AutismKB 2.0

Annotation Detail for CRY2


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Basic Information Top
Gene Symbol:CRY2 ( FLJ10332,HCRY2,KIAA0658,PHLL2 )
Gene Full Name: cryptochrome 2 (photolyase-like)
Band: 11p11.2
Quick LinksEntrez ID:1408; OMIM: 603732; Uniprot ID:CRY2_HUMAN; ENSEMBL ID: ENSG00000121671; HGNC ID: 2385
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
Pathway IDPathway Name
200068Circadian rhythm pathway
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
fasting glucose-related traits
METABOLIC
Desease Name
Fasting glucose-related traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CRY2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CRY2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CRY2 mRNAincreases expression 20458559
C018021 cobaltous chloride cobaltous chloride results in decreased expression of CRY2 mRNAdecreases expression 20105288
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CRY2 mRNAdecreases expression 16807920
C006253 pirinixic acid pirinixic acid results in increased expression of CRY2 mRNAincreases expression 17426115
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of CRY2 mRNAincreases expression 19122877
C009250 sevoflurane sevoflurane affects the expression of CRY2 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRY2 mRNAincreases expression 18295293
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 2.5218855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.5220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.117296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1114691202 15553829 15073043 11135700 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 8697196 15668235 15340226 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 8.142524372 11906362 18759878 12868966 11298694 8156756 8970840 14531868
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 8.1411298694 15059100 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.869653073 18692083 7440962 9328219 18648102 6679447 9022650 6482804 16192314 11289319 1440618 18289764 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.623581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 8.4115073043
MESH:D005234 Fatty Liver pirinixic acid 8.4119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 16959395 15340226 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007859 Learning Disorders sevoflurane 5.0319212262
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism 16999817
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 17050201 19850784 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3419642359 17217047 19035177 17869043 17712046 15622746 16891316 15748426 17107899 11161223 19075265 16331271 15213294 12018890 12712474 19225113 11468182 12679006 16112521 17649720 9834237 16823087 15336539 16966277 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7514682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.7515890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.516587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3419825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 4.3315318939
MESH:D008569 Memory Disorders sevoflurane 4.9919212262
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2511468182 15949261 19417148 14977855 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.686679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6810525206
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.683712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6819014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3112973940 20435036 11780464 12845720
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26905
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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