012371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2616154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.9519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9517681005 11677210 16919318 16105132 17333356 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 17.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0215340226 8697196 16354765 12621046 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3017616700
MESH:D015179 Colorectal Neoplasms capecitabine 6.3118448328 18473752
MESH:D015179 Colorectal Neoplasms decitabine 6.3118981723
MESH:D015179 Colorectal Neoplasms Fenretinide 6.3117273769
MESH:D015179 Colorectal Neoplasms Isoflavones 6.3117116718
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.3118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D003329 Coronary Vasospasm capecitabine 5.6117465463
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3512952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6114531868 12868966 11298694 18759878 8970840 11906362 2524372 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.302952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.4121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.4116192314 9022650 6679447 6482804 18692083 8291058 18289764 1440618 9653073 9328219 18648102 11289319 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4111739529 11461765 19923254 18071297 2444490 11834606 15619225 16227642 16081117 17906064 16177239 11287661 19164858 14986274 10774834 12705907 19420014 12958197 17562736 10915739 19085960 17522070 12392966 11421492 15968718 12540782 16393943 12153990 18713872 11529661 12594235 14550746 16485898 16781746 16109766 14725611 11743745 19416960 19370779 10663392 19739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.3617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.3219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.3219294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.3315700306 16804899
MESH:D004715 Endometriosis Mifepristone 14.2716134523
MESH:D004715 Endometriosis Progesterone 14.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.279294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.973581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9716530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.9716481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Cyclosporine 11.9019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.9015345470
MESH:D005234 Fatty Liver pirinixic acid 11.9020131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5316534752 16513791 15751030 16002989 16611131
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D005355 Fibrosis Cyclosporine 7.7912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7920067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.5619093184
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Fenretinide 7.3016187019
MESH:D005909 Glioblastoma trichostatin A 7.3018801729
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.9419215824
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 7.9418607998 15984520
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly pirinixic acid 7.5719772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5716120746 15340226 12621046
MESH:D019584 Hot Flashes Isoflavones 4.7714716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8318606429 15340226 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.1415034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.1412960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.5516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.5516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007246 Infertility Diethylstilbestrol 4.1515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male decitabine 6.2617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007249 Inflammation Progesterone 4.6215869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 5.4015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.408314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.3616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.366582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.3612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.3616762066 15003126 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8617184923
MESH:D007938 Leukemia decitabine 2.9719235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.8118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1419387464 18704418 17679729 18206229 19010910 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.1418206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8316707609
MESH:D008080 Liposarcoma Paclitaxel 4.6317353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.0715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.0712878042
MESH:D008107 Liver Diseases Acetaminophen 1.5819460945 12587719 19784758 16611625 19014921 16610002 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0517185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.4020195826 21137059
MESH:D008113 Liver Neoplasms dicyclanil 13.4020118626
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.4016712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 13.4020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.131399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental kojic acid 9.1318544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3117053015 20064080 20464547 20869020 6695378 18569708 18520028 18816296 20135361
MESH:D008175 Lung Neoplasms bexarotene 3.3117849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3119555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9415166399
MESH:D008223 Lymphoma decitabine 7.2419470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.2415700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9214749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9411161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3016002989
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.4419196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 9.4410697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4417203775 11408345
MESH:D008545 Melanoma decitabine 7.1016505122 17785578
MESH:D008545 Melanoma Fenretinide 7.1016270382
MESH:D008545 Melanoma Paclitaxel 7.1012025231 12040289 16342250
MESH:D008545 Melanoma trichostatin A 7.1016505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2516381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.2516274795
MESH:D009101 Multiple Myeloma decitabine 11.4618172295
MESH:D009101 Multiple Myeloma Paclitaxel 11.4614749477
MESH:D009101 Multiple Myeloma trichostatin A 11.4618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2619010910 19157545 18608210 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.283581430
MESH:D009362 Neoplasm Metastasis capecitabine 9.2812972520
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.2815867366
MESH:D009369 Neoplasms Benzo(a)pyrene 18.4711141357
MESH:D009369 Neoplasms capecitabine 18.4716374040
MESH:D009369 Neoplasms decitabine 18.4717925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 18.4715313581
MESH:D009369 Neoplasms Fenretinide 18.4715958647 17353921
MESH:D009369 Neoplasms pirinixic acid 18.4717405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5719196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.9711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.786679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7018514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4716303764
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2716049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.276482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010014 Osteolysis Paclitaxel 4.7715867366
MESH:D010024 Osteoporosis Isoflavones 3.9716562857
MESH:D010051 Ovarian Neoplasms decitabine 18.0219331143 19259094
MESH:D010051 Ovarian Neoplasms Fenretinide 18.0216133793
MESH:D010051 Ovarian Neoplasms Mifepristone 18.0216525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 18.0211161223
MESH:D010051 Ovarian Neoplasms Progesterone 18.0217393432 16525653
MESH:D010051 Ovarian Neoplasms trichostatin A 18.0219331143
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.4419294695
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.4415580305
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.4419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4616977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.8617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8611399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 11.7317616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.7317616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9015046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Fenretinide 1.9017024972
MESH:D011471 Prostatic Neoplasms Isoflavones 1.9017374662 16365062 17219775 17571952
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9017172428 17136230 16729912 16356831
MESH:D011471 Prostatic Neoplasms trichostatin A 1.9018798265 19789329
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.593692021
MESH:D012162 Retinal Degeneration Fenretinide 8.5916303925
MESH:D012208 Rhabdomyosarcoma decitabine 4.2119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4018551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9319755658 10029692
MESH:D012878 Skin Neoplasms Fenretinide 8.9316467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9316192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.0116709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.652093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.6519037991
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6518506536 18396642
MESH:D013274 Stomach Neoplasms S 1 (combination) 4.6518506536 16557585 18553229
MESH:D024801 Tauopathies Paclitaxel 4.6016930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.721399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms decitabine 6.7217967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 18.8216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.828074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.8217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.8219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.8217306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 18.8216720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.2316175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 9.2316154183
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8016690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8014692618
MESH:D014604 Uveal Neoplasms decitabine 4.7017785578
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2316513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05160 Hepatitis C
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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