AutismKB 2.0

Annotation Detail for TRPM6


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Basic Information Top
Gene Symbol:TRPM6 ( CHAK2,HMGX,HOMG,HOMG1,HSH )
Gene Full Name: transient receptor potential cation channel, subfamily M, member 6
Band: 9q21.13
Quick LinksEntrez ID:140803; OMIM: 607009; Uniprot ID:TRPM6_HUMAN; ENSEMBL ID: ENSG00000119121; HGNC ID: 17995
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Serum magnesium levels
Desease Name
Hypomagnesemia with secondary hypocalcemia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038237 1-oleoyl-2-acetylglycerol Gadolinium inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
C038237 1-oleoyl-2-acetylglycerol Lanthanum inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
C038237 1-oleoyl-2-acetylglycerol TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Barium]affects reaction|increases transport 11988098
C038237 1-oleoyl-2-acetylglycerol TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]affects reaction|increases transport 11988098
C038237 1-oleoyl-2-acetylglycerol TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]affects reaction|increases transport 11988098
C075809 1-stearoyl-2-arachidonoylglycerol TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Barium]affects reaction|increases transport 11988098
C075809 1-stearoyl-2-arachidonoylglycerol TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Calcium]affects reaction|increases transport 11988098
D001464 Barium TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Barium]affects reaction|increases transport 11988098
D001464 Barium TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Barium]affects reaction|increases transport 11988098
D002118 Calcium Gadolinium inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
D002118 Calcium Lanthanum inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
D002118 Calcium TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]affects reaction|increases transport 11988098
D002118 Calcium TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Calcium]affects reaction|increases transport 11988098
D005682 Gadolinium Gadolinium inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
D007811 Lanthanum Lanthanum inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]affects reaction|decreases reaction|increases transport 11988098
D013324 Strontium TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]affects reaction|increases transport 11988098
D014810 Vitamin E Vitamin E results in decreased expression of TRPM6 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
OMIM:602014 HYPOMAGNESEMIA 1, INTESTINAL marker/mechanism
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007674 Kidney Diseases Vitamin E 2.9312488133
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.4216316344
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D010018 Osteomalacia Strontium 7.0916815919
MESH:D010024 Osteoporosis Calcium 3.9217882678
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D020521 Stroke Vitamin E 3.7116517955
Pathway ID Pathway Name
KEGG:04978 Mineral absorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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