AutismKB 2.0

Annotation Detail for CRYZ


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Basic Information Top
Gene Symbol:CRYZ ( DKFZp779E0834,FLJ41475 )
Gene Full Name: crystallin, zeta (quinone reductase)
Band: 1p31.1
Quick LinksEntrez ID:1429; OMIM: 123691; Uniprot ID:QOR_HUMAN; ENSEMBL ID: ENSG00000116791; HGNC ID: 2419
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C040756 1,2-naphthoquinone CRYZ protein results in increased reduction of 1,2-naphthoquinoneincreases reduction 1370456
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CRYZ mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNAdecreases expression 12419474
C005399 9,10-phenanthrenequinone CRYZ protein affects the metabolism of 9,10-phenanthrenequinoneaffects metabolic processing 9204392
C005399 9,10-phenanthrenequinone CRYZ protein results in increased reduction of 9,10-phenanthrenequinoneincreases reduction 1370456
D000082 Acetaminophen Acetaminophen affects the expression of CRYZ mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CRYZ proteinaffects expression 20106945
D019324 beta-Naphthoflavone AHR protein promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased activity of CRYZ proteinincreases activity 15297030
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of CRYZ mRNAincreases expression 15297030
D019324 beta-Naphthoflavone Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D019324 beta-Naphthoflavone Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D019324 beta-Naphthoflavone Lead inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D019324 beta-Naphthoflavone Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D019324 beta-Naphthoflavone Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D001564 Benzo(a)pyrene AHR protein promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased activity of CRYZ proteinincreases activity 15297030
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CRYZ mRNAincreases expression 15297030
D001564 Benzo(a)pyrene Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D001564 Benzo(a)pyrene Lead inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D001564 Benzo(a)pyrene Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D001564 Benzo(a)pyrene Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D016227 Benzoquinones CRYZ protein results in increased reduction of Benzoquinonesincreases reduction 1370456
D020122 tert-Butylhydroperoxide CRYZ protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 15003993
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CRYZ mRNAincreases expression 15336504
14729362
15003993
C012842 Cibacron Blue F 3GA Cibacron Blue F 3GA results in decreased activity of CRYZ proteindecreases activity 9204392
D009249 NADP NADP binds to and results in decreased activity of CRYZ proteinaffects binding|decreases activity 9204392
D009249 NADP NADP binds to and affects the activity of CRYZ proteinaffects activity|affects binding 1370456
D009249 NADP NADP inhibits the reaction [Ethylmaleimide results in decreased activity of CRYZ protein]decreases activity|decreases reaction 1370456
D009249 NADP NADP inhibits the reaction [Hydrogen Peroxide results in decreased activity of CRYZ protein]decreases activity|decreases reaction 1370456
D003300 Copper Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D003300 Copper Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D003300 Copper Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D003300 Copper Copper inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D003300 Copper Copper inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D003300 Copper Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D003300 Copper Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D003300 Copper Copper results in increased activity of CRYZ proteinincreases activity 15297030
D016572 Cyclosporine Cyclosporine results in decreased expression of CRYZ mRNAdecreases expression 20106945
D001728 Dicumarol Dicumarol results in decreased activity of CRYZ proteindecreases activity 9204392
D001728 Dicumarol Dicumarol inhibits the reaction [CRYZ protein results in increased reduction of 2,6-Dichloroindophenol]decreases reaction|increases reduction 1370456
D001728 Dicumarol Dicumarol results in decreased activity of CRYZ proteindecreases activity 1370456
D004041 Dietary Fats Dietary Fats results in decreased expression of CRYZ mRNAdecreases expression 18457598
D004041 Dietary Fats Dietary Fats results in increased expression of CRYZ mRNAincreases expression 15238619
D004228 Dithionitrobenzoic Acid Dithionitrobenzoic Acid results in decreased activity of CRYZ proteindecreases activity 1370456
D005033 Ethylmaleimide Ethylmaleimide results in decreased activity of CRYZ proteindecreases activity 1370456
D005033 Ethylmaleimide NADP inhibits the reaction [Ethylmaleimide results in decreased activity of CRYZ protein]decreases activity|decreases reaction 1370456
D005472 Fluorouracil Fluorouracil results in decreased expression of CRYZ mRNAdecreases expression 17982676
D005472 Fluorouracil TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CRYZ mRNA]decreases expression|decreases reaction 17982676
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased activity of CRYZ proteindecreases activity 1370456
D006861 Hydrogen Peroxide NADP inhibits the reaction [Hydrogen Peroxide results in decreased activity of CRYZ protein]decreases activity|decreases reaction 1370456
C005134 juglone CRYZ protein results in increased reduction of jugloneincreases reduction 1370456
D007854 Lead AHR protein promotes the reaction [Lead results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D007854 Lead Lead inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D007854 Lead Lead inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D007854 Lead Lead inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D007854 Lead Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D007854 Lead Lead promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D007854 Lead Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D007854 Lead Lead results in increased activity of CRYZ proteinincreases activity 15297030
