AutismKB 2.0

Annotation Detail for S100A16


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Basic Information Top
Gene Symbol:S100A16 ( DT1P1A7,MGC17528,S100F )
Gene Full Name: S100 calcium binding protein A16
Band: 1q21.3
Quick LinksEntrez ID:140576; OMIM: NA; Uniprot ID:S10AG_HUMAN; ENSEMBL ID: ENSG00000188643; HGNC ID: 20441
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of S100A16 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of S100A16 mRNAaffects expression 21346803
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of S100A16 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of S100A16 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of S100A16 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of S100A16 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of S100A16 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of S100A16 mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of S100A16 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of S100A16 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9418815881 19066611 20544844 21152245 19011961 17261762 19189210 11161223 19189212 17242785 15565566 19487384 18855134 20065188 19084267 19244106 16873071 19410462 15668708 18629630 17893378 19103187 17440819 19059307 16202921 17049068 18351453 18997820 19115204 18984771 20859285 18821012 19221464 20005174 16273361 19155303 18425577 19142967 20135344 19288272 16818667 20390343 19200415 21138602 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.083786805 15700767 18705752 16227642 16124888 15721981 16011737 16050911 16097048 16192424 10355542 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8318788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8316924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3317110522 16105132 15861022 16919318 11677210 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 15668235 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.6818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.6810092053 4309450 3732212 16227642 6884620 6623471 2869522 19085960 15027814 7440962 19336974 16177239 21278145 11566570 7179309 9327722 7120509 15968718 10915739 15998439 3786805 17522070
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.6815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1917893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8612631006 19224547 15959796 12795759 16239168 17595544 61145 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8615345470
MESH:D005234 Fatty Liver pirinixic acid 20.8619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 20.8619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.3019176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3012621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 8697196 16354765 15340226 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.8116306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.8114714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.6118625569
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 17334410 17157831 21278145 16239168 11408273 16221502 17174718 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1117525996 17976157 15673190 18006644 11481614 14748882 16027843 14620537 17944888 18472332 16116963 17761835 18429990 15818738 17631135 15925388 18339082 17698563 18205269 15931870 12741479 18166357 18279442 12389079 12958196 12546737 14724832 18412020 18418968 14716496 12632512 14716833 17721639 15370692 18317297 17922224 16192424 18395095 18210741 17869086 12632514 18472094 15057751 17708605 17805973 16033810 17766677 16011737 15123356 18376398 15650968 18420326 16248980 16136751 15338365 18251166 15730626 12649538 13678700 18395914 15876570 17823541 15362042 12609069 18705752 12898905 15996030 18263696 12586293 12445418 17640975 16638106 18187930 17557913 12445421 17481882 15893842 16097048 17565644 18277467 18156304 12666154 12667390 16015684 10355542 14512876 20821823 15052691 15959796 17900296 18054572 17714472 18481824
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1317285989 15830285 16246199 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.087678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.0819294768
MESH:D008113 Liver Neoplasms pirinixic acid 15.0820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 15.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.616135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6112151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7611731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7717572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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