AutismKB 2.0

Annotation Detail for CRYGS


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Basic Information Top
Gene Symbol:CRYGS ( CRYG8 )
Gene Full Name: crystallin, gamma S
Band: 3q27.3
Quick LinksEntrez ID:1427; OMIM: 123730; Uniprot ID:CRBS_HUMAN; ENSEMBL ID: ENSG00000213139; HGNC ID: 2417
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Cataract, progressive polymorphic cortical
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CRYGS mRNAincreases expression 18648102
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CRYGS mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRYGS mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CRYGS mRNA]affects reaction|decreases expression 15016801
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRYGS mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of CRYGS mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5814692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5817638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Fluorouracil 9.8617963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.8611748828
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0219217205 18608205 16110121 16557594 18357371 15136595 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 9.1617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.1616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.217296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2118930000 17045692 17971768 16332177 16799960 17088986
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.977296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.9718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5717066447 16757204 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 18850075 16120746
MESH:D002386 Cataract marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.7419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7416919318 15861022 17681005 17110522 16105132 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215340226 16354765 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817016597 18772588 17287894 15001691 17169374 17725105 16340194 16510598 17018589 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 18802399 16391804 17695437 17594712 20501625 18949393 16524972 18448328 18383874 18288408 16331619 16282729 15148649 17016601 18509181 14970324 17094418 17401013 17255274 17454858 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2818759878 14531868 12868966 11906362 11298694 2524372 8970840 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9711289319 18289764 9328219 9022650 7440962 18692083 8291058 9653073 6482804 1440618 18648102 16192314 6679447
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.773581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7716481741 16337965 16785472 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6115102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16959395 8697196 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4217937319
MESH:D007248 Infertility, Male vinclozolin 7.4216467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.516582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5116985049
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.8617045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.421399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4212151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4315246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9016757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms Fluorouracil 2.7518600527 18239605 16928823
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7619003803 15113037 16500647 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3511399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.3519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3415538739 18286688 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017498489 18567086 16424979 15786421 17522103 18396642 16951190 19015929 17172411 19084572
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.151399818 6582329 3712494 7505956 6587162
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3416280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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