D008628 Mercury Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008628 Mercury Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D008628 Mercury Mercury results in increased activity of CRYZ proteinincreases activity 15297030
D008748 Methylcholanthrene AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008748 Methylcholanthrene Copper inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D008748 Methylcholanthrene Copper inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D008748 Methylcholanthrene Lead inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D008748 Methylcholanthrene Lead promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008748 Methylcholanthrene Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D008748 Methylcholanthrene Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D008748 Methylcholanthrene Methylcholanthrene results in increased activity of CRYZ proteinincreases activity 15297030
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of CRYZ mRNAincreases expression 15297030
D009582 Nitrofurantoin Nitrofurantoin binds to and results in decreased activity of CRYZ proteinaffects binding|decreases activity 9204392
D009582 Nitrofurantoin Nitrofurantoin results in decreased activity of CRYZ proteindecreases activity 1370456
C059514 resveratrol resveratrol affects the expression of CRYZ mRNAaffects expression 15748624
D015086 2,6-Dichloroindophenol CRYZ protein results in increased reduction of 2,6-Dichloroindophenolincreases reduction 1370456
D015086 2,6-Dichloroindophenol Dicumarol inhibits the reaction [CRYZ protein results in increased reduction of 2,6-Dichloroindophenol]decreases reaction|increases reduction 1370456
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CRYZ mRNAdecreases expression 12377990
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D013749 Tetrachlorodibenzodioxin Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]decreases reaction|increases activity 15297030
D013749 Tetrachlorodibenzodioxin Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D013749 Tetrachlorodibenzodioxin Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]decreases reaction|increases expression 15297030
D013749 Tetrachlorodibenzodioxin Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D013749 Tetrachlorodibenzodioxin Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]increases activity|increases reaction 15297030
D013749 Tetrachlorodibenzodioxin Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]increases expression|increases reaction 15297030
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of CRYZ proteinincreases activity 15297030
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNAincreases expression 15297030
D014635 Valproic Acid Valproic Acid results in increased expression of CRYZ mRNAincreases expression 19101580
C104536 xanthohumol xanthohumol results in increased activity of CRYZ proteinincreases activity 17590382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6819490988
MESH:D058186 Acute Kidney Injury resveratrol 3.6016538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.1617638652
MESH:D000236 Adenoma Benzo(a)pyrene 14.716695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.7119389873
MESH:D000236 Adenoma Methylcholanthrene 14.716695378 10545420
MESH:D000236 Adenoma resveratrol 14.7115688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1016835633
MESH:D000544 Alzheimer Disease Copper 4.4517119284 16866297 16325427 16886094 16410023 16962711
MESH:D000544 Alzheimer Disease resveratrol 4.4516183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.9517688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 7.9510965797
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 7.9510694572
MESH:D000740 Anemia Fluorouracil 7.8815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.6316614410
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3517497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.6215238619
MESH:D001169 Arthritis, Experimental resveratrol 3.3317115116
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4211922910
MESH:D050197 Atherosclerosis resveratrol 6.4217967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Mercury 2.1617497416
MESH:D001321 Autistic Disorder Valproic Acid 2.1618558336 18396377 18985861 19232924 18316065 18940202 17157402 19460635 17507914 18177632 17688650 20603192 16609825 15238991 18775368
MESH:D001327 Autoimmune Diseases Mercury 4.6016634805
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.438888407
MESH:D002545 Brain Ischemia resveratrol 4.0017600658
MESH:D001932 Brain Neoplasms Copper 4.3117079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5817474063 20146248
MESH:D001943 Breast Neoplasms Copper 3.5817079463 15986119
MESH:D001943 Breast Neoplasms Dietary Fats 3.5820435547
MESH:D001943 Breast Neoplasms Fluorouracil 3.5815136595 18357371 16557594 16595493 16110121 19217205 18608205
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.5817474063
MESH:D001943 Breast Neoplasms resveratrol 3.5817651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5820435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3816051944
MESH:D002277 Carcinoma Fluorouracil 12.7217121937
MESH:D002277 Carcinoma Methylcholanthrene 12.7210545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.7216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.3516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.353084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.3521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.3516332177 17971768 17045692 16799960 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.3519321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0820419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.0817066447 16757204 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.0816227395
MESH:D002295 Carcinoma, Transitional Cell Nitrofurantoin 5.2215028437
MESH:D006332 Cardiomegaly Copper 6.5517327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5518850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.3610334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9516936243
