AutismKB 2.0

Annotation Detail for SLC32A1


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Basic Information Top
Gene Symbol:SLC32A1 ( VGAT,VIAAT )
Gene Full Name: solute carrier family 32 (GABA vesicular transporter), member 1
Band: 20q11.23
Quick LinksEntrez ID:140679; OMIM: NA; Uniprot ID:VIAAT_HUMAN; ENSEMBL ID: ENSG00000101438; HGNC ID: 11018
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Synaptic Transmission
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
No data
Pathway IDPathway Name
500333Transport of inorganic cations/anions and amino acids/oligopeptides
500516Amino acid and oligopeptide SLC transporters
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC32A1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC32A1 mRNAdecreases expression 16644059
D000431 Ethanol Ethanol results in increased expression of SLC32A1 mRNAincreases expression 15729141
D005419 Flavonoids Flavonoids results in increased expression of SLC32A1 mRNAincreases expression 18035473
C030691 gluconic acid gluconic acid results in decreased expression of SLC32A1 mRNAdecreases expression 16556975
D012978 Sodium Oxybate SLC32A1 protein affects the uptake of Sodium Oxybateaffects uptake 15745703
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.3818926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 12.0618287403
MESH:D000138 Acidosis Ethanol 12.0611192467
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.8415451039 15451040
MESH:D000853 Anophthalmos Ethanol 5.2415513904
MESH:D001008 Anxiety Disorders Ethanol 4.2611141031
MESH:D002056 Burns Ethanol 5.0716374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016227642 15700767 16011737 16124888 15673190 16050911 16097048 10355542 16192424 15721981 18705752 3786805
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3418788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.3418788625 15763234 15289165
MESH:D006332 Cardiomegaly Ethanol 3.5919332462
MESH:D002971 Cleft Lip Ethanol 3.7315513904
MESH:D002972 Cleft Palate Ethanol 3.2815513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3411873399 15513904 11198716 19302082 10194807 15451039 15451040
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.3721278145 15968718 10915739 16227642 10092053 6884620 2869522 19336974 15027814 19085960 17522070 16177239 4309450 11566570 3732212 7120509 6623471 9327722 7440962 15998439 3786805 7179309
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.3711566570
MESH:D004832 Epilepsy, Absence Sodium Oxybate 6.706254150
MESH:D004938 Esophageal Neoplasms Ethanol 2.8116704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.1316045604 12795759 16239168 19224547 17595544 12631006 15959796 61145
MESH:D005234 Fatty Liver Ethanol 9.1319236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.1917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.7610194807 16946407 15451040 15513904
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D005756 Gastritis Ethanol 5.2115046732
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006930 Hyperalgesia Ethanol 3.9718783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Flavonoids 2.7917296493
MESH:D007569 Jaw Abnormalities Ethanol 4.7315513904
MESH:D007859 Learning Disorders Ethanol 4.6315451040
MESH:D017880 Limb Deformities, Congenital Ethanol 4.0317676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.3317157831 16239168 16943688 17174718 21278145 11408273 17334410 11903743 16221502
MESH:D008103 Liver Cirrhosis Ethanol 7.3315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.5618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7512445421 16011737 18277467 18705752 12546737 17976157 18472332 12609069 17708605 17565644 15730626 12649538 17631135 18395095 12632512 16638106 18156304 11481614 18418968 18472094 17525996 18263696 15362042 16097048 14716496 15931870 18205269 15650968 17721639 17869086 18412020 17944888 14620537 18317297 18187930 18166357 10355542 17922224 17698563 16033810 12667390 14724832 12632514 17481882 15673190 15959796 12389079 18420326 17766677 20821823 18210741 12586293 12898905 15057751 16192424 16136751 14748882 16116963 15123356 18481824 18339082 12958196 18006644 14716833 15925388 18054572 16015684 12741479 18395914 15893842 17761835 15996030 18279442 17900296 17805973 12445418 18429990 15052691 15818738 17823541 16248980 17557913 16027843 15338365 12666154 15370692 13678700 17640975 17714472 14512876 18376398 18251166 15876570
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.7518166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 15830285 15720792 17285989 16246199
MESH:D008108 Liver Diseases, Alcoholic Ethanol 5.0717207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3119294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7912014681 15583823
MESH:D008569 Memory Disorders Ethanol 4.5715451040 18411066
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0612384795
MESH:D012640 Seizures Ethanol 3.379754883
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 3.8516755016 9211565 17189318 17918041 11906479 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.569754883
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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