AutismKB 2.0

Annotation Detail for LYSMD4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LYSMD4 ( FLJ33008,MGC99501 )
Gene Full Name: LysM, putative peptidoglycan-binding, domain containing 4
Band: 15q26.3
Quick LinksEntrez ID:145748; OMIM: NA; Uniprot ID:LYSM4_HUMAN; ENSEMBL ID: ENSG00000183060; HGNC ID: 26571
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LYSMD4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LYSMD4 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of LYSMD4 mRNAincreases expression 20106945
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LYSMD4 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000419 Albuminuria Raloxifene 4.9817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001930 Brain Injuries Raloxifene 4.8916580743
MESH:D001943 Breast Neoplasms Raloxifene 1.8817952589 17440819 15758505 16837676 17893378 17595753 16912660 17242785 15572757 17049068 17261762 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 1.8819410462 16202921 16818667 19011961 17440819 20544844 16873071 18629630 21138602 19155303 17049068 18855134 18815881 19289846 19066611 15668708 18425577 15565566 17242785 18351453 20859285 20135344 19288272 19084267 17261762 11161223 19487384 19142967 19200415 19115204 19059307 19189212 18984771 20065188 16273361 19103187 19244106 19221464 17893378 20390343 21152245 18997820 18821012 19189210 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7721507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7716924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.5317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.5317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6515775269
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 15668235 8697196 16354765 12621046
MESH:D003072 Cognition Disorders Raloxifene 5.0415800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4517474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Raloxifene 10.0017308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.0019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8112705907 12594235 12958197 2444490 16081117 15619225 15968718 18713872 14725611 10915739 14986274 17562736 11834606 19420014 11461765 11743745 18071297 11287661 19416960 16393943 10774834 12540782 19085960 10663392 19739265 14550746 17522070 17906064 11421492 16485898 16227642 12392966 16177239 12153990 16781746 11529661 16109766 19370779 11739529 19164858 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Raloxifene 7.9515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.5415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.5419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2420544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 15.1319224547
MESH:D005234 Fatty Liver Raloxifene 15.1317473493
MESH:D005234 Fatty Liver Tamoxifen 15.1314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 9.9112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.7411110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 9.1710903974
MESH:D006973 Hypertension Raloxifene 9.1717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.1718850075 18670907
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.2012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2018625569
MESH:D007889 Leiomyoma Raloxifene 4.8516973256
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 19784758 19014921 12587719 19460945 16610002 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9915890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Tamoxifen 7.9916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.428603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5414755239
MESH:D008175 Lung Neoplasms Tamoxifen 3.5418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8116827153 19196723 14580682 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6516497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009232 Myxoma Raloxifene 6.0816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010024 Osteoporosis Raloxifene 3.5719059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5817823083 17893378 15758505 15579764
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3016220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3015067354
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011693 Purpura Raloxifene 6.0815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D020521 Stroke Raloxifene 4.0816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013978 Tibial Fractures Raloxifene 5.7319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5717572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.7316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved