AutismKB 2.0

Annotation Detail for CS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CS ( - )
Gene Full Name: citrate synthase
Band: 12q13.3
Quick LinksEntrez ID:1431; OMIM: 118950; Uniprot ID:CISY_HUMAN; ENSEMBL ID: ENSG00000062485; HGNC ID: 2422
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
ANARESP1-PWYrespiration (anaerobic)
PWY-5690TCA cycle variation III (eukaryotic)
Pathway IDPathway Name
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
Pathway IDPathway Name
P02772Pyruvate metabolism
Pathway IDPathway Name
500713Citric acid cycle (TCA cycle)
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000171 Acrolein Acrolein binds to CS proteinaffects binding 17023561
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CS mRNAaffects expression 16483693
D002995 Clofibric Acid Clofibric Acid affects the expression of CS mRNAaffects expression 17602206
D003474 Curcumin Curcumin affects the expression of CS mRNAaffects expression 18539377
D003513 Cycloheximide Cycloheximide inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D003609 Dactinomycin Dactinomycin inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D003609 Dactinomycin Dactinomycin promotes the reaction [Endosulfan results in decreased activity of CS protein]decreases activity|increases reaction 15202864
D004726 Endosulfan Dactinomycin promotes the reaction [Endosulfan results in decreased activity of CS protein]decreases activity|increases reaction 15202864
D004726 Endosulfan Endosulfan results in decreased activity of CS proteindecreases activity 15202864
D004726 Endosulfan Endosulfan results in decreased expression of CS mRNAdecreases expression 15202864
D004726 Endosulfan Endosulfan results in decreased expression of CS proteindecreases expression 15202864
D004967 Estrogens Estrogens results in increased activity of CS proteinincreases activity 15994367
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CS mRNAincreases expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CS mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CS mRNAincreases expression 17557909
C017690 fenvalerate fenvalerate results in decreased activity of CS proteindecreases activity 15313449
D008694 Methamphetamine Methamphetamine results in increased expression of CS mRNAincreases expression 19149911
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CS mRNAincreases expression 17616710
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of CS proteindecreases expression 19474218
C006253 pirinixic acid pirinixic acid results in increased expression of CS mRNAincreases expression 18445702
18301758
D011794 Quercetin Quercetin results in decreased expression of CS proteindecreases expression 18095365
D013974 Thyroxine Cycloheximide inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D013974 Thyroxine Dactinomycin inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D013974 Thyroxine Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]decreases activity|decreases reaction 12658717
D013974 Thyroxine Thyroxine inhibits the reaction [Thiourea results in decreased expression of CS mRNA]decreases expression|decreases reaction 12658717
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CS mRNAdecreases expression 11489354
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of CS mRNAaffects cotreatment|decreases expression 19465110
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CS mRNAaffects cotreatment|increases expression 17942748
D013890 Thiourea Cycloheximide inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D013890 Thiourea Dactinomycin inhibits the reaction [Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]]decreases activity|decreases reaction 12658717
D013890 Thiourea Thiourea results in decreased expression of CS mRNAdecreases expression 12658717
D013890 Thiourea Thiourea results in decreased expression of CS proteindecreases expression 12658717
D013890 Thiourea Thyroxine inhibits the reaction [Thiourea results in decreased activity of CS protein]decreases activity|decreases reaction 12658717
D013890 Thiourea Thyroxine inhibits the reaction [Thiourea results in decreased expression of CS mRNA]decreases expression|decreases reaction 12658717
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CS mRNAaffects expression 21346803
C025643 vinclozolin vinclozolin affects the expression of CS mRNAaffects expression 19015723
D015215 Zidovudine Zidovudine affects the expression of CS mRNAaffects expression 20032539
D015032 Zinc Zinc results in increased expression of CS mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of CS mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0614514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.067525203
MESH:D000138 Acidosis Ammonium Chloride 10.1118287403
MESH:D000138 Acidosis Zinc Sulfate 10.117265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.679612607
MESH:D000169 Acrodermatitis Zinc 5.2516889938 17202136 17190629
MESH:D055371 Acute Lung Injury Acrolein 8.8121297076 20525806
MESH:D055371 Acute Lung Injury pirinixic acid 8.8118653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9317887948
MESH:D000544 Alzheimer Disease Acrolein 6.6615207723 14715435 17570602
MESH:D000544 Alzheimer Disease Curcumin 6.6615590663
MESH:D000544 Alzheimer Disease Zinc 6.6617119284 16410023 16325427 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1017084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.7516916123
MESH:D000860 Anoxia Zinc Sulfate 4.877265320
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D001161 Arteriosclerosis Acrolein 9.8215014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7016807698
MESH:D001249 Asthma Zinc 2.9117085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8215336622
MESH:D050197 Atherosclerosis Acrolein 6.8817363696 16126721 16037261
MESH:D050197 Atherosclerosis Curcumin 6.8818704882
MESH:D001327 Autoimmune Diseases Curcumin 10.3619761891
MESH:D001327 Autoimmune Diseases Quercetin 10.3619761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.3914601052
