Annotation Detail for MACROD2
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D016604 |
Aflatoxin B1 |
Aflatoxin B1 affects the expression of MACROD2 protein | affects expression | 20106945
|
| D000638 |
Amiodarone |
Amiodarone results in increased expression of MACROD2 mRNA | increases expression | 19774075
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of MACROD2 mRNA | decreases expression | 20106945
|
| D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of MACROD2 mRNA | decreases expression | 20106945
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.06 | 20464547 20127859 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.86 | 6695378 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.64 | 19183758 |
| MESH:D001145 |
Arrhythmias, Cardiac |
|
Amiodarone |
4.20 | 18057881 20041841 18218290 |
| MESH:D001281 |
Atrial Fibrillation |
|
Amiodarone |
4.20 | 18651412 19698954 |
| MESH:D001321 |
Autistic Disorder |
marker/mechanism |
|
| 20663923 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Amiodarone |
4.32 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.99 | 20146248 17474063 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Aflatoxin B1 |
1.99 | 12619106 21507988 12907637 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
| MESH:D002311 |
Cardiomyopathy, Dilated |
|
Amiodarone |
3.00 | 19225199 15710769 |
| MESH:D002341 |
Carotid Artery Thrombosis |
|
Amiodarone |
5.72 | 18974383 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.79 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.21 | 19486331 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Amiodarone |
2.47 | 18218290 15265979 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.08 | 16530937 |
| MESH:D005234 |
Fatty Liver |
|
Amiodarone |
9.28 | 14986274 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
9.28 | 19224547 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.70 | 12639820 12168785 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.85 | 8708960 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.83 | 20471113 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.05 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
Amiodarone |
4.31 | 15265979 |
| MESH:D006937 |
Hypercholesterolemia |
|
Amiodarone |
4.30 | 8137927 9751232 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.21 | 10903974 |
| MESH:D007037 |
Hypothyroidism |
|
Amiodarone |
5.08 | 17991464 18020914 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.16 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.54 | 18776723 10903974 8314463 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.08 | 12371664 |
| MESH:D008064 |
Lipidoses |
|
Amiodarone |
3.79 | 17567588 15342952 |
| MESH:D008113 |
Liver Neoplasms |
|
Aflatoxin B1 |
4.97 | 18177683 2125692 15890375 9163691 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.97 | 21137059 20195826 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Aflatoxin B1 |
2.96 | 8603461 |
| MESH:D008133 |
Long QT Syndrome |
|
Amiodarone |
3.89 | 17391786 15350150 11989578 |
| MESH:D008171 |
Lung Diseases |
|
Amiodarone |
3.62 | 12587719 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Amiodarone |
5.20 | 18516814 |
| MESH:D008175 |
Lung Neoplasms |
|
Aflatoxin B1 |
2.50 | 14755239 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
2.50 | 18569708 20064080 18816296 17053015 20135361 20869020 20464547 6695378 18520028 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.51 | 16801185 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.50 | 16381670 |
| MESH:D009181 |
Mycoses |
|
Amiodarone |
5.62 | 12754197 17974566 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.33 | 11141357 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.16 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.65 | 19348381 18481113 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.59 | 12371664 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.91 | 17292933 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.33 | 16882103 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Amiodarone |
2.97 | 12490602 11597910 12832656 |
| OMIM:609620 |
SHORT QT SYNDROME 1 |
|
Amiodarone |
5.72 | 18724381 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.52 | 19755658 10029692 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 2093021 20155912 |
| MESH:D013276 |
Stomach Ulcer |
|
Amiodarone |
3.74 | 18087811 |
| MESH:D013610 |
Tachycardia |
|
Amiodarone |
4.80 | 11238279 |
| MESH:D017180 |
Tachycardia, Ventricular |
|
Amiodarone |
4.70 | 19225199 |
| MESH:D013959 |
Thyroid Diseases |
|
Amiodarone |
5.48 | 19731979 |
| MESH:D013971 |
Thyrotoxicosis |
|
Amiodarone |
5.42 | 18020914 19584973 |
| MESH:D016171 |
Torsades de Pointes |
|
Amiodarone |
4.82 | 17467628 11989578 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.30 | 17053015 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.71 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.16 | 17120751 |
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