AutismKB 2.0

Annotation Detail for CPT1A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CPT1A ( CPT1,CPT1-L,L-CPT1 )
Gene Full Name: carnitine palmitoyltransferase 1A (liver)
Band: 11q13.3
Quick LinksEntrez ID:1374; OMIM: 600528; Uniprot ID:CPT1A_HUMAN; ENSEMBL ID: ENSG00000110090; HGNC ID: 2328
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6111mitochondrial L-carnitine shuttle pathway
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Activated AMPK stimulates fatty-acid oxidation in muscle
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Atherosclerosis
CARDIOVASCULAR
METABOLIC
obesity
Hepatitis C, Chronic
INFECTION
No data
Desease Name
CPT deficiency, hepatic, type IA
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of CPT1A mRNAincreases expression 11779202
C430898 AGN 194204 AGN 194204 results in increased expression of CPT1A mRNAincreases expression 16339527
D017962 alpha-Linolenic Acid alpha-Linolenic Acid results in increased expression of CPT1A mRNAincreases expression 15307955
D000621 Aminoisobutyric Acids Aminoisobutyric Acids results in increased expression of CPT1A mRNAincreases expression 14576092
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of CPT1A mRNAincreases expression 15307955
C065179 atorvastatin atorvastatin results in increased expression of CPT1A mRNAincreases expression 19053045
C065179 atorvastatin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [atorvastatin results in increased expression of CPT1A mRNA]decreases reaction|increases expression 19053045
D001629 Bezafibrate Bezafibrate results in increased expression of CPT1A mRNAincreases expression 19682441
C006780 bisphenol A bisphenol A results in increased expression of CPT1A mRNAincreases expression 20678512
D002104 Cadmium Cadmium results in increased expression of CPT1A mRNAincreases expression 17066326
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of CPT1A mRNAincreases expression 17066326
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CPT1A mRNAaffects expression 16239168
D002331 Carnitine [Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 16283381
C515629 chiglitazar chiglitazar results in increased expression of CPT1A mRNAincreases expression 16751799
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 19509184
D002994 Clofibrate Clofibrate results in increased expression of CPT1A mRNAincreases expression 19224547
D003314 Corn Oil Corn Oil affects the expression of CPT1A mRNAaffects expression 16360708
D003345 Corticosterone Corticosterone results in increased expression of CPT1A mRNAincreases expression 15755911
D003474 Curcumin Curcumin results in increased expression of CPT1A mRNAincreases expression 19297423
D016572 Cyclosporine Cyclosporine results in decreased expression of CPT1A mRNAdecreases expression 19224547
D018119 Stavudine Stavudine results in increased expression of CPT1A mRNAincreases expression 14576092
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 18313992
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 19509184
D004041 Dietary Fats Dietary Fats results in decreased expression of CPT1A mRNAdecreases expression 18367378
D004041 Dietary Fats Dietary Fats results in increased expression of CPT1A mRNAincreases expression 18292748
18457598
15238619
D004041 Dietary Fats [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 19632207
D004041 Dietary Fats Dietary Fats results in increased expression of CPT1A mRNAincreases expression 18239587
D004280 Dobutamine Dobutamine results in increased expression of CPT1A mRNAincreases expression 8479178
D004280 Dobutamine Dobutamine results in increased expression of CPT1A proteinincreases expression 8479178
D004281 Docosahexaenoic Acids Docosahexaenoic Acids results in increased expression of CPT1A mRNAincreases expression 15307955
D004298 Dopamine Dopamine results in increased expression of CPT1A mRNAincreases expression 8479178
D004298 Dopamine Dopamine results in increased expression of CPT1A proteinincreases expression 8479178
D004317 Doxorubicin [Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 16283381
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 17942748
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of CPT1A mRNAincreases expression 15949695
D011345 Fenofibrate Fenofibrate results in increased expression of CPT1A mRNAincreases expression 17118139
D005472 Fluorouracil CPT1A protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D005485 Flutamide Flutamide results in decreased expression of CPT1A mRNAdecreases expression 17702527
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 19509184
D005632 Fructose [Dietary Fats co-treated with Fructose] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 19632207
D005978 Glutathione Glutathione deficiency results in increased expression of CPT1A mRNAincreases expression 15345336
C453899 GW 7647 GW 7647 results in increased expression of CPT1A mRNAincreases expression 19631232
D008042 Linolenic Acids Linolenic Acids results in increased expression of CPT1A mRNAincreases expression 18565938
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CPT1A mRNAincreases expression 11779202
D008701 Methapyrilene Methapyrilene results in decreased expression of CPT1A mRNAdecreases expression 15120968
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [atorvastatin results in increased expression of CPT1A mRNA]decreases reaction|increases expression 19053045
D019787 Linoleic Acid Linoleic Acid results in increased expression of CPT1A mRNAincreases expression 18565938
D019301 Oleic Acid Oleic Acid results in increased expression of CPT1A mRNAincreases expression 18565938
C046627 osthol osthol results in increased expression of CPT1A mRNAincreases expression 19682441
D010126 Ozone Ozone results in decreased expression of CPT1A mRNAdecreases expression 16183385
D010126 Ozone Ozone results in increased expression of CPT1A mRNAincreases expression 16330353
D010168 Palmitates Palmitates results in increased expression of CPT1A mRNAincreases expression 18565938
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] affects the expression of CPT1A mRNAaffects cotreatment|affects expression 17715259
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid affects the expression of CPT1A mRNAaffects expression 17383973
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CPT1A mRNAdecreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CPT1A mRNAincreases expression 17681415
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of CPT1A mRNAaffects expression 17383973
D010634 Phenobarbital Phenobarbital promotes the reaction [pirinixic acid results in increased expression of CPT1A mRNA]increases expression|increases reaction 19631232
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] affects the expression of CPT1A mRNAaffects cotreatment|affects expression 17715259
D010852 Picrotoxin Picrotoxin results in increased expression of CPT1A mRNAincreases expression 15170462
C006253 pirinixic acid pirinixic acid results in increased expression of CPT1A mRNAincreases expression 18565938
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPT1A mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPT1A mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CPT1A mRNAdecreases expression 16985257
C006253 pirinixic acid pirinixic acid results in increased expression of CPT1A mRNAincreases expression 15777286
17426115
18301758
17118139
16282640
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of CPT1A mRNA]affects reaction|increases expression 15777286
C006253 pirinixic acid Phenobarbital promotes the reaction [pirinixic acid results in increased expression of CPT1A mRNA]increases expression|increases reaction 19631232
C006253 pirinixic acid pirinixic acid results in increased expression of CPT1A mRNAincreases expression 19631232
C045950 propiconazole propiconazole affects the expression of CPT1A mRNAaffects expression 17383973
C488333 Ro 65-7199 Ro 65-7199 affects the expression of CPT1A mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of CPT1A mRNAaffects expression 14610520
D012402 Rotenone Rotenone results in decreased expression of CPT1A mRNAdecreases expression 17702527
C009250 sevoflurane sevoflurane affects the expression of CPT1A mRNAaffects expression 15967596
C009277 sodium arsenate sodium arsenate results in decreased expression of CPT1A mRNAdecreases expression 16882884
D013311 Streptozocin Streptozocin results in increased expression of CPT1A mRNAincreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CPT1A mRNA]decreases reaction|increases expression 16684804
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CPT1A mRNAincreases expression 17555868
20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CPT1A mRNAincreases expression 16960034
16054898
D013752 Tetracycline Tetracycline results in decreased expression of CPT1A mRNAdecreases expression 19224547
C410666 tetradecylselenoacetic acid tetradecylselenoacetic acid results in increased expression of CPT1A mRNAincreases expression 17185614
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of CPT1A mRNAdecreases expression 17217560
D014212 Tretinoin Tretinoin results in increased expression of CPT1A mRNAincreases expression 16840543
C032910 triadimefon triadimefon affects the expression of CPT1A mRNAaffects expression 17383973
D014508 Urea Urea analog results in increased expression of CPT1A mRNAincreases expression 15798002
D014635 Valproic Acid Valproic Acid results in increased expression of CPT1A mRNAincreases expression 19224547
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CPT1A mRNA]decreases reaction|increases expression 16684804
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNAaffects cotreatment|increases expression 18313992
D015215 Zidovudine Zidovudine results in increased expression of CPT1A mRNAincreases expression 14576092
D015032 Zinc Zinc results in increased expression of CPT1A mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of CPT1A mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.2715322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.278875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.3119490988
MESH:D000138 Acidosis Zinc Sulfate 4.237265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.169612607
MESH:D000169 Acrodermatitis Zinc 4.7217202136 17190629 16889938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 6.9418653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 6.9418653653
MESH:D000230 Adenocarcinoma Doxorubicin 5.7517418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.7514692618
MESH:D000230 Adenocarcinoma Fluorouracil 5.7517638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 13.3417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 13.3416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.3416835633
MESH:D000419 Albuminuria Doxorubicin 3.8921441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.3817887948
MESH:D000505 Alopecia Tretinoin 3.0615955085
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 7.7420157255
MESH:D000544 Alzheimer Disease Curcumin 7.7415590663
MESH:D000544 Alzheimer Disease Ozone 7.7415513908
MESH:D000544 Alzheimer Disease Zinc 7.7416580781 16410023 16325427 17119284
MESH:D000550 Amblyopia Valproic Acid 4.5317688650
MESH:D000740 Anemia Fluorouracil 6.6917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.6911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.2516916123
MESH:D000799 Angioedema Acetaminophen 3.1510982225
MESH:D000860 Anoxia Oleic Acid 9.5515090967
MESH:D000860 Anoxia Zinc Sulfate 9.557265320
MESH:D001008 Anxiety Disorders Valproic Acid 3.0217497229
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 13.3415552841
MESH:D001161 Arteriosclerosis Dietary Fats 13.3415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 13.3411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 5.6716412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 6.1516807698
MESH:D001172 Arthritis, Rheumatoid Ozone 6.1515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.1516292516
MESH:D001249 Asthma Ozone 6.3916373670 17854713
MESH:D001249 Asthma Tretinoin 6.3916456186
MESH:D001249 Asthma Zinc 6.3917085522
