AutismKB 2.0

Annotation Detail for CRHR1


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Basic Information Top
Gene Symbol:CRHR1 ( CRF-R,CRF1,CRFR1,CRH-R1h,CRHR,CRHR1L,CRHR1f )
Gene Full Name: corticotropin releasing hormone receptor 1
Band: 17q21.31
Quick LinksEntrez ID:1394; OMIM: 122561; Uniprot ID:CRFR1_HUMAN; ENSEMBL ID: ENSG00000120088; HGNC ID: 2357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P04380Cortocotropin releasing factor receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
1907Depression
2071Supranuclear palsy, progressive
2031Endometrial cancer
2044Pre-Eclampsia
Desease Name
Bone mineral density (spine)
progressive supranuclear palsy
CHEMDEPENDENCY
PSYCH
Asthma
Bone mineral density (hip)
depressive disorder, major
IMMUNE
alcohol abuse
NEUROLOGICAL
METABOLIC
depression
REPRODUCTION
patent ductus arteriosus
Desease Name
Bone mineral density (hip)
Bone mineral density (spine)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C471210 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 15593376
C471210 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 17392412
16420149
15831766
C002385 3-morpholino-sydnonimine 3-morpholino-sydnonimine results in increased expression of CRHR1 mRNAincreases expression 10460269
C417190 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 11641109
15673846
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CRHR1 mRNAaffects expression 16483693
C103016 antalarmin antalarmin binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 16014403
C103016 antalarmin antalarmin binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 9645712
C103016 antalarmin antalarmin binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 14997174
C104416 astressin astressin binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 15593376
C104416 astressin astressin binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 16014403
C120841 astressin B astressin B binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 11641109
12746300
D003346 Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone results in decreased activity of CRHR1 proteindecreases activity 12093084
D003346 Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNAincreases expression 12093084
D003346 Corticotropin-Releasing Hormone Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]decreases activity|decreases reaction 12093084
D003346 Corticotropin-Releasing Hormone Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]decreases reaction|increases expression 12093084
C045089 corticotropin releasing hormone (9-41) corticotropin releasing hormone (9-41) results in decreased activity of CRHR1 proteindecreases activity 15486230
C101628 CP 154526 CP 154526 binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 11751155
11641109
15994424
15831766
C117406 CRA1000 CRA1000 binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 12631246
D004041 Dietary Fats Dietary Fats results in decreased expression of CRHR1 mRNAdecreases expression 18721800
C030691 gluconic acid gluconic acid results in increased expression of CRHR1 mRNAincreases expression 16556975
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CRHR1 mRNAdecreases expression 12419474
D007608 Kainic Acid Kainic Acid results in increased expression of CRHR1 mRNAincreases expression 12093084
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CRHR1 mRNAincreases expression 12057914
D008713 Methimazole Methimazole results in decreased expression of CRHR1 mRNAdecreases expression 17403546
D009569 Nitric Oxide Nitric Oxide results in increased expression of CRHR1 mRNAincreases expression 10460269
D020030 Nitric Oxide Donors Nitric Oxide Donors results in increased expression of CRHR1 mRNAincreases expression 10460269
D010424 Pentobarbital Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]decreases activity|decreases reaction 12093084
D010424 Pentobarbital Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]decreases reaction|increases expression 12093084
C494474 perchlorate perchlorate results in decreased expression of CRHR1 mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in decreased expression of CRHR1 mRNAdecreases expression 17403546
C412383 R 121919 R 121919 binds to and results in decreased activity of CRHR1 proteinaffects binding|decreases activity 12746300
15936754
D018038 Sodium Selenite Sodium Selenite results in increased expression of CRHR1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8711850527 18653653
MESH:D000505 Alopecia astressin B 5.7521359208
MESH:D000544 Alzheimer Disease Nitric Oxide 3.2717556102
MESH:D000855 Anorexia marker/mechanism 16420149
MESH:D001008 Anxiety Disorders Pentobarbital 4.5911141031 18313124
MESH:D001161 Arteriosclerosis Dietary Fats 3.7215238619
MESH:D018771 Arthralgia 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine 7.5817392412
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 4.1119483382
MESH:D001919 Bradycardia antalarmin 6.1916710322
MESH:D001943 Breast Neoplasms Dietary Fats 2.6520435547
MESH:D001943 Breast Neoplasms Nitric Oxide 2.6515631943
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4016936243
MESH:D002779 Cholestasis Nitric Oxide 4.3316919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5815894690
MESH:D015140 Dementia, Vascular Nitric Oxide 5.7917556102
MESH:D003877 Dermatitis, Contact marker/mechanism 12631246
MESH:D003877 Dermatitis, Contact CRA1000 6.6112631246
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6316285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.2415131321
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2215821434 15328337 17637181
MESH:D005234 Fatty Liver Dietary Fats 3.0917967931 18296743 19551842 19004024
MESH:D005334 Fever Lipopolysaccharides 3.8611852909 9205823
MESH:D005355 Fibrosis Dietary Fats 3.3618296743
MESH:D006042 Goiter perchlorate 5.1418801409
MESH:D006261 Headache Nitric Oxide 5.0011284996 11554966
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2316366002
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006940 Hyperemia Nitric Oxide 5.4411156591
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.3015838368
MESH:D006980 Hyperthyroidism Methimazole 5.4514678291
MESH:D007037 Hypothyroidism Methimazole 11.3818031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.388137927 18031379
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Lipopolysaccharides 5.0012878042 9205823 17237260 17255318 17963957
MESH:D007333 Insulin Resistance Dietary Fats 7.1111836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 7.1114714311
MESH:D007410 Intestinal Diseases Nitric Oxide 4.7611574821 11713966 10210152
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4717255318
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1216518626
MESH:D007896 Leishmaniasis Nitric Oxide 4.5117218153
MESH:D007970 Leukopenia Lipopolysaccharides 4.5315821434
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7818296743
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2512878042
MESH:D055370 Lung Injury Lipopolysaccharides 8.9921114838
MESH:D055370 Lung Injury Nitric Oxide 8.9911395602
MESH:D008223 Lymphoma Nitric Oxide 4.1616166326
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9014737004
MESH:D008881 Migraine Disorders Nitric Oxide 4.1611701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.9514659530 11304026
MESH:D009765 Obesity Dietary Fats 2.2516723640 19632207 20132043 18674790 21332399 20518802 17217161 18457598 11836018
MESH:D010212 Papilloma Hydrogen Peroxide 3.9212065085
MESH:D011014 Pneumonia Lipopolysaccharides 4.3812224865 11605937
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.1618573544
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4418760546
MESH:D011629 Puberty, Precocious astressin B 6.6920002962
MESH:D012021 Reflex, Abnormal Pentobarbital 5.8510930210
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6210835634
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.279673227
MESH:D012640 Seizures Kainic Acid 6.661641125 16336964 19414003 17827730 14637104 10686065 19186208 15686955 18657176
MESH:D012640 Seizures Pentobarbital 6.669754883 10087439
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 2.9912065085
MESH:D012893 Sleep Disorders Kainic Acid 5.5219414003
MESH:D013276 Stomach Ulcer Nitric Oxide 4.0415138204
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.8311529278 9754883
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0115821434
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.5515710170
MESH:D020301 Vasospasm, Intracranial Nitric Oxide Donors 5.9719057314
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
Pathway ID Pathway Name
KEGG:04730 Long-term depression
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26874
    • No data
    Releated disease ID Related disease Name
    PA447207Depressive Disorder
    PA447196Anxiety Disorders
    PA447278Depression
    PA443450Asthma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA447178Pulmonary Disease, Chronic Obstructive
    Releated drug ID Related drug Name
    PA449673fluoxetine
    PA452229antidepressants
    PA10832corticosteroids
    PA450626nicotine
    PA452604xenobiotics
    PA452347glucocorticoids
    PA449661flunisolide
    PA449233desipramine
    PA449686fluticasone propionate
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    Drug Bank Top

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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