AutismKB 2.0

Annotation Detail for SLC34A3


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Basic Information Top
Gene Symbol:SLC34A3 ( FLJ38680,HHRH,NPTIIc )
Gene Full Name: solute carrier family 34 (sodium phosphate), member 3
Band: 9q34.3
Quick LinksEntrez ID:142680; OMIM: 609826; Uniprot ID:NPT2C_HUMAN; ENSEMBL ID: ENSG00000198569; HGNC ID: 20305
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500340Type II Na+/Pi cotransporters
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of ion transport and metabolism
H00214Hypophosphatemic rickets
Genetic disorders
No data
No data
No data
Desease Name
Hypophosphatemic rickets with hypercalciuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SLC34A3 mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC34A3 mRNAaffects expression 16483693
D000431 Ethanol Ethanol results in decreased expression of SLC34A3 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC34A3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC34A3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC34A3 mRNAaffects cotreatment|increases expression 17942748
D010710 Phosphates SLC34A3 protein affects the transport of [Phosphates co-treated with Sodium]affects cotreatment|affects transport 16358215
C025299 polyphenols polyphenols results in decreased expression of SLC34A3 mRNAdecreases expression 16293270
D012964 Sodium SLC34A3 protein affects the transport of [Phosphates co-treated with Sodium]affects cotreatment|affects transport 16358215
D013629 Tamoxifen Tamoxifen affects the expression of SLC34A3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC34A3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC34A3 mRNAincreases expression 17942748
D014050 Toluene Toluene affects the expression of SLC34A3 mRNAaffects expression 18653662
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.2717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 11.2818287403
MESH:D000138 Acidosis Ethanol 11.2811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5815451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000853 Anophthalmos Ethanol 5.0415513904
MESH:D001008 Anxiety Disorders Ethanol 4.1411141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9419288272 19155303 21138602 19011961 19221464 16273361 20544844 18629630 18997820 20005174 17893378 18855134 19189212 18425577 17261762 20135344 17440819 18984771 20859285 16202921 16873071 19103187 16818667 18351453 19244106 17242785 18815881 19289846 18821012 11161223 20065188 19059307 21152245 19084267 19487384 15668708 17049068 19142967 19066611 19115204 20390343 19189210 19200415 15565566 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002056 Burns Ethanol 4.8716374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.2915763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Ethanol 7.1419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1416120746 18850075 18670907
MESH:D002547 Cerebral Palsy Toluene 6.099294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016919318 16105132 11677210 17333356 15861022 17110522 17681005
MESH:D002971 Cleft Lip Ethanol 3.6615513904
MESH:D002972 Cleft Palate Ethanol 6.1615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1615668235 15340226 16354765 12621046 8697196
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0519302082 11198716 11873399 15513904 15451039 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 4.059294310
MESH:D003643 Death Toluene 5.936431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.6211566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.6219370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1519155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms Ethanol 2.7916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethanol 14.2016409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2015345470
MESH:D005234 Fatty Liver Tamoxifen 14.2014986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9317920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5415451040 16946407 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Ethanol 4.9615046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Ethanol 3.8518783367
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
OMIM:241530 HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA, HEREDITARY marker/mechanism
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation polyphenols 8.8516366677
MESH:D007249 Inflammation Tamoxifen 8.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8512878042 12200463
MESH:D007569 Jaw Abnormalities Ethanol 10.7015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7016580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1918625569
MESH:D007859 Learning Disorders Ethanol 4.4215451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9317676605
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.4615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3318295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6118166357
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D008107 Liver Diseases polyphenols 2.8216698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8717207112 17347304
MESH:D008113 Liver Neoplasms Tamoxifen 4.5816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2919555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7314580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008569 Memory Disorders Ethanol 4.3918411066 15451040
MESH:D001523 Mental Disorders Phosphates 5.2412686366
MESH:D008607 Mental Retardation Toluene 3.709294310
MESH:D019957 Motor Skills Disorders Toluene 5.429294310
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures Ethanol 6.929754883
MESH:D012640 Seizures Toluene 6.929294310 6431079
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.709211565 17918041 16755016 11906479 17189318 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.429754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D013733 Testicular Diseases Toluene 5.1910048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.418653321 17572228 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134930298
    • No data
    Releated disease ID Related disease Name
    PA144997875Hereditary Hypophosphatemic Rickets with Hypercalciuria(HHRH)
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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