MESH:D050197 Atherosclerosis Cadmium 5.5715687053
MESH:D050197 Atherosclerosis Curcumin 5.5718704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 4.3318448859
MESH:D001321 Autistic Disorder Acetaminophen 6.2418445737
MESH:D001321 Autistic Disorder Arachidonic Acid 6.2418582451
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 6.2418582451
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 6.2416920077
MESH:D001321 Autistic Disorder Glutathione 6.2419267885 16917939 18929414 19056591
MESH:D001321 Autistic Disorder Linoleic Acid 6.2418582451
MESH:D001321 Autistic Disorder Linolenic Acids 6.2418582451
MESH:D001321 Autistic Disorder Valproic Acid 6.2418177632 18985861 18940202 17688650 16609825 18316065 18396377 17157402 18775368 17507914 20603192 18558336 19232924 19460635 15238991
MESH:D001327 Autoimmune Diseases Curcumin 3.8219761891
MESH:D001471 Barrett Esophagus Tretinoin 3.7516935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.6820046352 17594078
MESH:D001778 Blood Coagulation Disorders Clofibrate 16.9219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.9212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.9216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.4415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.448888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.0014601052
MESH:D001862 Bone Resorption bisphenol A 3.2511985600
MESH:D001930 Brain Injuries Zinc 4.0217109824
MESH:D002545 Brain Ischemia Curcumin 3.6516770732
MESH:D001932 Brain Neoplasms Curcumin 6.9717596214
MESH:D001932 Brain Neoplasms Doxorubicin 6.9717150277
MESH:D001943 Breast Neoplasms bisphenol A 3.1117123778
MESH:D001943 Breast Neoplasms Curcumin 3.1118462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Dietary Fats 3.1120435547
MESH:D001943 Breast Neoplasms Doxorubicin 3.1118628466 15993339 15136595 15994142 16096432 15692762 15668708 15939500 11325840 16595493 16115903 18234424 19526202 16264153 17369602 17426702 18382427 18695136 15567936 16322301 15634643 16826403 17983394 16935488
MESH:D001943 Breast Neoplasms Fluorouracil 3.1115136595 18357371 16110121 16557594 19217205 16595493 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.1120435547
MESH:D001943 Breast Neoplasms Tretinoin 3.1116166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.1214754758 18315731 17626835 18417511 19059883 15516495 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9016813970
MESH:D002100 Cachexia Ozone 4.0516183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1116124888 16050911 16097048 18705752 15700767 16192424 16227642 16011737 15721981 3786805 10355542 15673190
MESH:D002276 Carcinoid Tumor Doxorubicin 17.2016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 17.2016051944
MESH:D002276 Carcinoid Tumor Streptozocin 17.2016051944
MESH:D002277 Carcinoma Curcumin 10.7518593918
MESH:D002277 Carcinoma Fluorouracil 10.7517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 10.7516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.283084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.2818788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.2818059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.2816799960 17045692 17971768 16332177 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.2817173139 20935162 1701930 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.281917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.3017123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7018414057
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.421485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.4218695887
MESH:D002294 Carcinoma, Squamous Cell Curcumin 14.6618462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.666189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.6616757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Glutathione 14.6617015178
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.6616096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 14.6616543248
MESH:D006332 Cardiomegaly atorvastatin 5.7918360054
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.7918850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.0516651473 17308081 15811867 16364871 16731534 15476868 15792986 16269455 17928571 18627295 17382496 15505089 16952015 17351982 16612575 16109756 16278810 17329180 17974986 17131338 17007740 16242529 17924179 16455267 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.6617334414 16243910
MESH:D002318 Cardiovascular Diseases Zinc 3.1716936243
MESH:C535588 Carnitine palmitoyl transferase 1A deficiency marker/mechanism
MESH:D002386 Cataract Acetaminophen 5.7410977129
MESH:D002386 Cataract Tretinoin 5.7417460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 8.4817332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 8.481399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.4812371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.584080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9016129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D002779 Cholestasis Cyclosporine 10.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.2817333356 15861022 17110522 11677210 17681005 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 10.2819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.4616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.9115340226 8697196 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 7.919407595
MESH:D002972 Cleft Palate triadimefon 7.9116781842
MESH:D003092 Colitis Curcumin 7.4316782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 7.4317035595
MESH:D003103 Coloboma Curcumin 3.9318809619
MESH:D003110 Colonic Neoplasms Curcumin 3.3516340194 19359593
MESH:D003110 Colonic Neoplasms Fluorouracil 3.3517018589 16510598 16340194 15001691 17016597 17725105 17169374 18772588 17172411 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.4318259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.4317255274 16282729 18509181 17401013 18383874 17695437 14970324 15148649 18949393 16524972 17594712 16331619 17454858 16391804 18288408 18802399 16303861 20501625 17094418 18448328 15289873 17016601
