AutismKB 2.0

Annotation Detail for CR2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CR2 ( C3DR,CD21,SLEB9 )
Gene Full Name: complement component (3d/Epstein Barr virus) receptor 2
Band: 1q32.2
Quick LinksEntrez ID:1380; OMIM: 120650; Uniprot ID:CR2_HUMAN; ENSEMBL ID: ENSG00000117322; HGNC ID: 2336
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04610Complement and coagulation cascades
hsa04662B cell receptor signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
lupus erythematosus
No data
Desease Name
Systemic lupus erythematosus, susceptibility to, 9
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CR2 mRNAdecreases expression 18648102
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNAaffects cotreatment|decreases expression 16443354
D010126 Ozone TTPA protein affects the reaction [Ozone results in decreased expression of CR2 mRNA]affects reaction|decreases expression 19555225
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CR2 mRNAaffects cotreatment|decreases expression 16443354
D014635 Valproic Acid Valproic Acid results in increased expression of CR2 mRNAincreases expression 19949822
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8916292516
MESH:D001249 Asthma Ozone 5.2516373670 17854713
MESH:D001249 Asthma Tretinoin 5.2516456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9820603192 17157402 18316065 18396377 15238991 18177632 17507914 19460635 18775368 19232924 17688650 18940202 18985861 18558336 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.4816443354
MESH:D001943 Breast Neoplasms Tretinoin 2.4816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9617626835 14754758 16777450 18315731 15516495 19059883 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.137296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.131917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D003139 Common Cold Ascorbic Acid 6.0917323712
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.768800419 9125849 9224671 14991402 9142499 10589399 9211117 17551590 16925845 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7617688650 8888407 16575769
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288156756 14531868 18759878 11298694 2524372 11906362 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.1616506275
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.2118289764 11289319 16192314 9022650 7440962 18692083 8291058 6482804 6679447 18648102 9328219 1440618 9653073
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:C538011 Eales disease Ascorbic Acid 6.099068938
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.6116080930
MESH:D006330 Heart Defects, Congenital Tretinoin 7.619664655 14991402
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5716490937 16863852
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0719285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0517596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0516294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3719035177 9834237 19642359 16766008 17107899 15748426 17712046 17368321 17339181 16331271 17649720 17294898 16788101 16140955 19075265 19029980 17301526 16935935 16891316 17506722 17217047 12679006 17361223 19225113 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.943712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 6.9418544905
MESH:D008171 Lung Diseases Ascorbic Acid 8.5616863852
MESH:D008171 Lung Diseases Ozone 8.5619066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Ascorbic Acid 2.9916401635
MESH:D008175 Lung Neoplasms Ozone 2.997614698 8597069
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.0017596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.416679447
MESH:D009436 Neural Tube Defects Tretinoin 13.419142499
MESH:D009436 Neural Tube Defects Valproic Acid 13.4116359493 8888407
MESH:D009765 Obesity Ascorbic Acid 3.2017217161
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011014 Pneumonia Ozone 4.9318929643 18007984 18381685
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.9414606601
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3816849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.2416116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 12.2419155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9616876388 14763951 11738929 15475178 17978042 3137016 1511512 11044598
MESH:D012871 Skin Diseases Ascorbic Acid 3.2818709164
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.2618726076
MESH:D020521 Stroke Ascorbic Acid 4.5816403987 16517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.056587162 7505956 1399818 3712494 6582329
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
KEGG:04610 Complement and coagulation cascades
KEGG:04640 Hematopoietic cell lineage
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved