AutismKB 2.0

Annotation Detail for CRKL


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Basic Information Top
Gene Symbol:CRKL ( - )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Band: 22q11.21
Quick LinksEntrez ID:1399; OMIM: 602007; Uniprot ID:CRKL_HUMAN; ENSEMBL ID: ENSG00000099942; HGNC ID: 2363
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by PDGF
Signaling in Immune system
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200178Paxillin-independent events mediated by a4b1 and a4b7
200128Neurotrophic factor-mediated Trk receptor signaling
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200157EPO signaling pathway
200084IGF1 pathway
200140PDGFR-alpha signaling pathway
200110IFN-gamma pathway
200117Paxillin-dependent events mediated by a4b1
200051Reelin signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
2166Influenza
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of CRKL proteindecreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of CRKL mRNAaffects expression 17331233
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CRKL mRNAaffects cotreatment|decreases expression 16054899
C479799 (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of CRKL mRNAdecreases expression 15528975
D004958 Estradiol Estradiol affects the expression of CRKL mRNAaffects expression 14699072
C097613 imatinib imatinib results in decreased phosphorylation of CRKL proteindecreases phosphorylation 17432977
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CRKL mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CRKL mRNAaffects cotreatment|decreases expression 16054899
D014212 Tretinoin [CRKL gene mutant form co-treated with TBX1 gene mutant form] affects the abundance of Tretinoinaffects abundance|affects cotreatment 16399080
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple imatinib 5.4618322153
MESH:D000022 Abortion, Spontaneous imatinib 6.5318322153
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8919621015
MESH:D001169 Arthritis, Experimental Dexamethasone 7.9217659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.9216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116197459 16206674
MESH:D001859 Bone Neoplasms imatinib 5.5515867366
MESH:D001943 Breast Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 2.1415528975
MESH:D001943 Breast Neoplasms Estradiol 2.1417261762 19861407 16675129 17018787 14630087 18497071 12948864 17289903
MESH:D001943 Breast Neoplasms imatinib 2.1417614352
MESH:D001943 Breast Neoplasms Tretinoin 2.1416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.091917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.1817728286
MESH:D019465 Craniofacial Abnormalities imatinib 4.1818322153
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.1817551590 14991402 16925845 9664655 10589399 9211117 9125849 9142499 8800419 9224671
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.6612438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4817446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9812642470
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D003967 Diarrhea Dexamethasone 3.937237001
MESH:D004062 DiGeorge Syndrome marker/mechanism 16399080
MESH:D004485 Eczema Dexamethasone 4.7012438553
MESH:D004487 Edema Dexamethasone 13.0919703484
MESH:D004487 Edema imatinib 13.0919703484
MESH:D004487 Edema rosiglitazone 13.0912083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.8411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8416569247
MESH:D005124 Eye Abnormalities Tretinoin 3.7316938888 9664655
MESH:D005234 Fatty Liver rosiglitazone 4.1419196556
MESH:D018222 Fibromatosis, Aggressive imatinib 5.9317453242
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9914991402 9664655
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.137520565
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia rosiglitazone 8.6212083418
MESH:D006930 Hyperalgesia Tretinoin 8.6216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Dexamethasone 3.0017042910
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.7618306037
MESH:D007249 Inflammation Dexamethasone 5.878960868 11099482
MESH:D007249 Inflammation rosiglitazone 5.8712083418
MESH:D007333 Insulin Resistance Estradiol 8.0516627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 8.0516306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.7618306037
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1515610895
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 4.9217301526 15107311 15748426 19208803
MESH:D007951 Leukemia, Myeloid imatinib 10.6617236224
MESH:D007951 Leukemia, Myeloid Tretinoin 10.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817294898 16140955 17649720 17368321 19075265 9834237 17339181 17506722 16788101 12679006 17107899 15748426 16823087 17217047 19642359 16331271 19035177 16766008 19029980 17712046 19225113 16935935 17361223 16891316 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 7.0216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.0214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental imatinib 7.0216596278
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 7.0215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.0216248980 18397230
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2817365036
MESH:D008175 Lung Neoplasms Dexamethasone 3.3511195469 15824018
MESH:D008175 Lung Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 3.3515528975
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6711807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.6716827153
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2518303189 16166281 16966607
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5517261469
MESH:D009101 Multiple Myeloma Dexamethasone 3.6515867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.909809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9017596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009362 Neoplasm Metastasis imatinib 4.0815867366
MESH:D009369 Neoplasms Tretinoin 2.4916594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.7817614352
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.4811399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.489125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D010014 Osteolysis imatinib 6.0215867366
MESH:D010051 Ovarian Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 8.4315528975
MESH:D010051 Ovarian Neoplasms Estradiol 8.4319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 8.4316936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1510923243
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 8.4121297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 8.4112476293
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0917365031 15814490 17975199 17322281
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2418379247 11700416
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013272 Stomach Diseases Dexamethasone 4.6015472012
MESH:D013274 Stomach Neoplasms imatinib 2.9915786421
MESH:D013274 Stomach Neoplasms Tretinoin 2.9917261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.6915138204
MESH:D013964 Thyroid Neoplasms imatinib 8.2216940797
MESH:D013964 Thyroid Neoplasms Tretinoin 8.2216026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Dexamethasone 5.131336536
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:04012 ErbB signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:04910 Insulin signaling pathway
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
KEGG:05131 Shigellosis
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26881
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    PA448948chloroquine
    PA10804imatinib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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