AutismKB 2.0

Annotation Detail for CR1


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Basic Information Top
Gene Symbol:CR1 ( C3BR,C4BR,CD35,KN )
Gene Full Name: complement component (3b/4b) receptor 1 (Knops blood group)
Band: 1q32.2
Quick LinksEntrez ID:1378; OMIM: 120620; Uniprot ID:CR1_HUMAN; ENSEMBL ID: ENSG00000203710; HGNC ID: 2334
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05140Leishmaniasis
hsa05144Malaria
hsa04610Complement and coagulation cascades
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
CARDIOVASCULAR
Malaria, Cerebral
nephropathy
Alzheimer's disease
RENAL
IMMUNE
NEUROLOGICAL
Severe Malaria
anemia, malaria related
Hepatitis C, Chronic
pulmonary fibrosis
INFECTION
sarcoidosis
idiopathic pulmonary fibrosis
Desease Name
Alzheimer's disease
Desease Name
SLE susceptibility
CR1 deficiency
Malaria, severe, resistance to
Blood group, Knops system
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D008345 Manganese Manganese results in increased expression of CR1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of CR1 mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000544 Alzheimer Disease marker/mechanism 21460841 19734903
MESH:D000756 Anemia, Sideroblastic Manganese 12.9216910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.9216910769
MESH:D005909 Glioblastoma Manganese 4.2117043766
MESH:D008288 Malaria marker/mechanism
MESH:D016778 Malaria, Falciparum marker/mechanism 11724985 9230440
MESH:D020149 Manganese Poisoning Manganese 6.5919453300 16568477 16551646
MESH:D009069 Movement Disorders Manganese 5.6216551646
MESH:D009410 Nerve Degeneration Manganese 4.6616551646
MESH:D010300 Parkinson Disease Manganese 3.5111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.9816140633
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:04640 Hematopoietic cell lineage
KEGG:05140 Leishmaniasis
KEGG:05144 Malaria
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26855
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA445724Spondylitis, Ankylosing
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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