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4714669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.2318497527
MESH:D003324 Coronary Artery Disease atorvastatin 3.8516368305
MESH:D003327 Coronary Disease Fructose 4.0018504504
MESH:D019465 Craniofacial Abnormalities sodium arsenate 7.9510525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.9510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.9517551590 8800419 10589399 9211117 16925845 9142499 9125849 14991402 9664655 9224671
MESH:D019465 Craniofacial Abnormalities triadimefon 7.9516875885 15834900
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.9516575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 7.9519302082
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 7.3419747007
MESH:D003550 Cystic Fibrosis Glutathione 7.3419747007
MESH:D007644 Darier Disease Fluorouracil 4.1116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0618249437
MESH:D003920 Diabetes Mellitus osthol 12.5019682441
MESH:D003920 Diabetes Mellitus Streptozocin 12.5016285004
MESH:D003920 Diabetes Mellitus Zinc 12.5016479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 11.0018603373
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 11.0015862027 1374869 18603373 12446591 19496084 16684804 11260395 12093613 15298345 19960420 8740154 16286809 19586609 2177838 17442507 7637645 15831366 18715473 12083368 6379147 11055810 19298542 12644472 17874149
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 11.0016684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.3818603373
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 8.4418403477
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 8.4418603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 8.4419586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 8.4417107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.0416025228
MESH:D003928 Diabetic Nephropathies Curcumin 7.5518204486
MESH:D003928 Diabetic Nephropathies Streptozocin 7.5519682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 4.7717662242
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.5616393943 2444490 12705907 19923254 12392966 12153990 16081117 15619225 17562736 12594235 12958197 18713872 19416960 19164858 14986274 10663392 15968718 19420014 17522070 11529661 16109766 11287661 16485898 14550746 10774834 10915739 16177239 12540782 19085960 19739265 18071297 11739529 11421492 17906064 11834606 11743745 19370779 11461765 16781746 14725611 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.567120509 10915739 19336974 7440962 16227642 16177239 3786805 19085960 17522070 15968718 4309450 21278145 3732212 2869522 9327722 6884620 10092053 15998439 11566570 6623471 7179309 15027814
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.5617416283
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 14.5618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.5620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 14.5617522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.561733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4019426721
MESH:D004362 Drug Toxicity Doxorubicin 20.1718602426
MESH:D004362 Drug Toxicity Lamivudine 20.1715040536
MESH:D004362 Drug Toxicity Stavudine 20.1715040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 20.1711462148
MESH:D004362 Drug Toxicity Zidovudine 20.1715040536
MESH:D004381 Duodenal Ulcer Curcumin 3.4017351913
MESH:D050171 Dyslipidemias chiglitazar 16.5516751799
MESH:D050171 Dyslipidemias Clofibrate 16.5516707586
MESH:D050171 Dyslipidemias Dietary Fats 16.5518367378
MESH:D050171 Dyslipidemias Fenofibrate 16.5516707586
MESH:D004421 Dystonia Phenobarbital 8.321851702
MESH:D004421 Dystonia Valproic Acid 8.321851702
MESH:D004487 Edema Arachidonic Acid 11.5116716910 15177302 9831321 9599246 7990266 11698051
MESH:D004487 Edema perfluorooctanoic acid 11.5117259670 12083418
MESH:D004487 Edema pirinixic acid 11.5112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.6215322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 9.6218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.5412538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 9.8417359293
MESH:D016889 Endometrial Neoplasms Fenofibrate 9.8416569247
MESH:D016889 Endometrial Neoplasms Tretinoin 9.8416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.429294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.4618037988
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7115328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 8.573659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.573659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 7.6611558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 7.663922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.3320417680
MESH:D004827 Epilepsy Valproic Acid 5.3318234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 6.926401628
MESH:D004832 Epilepsy, Absence Valproic Acid 6.926254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.087750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.213659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.213659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.0315173087 17638652 16337965 16481741 16785472
MESH:D004938 Esophageal Neoplasms Zinc 4.0316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.0611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.069664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 53.9716239168 17595544 61145 12795759 19224547 15959796 16045604 12631006
MESH:D005234 Fatty Liver Clofibrate 53.9719224547
MESH:D005234 Fatty Liver Curcumin 53.9719297423
MESH:D005234 Fatty Liver Cyclosporine 53.9719224547
MESH:D005234 Fatty Liver Dietary Fats 53.9718296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 53.9715345470
MESH:D005234 Fatty Liver Fructose 53.9719196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 53.9720131406 19236843
MESH:D005234 Fatty Liver Stavudine 53.9718299183
MESH:D005234 Fatty Liver Tetracycline 53.9716917069 19224547
