AutismKB 2.0

Annotation Detail for MIPOL1


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Basic Information Top
Gene Symbol:MIPOL1 ( DKFZp313M2036,MGC34010 )
Gene Full Name: mirror-image polydactyly 1
Band: 14q13.3-q21.1
Quick LinksEntrez ID:145282; OMIM: 606850; Uniprot ID:MIPO1_HUMAN; ENSEMBL ID: ENSG00000151338; HGNC ID: 21460
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Mirror-image polydactyly
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MIPOL1 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MIPOL1 mRNAaffects expression 17484886
D003010 Clorgyline Clorgyline results in increased expression of MIPOL1 mRNAincreases expression 19691856
D006918 Hydroxyurea Hydroxyurea results in increased mutagenesis of MIPOL1 geneincreases mutagenesis 16868089
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of MIPOL1 geneincreases mutagenesis 16868089
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.9020127859 20464547
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.9015113128 15688392
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4020146248 17474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.4016253758 11306469 14633655
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616227642 3786805 15673190 16011737 15721981 10355542 15700767 16192424 16124888 18705752 16050911 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Methylnitrosourea 4.1712484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 4.037505956 2727394
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1115968718 15998439 4309450 11566570 16177239 3732212 17522070 7120509 19085960 10915739 21278145 15027814 2869522 6623471 16227642 10092053 7440962 7179309 9327722 6884620 19336974 3786805
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5417595544 12795759 61145 12631006 19224547 15959796 16239168 16045604
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.7711555667
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D005910 Glioma Methylnitrosourea 3.679825942
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male Methylnitrosourea 4.027193160
MESH:C535689 Laurin-Sandrow syndrome marker/mechanism
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.3816532439
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4515526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9817174718 11408273 16239168 21278145 11903743 17157831 16221502 17334410 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517976157 14748882 18339082 18472094 18187930 17714472 18279442 15338365 15362042 12649538 16011737 16136751 12586293 18251166 11481614 14716496 20821823 14620537 12741479 17481882 17721639 12389079 12445421 18420326 16027843 14716833 15996030 17805973 12958196 18277467 15730626 17698563 10355542 17869086 17640975 17761835 18418968 16097048 12667390 12632514 18205269 16638106 13678700 16015684 15876570 18395914 17557913 17708605 16116963 15925388 14724832 17823541 15650968 18376398 15052691 14512876 12546737 16248980 17565644 17900296 18429990 18412020 12632512 12609069 16192424 18395095 17631135 15370692 15673190 16033810 18263696 12666154 18317297 12898905 17525996 15818738 15123356 18006644 15893842 15931870 18156304 18472332 15959796 17922224 17766677 18210741 18166357 18054572 17944888 12445418 18705752 18481824 15057751
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 16964402 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8819294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.9516080182
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.8020464547 17053015 18816296 20064080 6695378 20135361 18569708 18520028 20869020
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.8018062963
MESH:D008223 Lymphoma Methylnitrosourea 4.2616257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.1714633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.7914633655 11751437 16944150 10767621 19196723 15313902 12931682 11807958 16051031 15113128 17020996 16619500 15688392 14999141 10838139 17131329 16827153
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009369 Neoplasms Benzo(a)pyrene 5.8311141357
MESH:D009369 Neoplasms Methylnitrosourea 5.8315533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.9512696579
MESH:D009442 Neurilemmoma Methylnitrosourea 6.0311555667
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4616965848
MESH:D017689 Polydactyly marker/mechanism 11954550
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7417292933
MESH:D011471 Prostatic Neoplasms Clorgyline 2.7419691856
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.7415682402 12376480
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.6718155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 6.0311555667
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.742093021 20155912
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7418593901 16257854 15930296
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.7711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.197505956 3078959
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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