AutismKB 2.0

Annotation Detail for CRK


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Basic Information Top
Gene Symbol:CRK ( CRKII )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)
Band: 17p13.3
Quick LinksEntrez ID:1398; OMIM: 164762; Uniprot ID:CRK_HUMAN; ENSEMBL ID: ENSG00000167193; HGNC ID: 2362
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signalling by NGF
Hemostasis
Signaling by Insulin receptor
Signaling by PDGF
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200188VEGFR3 signaling in lymphatic endothelium
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200178Paxillin-independent events mediated by a4b1 and a4b7
200004Endothelins
200129JNK signaling in the CD4+ TCR pathway
200128Neurotrophic factor-mediated Trk receptor signaling
200012Insulin Pathway
200121EPHA forward signaling
200083CXCR4-mediated signaling events
200084IGF1 pathway
200140PDGFR-alpha signaling pathway
200066Angiopoietin receptor Tie2-mediated signaling
200011LPA receptor mediated events
200117Paxillin-dependent events mediated by a4b1
200041EPHB forward signaling
200105E-cadherin signaling in the nascent adherens junction
200192Signaling events mediated by focal adhesion kinase
200190RAC1 signaling pathway
200053Nectin adhesion pathway
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00005Angiogenesis
P00034Integrin signalling pathway
Pathway IDPathway Name
500007p130Cas linkage to MAPK signaling for integrins
500631ARMS-mediated activation
500505Signal attenuation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2038Gastritis
2166Influenza
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of CRK mRNAincreases expression 15800402
D000082 Acetaminophen Acetaminophen results in increased expression of CRK proteinincreases expression 15800402
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CRK mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of CRK mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CRK mRNAdecreases expression 20018196
19150397
D002087 Butyrates Butyrates results in decreased expression of CRK mRNAdecreases expression 14674679
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of CRK mRNAaffects cotreatment|decreases expression 18636392
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRK mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of CRK mRNAdecreases expression 18035473
D005472 Fluorouracil CRK protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D019833 Genistein Genistein results in increased expression of CRK mRNAincreases expression 17341692
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of CRK mRNAaffects cotreatment|decreases expression 18636392
D010634 Phenobarbital Phenobarbital results in decreased expression of CRK mRNAdecreases expression 19363144
D010656 Phenylephrine ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]affects binding|affects reaction|increases reaction 17615370
D010656 Phenylephrine ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]affects binding|affects reaction|increases reaction 17615370
D010656 Phenylephrine Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]affects binding|increases reaction 17615370
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CRK mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CRK mRNAdecreases expression 18445702
C045950 propiconazole propiconazole results in decreased expression of CRK mRNAdecreases expression 19363144
C009166 retinol acetate retinol acetate results in increased expression of CRK mRNAincreases expression 16772331
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRK mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRK mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRK mRNAincreases expression 15358164
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury Chlorine 9.0920601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.0918653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0817638652
MESH:D000230 Adenocarcinoma Genistein 7.0811473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.2517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2516835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Fluorouracil 8.6216511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D000741 Anemia, Aplastic Benzene 4.3511369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0917460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2316183116
MESH:D001919 Bradycardia Phenylephrine 4.5415306635
MESH:D001943 Breast Neoplasms Benzene 1.9917162533 11921183
MESH:D001943 Breast Neoplasms Fluorouracil 1.9915136595 18357371 19217205 18608205 16557594 16110121 16595493
MESH:D001943 Breast Neoplasms Genistein 1.9916873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6615516495 14754758 18417511 19059883 16777450 17626835 18315731
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6716051944
MESH:D002277 Carcinoma Fluorouracil 8.1317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.563084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.5616332177 16799960 17045692 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.5616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.5617173139 1701930 20935162 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.4916757204 16280240 17066447 18986760
MESH:D006332 Cardiomegaly Phenylephrine 6.8411754973 16170337 15728586 17287366 17124262 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8416120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.2916332659
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7120889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6911677210 17681005 15861022 16919318 16105132 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 7.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 16354765 15340226 15668235 8697196
MESH:D003110 Colonic Neoplasms Butyrates 5.9715936596
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9718772588 16340194 15001691 17018589 16510598 17287894 17725105 17016597 17172411 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.9717182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016282729 17094418 20501625 17594712 18802399 18288408 17401013 17255274 16524972 17454858 16391804 16303861 17695437 18949393 15148649 18383874 16331619 17016601 18448328 18509181 14970324 15289873
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 2.6715643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6710048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D003872 Dermatitis Benzene 4.7515902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5416081117 12153990 16781746 19164858 19416960 11529661 11461765 19923254 18071297 15619225 16109766 11287661 14986274 10663392 19085960 17906064 12958197 10915739 16177239 14550746 12705907 18713872 11834606 11743745 16227642 19739265 14725611 11739529 12392966 12540782 15968718 12594235 17522070 19420014 11421492 2444490 16393943 19370779 17562736 16485898 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.5816402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4920426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4917638652 15173087 16481741 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4815345470
MESH:D005234 Fatty Liver pirinixic acid 7.4819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005909 Glioblastoma Genistein 3.2416598420
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3715102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006402 Hematologic Diseases Benzene 4.6416183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Phenobarbital 20.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 20.6319176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly propiconazole 20.6317178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.6315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Benzene 8.7017940673
MESH:D006973 Hypertension Phenylephrine 8.708949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7018670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.5312791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Flavonoids 4.9617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1912587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 3.2916985049
MESH:D007938 Leukemia Benzene 6.6118335105 17119257 14694614 15935818
MESH:D007938 Leukemia Genistein 6.6117468513 18980019
MESH:D007951 Leukemia, Myeloid Benzene 4.3017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6919478238
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008107 Liver Diseases Acetaminophen 6.6119014921 11587558 12969438 16611625 19460945 19784758 12587719 16610002
MESH:D008107 Liver Diseases Phenobarbital 6.6119363144
MESH:D008107 Liver Diseases propiconazole 6.6119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 14.1817045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 14.1819812893 8742319 15975961 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.1820007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 14.1819028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1816984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.0912562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.0918308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental propiconazole 14.0917178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0912151625
MESH:D008171 Lung Diseases Ozone 3.3619066396 8266340
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8114698565
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Benzene 4.8712562636
MESH:D008175 Lung Neoplasms Fluorouracil 4.8715246190
MESH:D008175 Lung Neoplasms Ozone 4.877614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008223 Lymphoma Benzene 3.7217584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.3111921183
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3114578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6118986760 16757204
MESH:D009101 Multiple Myeloma Benzene 3.6517119195
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction Genistein 5.6517141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.6519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.3317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009369 Neoplasms Fluorouracil 4.9518600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009421 Nervous System Malformations Genistein 9.5516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5514600291
MESH:D009436 Neural Tube Defects Benzene 3.6615643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases Benzene 4.1617119257 15576619 16737584 17479406 15935809 17178637 15913788 15612468 15727169
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010024 Osteoporosis Genistein 3.2419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0716169203
MESH:D010051 Ovarian Neoplasms Benzene 5.1512562636
MESH:D010051 Ovarian Neoplasms Genistein 5.1519005980
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3316929163 16500647 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4218626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.4215256057 15378649 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.3015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9915538739 18286688 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012640 Seizures Phenobarbital 2.684039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012852 Sinusitis Phenylephrine 4.697327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms Benzene 2.7312562636
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7319015929 18567086 16424979 17522103 16951190 15786421 18396642 17498489 17172411 19084572
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013953 Thymus Neoplasms Benzene 4.9510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Butyrates 7.5317967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.531399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8616803524
MESH:D014594 Uterine Neoplasms Benzene 9.5212562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:04012 ErbB signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:13552 Integrin cell surface interactions
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
KEGG:05131 Shigellosis
REACT:498 Signaling by Insulin receptor
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26880
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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