MESH:D002318 Cardiovascular Diseases resveratrol 6.9515458977
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2112371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.2116192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Cyclosporine 2.7119486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915340226 8697196 15668235 12621046 16354765
MESH:D003092 Colitis resveratrol 3.8616474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7316340194 17018589 17172411 17169374 17287894 17016597 17725105 15001691 16510598 18772588
MESH:D003110 Colonic Neoplasms resveratrol 3.7316338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6117255274 20501625 18949393 18383874 15289873 16282729 16303861 15148649 14970324 16331619 17594712 18802399 17094418 17401013 17016601 18448328 18509181 17695437 17454858 16391804 18288408 16524972
MESH:D015179 Colorectal Neoplasms resveratrol 2.6116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D019465 Craniofacial Abnormalities Lead 3.7819769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7820055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7817688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7418551238
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D003704 Dementia Lead 5.0016140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.5316823706
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7316286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.1016081117 11287661 14986274 10663392 11421492 18713872 16109766 17906064 16227642 19739265 16393943 10915739 16781746 12153990 16485898 19420014 19085960 2444490 18071297 19923254 11461765 15619225 19416960 12540782 12958197 11739529 10774834 19164858 11834606 11743745 12705907 14550746 12392966 12594235 16177239 11529661 15968718 19370779 17522070 14725611 17562736
MESH:D056486 Drug-Induced Liver Injury Nitrofurantoin 11.101551546 19789166 19214031 8373174
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.1020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.101733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2618367378
MESH:D004421 Dystonia Valproic Acid 3.791851702
MESH:D004487 Edema resveratrol 6.058985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7617872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8817275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.633922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.366426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.793659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2316785472 16337965 17638652 15173087 16481741
MESH:D020329 Essential Tremor Lead 5.6518007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Cyclosporine 11.6919224547
MESH:D005234 Fatty Liver Dietary Fats 11.6917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Valproic Acid 11.6919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6016575769
MESH:D005317 Fetal Growth Retardation Lead 10.3619769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 10.368888407 18558336
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6610962813 14633661
MESH:D005355 Fibrosis Cyclosporine 13.1312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.1318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1320067830
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005910 Glioma Fluorouracil 2.7616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2018337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006521 Hepatitis, Chronic Copper 11.2417338147
MESH:D006521 Hepatitis, Chronic Nitrofurantoin 11.2414986274
MESH:D006527 Hepatolenticular Degeneration Copper 4.8917276780 19888908 17182432 16607473 17109627
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6216120746 15340226 12621046
MESH:D006561 Herpes Simplex resveratrol 3.9016876885
MESH:D006849 Hydrocephalus Valproic Acid 4.5917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 8.3921332399
MESH:D006937 Hypercholesterolemia resveratrol 8.3917188708
MESH:D006949 Hyperlipidemias Dietary Fats 8.4321332399
MESH:D006949 Hyperlipidemias resveratrol 8.4316873680
MESH:D006973 Hypertension Cyclosporine 4.5810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5818850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3717600658
MESH:D007248 Infertility, Male Lead 4.2016780224
MESH:D007249 Inflammation Dietary Fats 7.4920412841
MESH:D007249 Inflammation resveratrol 7.4916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.4912200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007333 Insulin Resistance Dietary Fats 2.9318457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 9.1712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.1718776723 10903974 8314463
MESH:D007674 Kidney Diseases Mercury 9.1717934191
MESH:D007676 Kidney Failure, Chronic Copper 9.5716518626
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.5716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.1116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1112371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.1116985049
MESH:D007855 Lead Poisoning Lead 5.6516700817
MESH:D007859 Learning Disorders Copper 9.5017134702
MESH:D007859 Learning Disorders Lead 9.5016384672
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4016087638
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7318296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2312878042
MESH:D008107 Liver Diseases Acetaminophen 4.3219784758 16611625 16610002 11587558 19014921 12587719 12969438 19460945
MESH:D008107 Liver Diseases Nitrofurantoin 4.3214966256
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9916871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.232125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.2320195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.2319389873 21295105
MESH:D008113 Liver Neoplasms Copper 20.2320302851
MESH:D008113 Liver Neoplasms Fluorouracil 20.2316603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms resveratrol 20.2319812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.2316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.748603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 12.7418164116