MESH:D005234 Fatty Liver Valproic Acid 53.9714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 53.9718299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.4818558336 8888407
MESH:D005334 Fever Arachidonic Acid 7.5511852909
MESH:D005334 Fever Lipopolysaccharides 7.5511852909 9205823
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 3.9019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 31.3218705752
MESH:D005355 Fibrosis Curcumin 31.3218705752
MESH:D005355 Fibrosis Cyclosporine 31.3212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 31.3218296743
MESH:D005355 Fibrosis Fructose 31.3218504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.3220067830
MESH:D005355 Fibrosis Tretinoin 31.3217994277
MESH:D005756 Gastritis Acetaminophen 8.8516983495
MESH:D005756 Gastritis Zinc 8.8517241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0218462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.538708960
MESH:D005909 Glioblastoma Curcumin 13.0817596214
MESH:D005909 Glioblastoma Doxorubicin 13.0817150277
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 13.0817162496
MESH:D005909 Glioblastoma Tretinoin 13.0817312396
MESH:D005910 Glioma Fluorouracil 2.5516145905
MESH:D018149 Glucose Intolerance Fructose 9.7519165636
MESH:D018149 Glucose Intolerance sodium arsenate 9.7519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8910696789
MESH:D006130 Growth Disorders Zinc 3.4917217573
MESH:D006258 Head and Neck Neoplasms Curcumin 14.4218829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 14.4215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 14.4215162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 14.4216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.1714991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 6.4412587719 16144979 18674790 18006777 16707910 14766674 16330681 16879835 16244372 17888722 17875725 16495754 16244371
MESH:D006331 Heart Diseases Streptozocin 6.4412093613
MESH:D006333 Heart Failure atorvastatin 17.3516360360
MESH:D006333 Heart Failure Dobutamine 17.3517440445
MESH:D006333 Heart Failure Doxorubicin 17.3517481944
MESH:D006333 Heart Failure pirinixic acid 17.3520558911
MESH:D006333 Heart Failure Zinc 17.3517162251
MESH:D006335 Heart Injuries Zinc 5.0717074742
MESH:D016481 Helicobacter Infections Zinc 3.9017241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.2915692506
MESH:D006402 Hematologic Diseases Zidovudine 4.0812579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 2.9519900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.4817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.4812044531 15631357 15274664 16476009 15309715
MESH:D006527 Hepatolenticular Degeneration Zinc 9.0917276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 9.0917063115
MESH:D006529 Hepatomegaly perfluorooctanoic acid 25.183609246
MESH:D006529 Hepatomegaly Phenobarbital 25.1816109766
MESH:D006529 Hepatomegaly pirinixic acid 25.1819176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly propiconazole 25.1817178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 25.1816120746 12621046 15340226
MESH:D006529 Hepatomegaly triadimefon 25.1817178689 17178688
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.3717701891
MESH:D015658 HIV Infections Lamivudine 8.779296927 11141242 20032539 17530837
MESH:D015658 HIV Infections Stavudine 8.7711141242
MESH:D015658 HIV Infections Zidovudine 8.7717358032 11698656 11141242 20032539 11363243
MESH:D006689 Hodgkin Disease Doxorubicin 2.8517606976 18501091 15147373
MESH:D006849 Hydrocephalus Valproic Acid 4.1817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3516959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 9.8816870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 9.8812083418
MESH:D006930 Hyperalgesia Tretinoin 9.8816870215
MESH:D017588 Hyperandrogenism Flutamide 4.7615356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8516899240
MESH:D006937 Hypercholesterolemia atorvastatin 16.8911583720
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 16.8910876104
MESH:D006937 Hypercholesterolemia Curcumin 16.8918704882
MESH:D006937 Hypercholesterolemia Dietary Fats 16.8921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9016778211
MESH:D006943 Hyperglycemia osthol 7.9919682441
MESH:D006943 Hyperglycemia pirinixic acid 7.9920558911
MESH:D006946 Hyperinsulinism Fructose 4.3218360027 19008412 15752949 18563319 14757778
MESH:D006949 Hyperlipidemias Dietary Fats 7.4521332399
MESH:D006949 Hyperlipidemias Fructose 7.4515752949
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 4.6116238680
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.1111484837
MESH:D006973 Hypertension atorvastatin 9.8217042910
MESH:D006973 Hypertension Cyclosporine 9.8210903974
MESH:D006973 Hypertension Fructose 9.8214573337 16843071 14568997 14633139 19008412
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4215338365
MESH:D015228 Hypertriglyceridemia Fructose 4.4719799862 19342510
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1416569931 16945680
MESH:D007022 Hypotension Dopamine 7.746740701
MESH:D007022 Hypotension Zinc Sulfate 7.747265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.0117937319
MESH:D007249 Inflammation Arachidonic Acid 21.5015177302 9831321 17371808
MESH:D007249 Inflammation atorvastatin 21.5016908763
MESH:D007249 Inflammation Curcumin 21.5016956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 21.5020412841
MESH:D007249 Inflammation Fatty Acids, Omega-3 21.5017296493
MESH:D007249 Inflammation Lipopolysaccharides 21.5017963957 17237260 17255318 12878042 9205823
MESH:D007249 Inflammation perfluorooctanoic acid 21.5012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.5012200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.8918596194 18200517
MESH:D007333 Insulin Resistance bisphenol A 22.7416393666
MESH:D007333 Insulin Resistance chiglitazar 22.7416751799
MESH:D007333 Insulin Resistance Dietary Fats 22.7411836018 18457598
MESH:D007333 Insulin Resistance Fructose 22.7414757778 19586609 19342510 18057795 19008412 14633139 19799862 18563319 17133782 14573337 18981581
MESH:D007333 Insulin Resistance Palmitates 22.7417471172
