AutismKB 2.0

Annotation Detail for CRY1


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Basic Information Top
Gene Symbol:CRY1 ( PHLL1 )
Gene Full Name: cryptochrome 1 (photolyase-like)
Band: 12q23.3
Quick LinksEntrez ID:1407; OMIM: 601933; Uniprot ID:CRY1_HUMAN; ENSEMBL ID: ENSG00000008405; HGNC ID: 2384
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
No data
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CRY1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of CRY1 mRNAdecreases expression 20406850
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CRY1 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CRY1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CRY1 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of CRY1 mRNAincreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CRY1 mRNAincreases expression 19031421
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CRY1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRY1 mRNAaffects cotreatment|increases expression 17942748
D008694 Methamphetamine Methamphetamine results in decreased expression of CRY1 mRNAdecreases expression 19149911
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CRY1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CRY1 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CRY1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRY1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRY1 mRNAincreases expression 17942748
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of CRY1 mRNAincreases expression 19031421
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2620127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.2616033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D000236 Adenoma Dimethylnitrosamine 7.0919555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216192424 16050911 3786805 15721981 10355542 15700767 16124888 16227642 18705752 15673190 16011737 16097048
MESH:D002277 Carcinoma Dimethylnitrosamine 8.6519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8520419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.8516033868
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.8518922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.586135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8216919318 11677210 16105132 17110522 17681005 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 15668235 8697196 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.3519336974 16227642 7440962 2869522 19085960 4309450 16177239 9327722 11566570 21278145 10092053 15968718 15027814 17522070 3786805 7120509 10915739 6623471 7179309 15998439 3732212 6884620
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 12.358172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 12.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1111000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 12.119599246 8273558 8113982 15177302 7812673 16716910 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4416530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.4417016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.6816239168 19224547 15959796 16045604 12631006 17595544 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 19.6819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.6815345470
MESH:D005234 Fatty Liver pirinixic acid 19.6819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.5518705752
MESH:D005355 Fibrosis Cyclosporine 15.5512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006948 Hyperkinesis Methamphetamine 5.6617658665
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.348273558 15177302 7562506 7812673 11698051
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4018776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism 16999817
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8621278145 11408273 17174718 17157831 17334410 16221502 11903743 16943688 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0515673190 18420326 10355542 17869086 18279442 12445418 15338365 14748882 18395914 17900296 17557913 16136751 16027843 18472332 15730626 17708605 15996030 17922224 17721639 17714472 18429990 18054572 12741479 15818738 16248980 17976157 12546737 18006644 18412020 17805973 18210741 12649538 12898905 16097048 18205269 12609069 12586293 17481882 12632514 15052691 14724832 16015684 16116963 17698563 18705752 12666154 15057751 12389079 18156304 16638106 17640975 18277467 12445421 17761835 17944888 18395095 18317297 17823541 17565644 18251166 15876570 18376398 18481824 15931870 18166357 15370692 17766677 14716496 13678700 16033810 15123356 14620537 15362042 14512876 18339082 18472094 18187930 15925388 16011737 18418968 14716833 18263696 12958196 17525996 20821823 11481614 15650968 15893842 12667390 12632512 16192424 17631135 15959796
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 5.0517666798 15793283 15298665 15723089 15942678 15744066 15366600 16603200 15339415 15591649 15067225 14643895 17036385 16627068 16544323 15369754 17465448 17203207 17196135 18567088 17881167 14726149 15733078 14568256 14709902 17201889 17640959 15383259 15161499 16570917 15798949 18629640 12918455 15504291 15492853 16009107 18637143 18239293 15086199 17432682 18237412 17719030 17348192 15577212 18371158 15763062 12925901 15099470 14659978 15081153 15479170 18364076 16042886 17724770 18672772 16169303 15864749 15571005 15138612 17198567 15842777 18095165 18210741 16270385 17534399
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015830285 15720792 17285989 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1914706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 10.1917457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.507678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.5020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.5019294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 18.5015890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 18.5015890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.5016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.702876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.706150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9820135361 18816296 18569708 20464547 6695378 20064080 17053015 20869020 18520028
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.9811884234 16061637 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.9811807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.428985016
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.438330346 12065085 18404319 18922899
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7616192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.7618404319 8985016 8330346 12065085 11807781
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.4412587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6120155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6116033868
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26904
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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