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.741399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7412151625
MESH:D008171 Lung Diseases Nitrofurantoin 4.6814966256 9429087
MESH:D017563 Lung Diseases, Interstitial Nitrofurantoin 10.8718516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.8717228818
MESH:D055370 Lung Injury Nitrofurantoin 5.061313237
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.2014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.2018569708 17053015 20464547 18520028 18816296 20135361 6695378 20064080 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 6.2015246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.2015390079 6695378 16337739 20512841 21163286 10545420 20970405 11893704 16271038 17909032 9230183 1399818 7750092
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9715688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 2.948985016 11606380
MESH:D008545 Melanoma resveratrol 2.3317992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008569 Memory Disorders Lead 4.9017263510 16384672
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.6017268249 17109627
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8316381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8316757204 18986760
MESH:D009101 Multiple Myeloma resveratrol 3.2716267019 17164350 16490592 17935668 14749477 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5917962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.788888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0017596541
MESH:D009203 Myocardial Infarction resveratrol 2.9116317513 16456233 17015251 17188708 16525036 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.2817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2812213967
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5818551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6111141357
MESH:D009369 Neoplasms Fluorouracil 4.6118239605 16928823 18600527
MESH:D009374 Neoplasms, Experimental resveratrol 3.738985016
MESH:D009389 Neovascularization, Pathologic Copper 4.6717308104
MESH:D009395 Nephritis, Interstitial Nitrofurantoin 5.4619214031
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0518481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.9516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6018514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6017652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1417929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D009765 Obesity Dietary Fats 2.2217217161 21332399 20518802 16723640 19632207 11836018 18457598 20132043 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1912819281 16049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0017513867
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.5715113037 16929163 16500647 19003803
MESH:D010212 Papilloma Hydrogen Peroxide 3.8212065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2211550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9912371664
MESH:D011248 Pregnancy Complications Nitrofurantoin 5.5319789166
MESH:D011297 Prenatal Exposure Delayed Effects Lead 21.0116384672
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 21.0116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.0111118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 21.0120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1917292933
MESH:D011471 Prostatic Neoplasms Copper 2.1917308104 17079463
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1918626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 2.1917804756 17675339 16731767 15767336 17636462 17718901
MESH:D019310 Pseudolymphoma Valproic Acid 4.2612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011654 Pulmonary Edema Nitrofurantoin 5.519429087
MESH:D011658 Pulmonary Fibrosis Nitrofurantoin 4.231551546
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7818722050 15538739 16160472 18286688
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury resveratrol 3.1417520802 16317513 16314181 17058453 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9219155313
MESH:D012559 Schizophrenia Copper 3.8016842975
MESH:D012559 Schizophrenia Valproic Acid 3.8019110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3218551238
MESH:D012640 Seizures Valproic Acid 5.3211044598 17978042 3137016 14763951 1511512 15475178 11738929 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.5219755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.5212065085
MESH:D012878 Skin Neoplasms resveratrol 16.5215837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.528532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.5216192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3520155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3518396642 17498489 16424979 17522103 19015929 17172411 16951190 19084572 18567086 15786421
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1816280240
MESH:D014062 Tongue Neoplasms resveratrol 9.1816227395
MESH:D014178 Translocation, Genetic Valproic Acid 4.9517262798
MESH:D014202 Tremor Lead 5.2121145352
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.243119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.8716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8717053015
MESH:D001749 Urinary Bladder Neoplasms Nitrofurantoin 7.8715028437
MESH:D014552 Urinary Tract Infections Nitrofurantoin 6.291551546
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.378888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0410091137
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.8016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.8017473185
MESH:D014594 Uterine Neoplasms resveratrol 3.8717044934
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Dietary Fats 3.5016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26925
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00266 antagonist Dicumarol Anticoagulants;Enzyme Inhibitors;Uncoupling Agents
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB04184 - Acetate Ion Indicators and Reagents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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