MESH:D007333 Insulin Resistance pirinixic acid 22.7416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1017994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.6210783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.9917255318
MESH:D007511 Ischemia Zinc 3.9616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 13.6816580747
MESH:D007569 Jaw Abnormalities Tretinoin 13.6815992940 17551590
MESH:D007569 Jaw Abnormalities triadimefon 13.6815992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7415604871
MESH:D007674 Kidney Diseases Acetaminophen 22.1615629191 12587719
MESH:D007674 Kidney Diseases Cadmium 22.1616322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 22.1616962696
MESH:D007674 Kidney Diseases Cyclosporine 22.1618776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 22.1616775033 15699352 15369732
MESH:D007674 Kidney Diseases Streptozocin 22.1612093613
MESH:D007674 Kidney Diseases Zinc 22.1616960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.1216707910
MESH:D007676 Kidney Failure, Chronic Zinc 8.1216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 9.2412371664
MESH:D007680 Kidney Neoplasms Fluorouracil 9.2416985049
MESH:D007680 Kidney Neoplasms Zidovudine 9.2412579204
MESH:D007859 Learning Disorders sevoflurane 4.1119212262
MESH:D007889 Leiomyoma Curcumin 3.9318555241
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.7015237267
MESH:D007938 Leukemia Curcumin 5.1918462866
MESH:D007938 Leukemia Tretinoin 5.1917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.4616085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 12.9116106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 12.9117077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 12.9120370541
MESH:D007951 Leukemia, Myeloid Tretinoin 3.0816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.3117596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.3117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.6819035177 17368321 17649720 16935935 17294898 17301526 19642359 16140955 17712046 16331271 16891316 15748426 16788101 16766008 17361223 19075265 17217047 17506722 16823087 19029980 17107899 12679006 17339181 19225113 9834237
MESH:D015458 Leukemia, T-Cell Curcumin 4.1116106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.0115821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.548812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.799224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.5617334410 17157831 16239168 16943688 21278145 16221502 11903743 11408273 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 8.5618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 8.5621047994
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 15.3317347453
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 15.3315057751 16248980 12667390 12649538 16097048 18395914 18279442 12445418 17721639 15931870 18429990 17708605 15650968 18412020 17525996 15338365 18054572 16638106 15370692 16015684 15052691 17805973 18205269 17922224 14724832 12632514 18006644 17761835 18166357 17481882 18395095 18472332 17976157 17869086 17823541 15730626 16116963 16136751 18418968 14748882 14512876 15673190 18317297 18472094 16027843 18210741 15876570 18277467 17565644 18187930 11481614 17714472 12609069 17631135 17640975 15362042 15123356 12958196 14716496 12741479 18481824 15818738 10355542 12586293 14716833 18376398 12666154 12632512 12389079 18339082 18705752 17557913 20821823 18251166 18263696 12898905 14620537 15996030 17944888 17766677 15959796 16192424 16033810 12546737 13678700 18156304 15925388 12445421 18420326 16011737 15893842 17900296 17698563
MESH:D008106 Liver Cirrhosis, Experimental Carnitine 15.3314748882
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 15.3318705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 15.3316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 15.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 15.3312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 15.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 15.3318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 15.6812969438 12587719 19014921 16611625 19460945 11587558 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 15.6816246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Curcumin 15.6816956363
MESH:D008107 Liver Diseases Docosahexaenoic Acids 15.6817056761
MESH:D008107 Liver Diseases Phenobarbital 15.6819363144
MESH:D008107 Liver Diseases propiconazole 15.6819363144
MESH:D008107 Liver Diseases triadimefon 15.6819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 9.6215123358
MESH:D017093 Liver Failure Stavudine 9.6218299183
MESH:D017114 Liver Failure, Acute Acetaminophen 7.4116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.4116899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.0019294768
MESH:D008113 Liver Neoplasms Carnitine 31.0019294768
MESH:D008113 Liver Neoplasms Fenofibrate 31.0018978307
MESH:D008113 Liver Neoplasms Fluorouracil 31.0016603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Methapyrilene 31.0015890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 31.0014757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 31.0015975961 19812893 19073162 19482888 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 31.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 31.0019028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.0016984957
MESH:D008113 Liver Neoplasms triadimefon 31.0019028983
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.1815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 21.1817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 21.1818253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.186150874 17172636 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental propiconazole 21.1817178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.1812151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 21.1817178689
MESH:D008133 Long QT Syndrome Dobutamine 4.2019353679
MESH:D008171 Lung Diseases Dobutamine 6.3816638327
MESH:D008171 Lung Diseases Ozone 6.388266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5717228818