MESH:D001930 Brain Injuries Zinc 4.5417109824
MESH:D002545 Brain Ischemia Curcumin 4.1816770732
MESH:D001932 Brain Neoplasms Curcumin 3.8017596214
MESH:D001943 Breast Neoplasms Curcumin 1.9618593918 19250217 18462866 16243823
MESH:D001943 Breast Neoplasms Quercetin 1.9618628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002105 Cadmium Poisoning Quercetin 5.3916962696
MESH:D002277 Carcinoma Curcumin 7.8818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D006528 Carcinoma, Hepatocellular Estrogens 3.6215341023
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.6212508355 19519916
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9318414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8017234771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9118462866
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.9116543248
MESH:D006332 Cardiomegaly Quercetin 11.0719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.0718670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 11.0718093424
MESH:D002318 Cardiovascular Diseases Zinc 3.5616936243
MESH:D002386 Cataract Trinitrotoluene 3.7814694615 15817613
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3717110522 15861022 11677210 16105132 17333356 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Curcumin 4.0318200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.4118809619
MESH:D003110 Colonic Neoplasms Curcumin 3.9019359593 16340194
MESH:D003110 Colonic Neoplasms Quercetin 3.9019440933 11134977 19056647 17191121 16640504 17148506 15741050
MESH:D015179 Colorectal Neoplasms Acrolein 2.9717597105
MESH:D015179 Colorectal Neoplasms Quercetin 2.9718095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8417141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.8415095906
MESH:D016510 Corneal Neovascularization Curcumin 4.7518497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.6319302082
MESH:D016638 Critical Illness Estrogens 5.7916670151
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis Endosulfan 11.297900959
MESH:D003490 Cyanosis Trinitrotoluene 11.2918551238
MESH:D003556 Cystitis Acrolein 5.2412161096
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003920 Diabetes Mellitus Zinc 4.0716479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6119496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.2818403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.8818204486
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8820420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 3.8821346803 18551238
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8611462148
MESH:D004362 Drug Toxicity Zidovudine 7.8615040536
MESH:D004381 Duodenal Ulcer Curcumin 3.9017351913
MESH:D004417 Dyspnea Endosulfan 5.133388749 7900959
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004646 Emphysema Endosulfan 6.407900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7915150132 16510608 15623463 15878914 16805852 15547721 15547733 15264214 16704527
MESH:D004938 Esophageal Neoplasms Zinc 4.7916543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Curcumin 17.6719297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.6715345470
MESH:D005234 Fatty Liver pirinixic acid 17.6720131406 19236843
MESH:D005234 Fatty Liver Zidovudine 17.6718299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Curcumin 14.0118705752
MESH:D005355 Fibrosis Quercetin 14.0119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0120067830
MESH:D005756 Gastritis Zinc 4.6517241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5418462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005909 Glioblastoma Curcumin 11.5717596214
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 11.5717162496
MESH:D005909 Glioblastoma Quercetin 11.5719804834
MESH:D005910 Glioma Quercetin 3.0017643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006130 Growth Disorders Zinc 3.8717217573
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5518829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.8420558911
MESH:D006333 Heart Failure Zinc 6.8417162251
MESH:D006335 Heart Injuries Zinc 5.6217074742
MESH:D016481 Helicobacter Infections Zinc 4.3917241300
MESH:D006402 Hematologic Diseases Zidovudine 4.5712579204
MESH:D006470 Hemorrhage Endosulfan 9.987900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 9.9811000095
MESH:D006527 Hepatolenticular Degeneration Zinc 10.8117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.8117063115
MESH:D006529 Hepatomegaly fenvalerate 19.5415602828
MESH:D006529 Hepatomegaly pirinixic acid 19.5416221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.5415340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 19.5415817613
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8917701891
MESH:D015658 HIV Infections Zidovudine 3.4111141242 20032539 11363243 11698656 17358032
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16959395 8697196 18606429 16354765
MESH:D006937 Hypercholesterolemia Curcumin 3.9118704882
MESH:D006943 Hyperglycemia pirinixic acid 8.8020558911
MESH:D006943 Hyperglycemia Quercetin 8.8018262572 11834736
MESH:D006948 Hyperkinesis Methamphetamine 5.3517658665
MESH:D006973 Hypertension Quercetin 5.0318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.337265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Endosulfan 15.328588293 9432128
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.3217937319
MESH:D007248 Infertility, Male Trinitrotoluene 15.3212150543
MESH:D007248 Infertility, Male vinclozolin 15.3216467254
MESH:D007249 Inflammation Curcumin 4.8318403477 16956363 17151092
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1518596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.3616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.0910783313
MESH:D007511 Ischemia Zinc 4.4816584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007627 Keloid Quercetin 4.8017086741
MESH:D007674 Kidney Diseases Acrolein 9.9012488133
