AutismKB 2.0

Annotation Detail for CPT1B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CPT1B ( CPT1-M,CPT1M,CPTI,CPTI-M,FLJ55729,FLJ58750,KIAA1670,M-CPT1,MCCPT1,MCPT1 )
Gene Full Name: carnitine palmitoyltransferase 1B (muscle)
Band: 22q13.33
Quick LinksEntrez ID:1375; OMIM: 601987; Uniprot ID:CPT1B_HUMAN; ENSEMBL ID: ENSG00000205560; HGNC ID: 2329
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY4FS-6phosphatidylethanolamine biosynthesis II
PWY3O-450phosphatidylcholine biosynthesis I
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Activated AMPK stimulates fatty-acid oxidation in muscle
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
METABOLIC
narcolepsy
obesity
Desease Name
Narcolepsy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CPT1B mRNAaffects expression 21346803
C520164 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|decreases reaction 15721863
C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|increases reaction 19699196
C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]decreases expression|increases reaction 19699196
C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of CPT1B mRNAdecreases expression 19699196
C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of CPT1B proteindecreases expression 19699196
C031143 AICA ribonucleotide AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|decreases reaction 19699196
C031143 AICA ribonucleotide AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]decreases expression|decreases reaction 19699196
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPT1B mRNAaffects expression 16483693
D002713 Chlorine Chlorine results in increased expression of CPT1B mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of CPT1B mRNAaffects cotreatment|decreases expression 18636392
D002994 Clofibrate Clofibrate results in increased expression of CPT1B mRNAincreases expression 12011481
C121718 dicyclanil dicyclanil results in increased expression of CPT1B mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of CPT1B mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPT1B mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of CPT1B mRNAincreases expression 18035473
D015248 Gemfibrozil Gemfibrozil results in increased expression of CPT1B mRNAincreases expression 12011481
C425931 GW 501516 GW 501516 results in increased expression of CPT1B mRNAincreases expression 18701451
C425931 GW 501516 RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA]decreases reaction|increases expression 18701451
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of CPT1B mRNAdecreases expression 18940942
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of CPT1B mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in increased expression of CPT1B mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CPT1B mRNAincreases expression 17681415
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CPT1B mRNAincreases expression 16221955
D010634 Phenobarbital Phenobarbital affects the expression of CPT1B mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital affects the expression of CPT1B mRNAaffects expression 12011481
D010656 Phenylephrine 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|decreases reaction 15721863
D010656 Phenylephrine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|increases reaction 19699196
D010656 Phenylephrine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]decreases expression|increases reaction 19699196
D010656 Phenylephrine AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]decreases expression|decreases reaction 19699196
D010656 Phenylephrine AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]decreases expression|decreases reaction 19699196
D010656 Phenylephrine Phenylephrine results in decreased expression of CPT1B mRNAdecreases expression 15721863
19699196
D010656 Phenylephrine Phenylephrine results in decreased expression of CPT1B proteindecreases expression 19699196
D010656 Phenylephrine Phenylephrine results in increased expression of CPT1B mRNAincreases expression 11879187
D010795 Phthalic Acids Phthalic Acids results in decreased expression of CPT1B mRNAdecreases expression 15728792
D010852 Picrotoxin Picrotoxin results in increased expression of CPT1B mRNAincreases expression 15170462
C006253 pirinixic acid pirinixic acid affects the expression of CPT1B mRNAaffects expression 19136022
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPT1B mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid co-treated with PPARA protein] results in increased expression of CPT1B mRNAaffects cotreatment|increases expression 17275789
C006253 pirinixic acid pirinixic acid results in increased expression of CPT1B mRNAincreases expression 17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of CPT1B mRNA]increases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of CPT1B mRNAincreases expression 12011481
18701451
C006253 pirinixic acid RELA protein inhibits the reaction [pirinixic acid results in increased expression of CPT1B mRNA]decreases reaction|increases expression 18701451
D010936 Plant Extracts Plant Extracts results in increased expression of CPT1B mRNAincreases expression 15975614
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPT1B mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of CPT1B mRNAincreases expression 16840543
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.666195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury Chlorine 14.2920601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 14.2918653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 14.2918653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7714692618
MESH:D018248 Adenoma, Liver Cell dicyclanil 23.3317162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.3317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.3316835633
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease Ozone 4.4015513908
MESH:D000544 Alzheimer Disease Plant Extracts 4.4016962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.6615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 11.6614686799
MESH:D001169 Arthritis, Experimental Tretinoin 11.6616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5115570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5116292516
MESH:D001249 Asthma Ozone 4.7616373670 17854713
MESH:D001249 Asthma Tretinoin 4.7616456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2320106747
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders Clofibrate 20.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.5512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.5516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D002545 Brain Ischemia Plant Extracts 4.5416041641
MESH:D001943 Breast Neoplasms Dietary Fats 1.8420435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8416166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5317626835 18315731 19059883 15516495 18417511 14754758 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002057 Burns, Chemical Plant Extracts 5.149625245
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.5716705839
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 8.5717162532
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.5720935162 6705139 20007298 17173139 1701930
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 8.5718834353
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.571917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2416096774 16051514
MESH:D006332 Cardiomegaly Phenylephrine 10.9317124262 15728586 16170337 11754973 17287366 11179087
MESH:D006332 Cardiomegaly Plant Extracts 10.9317645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.9318850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 2.9817460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 3.391399818
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2816919318 17110522 11677210 17333356 17681005 15861022 16105132
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.508697196 16354765 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003092 Colitis Tretinoin 3.5217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3916925845 9664655 9142499 10589399 9211117 14991402 9224671 17551590 8800419 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.2519706694
