AutismKB 2.0

Annotation Detail for CSF3R


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CSF3R ( CD114,GCSFR )
Gene Full Name: colony stimulating factor 3 receptor (granulocyte)
Band: 1p34.3
Quick LinksEntrez ID:1441; OMIM: 138971; Uniprot ID:CSF3R_HUMAN; ENSEMBL ID: ENSG00000119535; HGNC ID: 2439
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1848Embryoma
1873Neutropenia
2051Leukemia
2125Bladder cancer
No data
No data
Desease Name
Neutrophilia, hereditary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CSF3R mRNAdecreases expression 18648102
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of CSF3R mRNAaffects cotreatment|increases expression 18585445
D001151 Arsenic Arsenic results in decreased expression of CSF3R mRNAdecreases expression 19654921
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of CSF3R mRNAaffects cotreatment|increases expression 18585445
D004317 Doxorubicin CSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of CSF3R protein]decreases expression|decreases reaction 17334414
D004317 Doxorubicin Doxorubicin results in decreased expression of CSF3R proteindecreases expression 17334414
D004958 Estradiol Estradiol results in increased expression of CSF3R mRNAincreases expression 12469912
C027185 indirubin indirubin results in increased expression of CSF3R proteinincreases expression 16115123
D009151 Mustard Gas Mustard Gas results in decreased expression of CSF3R mRNAdecreases expression 16173061
D009151 Mustard Gas Mustard Gas results in increased expression of CSF3R mRNAincreases expression 15674843
D010126 Ozone Ozone results in decreased expression of CSF3R mRNAdecreases expression 17095637
D014212 Tretinoin Tretinoin results in increased expression of CSF3R mRNAincreases expression 16054129
7579340
C030665 triphenyltin triphenyltin results in increased expression of CSF3R mRNAincreases expression 12788061
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.6017418594
MESH:D000230 Adenocarcinoma Estradiol 4.6011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4211874814
MESH:D000419 Albuminuria Doxorubicin 4.7021441931
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D020261 Arsenic Poisoning Arsenic 2.9016835338 12569548 18414634 16251483
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7716292516
MESH:D001249 Asthma Mustard Gas 8.1910378619
MESH:D001249 Asthma Ozone 8.1916373670 17854713
MESH:D001249 Asthma Tretinoin 8.1916456186
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7516206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9214601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9417150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9415136595 18695136 15939500 16935488 19526202 17426702 17983394 16264153 17369602 15567936 18234424 15634643 16096432 16322301 16826403 15668708 15994142 15993339 16595493 18628466 18382427 11325840 15692762 16115903
MESH:D001943 Breast Neoplasms Estradiol 1.9412948864 17289903 17018787 17261762 19861407 16675129 18497071 14630087
MESH:D001943 Breast Neoplasms Tretinoin 1.9416873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7919059883 18315731 14754758 15516495 18417511 16777450 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0316051944
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.107296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.1017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.1016023760 17876044 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.101917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.757296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.751485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.8515504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.856189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D009202 Cardiomyopathies Doxorubicin 3.6217974986 18627295 16612575 16269455 16242529 16651473 17382496 17928571 15811867 15505089 16278810 15792986 16455267 17131338 16952015 16109756 17924179 16731534 17519947 16364871 17308081 17329180 17007740 17351982 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 3.5419152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.4318022660 16973168
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.977505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9718566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829224671 8800419 9142499 9125849 9211117 14991402 16925845 10589399 17551590 9664655
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9711298694 18759878 8970840 11906362 2524372 8156756 14531868 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1518648102 16192314 18289764 7440962 9653073 9328219 6482804 9022650 11289319 1440618 18692083 6679447 8291058
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.1517416283
MESH:D004362 Drug Toxicity Doxorubicin 3.7718602426
MESH:D004487 Edema Mustard Gas 3.4511428631 9260866 11428647 11402378
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 13.0017359293
MESH:D016889 Endometrial Neoplasms Estradiol 13.0011473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 13.0016569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3718037988
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005124 Eye Abnormalities Tretinoin 3.6816938888 9664655
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7819069698
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005909 Glioblastoma Doxorubicin 7.5417150277
MESH:D005909 Glioblastoma Tretinoin 7.5417312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.1515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.5817888722 16144979 12587719 18674790 16330681 16707910 16244372 16244371 16879835 17875725 16495754 18006777 14766674
MESH:D006333 Heart Failure Doxorubicin 3.4217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0415692506
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.5315147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia triphenyltin 5.8010522495
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006968 Hypersensitivity, Delayed indirubin 6.1511275354
