AutismKB 2.0

Annotation Detail for E2F7


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Basic Information Top
Gene Symbol:E2F7 ( FLJ12981 )
Gene Full Name: E2F transcription factor 7
Band: 12q21.2
Quick LinksEntrez ID:144455; OMIM: 612046; Uniprot ID:E2F7_HUMAN; ENSEMBL ID: ENSG00000165891; HGNC ID: 23820
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of E2F7 mRNAincreases expression 20713471
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of E2F7 proteinaffects expression 20106945
D000968 Antimycin A Antimycin A results in decreased expression of E2F7 mRNAdecreases expression 19304788
D001151 Arsenic Arsenic results in decreased expression of E2F7 mRNAdecreases expression 19945496
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of E2F7 mRNAincreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of E2F7 mRNAincreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of E2F7 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine affects the expression of E2F7 mRNAaffects expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of E2F7 mRNAincreases expression 20713471
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of E2F7 mRNAdecreases expression 19945496
D012402 Rotenone Rotenone results in decreased expression of E2F7 mRNAdecreases expression 19304788
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of E2F7 mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.136695378
MESH:D000236 Adenoma Methylcholanthrene 7.136695378 10545420
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9018414634 16835338 16251483 12569548
MESH:D050197 Atherosclerosis Arsenic 7.2212928151 19371607
MESH:D050197 Atherosclerosis Methylcholanthrene 7.2211922910
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0811921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0820146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0817474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516050911 15673190 16097048 18705752 16124888 15721981 3786805 15700767 10355542 16227642 16192424 16011737
MESH:D002277 Carcinoma Methylcholanthrene 4.0810545420
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7818788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8318922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8320419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4318022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9612371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.9616192471
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 11.9619716837
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0719336974 15027814 7120509 3732212 3786805 6623471 7440962 7179309 2869522 11566570 10915739 15998439 19085960 6884620 15968718 4309450 16227642 17522070 21278145 10092053 9327722 16177239
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1861145 16045604 12795759 16239168 15959796 17595544 12631006 19224547
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1310962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2618705752
MESH:D005355 Fibrosis Cyclosporine 9.2612639820 12168785
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 5.4616076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.4610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816221502 11408273 17174718 11903743 17334410 16943688 16239168 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518187930 15673190 18339082 17481882 17900296 18210741 16033810 14716496 15893842 17708605 12586293 18472094 12741479 14512876 17976157 15370692 15057751 12666154 17565644 17823541 18395095 18472332 15052691 17698563 18317297 17761835 17631135 12389079 16011737 15818738 18166357 12632514 12632512 18006644 18705752 12649538 14716833 14620537 12609069 15925388 18481824 18277467 18205269 17805973 15362042 15338365 18263696 16136751 16116963 17869086 17766677 18054572 17944888 14748882 15996030 12445418 16097048 16015684 16638106 15730626 12958196 16248980 11481614 18156304 15959796 18376398 13678700 17721639 18420326 16027843 15650968 18279442 20821823 15876570 16192424 12445421 15123356 12546737 15931870 12898905 14724832 17714472 17922224 17640975 12667390 10355542 18395914 17525996 18418968 18251166 18429990 18412020 17557913
MESH:D008107 Liver Diseases Arsenic 4.3411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3416964402 15720792 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.142125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Arsenic 11.1416368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1419294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.468603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.46598648 1399818
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0214755239
MESH:D008175 Lung Neoplasms Arsenic 5.0217976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0220135361 20464547 18520028 17053015 20064080 18569708 20869020 18816296 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.0210545420 6695378 11893704 17909032 1399818 21163286 16337739 20512841 20970405 9230183 16271038 7750092 15390079
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6611921183
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.9915790535 18619942 17356569
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010300 Parkinson Disease Rotenone 3.0216140633 18191903 15451049 19232380 11445065 16412576 19114014 18619942 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 4.2118197244 15795934 15574749 15927086
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 6392382 15371236
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Arsenic 3.2716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2717292933
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012871 Skin Diseases Arsenic 5.4919834688 16702368 18709164 15952646 6392382 17050553 17453740 16759981 17548696 16353154 17938729
MESH:D012871 Skin Diseases monomethylarsonous acid 5.4917431481
MESH:D012878 Skin Neoplasms Arsenic 6.0315504454 17029826 19538983 17976673 17050553 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0319755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7819322015 15987713 11144890 17976673 19429237 17306315 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7817053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.7820375083
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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