AutismKB 2.0

Annotation Detail for ATF2


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Basic Information Top
Gene Symbol:ATF2 ( CRE-BP1,CREB2,HB16,MGC111558,TREB7 )
Gene Full Name: activating transcription factor 2
Band: 2q31.1
Quick LinksEntrez ID:1386; OMIM: 123811; Uniprot ID:ATF2_HUMAN; ENSEMBL ID: ENSG00000115966; HGNC ID: 784
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200034IL12-mediated signaling events
200002Regulation of nuclear SMAD2/3 signaling
200007RhoA signaling pathway
200154Signaling mediated by p38-alpha and p38-beta
200118AP-1 transcription factor network
200113ErbB1 downstream signaling
200116ATF-2 transcription factor network
200190RAC1 signaling pathway
200191Regulation of retinoblastoma protein
200057CDC42 signaling events
Pathway IDPathway Name
P00046Oxidative stress response
P00052TGF-beta signaling pathway
P00006Apoptosis signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500458Activation of the AP-1 family of transcription factors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031278 2-chloroethyl ethyl sulfide 2-chloroethyl ethyl sulfide results in increased expression of ATF2 proteinincreases expression 18675330
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of ATF2 mRNAincreases expression 19643169
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]decreases reaction|decreases response to substance 12663670
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]decreases reaction|increases activity 12663670
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]decreases reaction|increases activity|increases phosphorylation 12663670
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 15772366
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 10661865
D000171 Acrolein [Acrolein results in increased phosphorylation of MAPK14 protein] which results in increased phosphorylation of ATF2 proteinincreases phosphorylation 12487375
D024502 alpha-Tocopherol alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 14645110
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATF2 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of ATF2 proteinincreases expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of ATF2 mRNAincreases expression 18305237
D000841 Anisomycin Anisomycin results in increased phosphorylation of ATF2 proteinincreases phosphorylation 12663670
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]decreases reaction|decreases response to substance 12663670
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]decreases reaction|increases activity 12663670
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]decreases reaction|increases activity|increases phosphorylation 12663670
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ATF2 mRNAincreases expression 17879257
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATF2 mRNAdecreases expression 19150397
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of ATF2 mRNAaffects cotreatment|decreases expression 18636392
D003300 Copper Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]decreases activity|increases reaction 15367699
D003300 Copper [Disulfiram co-treated with Copper] results in decreased activity of ATF2 proteinaffects cotreatment|decreases activity 15367699
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of ATF2 mRNAincreases expression 11599041
D016572 Cyclosporine Cyclosporine results in increased expression of ATF2 mRNAincreases expression 20106945
C007262 deoxynivalenol 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 15772366
C007262 deoxynivalenol deoxynivalenol affects the localization of ATF2 proteinaffects localization 12604842
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of ATF2 proteinincreases phosphorylation 15772366
D002945 Cisplatin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]decreases reaction|decreases response to substance 12663670
D002945 Cisplatin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]decreases reaction|increases activity 12663670
D002945 Cisplatin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]decreases reaction|increases activity|increases phosphorylation 12663670
D002945 Cisplatin anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]decreases reaction|decreases response to substance 12663670
D002945 Cisplatin anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]decreases reaction|increases activity 12663670
D002945 Cisplatin anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]decreases reaction|increases activity|increases phosphorylation 12663670
D002945 Cisplatin ATF2 protein results in decreased susceptibility to Cisplatindecreases response to substance 12663670
D002945 Cisplatin Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 proteinincreases activity|increases phosphorylation 12663670
D002945 Cisplatin Cisplatin results in increased phosphorylation of ATF2 proteinincreases phosphorylation 15701814
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of ATF2 mRNAaffects cotreatment|increases expression 19690152
D004221 Disulfiram Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]decreases activity|increases reaction 15367699
D004221 Disulfiram [Disulfiram co-treated with Copper] results in decreased activity of ATF2 proteinaffects cotreatment|decreases activity 15367699
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATF2 mRNAaffects expression 17555576