MESH:D055370 Lung Injury Lipopolysaccharides 11.5821114838
MESH:D055370 Lung Injury Oleic Acid 11.5815090967
MESH:D055370 Lung Injury Ozone 11.5820417186
MESH:D008175 Lung Neoplasms Curcumin 6.9318462866 19359593 16243823
MESH:D008175 Lung Neoplasms Doxorubicin 6.936189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 6.9315246190
MESH:D008175 Lung Neoplasms Ozone 6.938597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.9311884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 6.9318800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1115086387
MESH:D008223 Lymphoma Curcumin 6.0818462866
MESH:D008223 Lymphoma Doxorubicin 6.0816098063
MESH:D008228 Lymphoma, Non-Hodgkin Carnitine 7.6116283381
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.6117654614
MESH:D016399 Lymphoma, T-Cell Curcumin 9.3416173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.3415621674
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 7.5012807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 7.5015458769
MESH:D008325 Mammary Neoplasms, Experimental Zinc 7.5012773700
MESH:D008527 Medulloblastoma Tretinoin 2.4617453147
MESH:D008545 Melanoma Curcumin 4.2118462866 17885582
MESH:D008545 Melanoma Doxorubicin 4.2116827129
MESH:D008545 Melanoma Tretinoin 4.2116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9019513568
MESH:D008569 Memory Disorders Curcumin 7.8017263510
MESH:D008569 Memory Disorders sevoflurane 7.8019212262
MESH:D008591 Meningomyelocele Tretinoin 3.7516940565
MESH:D008654 Mesothelioma Doxorubicin 2.7417638057
MESH:D024821 Metabolic Syndrome X Fructose 4.2418497449 16815490 17261469 17098227 19165636
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0916801185
MESH:D008679 Metaplasia Ozone 4.4110496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.1417358032
MESH:D008881 Migraine Disorders Valproic Acid 2.6818765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.8815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.0916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.1017415656
MESH:D009101 Multiple Myeloma Curcumin 3.0119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.2317962980
MESH:D009135 Muscular Diseases atorvastatin 14.0716239165
MESH:D009135 Muscular Diseases Bezafibrate 14.0716239165
MESH:D009135 Muscular Diseases pirinixic acid 14.0716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 8.6218186108
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 8.628888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 5.9417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 5.9417596541
MESH:D009203 Myocardial Infarction Doxorubicin 4.5815857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 4.5819151258
MESH:D017202 Myocardial Ischemia Dobutamine 7.5312447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.7917484760
MESH:D009361 Neoplasm Invasiveness Curcumin 3.7218495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.6418259882
MESH:D009369 Neoplasms Fluorouracil 6.0016928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 6.0017405874
MESH:D009369 Neoplasms Tretinoin 6.0016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.8412497104
MESH:D009395 Nephritis, Interstitial Tetracycline 4.099884423
MESH:D009401 Nephrosis Doxorubicin 4.1016636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7417954296
MESH:D009404 Nephrotic Syndrome atorvastatin 12.5019348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 12.5018481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 12.5016889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.3417356569 15790535 18619942
MESH:D009421 Nervous System Malformations bisphenol A 12.6111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.6114600291
MESH:D009421 Nervous System Malformations Tretinoin 12.619125849
MESH:D009423 Nervous System Neoplasms Curcumin 4.9318462866
MESH:D009436 Neural Tube Defects sodium arsenate 9.4818186108 19446573 10525206 11749123
MESH:D009436 Neural Tube Defects Tretinoin 9.489142499
MESH:D009436 Neural Tube Defects Valproic Acid 9.4816359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 2.8715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.3118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9516436463
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 9.839802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 9.839802331
MESH:D009765 Obesity Curcumin 8.7719297423
MESH:D009765 Obesity Dietary Fats 8.7720518802 11836018 17217161 18457598 20132043 21332399 16723640 19632207 18674790
MESH:D009765 Obesity Fructose 8.7718585860 17707055
MESH:D009765 Obesity pirinixic acid 8.7720558911
MESH:D010018 Osteomalacia Phenobarbital 3.6817016548
MESH:D010024 Osteoporosis Curcumin 3.0218719352
MESH:D012516 Osteosarcoma Doxorubicin 3.5515930896
MESH:D010049 Ovarian Diseases bisphenol A 4.3011985600
MESH:D010051 Ovarian Neoplasms Curcumin 4.1219020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 4.1216936753
MESH:D010146 Pain Acetaminophen 4.7416870215
MESH:D010146 Pain Tretinoin 4.7416870215
MESH:D010190 Pancreatic Neoplasms Curcumin 9.8217440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.8219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.8216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.8215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0511578682
MESH:D010300 Parkinson Disease Cholesterol, Dietary 5.0419014385
MESH:D010300 Parkinson Disease Rotenone 5.0418191903 19232380 19114014 11445065 15451049 16412576 18619942 16140633 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 3.4815574749 18197244 15927086 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5512520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.7311026799
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.7015687053
MESH:D010538 Peritonitis Ozone 3.4716369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4617638057
MESH:D011014 Pneumonia Lipopolysaccharides 8.8312224865 11605937
MESH:D011014 Pneumonia Ozone 8.8318007984 18929643 18381685
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.3915356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9118163543
MESH:D011230 Precancerous Conditions Corn Oil 12.0814668109
MESH:D011230 Precancerous Conditions Cyclosporine 12.0812371664
MESH:D011230 Precancerous Conditions Phenobarbital 12.082563599
MESH:D011225 Pre-Eclampsia Zinc 3.6317114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.6810548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 17.6817132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.6811399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.6820603192
MESH:D017096 Prion Diseases Tetracycline 4.7310903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.5920887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.2116000583
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2116740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.2117075824
MESH:D011471 Prostatic Neoplasms Curcumin 2.2111398177 18156803 18226269 18769126 12497104 10851300 15129424
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2116888761 18437689 16868541 16729912 15749863 15897917
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2118626508 19082440
MESH:D011471 Prostatic Neoplasms Flutamide 2.213169114
MESH:D011471 Prostatic Neoplasms Zinc 2.2116606632 16700911 12429649 16517595
MESH:D011507 Proteinuria Tretinoin 2.9716636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.6416919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 9.8712752131
MESH:D019310 Pseudolymphoma Valproic Acid 9.8712752131 11422049
MESH:D011565 Psoriasis Cyclosporine 1.9416882103
MESH:D011625 Pterygium Tretinoin 4.1116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1010548101
MESH:D011654 Pulmonary Edema Oleic Acid 5.1115090967
MESH:D011656 Pulmonary Emphysema Curcumin 3.9219168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4215538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.5617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.0119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.7018379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 7.7018549715
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.2510835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1818990726
MESH:D012162 Retinal Degeneration Zinc 3.5916584753
MESH:D012206 Rhabdomyolysis Lamivudine 4.859296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.7516116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.7519155313
MESH:D012509 Sarcoma Curcumin 7.5718462866
MESH:D012509 Sarcoma Doxorubicin 7.5718313854 17710206 15625365 17203757 15675481 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.5914601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1017846226
MESH:D012559 Schizophrenia Valproic Acid 1.9615737665 19110320
MESH:D012640 Seizures Phenobarbital 7.193137016 16876388 11442880 4039156
MESH:D012640 Seizures Picrotoxin 7.198954991 8635557
MESH:D012640 Seizures Valproic Acid 7.1911738929 14763951 11044598 15475178 1511512 17978042 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.136407741
MESH:D018805 Sepsis Curcumin 3.5018389075
MESH:D012878 Skin Neoplasms Doxorubicin 7.2815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.2816192470
MESH:D012878 Skin Neoplasms Tretinoin 7.2816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9016767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.2416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.2319490988
MESH:D013226 Status Epilepticus Valproic Acid 3.8412833885
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 4.0019015929
MESH:D013274 Stomach Neoplasms Fluorouracil 4.0016951190 17522103 19015929 17498489 18396642 17172411 16424979 19084572 18567086 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.0017261132
MESH:D013274 Stomach Neoplasms Zidovudine 4.0017696246
MESH:D013276 Stomach Ulcer Curcumin 2.9116631530 19188055
MESH:D019966 Substance-Related Disorders bisphenol A 3.3116045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5615821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.7616010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.761399818
MESH:D013964 Thyroid Neoplasms Tretinoin 12.7616026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 12.7617178689
MESH:D014062 Tongue Neoplasms Fluorouracil 13.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 13.1216051514
MESH:D014062 Tongue Neoplasms Zinc 13.1216543248
MESH:D016171 Torsades de Pointes Dobutamine 4.6719353679
MESH:D014178 Translocation, Genetic Valproic Acid 4.5317262798
MESH:D014376 Tuberculosis Tretinoin 2.7716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.843119515
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.3418593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 4.3417653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.978888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.5818462866
MESH:D014581 Urticaria Acetaminophen 2.3510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.4516803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.4516129372
MESH:D014591 Uterine Diseases bisphenol A 4.3114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.6514692618
MESH:D014604 Uveal Neoplasms Tretinoin 3.9116752155
MESH:D014605 Uveitis Cyclosporine 3.291336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.0912579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.5617678736 16364871 17334414 17638931
MESH:D014820 Vitiligo Tretinoin 3.4016761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5515886252
MESH:D015430 Weight Gain Dietary Fats 3.1516723640
MESH:D009396 Wilms Tumor Tretinoin 3.3816287080
MESH:D014985 Xerophthalmia Cyclosporine 3.7417120751
Pathway ID Pathway Name
REACT:11163 Activated AMPK stimulates fatty-acid oxidation in muscle
KEGG:04920 Adipocytokine signaling pathway
KEGG:00071 Fatty acid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00583 activator L-Carnitine Vitamins (Vitamin B Complex);Nootropic Agents;Metabolite;Nutraceutical;Vitamin B Complex
DB01074 antagonist Perhexiline Vasodilator Agents;Calcium Channel Blockers;Cardiovascular Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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