AutismKB 2.0

Annotation Detail for CRYM


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Basic Information Top
Gene Symbol:CRYM ( DFNA40,THBP )
Gene Full Name: crystallin, mu
Band: 16p12.2
Quick LinksEntrez ID:1428; OMIM: 123740; Uniprot ID:CRYM_HUMAN; ENSEMBL ID: ENSG00000103316; HGNC ID: 2418
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2207Deafness
No data
No data
Desease Name
Deafness, autosomal dominant 40
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CRYM mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CRYM mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of CRYM mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of CRYM mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CRYM mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CRYM mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CRYM mRNAdecreases expression 17557909
C041786 palm oil palm oil results in increased expression of CRYM mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CRYM mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CRYM mRNAincreases expression 19482888
19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CRYM mRNAaffects binding|increases activity|increases expression 19710929
C025299 polyphenols polyphenols results in decreased expression of CRYM mRNAdecreases expression 16293270
D013629 Tamoxifen Tamoxifen results in decreased expression of CRYM mRNAdecreases expression 15590111
D014635 Valproic Acid Valproic Acid results in increased expression of CRYM mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.056195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.836695378
MESH:D000236 Adenoma Diethylnitrosamine 6.836695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.3019061943 16434500 19052882 17162532 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.3017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.3016434500
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 18985861 19232924 17507914 19460635 18396377 18775368 18558336 16609825 15238991 18177632 18940202 17688650 20603192 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9619200415 19084267 21152245 21138602 17261762 19011961 19244106 17049068 20390343 17440819 18984771 11161223 20005174 19189212 19059307 19410462 20859285 20544844 19288272 19189210 16273361 15565566 19103187 19115204 20065188 18815881 18629630 19221464 18425577 19487384 16818667 16202921 18821012 18351453 20135344 17893378 17242785 15668708 19066611 19142967 18997820 18855134 19289846 16873071 19155303
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6918506893 18665156 17138121 20084675 16288022 20514400 17173139 17428255 21159647 16698587 11831363 18691550 20007298 3581430 19822196 19383236 19171122 16830150 17978847 19418558 20524982 10737359 16779866 20101231 16569478 18056438 18393292 10672840 20727157 19394651 16328049 18494052 16502159 18788625 19208518 20512989 19539802 19919837 3084413 17162532 17761372 19107877 19701751 19335982 17055752 18971187 18210153 18978308 20214788 19519916 16935385 16681979 19052882 20432363 16540662 20935162 18785209 16878318 16807293
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6917173139 6705139 20007298 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8517174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8217110522 11677210 15861022 17333356 17681005 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 8888407 17688650
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2714550746 19416960 18713872 15968718 17562736 11743745 10663392 10915739 19370779 18071297 11529661 19739265 16393943 12705907 12392966 16109766 19164858 11287661 2444490 11739529 12594235 16781746 19923254 16177239 12540782 19085960 12153990 14725611 16485898 11461765 14986274 16081117 15619225 17906064 11421492 17522070 11834606 12958197 16227642 10774834 19420014
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2719107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.2719370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.2719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 10.831851702
MESH:D004421 Dystonia Valproic Acid 10.831851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1117893378 19155303 16202921 20544844
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.263659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.2617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.563922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 10.563922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.8420417680
MESH:D004827 Epilepsy Valproic Acid 6.8418234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.196401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.196254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.777750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.777750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.003659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.003659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 38.9519224547
MESH:D005234 Fatty Liver Dietary Fats 38.9517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 38.9520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.9515345470
MESH:D005234 Fatty Liver pirinixic acid 38.9520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 38.9519224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 38.9514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 9.1612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.1618296743
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly Phenobarbital 8.9516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.9519176532 16221962 19772884 18467677
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 12.4620412841
MESH:D007249 Inflammation Diethylnitrosamine 12.4618785209
MESH:D007249 Inflammation polyphenols 12.4616366677
MESH:D007249 Inflammation Tamoxifen 12.4619457130
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 11.3618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3619638242 20032147 18407596 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 11.3621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008107 Liver Diseases Acetaminophen 9.6312587719 12969438 11587558 16611625 19014921 16610002 19460945 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 9.6317034775
MESH:D008107 Liver Diseases Phenobarbital 9.6319363144
MESH:D008107 Liver Diseases polyphenols 9.6316698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6520195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.6518648771 15885732 20101389 20118626 19426721 19427195 19254457 20434301 15175105 21167192 19690152 19255062 19812893 20492335 18644402 19850985 19294768 19090486 18754104 18978307 18977376 21047994 20137499 19551842 19499222 20405173 21278145 10737359 12771043 21071580 19638242 2862719 16942905 2422723 19073162 19833225 20452335 9163691 12112319 19256749 19996281 20583210 20501860 19642983
MESH:D008113 Liver Neoplasms Phenobarbital 14.6519482888 15975961 21047994 19073162 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 14.6520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.6516684651
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2017942915 18775883 19009564 19126423 17174075 18164116 18282651 18079962 16267830 18544905 18308698 18253720 19539802 19519916 18093689 9362446 16842330 3124819 2563599 21159647 17854601 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.202563599 17172636 18308698 1399818 6150874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4718816296 20064080 18569708 20135361 20464547 18520028 6695378 17053015 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.476695378 21163286 20970405 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 3.4718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6914580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.869029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity Dietary Fats 4.5211836018 21332399 20518802 18457598 16723640 20132043 17217161 18674790 19632207
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D011230 Precancerous Conditions Cyclosporine 15.8512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.852563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.852563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9820603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 12.7812752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.7811422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Phenobarbital 6.2516876388 11442880 4039156 3137016
MESH:D012640 Seizures Valproic Acid 6.2516876388 3137016 15475178 14763951 17978042 11044598 11738929 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4119755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.352093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3518456281
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.467505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.461399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1316712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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