D005047 Etoposide Etoposide results in increased phosphorylation of and results in increased activity of ATF2 proteinincreases activity|increases phosphorylation 12663670
C007845 gingerol gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 18577375
D008094 Lithium [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 proteinaffects cotreatment|decreases expression 19430551
C081145 methionylmethylsulfonium chloride methionylmethylsulfonium chloride results in increased phosphorylation of and results in increased activity of ATF2 proteinincreases activity|increases phosphorylation 12663670
C005219 methyl cellosolve methyl cellosolve results in increased expression of ATF2 mRNAincreases expression 19643169
C008493 methylselenic acid methylselenic acid results in increased phosphorylation of and results in increased activity of ATF2 proteinincreases activity|increases phosphorylation 11830524
D009151 Mustard Gas Mustard Gas results in increased phosphorylation of ATF2 proteinincreases phosphorylation 18200059
D009151 Mustard Gas Mustard Gas affects the expression of ATF2 mRNAaffects expression 18988085
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of ATF2 mRNAaffects cotreatment|decreases expression 18636392
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ATF2 mRNAincreases expression 17560707
D010862 Pilocarpine [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 proteinaffects cotreatment|decreases expression 19430551
C008922 piperine piperine results in decreased localization of ATF2 proteindecreases localization 15531295
D010882 Piperonyl Butoxide [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of ATF2 mRNAaffects cotreatment|increases expression 19690152
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of ATF2 mRNAincreases expression 19690152
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased phosphorylation of ATF2 proteinincreases phosphorylation 18228000
C526689 punarnavine punarnavine results in decreased localization of ATF2 proteindecreases localization 20192578
C020972 pyrrolidine dithiocarbamic acid Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 10661865
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid results in increased phosphorylation of ATF2 proteinincreases phosphorylation 10661865
D012645 Selenomethionine Selenomethionine affects the expression of ATF2 mRNAaffects expression 17222674
C017947 sodium arsenite sodium arsenite results in increased activity of ATF2 proteinincreases activity 15292961
12220541
C017947 sodium arsenite sodium arsenite results in increased expression of ATF2 mRNAincreases expression 17879257
12016162
D013629 Tamoxifen alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]decreases reaction|increases phosphorylation 14645110
D013629 Tamoxifen Tamoxifen results in increased phosphorylation of ATF2 proteinincreases phosphorylation 14645110
D013629 Tamoxifen Tamoxifen affects the expression of ATF2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATF2 mRNAincreases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATF2 mRNAincreases expression 15897893
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of ATF2 proteinincreases phosphorylation 15897893
D014212 Tretinoin Tretinoin affects the localization of ATF2 proteinaffects localization 16511568
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1114745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 16.986499812 6499823 6499820 6499796 7151721
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 16.9817676605
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 16.983652986 6474471 6499812
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.9814514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.139207937
MESH:D058186 Acute Kidney Injury Cisplatin 3.5815814532 17670903 12690470
MESH:D055371 Acute Lung Injury Acrolein 8.4220525806 21297076
MESH:D055371 Acute Lung Injury Chlorine 8.4220601635
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.3520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 6.3517638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 5.776695378
MESH:D000236 Adenoma Diethylnitrosamine 5.776695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.6216434500 17620307 18056438 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4617306315 16712894
MESH:D000437 Alcoholism Disulfiram 4.6418968458 10841824 17079463
MESH:D000505 Alopecia Tretinoin 3.2715955085
MESH:D000544 Alzheimer Disease Acrolein 8.6314715435 17570602 15207723
MESH:D000544 Alzheimer Disease Copper 8.6317119284 16866297 16886094 16962711 16325427 16410023
MESH:D000544 Alzheimer Disease Lithium 8.6319621015
MESH:D000544 Alzheimer Disease Ozone 8.6315513908
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.0210694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.5016614410
MESH:D000748 Anemia, Macrocytic methyl cellosolve 5.913699323
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6519183758
MESH:D001161 Arteriosclerosis Acrolein 14.7815014928
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.7815014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 14.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3016412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.2715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2716292516
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.1710689203 6499807 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 11.173987992
MESH:D001249 Asthma Mustard Gas 7.0810378619
MESH:D001249 Asthma Ozone 7.0817854713 16373670
MESH:D001249 Asthma Tretinoin 7.0816456186
MESH:D001259 Ataxia 2-ethoxyethanol 5.067151721
MESH:D050197 Atherosclerosis Acrolein 3.7216126721 17363696 16037261
MESH:D001284 Atrophy 2-ethoxyethanol 10.056499799 15850284
MESH:D001284 Atrophy methyl cellosolve 10.052626667 6705890 3699323
MESH:D053713 Azoospermia 2-ethoxyethanol 5.166499807 6492198
MESH:D001471 Barrett Esophagus Tretinoin 3.9916935849
MESH:D001714 Bipolar Disorder Lithium 4.0920338123 17594078 19153942 20046352
MESH:D001724 Birth Weight 2-ethoxyethanol 6.072884743 6499823
MESH:D001768 Blister Mustard Gas 4.7319167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.6616206674 16197459
MESH:D001836 Body Weight Changes 2-ethoxyethanol 10.566499796 7151721
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 10.7614601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.7614601052
MESH:D001932 Brain Neoplasms Copper 4.1817079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.6617474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 7.6619526202 18382427
MESH:D001943 Breast Neoplasms Copper 7.6615986119 17079463
MESH:D001943 Breast Neoplasms Cyclophosphamide 7.6611325840 18234424 18323546 17388661 12006526 17020986 15093573 15136595 16978400
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.6617474063
MESH:D001943 Breast Neoplasms Disulfiram 7.6617026967
MESH:D001943 Breast Neoplasms Etoposide 7.6616322251
MESH:D001943 Breast Neoplasms gingerol 7.6617683926
MESH:D001943 Breast Neoplasms Tamoxifen 7.6618984771 19289846 17242785 20544844 19244106 20390343 19155303 17440819 11161223 21138602 20135344 17261762 20005174 19103187 19066611 15668708 19059307 19487384 18997820 16873071 16818667 19115204 20065188 19200415 16273361 15565566 18821012 20859285 19011961 19288272 19221464 19410462 18855134 17049068 17893378 18425577 18815881 21152245 18629630 19142967 18351453 19189210 19189212 16202921 19084267
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.6620435547
MESH:D001943 Breast Neoplasms Tretinoin 7.6616166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3416777450 18315731 15516495 19059883 18417511 14754758 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1616813970
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002177 Candidiasis Disulfiram 5.4215325261
MESH:D002277 Carcinoma Disulfiram 7.5017026967
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7216168501
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 12.7919418558
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 12.7917982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 12.7919701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 12.7917761372 18978308 17138121 11831363 19539802 20524982 19335982 16698587 20007298 17428255 17173139 16540662 19822196 16830150 16288022 20432363 19701751 18494052 16779866 18785209 21159647 20935162 3581430 16807293 18506893 19519916 19171122 20084675 17978847 19394651 19919837 19418558 10737359 18691550 10672840 20101231 16502159 19052882 17162532 19107877 16681979 20514400 20727157 20214788 19383236 18788625 16878318 16935385 20512989 17055752 18210153 3084413 16328049 18665156 18393292 18056438 18971187 16569478 19208518
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.7917306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.7916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.791917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4616152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.5712023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 5.5717026967
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.3316201981
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 12.8217015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.8220419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.826189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.8218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.8216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2417572228
MESH:D006332 Cardiomegaly Copper 6.2317327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2318850075 18670907 16120746
MESH:D002386 Cataract Disulfiram 7.0615003327 17936468
MESH:D002386 Cataract Tretinoin 7.0617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.9220889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 17.9218226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.9212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.9217174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.9220056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1216835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.196499794
MESH:D002764 Cholecystitis methyl cellosolve 12.196499794
MESH:D002779 Cholestasis Cyclosporine 6.7119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7117333356 17110522 15861022 17681005 16919318 11677210 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.7216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1216354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.129407595
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.3119462300
MESH:D003092 Colitis Tretinoin 3.2917035595
MESH:D015179 Colorectal Neoplasms Acrolein 2.9417597105
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9415273666
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.226499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.2920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.2916925845 14991402 9142499 9125849 9211117 9664655 9224671 10589399 8800419 17551590
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.0119747007
MESH:D003556 Cystitis Acrolein 10.6212161096
MESH:D003556 Cystitis Cyclophosphamide 10.6216614059 18710439 18093676 16651033 15643279 10700343 10498854 17010015 18433785 12161096 12913760 16989017 15276878 12388444 18295254 11948286 18372110 18483878 17979934 16413132
MESH:D007644 Darier Disease Lithium 5.4820338123
MESH:D003643 Death 2-ethoxyethanol 5.526499796
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9419031437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.3219244398
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.7211751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0818772604
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 6.5516506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1219279558
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 5.4911287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.4919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.4920420201
MESH:D004362 Drug Toxicity Cisplatin 7.1112231392 19839026 15033597 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1111462148
MESH:D004417 Dyspnea Chlorine 4.1920016425
MESH:D004487 Edema Mustard Gas 9.3711428631 11428647 9260866 11402378
MESH:D004487 Edema perfluorooctanoic acid 9.3717259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.3711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4818230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.4818230668
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.076499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.5919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.4817893378 19155303 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.659294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 3.8011006010
MESH:D004827 Epilepsy Pilocarpine 4.4219700373 11162239 19439326
MESH:D004890 Erythema Mustard Gas 4.739357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.5215173087 16481741 17638652 16785472 15464296
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.769664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 15.6019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.6021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6015345470
MESH:D005234 Fatty Liver Tamoxifen 15.6014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9716709447
MESH:D005313 Fetal Death 2-ethoxyethanol 9.442884743 7198755 6499823 7151721 6499820
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.4411858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.006499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.216499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 11.216499821 6474471 3987992 6499812
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.197151721 2884743 6499820
MESH:D020567 Fetal Weight methyl cellosolve 12.196499821 6474471 6499812
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7519069698
MESH:D005355 Fibrosis Cyclosporine 12.2912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.2920067830
MESH:D005355 Fibrosis Tretinoin 12.2917994277
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.073652986
MESH:D005739 Gas Poisoning Chlorine 4.5720016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.798708960
MESH:D005909 Glioblastoma Tretinoin 2.7217312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0811389073
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.6715173396 16524712
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6111014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Cisplatin 6.9315464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9316096774
MESH:D034381 Hearing Loss Cisplatin 3.9319898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7216084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0715464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.0720471113
MESH:D006330 Heart Defects, Congenital Lithium 14.0719638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.0710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.0714991402 9664655
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.356499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 4.9910514026 20172899
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9915720958
MESH:D006461 Hemolysis 2-ethoxyethanol 10.8817874071 19051582
MESH:D006461 Hemolysis methyl cellosolve 10.8817874071
MESH:D006467 Hemophilia A Cyclophosphamide 4.8711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0914986274
MESH:D006521 Hepatitis, Chronic Copper 4.8417338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.7516607473 17109627 19888908 17182432 17276780
MESH:D006529 Hepatomegaly perfluorooctanoic acid 7.283609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2812621046 15340226 16120746
MESH:D006561 Herpes Simplex Etoposide 4.1310809021
MESH:D006689 Hodgkin Disease Cisplatin 14.5916200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 14.5917606976 16135485
MESH:D006689 Hodgkin Disease Etoposide 14.5916135485 18180244 17606976 16200630 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 14.5912676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6116354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.9212083418
MESH:D006930 Hyperalgesia Tretinoin 6.9216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1516778211
MESH:D006973 Hypertension Cyclosporine 4.3510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.3518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8916076520
MESH:D007247 Infertility, Female 2-ethoxyethanol 9.086499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.0812013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 18.066499823
MESH:D007248 Infertility, Male Cyclophosphamide 18.0616517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 18.0617937319
MESH:D007248 Infertility, Male methyl cellosolve 18.063987992
MESH:D007248 Infertility, Male sodium arsenite 18.0612646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 13.3618785209
MESH:D007249 Inflammation Mustard Gas 13.369260866 16001271 11428631 11428647 11428620 11402378 17524151 9357497 8975870
MESH:D007249 Inflammation perfluorooctanoic acid 13.3612083418
MESH:D007249 Inflammation Tamoxifen 13.3619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.3612200463 12878042
MESH:D007251 Influenza, Human pyrrolidine dithiocarbamic acid 5.1218473937
MESH:D007410 Intestinal Diseases Tretinoin 3.3517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0015604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7015464296
MESH:D007674 Kidney Diseases Acrolein 12.4112488133
MESH:D007674 Kidney Diseases Cisplatin 12.4118289764 15190930 12231392 12649298 19839026
MESH:D007674 Kidney Diseases Cyclosporine 12.418314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 12.4120008137
MESH:D007676 Kidney Failure, Chronic Copper 4.5116518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.1412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.1418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3611231351
MESH:D007859 Learning Disorders Copper 4.3817134702
MESH:D007938 Leukemia Cyclophosphamide 5.8310602166
MESH:D007938 Leukemia Tretinoin 5.8317143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 6.4717802794 18172266 17008537 17296974 17658394 18587576
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 6.4717026967
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7710373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8717301526 19642359 17361223 19075265 16140955 17712046 17294898 17107899 19029980 16788101 19225113 17339181 16823087 19035177 17649720 16331271 12679006 17368321 17506722 15748426 16935935 9834237 16891316 16766008 17217047
MESH:D007970 Leukopenia Cyclophosphamide 4.5310052129 11830472
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.808812269
MESH:D017880 Limb Deformities, Congenital Disulfiram 12.1717676605
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 12.176499821
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.179224671
MESH:D008064 Lipidoses Tamoxifen 2.8515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5818522880 18407596 18665156 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental pyrrolidine dithiocarbamic acid 4.5015078482
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.5016248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 1.9917034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.7921137059 20195826
MESH:D008113 Liver Neoplasms Copper 22.7920302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.792862719 20434301 20583210 19254457 9163691 18644402 19996281 20501860 19833225 19090486 19255062 15885732 19256749 20118626 19642983 18978307 20405173 19294768 21167192 18648771 21071580 19551842 20492335 20101389 10737359 18977376 19812893 19850985 19499222 2422723 12112319 15175105 21047994 20452335 12771043 18754104 21278145 16942905 19073162 19638242 20137499 19427195 19690152 19426721
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 22.7914757943 18709148
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 22.7915890375 19690152 18648771 20101389
MESH:D008113 Liver Neoplasms sodium arsenite 22.7916712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 22.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.7916984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 4.8619126423 19539802 18544905 2563599 3124819 16267830 18164116 21159647 16842330 17174075 9362446 17854601 18253720 19009564 18093689 18079962 18282651 19004024 19519916 18775883 18308698 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.8612151625
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 24.9812815614 18675330 16252256
MESH:D008171 Lung Diseases Acetylcysteine 24.9812815614
MESH:D008171 Lung Diseases Acrolein 24.9811504702
MESH:D008171 Lung Diseases Mustard Gas 24.9818161513 18702808
MESH:D008171 Lung Diseases Ozone 24.988266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 24.9819095001
MESH:D055370 Lung Injury Ozone 8.2120417186
MESH:D055370 Lung Injury pyrrolidine dithiocarbamic acid 8.2116129981
MESH:D008175 Lung Neoplasms alpha-Tocopherol 14.1016401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.1020064080 17053015 20135361 18520028 18569708 20464547 6695378 20869020 18816296
MESH:D008175 Lung Neoplasms Cisplatin 14.1017225452 6189445 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.1020970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 14.108781369 3148597
