AutismKB 2.0

Annotation Detail for ASB14


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Basic Information Top
Gene Symbol:ASB14 ( DKFZp313L0121 )
Gene Full Name: ankyrin repeat and SOCS box-containing 14
Band: 3p14.3
Quick LinksEntrez ID:142686; OMIM: NA; Uniprot ID:ASB14_HUMAN; ENSEMBL ID: ENSG00000174844,ENSG00000239388; HGNC ID: 19766
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ASB14 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ASB14 mRNAdecreases expression 18648102
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ASB14 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ASB14 mRNA]decreases reaction|increases expression 17942915
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.433712494
MESH:D000236 Adenoma Diethylnitrosamine 7.436695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.6416434500 19061943 19052882 17162532 17620307 18056438
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.877296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8718971187 20432363 16830150 20101231 18665156 18691550 18978308 16779866 20512989 3084413 16328049 19107877 16698587 18210153 10737359 20524982 16502159 17162532 16540662 11831363 20514400 19052882 19418558 3581430 20727157 19519916 17978847 18056438 16569478 20935162 16935385 19335982 18506893 17428255 19919837 18494052 19701751 19383236 18788625 16681979 20214788 21159647 19208518 20084675 10672840 20007298 16878318 19394651 16288022 18785209 17173139 18393292 17055752 19822196 19171122 16807293 17138121 17761372 19539802
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.936135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.937505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.9321159647 17174075 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.1019052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4719486331 9022650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.6718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4414531868 8156756 11298694 11906362 8970840 12868966 2524372 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.023621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2720387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.8418648102 9328219 11289319 7440962 6482804 6679447 16192314 18692083 9653073 9022650 1440618 18289764 8291058
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.8419107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.9816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005234 Fatty Liver Diethylnitrosamine 3.6720387270 21071580
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007249 Inflammation Diethylnitrosamine 2.5718785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.676582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 3.0318407596 18522880 20032147 18665156 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.449327722 15034207
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1817034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.017678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0116942905 12112319 18754104 21278145 20501860 19426721 9163691 18977376 20118626 20101389 20405173 19499222 21047994 19638242 19427195 19254457 20492335 12771043 10737359 20137499 20452335 15175105 18644402 19690152 19073162 18648771 18978307 19850985 19256749 19294768 19812893 21071580 2422723 19996281 15885732 19551842 19833225 20434301 19642983 2862719 19255062 19090486 21167192 20583210
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.352876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.356587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.3518164116 19009564 19004024 16267830 3124819 19539802 18544905 19519916 17942915 17854601 21159647 9362446 18775883 2563599 18093689 16842330 18079962 18308698 19126423 18282651 18253720 17174075
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.776695378 20970405 21163286 20512841
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.607678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.173581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.179029167 3581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.7320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.9820387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.4116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.416482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5416540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.972563599
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8218551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.281399818 6587162 6582329 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.287505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.0610091137
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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