AutismKB 2.0

Annotation Detail for CLDN23


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Basic Information Top
Gene Symbol:CLDN23 ( CLDNL,hCG1646163 )
Gene Full Name: claudin 23
Band: 8p23.1
Quick LinksEntrez ID:137075; OMIM: 609203; Uniprot ID:CLD23_HUMAN; ENSEMBL ID: ; HGNC ID: 17591
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLDN23 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CLDN23 mRNAincreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CLDN23 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone NCOA2 protein affects the reaction [Progesterone results in increased expression of CLDN23 mRNA]affects reaction|increases expression 17556502
D011374 Progesterone Progesterone results in increased expression of CLDN23 mRNAincreases expression 17556502
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1320146248 17474063
MESH:D001943 Breast Neoplasms Progesterone 2.1315562024 16175315 17614352
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7916705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0521346803 18551238
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D004715 Endometriosis Progesterone 4.1616134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver pirinixic acid 3.1920131406 19236843
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 18467677 19176532 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 2.7715869954
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.7720007298 15890375 16377806
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718569708 20464547 18816296 18520028 20135361 17053015 20064080 6695378 20869020
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.1011408345 17203775
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms pirinixic acid 5.3917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8212819281 16049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.6216525653 17393432
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.9115862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05160 Hepatitis C
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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