AutismKB 2.0

Annotation Detail for CRH


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Basic Information Top
Gene Symbol:CRH ( CRF )
Gene Full Name: corticotropin releasing hormone
Band: 8q13.1
Quick LinksEntrez ID:1392; OMIM: 122560; Uniprot ID:CRF_HUMAN; ENSEMBL ID: ENSG00000147571; HGNC ID: 2355
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04730Long-term depression
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200090Rapid glucocorticoid signaling
Pathway IDPathway Name
P04380Cortocotropin releasing factor receptor signaling pathway
Pathway IDPathway Name
500428Class B/2 (Secretin family receptors)
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1781Rheumatoid arthritis
1836Panic disorder
1859Ovarian cancer
1870Drug abuse
2044Pre-Eclampsia
2057Premature birth
1874Stress disorder, post-traumatic
1796Labor, Premature
Desease Name
PSYCH
depression
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002385 3-morpholino-sydnonimine 3-morpholino-sydnonimine results in increased expression of CRH mRNAincreases expression 10460269
C002385 3-morpholino-sydnonimine CRH protein affects the reaction [3-morpholino-sydnonimine results in increased secretion of POMC protein alternative form]affects reaction|increases secretion 10460269
C001969 acephate acephate promotes the reaction [FOS protein binds to CRH promoter]affects binding|increases reaction 12039681
C001969 acephate acephate results in increased expression of CRH mRNAincreases expression 12039681
C001969 acephate acephate results in increased secretion of CRH proteinincreases secretion 12039681
C001969 acephate Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C001969 acephate Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
C001969 acephate gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C001969 acephate gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
C001969 acephate Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C001969 acephate Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D000109 Acetylcholine Acetylcholine results in increased expression of CRH mRNAincreases expression 7588217
D000324 Adrenocorticotropic Hormone Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
D000324 Adrenocorticotropic Hormone Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]decreases reaction|increases secretion 18835572
D000324 Adrenocorticotropic Hormone CRH protein results in increased secretion of Adrenocorticotropic Hormoneincreases secretion 18835572
D000324 Adrenocorticotropic Hormone E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
D000324 Adrenocorticotropic Hormone Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]increases reaction|increases secretion 18835572
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CRH mRNAaffects expression 16483693
C103016 antalarmin antalarmin affects the reaction [CRH protein results in increased abundance of Hydrocortisone]affects reaction|increases abundance 14997174
C103016 antalarmin antalarmin affects the reaction [CRH protein results in increased expression of POMC protein alternative form]affects reaction|increases expression 14997174
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CRH mRNAdecreases expression 15761015
D016589 Astemizole Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
C120841 astressin B astressin B inhibits the reaction [CRH protein results in increased abundance of Hydrocortisone]decreases reaction|increases abundance 14997174
C120841 astressin B astressin B inhibits the reaction [CRH protein results in increased expression of POMC protein alternative form]decreases reaction|increases expression 14997174
C120841 astressin B astressin B inhibits the reaction [CRH protein results in increased secretion of POMC protein alternative form]decreases reaction|increases secretion 10447963
D001285 Atropine Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D001285 Atropine Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D001285 Atropine Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D001285 Atropine Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D002746 Chlorpromazine Chlorpromazine results in decreased expression of CRH mRNAdecreases expression 16205782
D003024 Clozapine Clozapine results in decreased expression of CRH mRNAdecreases expression 16205782
D003345 Corticosterone CRH protein results in increased abundance of Corticosteroneincreases abundance 21359208
D003345 Corticosterone Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
D003345 Corticosterone Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]decreases reaction|increases secretion 18835572
D003345 Corticosterone E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
D003484 Cyanamide Cyanamide results in increased expression of CRH mRNAincreases expression 12217933
D003484 Cyanamide [Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNAaffects cotreatment|increases expression 11139417
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of CRH mRNAincreases expression 15276878
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of CRH proteinincreases expression 16614059
C017180 decamethrin decamethrin results in increased expression of CRH mRNAincreases expression 19017407
D003907 Dexamethasone Dexamethasone results in increased expression of CRH mRNAincreases expression 18819432
D004177 Dipyrone Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D004177 Dipyrone Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D004177 Dipyrone Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D004177 Dipyrone Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
C063968 E 4031 E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]decreases reaction|increases secretion 18835572
D000431 Ethanol Ethanol affects the expression of CRH mRNAaffects expression 18819432
D000431 Ethanol [Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNAaffects cotreatment|increases expression 11139417
D000431 Ethanol Ethanol results in increased expression of CRH mRNAincreases expression 16925589
D005283 Fentanyl Fentanyl affects the expression of CRH mRNAaffects expression 18819432
D005419 Flavonoids Flavonoids results in decreased expression of CRH mRNAdecreases expression 18035473
C081021 Go 6976 CRH protein inhibits the reaction [Go 6976 results in increased abundance of Progesterone]decreases reaction|increases abundance 17170093
C081021 Go 6976 CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 17170093
C081021 Go 6976 CRH protein inhibits the reaction [Go 6976 results in increased expression of HSD3B1 mRNA]decreases reaction|increases expression 17170093
D006220 Haloperidol Haloperidol results in decreased expression of CRH mRNAdecreases expression 16205782
D006854 Hydrocortisone antalarmin affects the reaction [CRH protein results in increased abundance of Hydrocortisone]affects reaction|increases abundance 14997174
D006854 Hydrocortisone astressin B inhibits the reaction [CRH protein results in increased abundance of Hydrocortisone]decreases reaction|increases abundance 14997174
D007213 Indomethacin Indomethacin inhibits the reaction [IL1B protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D007213 Indomethacin Indomethacin inhibits the reaction [IL6 protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D007213 Indomethacin Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D007213 Indomethacin Indomethacin inhibits the reaction [TNF protein results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D008070 Lipopolysaccharides Lipopolysaccharides affects the expression of CRH mRNAaffects expression 15667454
D008070 Lipopolysaccharides Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D008070 Lipopolysaccharides Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]decreases reaction|increases secretion 11852909
D008070 Lipopolysaccharides Lipopolysaccharides results in increased secretion of CRH proteinincreases secretion 11852909
C014655 methamidophos Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C014655 methamidophos Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
C014655 methamidophos gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C014655 methamidophos gamma-Aminobutyric Acid inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
C014655 methamidophos methamidophos promotes the reaction [FOS protein binds to CRH promoter]affects binding|increases reaction 12039681
C014655 methamidophos methamidophos results in increased expression of CRH mRNAincreases expression 12039681
C014655 methamidophos methamidophos results in increased secretion of CRH proteinincreases secretion 12039681
C014655 methamidophos Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
C014655 methamidophos Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D009569 Nitric Oxide CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]affects reaction|increases secretion 10460269
D009569 Nitric Oxide Nitric Oxide results in increased expression of CRH mRNAincreases expression 10460269
D020030 Nitric Oxide Donors CRH protein affects the reaction [Nitric Oxide Donors results in increased secretion of POMC protein alternative form]affects reaction|increases secretion 10460269
D020030 Nitric Oxide Donors Nitric Oxide Donors results in increased expression of CRH mRNAincreases expression 10460269
D010424 Pentobarbital Pentobarbital affects the expression of CRH mRNAaffects expression 18819432
D026023 Permethrin Permethrin results in increased expression of CRH mRNAincreases expression 19017407
D011374 Progesterone CRH protein inhibits the reaction [Go 6976 results in increased abundance of Progesterone]decreases reaction|increases abundance 17170093
D011374 Progesterone CRH protein results in decreased abundance of Progesteronedecreases abundance 17170093
D011395 Promazine Promazine results in decreased expression of CRH mRNAdecreases expression 16205782
D011433 Propranolol Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D011433 Propranolol Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D011433 Propranolol Propranolol inhibits the reaction [methamidophos results in increased expression of CRH mRNA]decreases reaction|increases expression 12039681
D011433 Propranolol Propranolol inhibits the reaction [methamidophos results in increased secretion of CRH protein]decreases reaction|increases secretion 12039681
D011794 Quercetin Quercetin affects the expression of CRH mRNAaffects expression 19423323
D020891 Raclopride Raclopride results in decreased expression of CRH mRNAdecreases expression 16205782
D018967 Risperidone Risperidone results in decreased expression of CRH mRNAdecreases expression 16205782
C025759 saikosaponin saikosaponin results in increased expression of CRH mRNAincreases expression 8552307
C080903 sairei-to CRH protein affects the reaction [sairei-to results in increased expression of POMC protein]affects reaction|increases expression 8247339
C080903 sairei-to sairei-to results in increased expression of CRH proteinincreases expression 8233027
C080903 sairei-to [sairei-to results in increased expression of CRH protein] which results in increased expression of POMC mRNAincreases expression 8233027
C080903 sairei-to [sairei-to results in increased expression of CRH protein] which results in increased expression of POMC proteinincreases expression 8233027
D013726 Terbutaline Terbutaline results in decreased expression of CRH mRNAdecreases expression 17127497
D013739 Testosterone CRH protein inhibits the reaction [CGB results in increased abundance of Testosterone]decreases reaction|increases abundance 18719027
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRH mRNAincreases expression 11568361
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRH mRNAincreases expression 18824019
D019789 Tetraethylammonium Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]increases reaction|increases secretion 18835572
D013881 Thioridazine Thioridazine results in decreased expression of CRH mRNAdecreases expression 16205782
D014050 Toluene Toluene results in increased expression of CRH proteinincreases expression 15707876
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of CRH mRNAdecreases expression 16330358
D020888 Vigabatrin Vigabatrin results in increased expression of CRH mRNAincreases expression 15869561
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.4718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 11.4714610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 8.7518287403
MESH:D000138 Acidosis Ethanol 8.7511192467
OMIM:201400 ACTH DEFICIENCY, ISOLATED marker/mechanism
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.5618653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 4.1219825857 11798837
MESH:D000230 Adenocarcinoma Indomethacin 4.1216537180
MESH:D000236 Adenoma Indomethacin 3.1411497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8616835633
MESH:D000380 Agranulocytosis Clozapine 4.5514617031 12649775 16160616
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7915451039 15451040
MESH:D000505 Alopecia marker/mechanism 21359208
MESH:D000505 Alopecia astressin B 5.4721359208
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8417225004
MESH:D000544 Alzheimer Disease therapeutic 7477348
MESH:D000544 Alzheimer Disease Indomethacin 4.2715579461 17627676
MESH:D000544 Alzheimer Disease Nitric Oxide 4.2717556102
MESH:D000686 Amyloidosis Terbutaline 5.137986221
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5011748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7817084956
MESH:D000799 Angioedema Astemizole 5.132883202
MESH:D000853 Anophthalmos Ethanol 4.3115513904
MESH:D000855 Anorexia marker/mechanism 16420149
MESH:D000987 Antisocial Personality Disorder Testosterone 5.337506515
MESH:D001008 Anxiety Disorders Ethanol 8.0411141031
MESH:D001008 Anxiety Disorders Pentobarbital 8.0411141031 18313124
MESH:D001014 Aortic Aneurysm Indomethacin 4.3610231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.3710388637
MESH:D001145 Arrhythmias, Cardiac E 4031 5.8218724381
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.1015014928
MESH:D018771 Arthralgia Indomethacin 4.642160914
MESH:D001169 Arthritis, Experimental Dexamethasone 3.2117659584
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.6911248219
MESH:D020817 Asperger Syndrome Risperidone 5.0516401163
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4615336622
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.4318349709
MESH:D001321 Autistic Disorder Haloperidol 2.7118080171 19368416
MESH:D001321 Autistic Disorder Propranolol 2.7118766980
MESH:D001321 Autistic Disorder Risperidone 2.7116601648 19013209 15492353 19368416 17929164 18349709 18775368 16948927 15994720 16379507 19232924 18026891 17019624 17069546 19154706 16239862 18278980 15543515 16730335 18080171 15930063
MESH:D001321 Autistic Disorder Terbutaline 2.7117400887 16417856
MESH:D001327 Autoimmune Diseases Quercetin 3.9019761891
MESH:D001342 Autonomic Nervous System Diseases methamidophos 6.2511527224
MESH:D001477 Bartter Syndrome Indomethacin 4.4810684365
MESH:D001714 Bipolar Disorder Risperidone 4.2418278980 19154706
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.4216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4215746008
MESH:D001919 Bradycardia antalarmin 10.0516710322
MESH:D001919 Bradycardia Propranolol 10.056740701
MESH:D001929 Brain Edema Indomethacin 4.5011481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8117868700
MESH:D001930 Brain Injuries Progesterone 3.7515665606 15845082 15380490
MESH:D002545 Brain Ischemia Indomethacin 3.9012524144
MESH:D001943 Breast Neoplasms Atropine 4.1912762645
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.1918323546 17020986 17388661 12006526 11325840 15136595 18234424 15093573 16978400
MESH:D001943 Breast Neoplasms Indomethacin 4.1917401462
MESH:D001943 Breast Neoplasms Nitric Oxide 4.1915631943
MESH:D001943 Breast Neoplasms Progesterone 4.1915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Quercetin 4.1918628248
MESH:D001943 Breast Neoplasms Testosterone 4.1917261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.1920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8511589617
MESH:D002056 Burns Ethanol 9.7016374292
MESH:D002056 Burns Indomethacin 9.7010459503
MESH:D002100 Cachexia Indomethacin 4.4915625704 16537180 11239499 15141370
MESH:D002105 Cadmium Poisoning Quercetin 5.0216962696
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.339428835 11713377
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 7.7714691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 7.7719701751
MESH:D006528 Carcinoma, Hepatocellular Ethanol 7.7715289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 7.7716391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 7.7719519916 12508355
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.8116152834
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.8111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8318791128 14736730 11352223
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4517234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3519014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.0616201981
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.0617341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6612490120
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.6915482327 12636206
MESH:D006332 Cardiomegaly Ethanol 9.6819332462
MESH:D006332 Cardiomegaly Quercetin 9.6819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.6818670907 16120746 18850075
MESH:D002375 Catalepsy Haloperidol 4.391977408 15215559
MESH:D002547 Cerebral Palsy Toluene 5.339294310
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4720678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002764 Cholecystitis Indomethacin 4.6411181007
MESH:D002779 Cholestasis Nitric Oxide 4.0716919318
MESH:D002971 Cleft Lip Ethanol 3.3015513904
MESH:D002972 Cleft Palate Ethanol 8.6315513904
MESH:D002972 Cleft Palate Hydrocortisone 8.6315826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.6316354765 15668235 12621046 15340226 8697196
MESH:D003072 Cognition Disorders Clozapine 4.4617123785
MESH:D003110 Colonic Neoplasms Dexamethasone 5.2415824018
MESH:D003110 Colonic Neoplasms Indomethacin 5.2411260862 15936596 15637740 15625704 15963497 15786552
MESH:D003110 Colonic Neoplasms Quercetin 5.2416640504 19056647 15741050 11134977 19440933 17191121 17148506
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.1920501625
MESH:D015179 Colorectal Neoplasms Indomethacin 3.1917054584 18059344 11197048 12606626
MESH:D015179 Colorectal Neoplasms Quercetin 3.1918095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6217141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6912609071
MESH:D018352 Coronavirus Infections Indomethacin 5.1917302372
MESH:D003371 Cough Terbutaline 5.0419679606
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 12.9010525206
MESH:D019465 Craniofacial Abnormalities decamethrin 12.9019861644
MESH:D019465 Craniofacial Abnormalities Dexamethasone 12.9017728286
MESH:D019465 Craniofacial Abnormalities Ethanol 12.9015513904 19302082 11198716 10194807 15451040 15451039 11873399
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 12.9017728286
MESH:D019465 Craniofacial Abnormalities Permethrin 12.9019861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 12.9015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 12.909294310
MESH:D003480 Cushing Syndrome marker/mechanism 21359208
MESH:D003556 Cystitis Cyclophosphamide 4.4616614059 18295254 18710439 10700343 12161096 11948286 17010015 16989017 16651033 17979934 18433785 18483878 15276878 18372110 15643279 12388444 10498854 16413132 18093676 12913760
MESH:D003643 Death Toluene 5.146431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 22.1515213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 22.1520210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 22.1520210726
MESH:D016757 Death, Sudden, Cardiac Thioridazine 22.1520210726
MESH:D003704 Dementia Haloperidol 14.2611575062
MESH:D003704 Dementia Risperidone 14.2611575062
MESH:D003704 Dementia Thioridazine 14.2611575062
MESH:D015140 Dementia, Vascular Nitric Oxide 5.4417556102
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9312438553
MESH:D003877 Dermatitis, Contact Permethrin 4.5214617103
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 11.6815331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 11.6819496084
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 11.6816684804
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0418772604
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.9916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D003929 Diabetic Neuropathies Progesterone 3.9917187935
MESH:D003967 Diarrhea Atropine 15.0710867622
MESH:D003967 Diarrhea Dexamethasone 15.077237001
MESH:D003967 Diarrhea Hydrocortisone 15.077237001
MESH:D003967 Diarrhea Indomethacin 15.077237001 7907874
MESH:D006970 Disorders of Excessive Somnolence Clozapine 12.6815331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 12.6816379507
MESH:D053207 Diurnal Enuresis Risperidone 6.1517822346
MESH:D004244 Dizziness Astemizole 5.943105558
MESH:D004314 Down Syndrome Risperidone 4.6918349709
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 5.4311461765
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.4311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3711462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6318446180 16326151 17190690 18043480 12774134 16133044
MESH:D004381 Duodenal Ulcer Atropine 8.2511595415
MESH:D004381 Duodenal Ulcer Indomethacin 8.2517351913 11595415 11991626 16699067 17151854 11595431 17329845 17202747 11535926 10671773 17045617
MESH:D050171 Dyslipidemias Clozapine 3.8016402076
MESH:D004485 Eczema Dexamethasone 3.9712438553
MESH:D004487 Edema Dexamethasone 8.9319703484
MESH:D004487 Edema Indomethacin 8.9316100529 7907874 19703484 10653021 8985016 8273558 7990266
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.9311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.2917692515
MESH:D004715 Endometriosis Indomethacin 12.7015652904
MESH:D004715 Endometriosis Progesterone 12.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.7010568697 9294722
MESH:D019446 Endotoxemia Indomethacin 8.9318509659
MESH:D019446 Endotoxemia Lipopolysaccharides 8.9315328337 15821434 17637181
MESH:D004751 Enteritis Indomethacin 4.2216328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4817980183
MESH:D004802 Eosinophilia Astemizole 12.171355641
MESH:D004802 Eosinophilia Cyclophosphamide 12.1711006010
MESH:D004802 Eosinophilia Indomethacin 12.1711298111
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.4512903497
MESH:D004938 Esophageal Neoplasms Ethanol 6.4516704527
MESH:D004938 Esophageal Neoplasms Indomethacin 6.4511005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6211564622
MESH:D005234 Fatty Liver arsenic trioxide 6.5515073043
MESH:D005234 Fatty Liver Ethanol 6.5518620774 19236843 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7815513904 10194807 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9511858732
MESH:D005334 Fever marker/mechanism 11852909
MESH:D005334 Fever Dipyrone 12.9711852909
MESH:D005334 Fever Indomethacin 12.9710431976 17627676 11852909
MESH:D005334 Fever Lipopolysaccharides 12.9711852909 9205823
MESH:D005354 Fibrosarcoma Indomethacin 4.3810962813
MESH:D005355 Fibrosis Indomethacin 17.1417994277
MESH:D005355 Fibrosis Quercetin 17.1419474275
MESH:D005355 Fibrosis Terbutaline 17.1415467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.1420067830
MESH:D005391 Firesetting Behavior Testosterone 5.337506515
MESH:D005499 Folliculitis Astemizole 11.641671328
MESH:D005499 Folliculitis Indomethacin 11.6411298111
MESH:D005517 Foodborne Diseases methamidophos 6.6111527224
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7716904648
MESH:D005756 Gastritis Ethanol 9.7715046732
MESH:D005756 Gastritis Indomethacin 9.7715046732
MESH:D005909 Glioblastoma Indomethacin 10.0912870263
MESH:D005909 Glioblastoma Quercetin 10.0919804834
MESH:D005909 Glioblastoma Testosterone 10.0917162496
MESH:D005910 Glioma Indomethacin 5.5516487511 18371953
MESH:D005910 Glioma Quercetin 5.5517643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9911389073
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0710696789
MESH:D006073 Gout Indomethacin 4.8311248219
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5311014644 16376943 15172196
MESH:D006261 Headache Fentanyl 10.1211554966
MESH:D006261 Headache Nitric Oxide 10.1211284996 11554966
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.3915482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0410048152 11294989
MESH:D006333 Heart Failure Propranolol 4.2920082655
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9316366002
MESH:D006467 Hemophilia A Cyclophosphamide 4.7811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1015633222
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0014986274
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1915135802
MESH:D006529 Hepatomegaly Propranolol 7.3616371745
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3616120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.877520565
MESH:D006561 Herpes Simplex Chlorpromazine 4.771682908
MESH:D006628 Hirsutism Testosterone 5.1217019078
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.3616135485 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.528697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Ethanol 6.8418783367
MESH:D006930 Hyperalgesia Indomethacin 6.8412727271
MESH:D034321 Hyperamylasemia Indomethacin 5.1917883296
MESH:D017588 Hyperandrogenism Testosterone 4.7817019078
MESH:D006940 Hyperemia Indomethacin 10.9912524144
MESH:D006940 Hyperemia Nitric Oxide 10.9911156591
MESH:D006943 Hyperglycemia Quercetin 8.4718262572 11834736
MESH:D006943 Hyperglycemia Risperidone 8.4718278980
MESH:D006948 Hyperkinesis Clozapine 4.3916046005
MESH:D006949 Hyperlipidemias Indomethacin 3.6917546600
MESH:D006973 Hypertension Dexamethasone 7.3817042910
MESH:D006973 Hypertension Quercetin 7.3818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.3818850075 18670907
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.0415838368
MESH:D006985 Hyperventilation Terbutaline 5.5610895896
MESH:D007006 Hypogonadism Testosterone 4.2112002444
MESH:D007008 Hypokalemia Terbutaline 5.5717292646
MESH:D007018 Hypopituitarism Testosterone 5.6717426086
MESH:D007022 Hypotension Propranolol 4.716740701
MESH:D007077 Ileal Diseases Indomethacin 4.5010574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8316133968 10651667 10647630
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8016076520
MESH:D007174 Impulse Control Disorders Testosterone 5.337506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8416133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9015869954
MESH:D007248 Infertility, Male Cyclophosphamide 6.577193160 16517039
MESH:D007248 Infertility, Male methamidophos 6.5710828210
MESH:D007249 Inflammation Dexamethasone 16.188960868 11099482
MESH:D007249 Inflammation Flavonoids 16.1817296493
MESH:D007249 Inflammation Indomethacin 16.1812568917 3291741 7812673
MESH:D007249 Inflammation Lipopolysaccharides 16.1812878042 17255318 17237260 9205823 17963957
MESH:D007249 Inflammation Progesterone 16.1815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.1812878042 12200463
MESH:D007251 Influenza, Human Quercetin 3.9816624496
MESH:D007299 Insect Bites and Stings decamethrin 11.3815189238
MESH:D007299 Insect Bites and Stings Permethrin 11.3812971516 15189238 12749493
MESH:D007410 Intestinal Diseases Indomethacin 8.6417329856 15610444 11713966 10210152 11686837 18236018 11855677 17994277 15831440
MESH:D007410 Intestinal Diseases Nitric Oxide 8.6410210152 11574821 11713966
MESH:D019586 Intracranial Hypertension Indomethacin 4.8415241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1517255318
MESH:D007569 Jaw Abnormalities Ethanol 8.5715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.5010574470 16133968 18306037
MESH:D007627 Keloid Quercetin 4.4517086741
MESH:D007674 Kidney Diseases Indomethacin 5.4217190690
MESH:D007674 Kidney Diseases Quercetin 5.4216962696
MESH:D007859 Learning Disorders Ethanol 3.7115451040
MESH:D007896 Leishmaniasis Nitric Oxide 4.2217218153
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4811703811 12228301 10320625
MESH:D053609 Lethargy Terbutaline 5.7910895896
MESH:D007938 Leukemia arsenic trioxide 12.7515070760
MESH:D007938 Leukemia Cyclophosphamide 12.7510602166
MESH:D007938 Leukemia Permethrin 12.7512937054
MESH:D007938 Leukemia Quercetin 12.7517468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2618172266 18587576 17802794 17296974 17658394 17008537
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 11.9014633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 11.9010373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 11.9015631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.3019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6919850784 20471514 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.6918360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.8715622746 11468182 19075265 19642359 12679006 17107899 11161223 9834237 15336539 19035177 19225113 17217047 16330433 17649720 16966277 12712474 17869043 16823087 16331271 15213294 15748426 17712046 16891316 12018890 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8616882451
MESH:D007964 Leukocytosis Indomethacin 4.8416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1917980183
MESH:D007970 Leukopenia Cyclophosphamide 10.0510052129 11830472
MESH:D007970 Leukopenia Lipopolysaccharides 10.0515821434
MESH:D017513 Lichen Nitidus Astemizole 5.942563723
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4417676605
MESH:D008064 Lipidoses Chlorpromazine 11.4615342952 17567588
MESH:D008064 Lipidoses Clozapine 11.4617567588
MESH:D008064 Lipidoses Thioridazine 11.4617567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1911479899
MESH:D008103 Liver Cirrhosis Ethanol 3.0715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5818295389
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 7.6516718785
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.6518166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.6518194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.6512878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.6512741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6512878042
MESH:D008107 Liver Diseases Chlorpromazine 3.5414986274
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1517207112 17347304
MESH:D008113 Liver Neoplasms arsenic trioxide 6.1714682389
MESH:D008113 Liver Neoplasms Quercetin 6.1718980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.1716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.4720377131
MESH:D008114 Liver Neoplasms, Experimental Dipyrone 11.476150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.4719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.4712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 11.6215213294
MESH:D008133 Long QT Syndrome Astemizole 11.6211989578 18472280
MESH:D008133 Long QT Syndrome Thioridazine 11.6220210726
MESH:D055370 Lung Injury Lipopolysaccharides 7.8921114838
MESH:D055370 Lung Injury Nitric Oxide 7.8911395602
MESH:D008175 Lung Neoplasms arsenic trioxide 5.7411798837 19825857
MESH:D008175 Lung Neoplasms Dexamethasone 5.7411195469 15824018
MESH:D008175 Lung Neoplasms Indomethacin 5.7411497255 11053908 16537180
MESH:D008175 Lung Neoplasms Quercetin 5.7416280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.7411884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 6.9312854902
MESH:D008223 Lymphoma Nitric Oxide 6.9316166326
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7411911406
MESH:D008288 Malaria Astemizole 4.3816816845
MESH:D016778 Malaria, Falciparum Thioridazine 5.2716882315
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.3112807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.3111408345 17203775
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.3016388313
MESH:D008569 Memory Disorders Ethanol 3.7015451040 18411066
MESH:D001523 Mental Disorders Chlorpromazine 19.1016856516
MESH:D001523 Mental Disorders Clozapine 19.1016856516
MESH:D001523 Mental Disorders Haloperidol 19.1016856516
MESH:D001523 Mental Disorders Risperidone 19.1016596465 16856516
MESH:D001523 Mental Disorders Thioridazine 19.1016856516
MESH:D008607 Mental Retardation Risperidone 5.9918349709
MESH:D008607 Mental Retardation Toluene 5.999294310
MESH:D024821 Metabolic Syndrome X Clozapine 8.7719142101
MESH:D024821 Metabolic Syndrome X Risperidone 8.7719142101
MESH:D008881 Migraine Disorders Indomethacin 6.8711903285
MESH:D008881 Migraine Disorders Nitric Oxide 6.8711701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.6211304026 14659530
MESH:D019964 Mood Disorders Risperidone 5.3217019624
MESH:D019957 Motor Skills Disorders Toluene 4.759294310
MESH:D009062 Mouth Neoplasms Indomethacin 3.5912636206
MESH:D009101 Multiple Myeloma arsenic trioxide 6.1819549372 14977855 11468182 15949261 19417148
MESH:D009101 Multiple Myeloma Dexamethasone 6.1815867202 16118317 15744524
MESH:D018908 Muscle Weakness methamidophos 6.2517849254
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.4710773494
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.5116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.519809623
MESH:D009203 Myocardial Infarction Quercetin 2.7619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.3919207477
MESH:D009216 Myopia Atropine 4.6612601066
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4716624393
MESH:D009362 Neoplasm Metastasis Indomethacin 2.9411053908 11239499 16537180
MESH:D009369 Neoplasms Cyclophosphamide 4.5818854779
MESH:D009369 Neoplasms Quercetin 4.5815185748
MESH:D009374 Neoplasms, Experimental Indomethacin 3.6410663608 15625704
MESH:D009422 Nervous System Diseases methamidophos 5.2015938848 2238440
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.7214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.7710525206
MESH:D009447 Neuroblastoma Cyclophosphamide 3.368761367 15176712 16115947
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.5212349958
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.378761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.8817929310
MESH:D009503 Neutropenia Cyclophosphamide 3.858291058
MESH:D053206 Nocturnal Enuresis Risperidone 5.8017822346
MESH:D009759 Nystagmus, Pathologic Astemizole 5.946135121
MESH:D009765 Obesity Clozapine 2.8719142110 18515891
MESH:D007752 Obstetric Labor, Premature Indomethacin 11.726374098
MESH:D007752 Obstetric Labor, Premature Terbutaline 11.7214998686
MESH:D009845 Oligospermia Cyclophosphamide 4.2016517039
MESH:D010003 Osteoarthritis Indomethacin 3.347009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.7419495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 6.8419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Progesterone 6.8416525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 6.8419005980
MESH:D010146 Pain Cyclophosphamide 5.8712161096 18093676
MESH:D010146 Pain Indomethacin 5.8717627676 13679232 17440234 3291741
MESH:D010149 Pain, Postoperative Fentanyl 10.2911554966
MESH:D010149 Pain, Postoperative Indomethacin 10.2918702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 10.6315580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 10.6311332152
MESH:D010190 Pancreatic Neoplasms Ethanol 10.6312384795
MESH:D010190 Pancreatic Neoplasms Quercetin 10.6316965848
MESH:D010195 Pancreatitis Indomethacin 3.4515028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 3.6819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 8.5312349958
MESH:D020734 Parkinsonian Disorders Raclopride 8.5312476322
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7212520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6311148446
MESH:D010518 Periodontitis Indomethacin 4.3917225004
MESH:D010523 Peripheral Nervous System Diseases methamidophos 5.2710447555 2170085 7654138
MESH:D011014 Pneumonia Lipopolysaccharides 4.0412224865 11605937
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.8218573544
MESH:D011041 Poisoning Atropine 8.3317849254 18072136
MESH:D011041 Poisoning methamidophos 8.3317849254 16119251
MESH:D011115 Polyneuropathies methamidophos 5.567654138
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0718163543
MESH:D011230 Precancerous Conditions Quercetin 3.5419056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.7821297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.7821297632
MESH:D047928 Premature Birth Indomethacin 4.6217000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.6811222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.5920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.9219131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.9217136230
MESH:D011471 Prostatic Neoplasms Quercetin 2.9217292933 14715546
MESH:D011507 Proteinuria Indomethacin 3.6911849393
MESH:D011595 Psychomotor Agitation Haloperidol 4.4511575062
MESH:D011618 Psychotic Disorders Clozapine 12.6815331141
MESH:D011618 Psychotic Disorders Haloperidol 12.6811575062
MESH:D011618 Psychotic Disorders Thioridazine 12.6816882315
MESH:D011628 Puberty, Delayed marker/mechanism 20002962