MESH:D008175 Lung Neoplasms Ozone 14.107614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 14.1015276417 19931552 17306315 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 14.1018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.1019555203 11884234
MESH:D008223 Lymphoma Cyclophosphamide 7.0212854902
MESH:D008223 Lymphoma Etoposide 7.0212556972 12854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.2016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.8211911406
MESH:D008231 Lymphopenia methyl cellosolve 5.353699323
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3319428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.3511731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.1119453300
MESH:D008527 Medulloblastoma Tretinoin 2.6017453147
MESH:D008545 Melanoma Cisplatin 8.8318505091 15577323 16432458 18332650 17023156 18176117 16809738 12883367 17761969 12393984 11135225 16248763 12374674
MESH:D008545 Melanoma Disulfiram 8.8315367699
MESH:D008545 Melanoma sodium arsenite 8.8316487513 19082730
MESH:D008545 Melanoma Tamoxifen 8.8312393984 19393235
MESH:D008545 Melanoma Tretinoin 8.8316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.0715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.0715990972
MESH:D008546 Melanoma, Experimental Acrolein 10.0410803710
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.0416388313
MESH:D008591 Meningomyelocele Tretinoin 4.0016940565
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.4517268249 17109627
MESH:D008654 Mesothelioma Cisplatin 3.0617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3516801185
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D009041 Motion Sickness Dextroamphetamine 5.081613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8616381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8317596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 6.1619595682
MESH:D009203 Myocardial Infarction Lithium 6.1616288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6812213967
MESH:D009336 Necrosis 2-ethoxyethanol 4.9120172899
MESH:D009361 Neoplasm Invasiveness Disulfiram 4.9018047805
MESH:D009362 Neoplasm Metastasis Acetylcysteine 16.0114720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 16.013581430 9029167
MESH:D009362 Neoplasm Metastasis Disulfiram 16.0115367699
MESH:D009362 Neoplasm Metastasis punarnavine 16.0119171408
MESH:D009362 Neoplasm Metastasis Tamoxifen 16.0119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3619410462
MESH:D009369 Neoplasms Acrolein 20.5817329238
MESH:D009369 Neoplasms Benzo(a)pyrene 20.5811141357
MESH:D009369 Neoplasms Cisplatin 20.5816773208
MESH:D009369 Neoplasms Cyclophosphamide 20.5818854779
MESH:D009369 Neoplasms Disulfiram 20.5817079463
MESH:D009369 Neoplasms sodium arsenite 20.5811559025
MESH:D009369 Neoplasms Tretinoin 20.5816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2520056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5619196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Copper 9.4817308104
MESH:D009389 Neovascularization, Pathologic Disulfiram 9.4815367699
MESH:D009393 Nephritis Acrolein 5.8512653641
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9219348381 18481113
MESH:D009421 Nervous System Malformations Pilocarpine 14.2215987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2214600291
MESH:D009421 Nervous System Malformations Tretinoin 14.229125849
MESH:D009436 Neural Tube Defects Acetylcysteine 10.6219446573
MESH:D009436 Neural Tube Defects sodium arsenite 10.6212854658
MESH:D009436 Neural Tube Defects Tretinoin 10.629142499
MESH:D009447 Neuroblastoma Cisplatin 6.518761367
MESH:D009447 Neuroblastoma Cyclophosphamide 6.5115176712 8761367 16115947
MESH:D019636 Neurodegenerative Diseases Acrolein 7.6211342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.098761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.0912837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6820387270
MESH:D020258 Neurotoxicity Syndromes Disulfiram 4.3511005259
MESH:D009503 Neutropenia Cyclophosphamide 8.218291058
MESH:D009503 Neutropenia Mustard Gas 8.217688884 16761898
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.539802331
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 3.7116289378
MESH:D009845 Oligospermia 2-ethoxyethanol 15.6620172899
MESH:D009845 Oligospermia Cyclophosphamide 15.6616517039
MESH:D009845 Oligospermia methyl cellosolve 15.663987992
MESH:D012516 Osteosarcoma Disulfiram 4.8318047805
MESH:D010051 Ovarian Neoplasms Cisplatin 10.1217225452 6897625 15464296 19769630
MESH:D010051 Ovarian Neoplasms Disulfiram 10.1217026967
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.1215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 10.1216936753
MESH:D010146 Pain Cyclophosphamide 5.9018093676 12161096
MESH:D010146 Pain Tretinoin 5.9016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.5219003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 14.5211332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.5216540662
MESH:D010190 Pancreatic Neoplasms Etoposide 14.5219003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.5215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010300 Parkinson Disease Acrolein 3.4217690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9015464296
MESH:D010538 Peritonitis Ozone 3.7116369182
