AutismKB 2.0

Annotation Detail for VPS37A


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Basic Information Top
Gene Symbol:VPS37A ( FLJ32642,FLJ42616,HCRP1,PQBP2 )
Gene Full Name: vacuolar protein sorting 37 homolog A (S. cerevisiae)
Band: 8p22
Quick LinksEntrez ID:137492; OMIM: 609927; Uniprot ID:VP37A_HUMAN; ENSEMBL ID: ENSG00000155975; HGNC ID: 24928
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
tonometry
Desease Name
Tonometry
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VPS37A mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of VPS37A mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of VPS37A mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of VPS37A mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in decreased expression of VPS37A mRNAdecreases expression 18445702
D013629 Tamoxifen Tamoxifen affects the expression of VPS37A mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819189210 21138602 16873071 17049068 19189212 18855134 15668708 19066611 17893378 19288272 19084267 18629630 15565566 20859285 20544844 18425577 19115204 20135344 19221464 19289846 18815881 18351453 21152245 11161223 19200415 17242785 17440819 19244106 20065188 19059307 18997820 19410462 17261762 19155303 16202921 19103187 16273361 20390343 19142967 16818667 19011961 18984771 18821012 19487384 20005174
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2612371664
MESH:D002779 Cholestasis Cyclosporine 14.7119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.7111677210 16919318 17110522 16105132 17333356 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 14.7119176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2419155303 17893378 20544844 16202921
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Cyclosporine 21.6019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.6015345470
MESH:D005234 Fatty Liver pirinixic acid 21.6019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 21.6019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 16221962 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 8.2012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2018625569
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.7615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 4.7616684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Clorgyline 3.5519691856
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.5515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4517572228 8653321 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:11123 Membrane Trafficking
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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