MESH:D006973 Hypertension Arsenic 2.9116076760 11953799 9931084
MESH:D015228 Hypertriglyceridemia triphenyltin 6.0910522495
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007246 Infertility triphenyltin 6.1815205045
MESH:D007248 Infertility, Male Atrazine 3.8012948887
MESH:D007249 Inflammation Mustard Gas 2.8511428620 11428647 9260866 9357497 8975870 11402378 17524151 16001271 11428631
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007642 Keratosis Arsenic 5.1816930632 12749816
MESH:D007674 Kidney Diseases Doxorubicin 6.4515369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 6.4515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2916707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.756582329
MESH:D007680 Kidney Neoplasms Estradiol 7.7515610895
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3716085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0517339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.0512679006 19225113 17294898 17368321 17339181 17301526 17649720 19029980 17506722 16935935 19075265 16140955 17712046 16766008 16891316 19035177 16823087 19642359 9834237 17217047 16788101 15748426 17361223 17107899 16331271
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6416248980 18397230
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms Arsenic 2.7216368122
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.343712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.3417085340 16842330
MESH:D008171 Lung Diseases Mustard Gas 7.9218161513 18702808
MESH:D008171 Lung Diseases Ozone 7.9219066396 8266340
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Arsenic 5.0517306315 17976673 19168569
MESH:D008175 Lung Neoplasms Doxorubicin 5.0517418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 5.053148597 8781369
MESH:D008175 Lung Neoplasms Ozone 5.057614698 8597069
MESH:D008223 Lymphoma Doxorubicin 3.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4111807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Doxorubicin 3.5016827129
MESH:D008545 Melanoma Tretinoin 3.5016752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Atrazine 6.721916698
MESH:D008654 Mesothelioma Doxorubicin 6.7217638057
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6415792986
MESH:D052016 Mucositis Doxorubicin 4.9817415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0019429709 15857846
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.013581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0118259882
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009401 Nephrosis Doxorubicin 4.9416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1215640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 10.2211399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.229125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.696679447
MESH:D009436 Neural Tube Defects Arsenic 12.6916620997
MESH:D009436 Neural Tube Defects Tretinoin 12.699142499
MESH:D009447 Neuroblastoma Doxorubicin 3.3315555623
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009503 Neutropenia Mustard Gas 4.1216761898 7688884
OMIM:162830 NEUTROPHILIA, HEREDITARY marker/mechanism
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D012516 Osteosarcoma Doxorubicin 4.2315930896
MESH:D010051 Ovarian Neoplasms Arsenic 8.1517306315
MESH:D010051 Ovarian Neoplasms Estradiol 8.1519401270
MESH:D010051 Ovarian Neoplasms Tretinoin 8.1516936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3717638057
MESH:D011014 Pneumonia Ozone 4.5918929643 18007984 18381685
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6216140617
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6215749863 16868541 16888761 18437689 16729912 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.6216740699
MESH:D011507 Proteinuria Arsenic 9.7821343184
MESH:D011507 Proteinuria Tretinoin 9.7816636307
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717720292 17266442 17620002 17894541 10334151
MESH:D051437 Renal Insufficiency Doxorubicin 4.4017922066
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012509 Sarcoma Doxorubicin 4.1215675481 17203757 17710206 16767912 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9817846226
MESH:D012871 Skin Diseases Arsenic 5.2517453740 16759981 17938729 16702368 19834688 6392382 18709164 16353154 17050553 17548696 15952646
MESH:D012871 Skin Diseases Mustard Gas 5.2515451306 16961503 12880345
MESH:D012878 Skin Neoplasms Arsenic 9.9515504454 17029826 19538983 16251483 17976673 17050553
MESH:D012878 Skin Neoplasms Doxorubicin 9.9515692506
MESH:D012878 Skin Neoplasms Tretinoin 9.9516467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7417203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.646582329 6587162 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.6416010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 12.6417045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.718074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7117976673 19322015 19429237 11144890 18640142 15987713 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.7117653716
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4016364871 17678736 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
KEGG:04630 Jak-STAT signaling pathway
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26942
    • No data
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA446357Neoplasms, Second Primary
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443796Coronary Artery Disease
    PA445019Myocardial Infarction
    Releated drug ID Related drug Name
    PA449552etoposide
    PA130620649granulocyte colony-stimulating factor
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00019 agonist Pegfilgrastim Immunomodulatory Agents;Anti-Infective Agents;Antineutropenic Agents
    DB00099 - Filgrastim Immunomodulatory Agents;Anti-Infective Agents;Antineutropenic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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