MESH:D010787 Photosensitivity Disorders Acrolein 5.3011550810
MESH:D010997 Pleural Neoplasms Cisplatin 4.9017638057
MESH:D011014 Pneumonia Ozone 3.9618007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.4115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.7412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.742563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 19.847198755 6499817 2884743
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 19.846499817 7974496 12530607
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 19.8417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.8411896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7717292933
MESH:D011471 Prostatic Neoplasms Copper 2.7717308104 17079463
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7717136230
MESH:D011471 Prostatic Neoplasms Disulfiram 2.7719789329
MESH:D011471 Prostatic Neoplasms Etoposide 2.7717172428
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7716205645
MESH:D011471 Prostatic Neoplasms pyrrolidine dithiocarbamic acid 2.7716139439
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7715067354
MESH:D011507 Proteinuria Tretinoin 3.2116636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.1015861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.1018058305
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011625 Pterygium Tretinoin 4.3616723453
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.5514606601
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.4016636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.4017894541 10334151 17720292 17620002 17266442
MESH:D051437 Renal Insufficiency Acrolein 9.2712732208
MESH:D051437 Renal Insufficiency Cisplatin 9.2715464296
MESH:D012120 Respiration Disorders Chlorine 4.7718579056
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 13.3318257742 12210543 16292752
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 13.3312210543
MESH:D012128 Respiratory Distress Syndrome, Adult pyrrolidine dithiocarbamic acid 13.3316129981
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.8416849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7016283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.2614601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.2614601052
MESH:D012559 Schizophrenia Copper 3.0216842975
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4216636934
MESH:D012640 Seizures Lithium 6.1319660546
MESH:D012640 Seizures Pilocarpine 6.137750514 19660546
MESH:D012871 Skin Diseases Mustard Gas 2.5912880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.6519755658 10029692
MESH:D012878 Skin Neoplasms gingerol 15.6519481070
MESH:D012878 Skin Neoplasms sodium arsenite 15.6519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.6516192470
MESH:D012878 Skin Neoplasms Tretinoin 15.6516467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9015464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.1016709447
MESH:D013088 Spermatocele Tamoxifen 10.1016709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0816517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4612854658
MESH:D013226 Status Epilepticus Lithium 11.8319570321 19430551 19951488
MESH:D013226 Status Epilepticus Pilocarpine 11.8311259499 19570321 19430551 15987249 19055492 19951488 15857427
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.3020155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 4.3017522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3018456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.3017261132
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 6.796499799
MESH:D013276 Stomach Ulcer Acetylcysteine 6.7917918041
MESH:D020521 Stroke Acrolein 4.2216269634
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.6312837982
MESH:D013733 Testicular Diseases 2-ethoxyethanol 9.6310048760 6499806 10514026
MESH:D013733 Testicular Diseases methyl cellosolve 9.636499806
MESH:D013736 Testicular Neoplasms Cisplatin 4.2315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 10.3116940797
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.317505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.3116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.4116051514
MESH:D014202 Tremor Pilocarpine 5.3717594079
MESH:D014376 Tuberculosis Tretinoin 2.9516040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.8517053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 13.8512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.8514692829
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.8511723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.858653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.7516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.7511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1716752155
MESH:D014605 Uveitis Cyclosporine 3.541336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.1915577323
MESH:D014652 Vascular Diseases sodium arsenite 3.9917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6516761959
MESH:D014839 Vomiting Cisplatin 4.2811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D009396 Wilms Tumor Tretinoin 3.6016287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0017120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25084
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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