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Clofibrate 13.9916707586
MESH:D050171 Dyslipidemias Dietary Fats 13.9918367378
MESH:D050171 Dyslipidemias Gemfibrozil 13.9916707586
MESH:D004417 Dyspnea Chlorine 4.4320016425
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema perfluorooctanoic acid 15.0717259670 12083418
MESH:D004487 Edema pirinixic acid 15.0712083418
MESH:D004487 Edema Plant Extracts 15.0712787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.0712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0112538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.4915268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2017637181 15821434 15328337
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.683922381 11558140
MESH:D004827 Epilepsy Phenobarbital 6.6320417680
MESH:D004827 Epilepsy Plant Extracts 6.6319439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3716938888 9664655
MESH:D005234 Fatty Liver Clofibrate 22.8319224547
MESH:D005234 Fatty Liver Dietary Fats 22.8319004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.8315345470
MESH:D005234 Fatty Liver pirinixic acid 22.8320131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 22.8315975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Lipopolysaccharides 3.859205823 11852909
MESH:D005355 Fibrosis Dietary Fats 13.6718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6720067830
MESH:D005355 Fibrosis Tretinoin 13.6717994277
MESH:D005739 Gas Poisoning Chlorine 4.8220016425
MESH:D005909 Glioblastoma Tretinoin 2.8817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.2014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.8620558911
MESH:D006333 Heart Failure Plant Extracts 6.8618097624
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 19.143609246
MESH:D006529 Hepatomegaly Phenobarbital 19.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 19.1418467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.1415340226 16120746 12621046
MESH:D006561 Herpes Simplex Plant Extracts 4.4310715843
MESH:D015658 HIV Infections Plant Extracts 3.5812878215
MESH:D019584 Hot Flashes Plant Extracts 4.5617454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.5512083418
MESH:D006930 Hyperalgesia Tretinoin 7.5516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.3016484555
MESH:D006949 Hyperlipidemias Dietary Fats 8.8621332399
MESH:D006949 Hyperlipidemias Plant Extracts 8.8615268973 15975614
MESH:D006973 Hypertension Phenylephrine 5.0612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0618670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.3812791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Dietary Fats 18.7020412841
MESH:D007249 Inflammation Flavonoids 18.7017296493
MESH:D007249 Inflammation Lipopolysaccharides 18.709205823 17255318 12878042 17963957 17237260
MESH:D007249 Inflammation perfluorooctanoic acid 18.7012083418
MESH:D007249 Inflammation Plant Extracts 18.7019332304 15997105 16366677 12787963
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.7012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 6.8418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.8416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.4512628509 12584176 12351151
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3617551590 15992940
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.8216705839
MESH:D007938 Leukemia Tretinoin 2.6817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0317649720 17294898 17712046 17506722 19035177 12679006 9834237 16788101 17361223 16823087 16891316 17339181 19642359 15748426 19075265 17107899 19225113 17301526 16766008 16140955 17368321 16331271 17217047 19029980 16935935
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.048812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.5518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.5521047994
MESH:D008103 Liver Cirrhosis Plant Extracts 10.5517157831
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.4912878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.4915479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4916248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 4.2719363144
MESH:D008107 Liver Diseases Plant Extracts 4.2717034775
MESH:D008113 Liver Neoplasms dicyclanil 17.0520118626
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.0514757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 17.0519482888 19812893 19073162 21047994 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 17.0516377806 15890375 20007298
MESH:D008113 Liver Neoplasms Plant Extracts 17.0519168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0516984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.4017172636 2563599 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4012151625
MESH:D008171 Lung Diseases Ozone 3.2519066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 8.6121114838
MESH:D055370 Lung Injury Ozone 8.6120417186
MESH:D008175 Lung Neoplasms Ozone 3.427614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 3.4220869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D009135 Muscular Diseases Gemfibrozil 17.0016239165
MESH:D009135 Muscular Diseases GW 501516 17.0016239165
MESH:D009135 Muscular Diseases pirinixic acid 17.0016239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009290 Narcolepsy marker/mechanism 18820697
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009369 Neoplasms pirinixic acid 4.6017405874
MESH:D009369 Neoplasms Tretinoin 4.6016594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 8.909125849
MESH:D009436 Neural Tube Defects Tretinoin 2.939142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.9917168769
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.439802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.439802331
MESH:D009765 Obesity Dietary Fats 7.2020518802 17217161 11836018 21332399 19632207 18674790 20132043 16723640 18457598
MESH:D009765 Obesity pirinixic acid 7.2020558911
MESH:D009765 Obesity Plant Extracts 7.2019056576 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2612819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2916936753
MESH:D010146 Pain Tretinoin 2.7516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma Plant Extracts 4.3015173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D011014 Pneumonia Lipopolysaccharides 10.4612224865 11605937
MESH:D011014 Pneumonia Ozone 10.4618381685 18007984 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.462563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.0317132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0311222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Plant Extracts 4.1314666653 17804756
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012120 Respiration Disorders Chlorine 5.0218579056
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 9.2618551238
MESH:D012640 Seizures Phenobarbital 9.2616876388 11442880 4039156 3137016
MESH:D012640 Seizures Picrotoxin 9.268635557 8954991
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012878 Skin Neoplasms Plant Extracts 9.0215173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.0216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.7315255614 17135157 18237397 18193104 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.2917997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.721399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.7216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6216051514
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.5618097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.1218097624
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.1020213670 19894650
Pathway ID Pathway Name
REACT:11163 Activated AMPK stimulates fatty-acid oxidation in muscle
KEGG:04920 Adipocytokine signaling pathway
KEGG:00071 Fatty acid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26848
    • No data
    Releated disease ID Related disease Name
    PA445042Narcolepsy
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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