MESH:D007674 Kidney Diseases Quercetin 9.9016962696
MESH:D007674 Kidney Diseases Zinc 9.9016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2816518626
MESH:D007680 Kidney Neoplasms Zidovudine 3.6612579204
MESH:D007859 Learning Disorders Endosulfan 4.958157075
MESH:D007889 Leiomyoma Curcumin 4.4318555241
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.1415237267
MESH:D007938 Leukemia Curcumin 6.3818462866
MESH:D007938 Leukemia Quercetin 6.3817468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.5316106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.5320370541
MESH:D015458 Leukemia, T-Cell Curcumin 4.6116106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.8118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.8112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8112878042
MESH:D008107 Liver Diseases Curcumin 2.5816956363
MESH:D008113 Liver Neoplasms Clofibric Acid 10.2417602206
MESH:D008113 Liver Neoplasms pirinixic acid 10.2416377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 10.2418980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2416984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.6119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6112151625
MESH:D008171 Lung Diseases Acrolein 4.1111504702
MESH:D008175 Lung Neoplasms Curcumin 4.7616243823 19359593 18462866
MESH:D008175 Lung Neoplasms Quercetin 4.7616280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7619555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 4.7618800350
MESH:D008223 Lymphoma Curcumin 3.4818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5416173963
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2012773700
MESH:D008545 Melanoma Curcumin 2.3918462866 17885582
MESH:D008546 Melanoma, Experimental Acrolein 5.0610803710
MESH:D008569 Memory Disorders Curcumin 4.0117263510
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6917358032
MESH:D009101 Multiple Myeloma Curcumin 3.4119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.5219151258
MESH:D009203 Myocardial Infarction Quercetin 5.5219595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.0519207477
MESH:D009336 Necrosis Trinitrotoluene 4.6118551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2218495463
MESH:D009369 Neoplasms Acrolein 11.3917329238
MESH:D009369 Neoplasms fenvalerate 11.392895627
MESH:D009369 Neoplasms pirinixic acid 11.3917405874
MESH:D009369 Neoplasms Quercetin 11.3915185748
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3812497104
MESH:D009393 Nephritis Acrolein 6.1412653641
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4818462866
MESH:D019636 Neurodegenerative Diseases Acrolein 4.3911342003
MESH:D020078 Neurogenic Inflammation Quercetin 4.2217929310
MESH:D009765 Obesity Curcumin 4.4819297423
MESH:D009765 Obesity pirinixic acid 4.4820558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.2012819281 17852074 14694615
MESH:D010024 Osteoporosis Curcumin 3.3818719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0819495926
MESH:D010051 Ovarian Neoplasms Curcumin 5.0118462866 19020741
MESH:D010051 Ovarian Neoplasms Quercetin 5.0119005980
MESH:D010190 Pancreatic Neoplasms Curcumin 5.4019401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Quercetin 5.4016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010243 Paralysis fenvalerate 5.858952708
MESH:D010300 Parkinson Disease Acrolein 3.5417690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010787 Photosensitivity Disorders Acrolein 5.5911550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Quercetin 3.8519056647
MESH:D011225 Pre-Eclampsia Zinc 4.0617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9811399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.9818220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D011471 Prostatic Neoplasms Curcumin 2.8018226269 18769126 18156803 11398177 15129424 10851300 12497104
MESH:D011471 Prostatic Neoplasms Quercetin 2.8014715546 17292933
MESH:D011471 Prostatic Neoplasms Zinc 2.8016700911 16517595 16606632 12429649
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D011654 Pulmonary Edema Thiourea 5.7610849556
MESH:D011656 Pulmonary Emphysema Curcumin 4.3919168576
MESH:D051437 Renal Insufficiency Acrolein 4.8612732208
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration Zinc 4.0116584753
MESH:D012509 Sarcoma Curcumin 3.9818462866
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.9314601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.3916862918
MESH:D012640 Seizures Endosulfan 6.4210698677 7539098
MESH:D012640 Seizures Trinitrotoluene 6.4218551238
MESH:D018805 Sepsis Curcumin 3.9518389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.0515817613
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.8412958204 17575124
MESH:D013274 Stomach Neoplasms Zidovudine 2.8417696246
MESH:D013276 Stomach Ulcer Curcumin 3.3616631530 19188055
MESH:D020521 Stroke Acrolein 4.4316269634
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.8712697716
MESH:D013959 Thyroid Diseases Thyroxine 11.8719910387
MESH:D014062 Tongue Neoplasms Zinc 4.2616543248
MESH:D014202 Tremor fenvalerate 5.418952708
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.2318593936
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.2316720314
MESH:D014565 Urogenital Neoplasms Curcumin 5.1118462866
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6112579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014947 Wounds and Injuries Estrogens 4.6111172683
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:00630 Glyoxylate and dicarboxylate metabolism
KEGG:01100 Metabolic pathways
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01969 - Trifluoroacetonyl Coenzyme A
DB01992 - Coenzyme A
DB02637 - Oxaloacetate Ion
DB03182 - Alpha-Fluoro-Carboxymethyldethia Coenzyme a Complex
DB03499 - Malate Ion
DB04230 - Nitromethyldethia Coenzyme A
DB04272 - Citric Acid Anticoagulants;Chelating Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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