MESH:D011629 Puberty, Precocious astressin B 6.3420002962
MESH:D011654 Pulmonary Edema Terbutaline 4.9910903255
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.0716636934
MESH:D012021 Reflex, Abnormal Pentobarbital 5.5010930210
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.1018379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 8.102878809
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 7.389413022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 7.3810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3418990726
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 4.9010822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4716646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.0216862918
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 4.959673227
MESH:D012559 Schizophrenia Clozapine 5.3118855531 17667964 11763009 20168265 20452607 17726453 20107430 20521320 20580759 18806925 20521326 11151749 16141801 17123785 19369910
MESH:D012559 Schizophrenia Haloperidol 5.3120107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia Risperidone 5.3118278980 19154706 20107430
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3416636934
MESH:D012640 Seizures Atropine 14.8617157343 12660363 11218047
MESH:D012640 Seizures Ethanol 14.869754883
MESH:D012640 Seizures Pentobarbital 14.8610087439 9754883
MESH:D012640 Seizures Toluene 14.866431079 9294310
MESH:D012640 Seizures Vigabatrin 14.869844417 10454489
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.6716631401
MESH:D012772 Shock, Septic Terbutaline 4.983431524
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.7916192470
MESH:D012893 Sleep Disorders Risperidone 4.9918278980
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9916517039
MESH:D013119 Spinal Cord Injuries Progesterone 3.7616503802 15862959
MESH:D013272 Stomach Diseases Dexamethasone 8.6515472012
MESH:D013272 Stomach Diseases Indomethacin 8.6518209964 15472012 10215738 15038085 17160473 17207306 10486359 16113693 17638125 16280098 10192188 16184426 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.1717007042
MESH:D013274 Stomach Neoplasms Ethanol 3.1718456281
MESH:D013274 Stomach Neoplasms Indomethacin 3.1715609394
MESH:D013276 Stomach Ulcer Atropine 17.7311595415
MESH:D013276 Stomach Ulcer Dexamethasone 17.7315138204
MESH:D013276 Stomach Ulcer Ethanol 17.739562338 17918041 9211565 16755016 17189318 11906479
MESH:D013276 Stomach Ulcer Indomethacin 17.7318431645 18299717 17977527 18726076 17627676 11729361 16631530 11145282 10878458 11595415 15104355 18543354 10750652 18087811 16150113 16252198 11906479 17654042 16397915 14567935 12077510 18237397 15138204 12467913 17895592 12787963 16755016 15255614 10423059 17135157 18209962 16169175 18181030 11523592 16934674 12498302 11595431 17657623 1323529 12500499 17918041 18193104
MESH:D013276 Stomach Ulcer Nitric Oxide 17.7315138204
MESH:D013375 Substance Withdrawal Syndrome Ethanol 8.769754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.7611529278 9754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5412837982
MESH:D013610 Tachycardia Terbutaline 5.0110895896
MESH:D017180 Tachycardia, Ventricular Haloperidol 14.8820210726
MESH:D017180 Tachycardia, Ventricular Risperidone 14.8820210726
MESH:D017180 Tachycardia, Ventricular Thioridazine 14.8820210726
MESH:D013733 Testicular Diseases Toluene 4.4410514026 10048760
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7115821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.1019014326
MESH:D013964 Thyroid Neoplasms Indomethacin 6.1018791128 11352223 14736730
MESH:D016171 Torsades de Pointes arsenic trioxide 8.9215213294
MESH:D016171 Torsades de Pointes Astemizole 8.928256756 9583453
MESH:D005879 Tourette Syndrome Risperidone 5.4419154706
MESH:D014202 Tremor Atropine 5.2017594079
MESH:D014456 Ulcer Indomethacin 4.3810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.1511780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 7.1514692829
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.1516720314
MESH:D014581 Urticaria Astemizole 4.323080510 2859714 2885854 2147912 2565098 2568189 3134034 1683191 1976298 3097109 2568013 2883202
MESH:D014605 Uveitis Dexamethasone 4.291336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0712125929
MESH:D020301 Vasospasm, Intracranial Nitric Oxide Donors 5.6319057314
MESH:D014717 Vertigo Astemizole 5.943105558
MESH:D014839 Vomiting Indomethacin 4.2211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7215886252
MESH:D015430 Weight Gain Clozapine 8.9216141801 20107430 20521320 20564506 16402076 17502770
MESH:D015430 Weight Gain Risperidone 8.9220564506 16379507
MESH:D015431 Weight Loss Clozapine 4.5617933447
Pathway ID Pathway Name
KEGG:04730 Long-term depression
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA119
    • No data
    Releated disease ID Related disease Name
    PA443264Addison Disease
    PA447278Depression
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA450626nicotine
    PA452347glucocorticoids
    PA452229antidepressants
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01285 agonist Corticotropin Diagnostic Agents
    DB02556 - D-Phenylalanine
    DB02952 - Alpha-Aminoisobutyric Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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