AutismKB 2.0

Annotation Detail for SESN3


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Basic Information Top
Gene Symbol:SESN3 ( MGC29667,SEST3 )
Gene Full Name: sestrin 3
Band: 11q21
Quick LinksEntrez ID:143686; OMIM: 607768; Uniprot ID:SESN3_HUMAN; ENSEMBL ID: ENSG00000149212; HGNC ID: 23060
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SESN3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SESN3 proteinaffects expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SESN3 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of SESN3 mRNAdecreases expression 20106945
D007501 Iron Iron deficiency results in decreased expression of SESN3 mRNAdecreases expression 20368581
D015735 Mifepristone Mifepristone results in increased expression of SESN3 mRNAincreases expression 17584828
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SESN3 mRNAaffects binding|decreases expression|increases activity 19710929
C410733 scriptaid scriptaid affects the expression of SESN3 mRNAaffects expression 18813790
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SESN3 mRNAincreases expression 16714409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SESN3 mRNAdecreases expression 20106945
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of SESN3 mRNAdecreases expression 17951470
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of SESN3 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000138 Acidosis Zinc Sulfate 5.107265320
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.8516640825
MESH:D000544 Alzheimer Disease Iron 3.0316563566 16640825
MESH:D000740 Anemia Iron 9.3716566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3711748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.7816569441 17375513 17147795 17163184 17162259
MESH:D000756 Anemia, Sideroblastic Iron 4.9516910769
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D000860 Anoxia Zinc Sulfate 5.217265320
MESH:D001145 Arrhythmias, Cardiac Iron 4.5016604332
MESH:D001260 Ataxia Telangiectasia Iron 5.6415336622
MESH:D050197 Atherosclerosis Iron 3.7816632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.3916640825
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516192424 15700767 16097048 16227642 18705752 15721981 10355542 3786805 16011737 15673190 16050911 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6512619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D009202 Cardiomyopathies Iron 4.1316640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5016604332
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms Iron 2.9116640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Iron 4.5816604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3916506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.6516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6517107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3418071297 19164858 11461765 17522070 18713872 16177239 14986274 19923254 19416960 15619225 17906064 11421492 11287661 2444490 12705907 16393943 16227642 19370779 14725611 10774834 12153990 11743745 11834606 16485898 16781746 17562736 10663392 11739529 12958197 12392966 19739265 19420014 10915739 16081117 12540782 19085960 15968718 12594235 14550746 11529661 16109766
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3415968718 3732212 16177239 3786805 6623471 10092053 10915739 7179309 11566570 15027814 17522070 6884620 16227642 19336974 7440962 7120509 21278145 2869522 4309450 19085960 9327722 15998439
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004715 Endometriosis Mifepristone 9.5916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.599294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.0015959796 19224547 12795759 61145 17595544 16239168 16045604 12631006
MESH:D005234 Fatty Liver Cyclosporine 20.0019224547
MESH:D005234 Fatty Liver Iron 20.0016640825
MESH:D005234 Fatty Liver pirinixic acid 20.0020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.7718705752
MESH:D005355 Fibrosis Cyclosporine 15.7712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7720067830
MESH:D005621 Friedreich Ataxia Iron 5.6016640825 16604332
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006432 Hemochromatosis Iron 4.5917053826 17236123 17255318 16640825 16574947 16604332
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006486 Hemosiderosis Iron 5.4316604332
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006525 Hepatitis, Viral, Human Iron 5.6916640825
MESH:D006527 Hepatolenticular Degeneration Iron 12.0017182432
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 12.0017063115
MESH:D006529 Hepatomegaly Iron 15.5616890145
MESH:D006529 Hepatomegaly pirinixic acid 15.5619772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.5616120746 12621046 15340226
MESH:D015658 HIV Infections Iron 3.7416597321
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 8697196 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007006 Hypogonadism Iron 4.5016640825
MESH:D007022 Hypotension Zinc Sulfate 4.627265320
MESH:D007037 Hypothyroidism Iron 5.2616640825
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D019189 Iron Metabolism Disorders Iron 5.1917163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.3815237267
MESH:D020961 Lewy Body Disease Iron 5.6016563566
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1811408273 11903743 16239168 17174718 21278145 17334410 16943688 17157831 16221502
MESH:D008103 Liver Cirrhosis Iron 7.1816640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4611481614 18187930 20821823 14716833 12666154 12958196 15925388 12586293 16015684 15730626 17805973 18420326 14748882 15338365 16097048 17766677 17944888 18156304 18006644 18339082 15818738 16027843 18481824 17708605 17714472 17631135 17698563 17640975 15052691 18279442 17900296 12445421 16638106 12609069 15057751 17525996 18705752 12632514 17922224 18429990 18210741 15123356 14620537 12667390 15650968 12741479 16116963 16192424 16248980 17721639 14512876 15673190 12389079 16011737 17823541 18418968 18395914 15959796 14724832 18205269 15370692 12632512 15893842 18263696 18054572 10355542 18317297 15876570 12445418 15362042 18472094 15996030 18166357 17976157 14716496 13678700 17557913 17761835 18277467 18395095 12546737 12898905 17565644 12649538 18376398 16033810 15931870 18412020 17481882 17869086 18472332 16136751 18251166
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0011587558 16611625 19014921 12587719 19784758 19460945 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0017285989 16246199 16964402 15720792 15830285
MESH:D008108 Liver Diseases, Alcoholic Iron 5.1816737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.772125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7719294768
MESH:D008113 Liver Neoplasms Iron 14.7716640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 14.7715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.308603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5814755239
MESH:D008175 Lung Neoplasms Iron 3.5816640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008268 Macular Degeneration Iron 4.0516640825
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.8917086897
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009181 Mycoses Iron 5.6916640825
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Iron 9.5516604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5512213967
MESH:D015428 Myocardial Reperfusion Injury Iron 8.9716604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9716411023
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.9018481113 19348381
MESH:D009404 Nephrotic Syndrome Iron 9.9017178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9118514411
MESH:D019636 Neurodegenerative Diseases Iron 8.9116604332 17296847
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010003 Osteoarthritis Iron 4.0416640825
MESH:D010024 Osteoporosis Iron 3.9416648989 16640825
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1616525653
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma Iron 4.6612065085
MESH:D020447 Parasomnias Iron 6.2417352947
MESH:D010300 Parkinson Disease Iron 3.3616563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Iron 5.8916604332
MESH:D011041 Poisoning Iron 4.4416604332
MESH:D017119 Porphyria Cutanea Tarda Iron 11.5716640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011225 Pre-Eclampsia Iron 4.5316640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11896295 11222880 11118676
MESH:D011528 Protozoan Infections Iron 6.2416640825
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012148 Restless Legs Syndrome Iron 4.6516930377
MESH:D012878 Skin Neoplasms Iron 6.0812065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0816192470
MESH:D013398 Sudden Infant Death Iron 5.6416640825
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014376 Tuberculosis Iron 4.1716597321
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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