AutismKB 2.0

Annotation Detail for MPP7


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Basic Information Top
Gene Symbol:MPP7 ( FLJ32798 )
Gene Full Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Band: 10p12.1
Quick LinksEntrez ID:143098; OMIM: 610973; Uniprot ID:MPP7_HUMAN; ENSEMBL ID: ENSG00000150054; HGNC ID: 26542
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MPP7 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MPP7 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MPP7 mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of MPP7 mRNAincreases expression 19691856
D005472 Fluorouracil Fluorouracil results in decreased expression of MPP7 mRNAdecreases expression 16510598
C051890 irinotecan irinotecan analog results in increased expression of MPP7 mRNAincreases expression 18927307
C006253 pirinixic acid pirinixic acid results in increased expression of MPP7 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in decreased expression of MPP7 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MPP7 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5520127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Fluorouracil 9.3317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8317474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 1.8318608205 15136595 16557594 16110121 16595493 19217205 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2317088986 16332177 16799960 17045692 18930000 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8117066447 16280240 16757204 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0715001691 17287894 16510598 17018589 17725105 17172411 16340194 17016597 18772588 17169374
MESH:D003110 Colonic Neoplasms irinotecan 4.0717725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7717255274 20501625 16331619 17401013 14970324 16282729 15289873 17454858 18949393 16303861 18288408 18509181 17594712 18802399 18448328 18383874 17016601 15148649 16391804 16524972 17094418 17695437
MESH:D015179 Colorectal Neoplasms irinotecan 2.7716303861 18259882 15273666 17159606 17454858 16391804 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5016337965 16481741 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver pirinixic acid 2.9720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5215162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 18606429 16354765 16959395 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.982125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9820195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 14.9817045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 14.9820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.218603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020869020 20464547 20135361 17053015 6695378 18520028 20064080 18569708 18816296
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0618986760 16757204
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7611141357
MESH:D009369 Neoplasms Fluorouracil 8.7618600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.7617405874
MESH:D009410 Nerve Degeneration Rotenone 4.0418619942 17356569 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216500647 16929163 15113037 19003803
MESH:D010300 Parkinson Disease Rotenone 3.0416140633 11445065 18619942 15451049 18191903 11535288 19232380 19114014 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.2715795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6617292933
MESH:D011471 Prostatic Neoplasms Clorgyline 2.6619691856
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6618626508 19082440
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918722050 16160472 18286688 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.532093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5317522103 15786421 18396642 16951190 18567086 19015929 16424979 19084572 17498489 17172411
MESH:D013274 Stomach Neoplasms irinotecan 3.5315723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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